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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diallyl disulfide
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Accession:CHEBI:4488 term browser browse the term
Definition:An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Synonyms:exact_synonym: 3-(prop-2-en-1-yldisulfanyl)prop-1-ene
 related_synonym: 2-propenyl disulphide;   3,3'-disulfanediylbis(prop-1-ene);   3,3'-dithiobis(prop-1-ene);   3-(allyldisulfanyl)-1-propene;   4,5-dithia-1,7-octadiene;   Formula=C6H10S2;   InChI=1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2;   InChIKey=PFRGXCVKLLPLIP-UHFFFAOYSA-N;   SMILES=C=CCSSCC=C;   allyl disulfide;   diallyl disulphide
 xref: Beilstein:1699241;   CAS:2179-57-9;   Gmelin:217847;   HMDB:HMDB0033966;   KEGG:C08369;   KNApSAcK:C00001243
 xref_mesh: MESH:C028009
 xref: PMID:11375895;   PMID:16462049;   PMID:17534841;   Reaxys:1699241;   Wikipedia:Diallyl_disulfide


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diallyl disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO diallyl disulfide results in increased expression of ABCB1 mRNA CTD PMID:22397993 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of ABCC1 mRNA
diallyl disulfide results in increased expression of ABCC1 mRNA
CTD PMID:22397993 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
affects expression
ISO diallyl disulfide results in increased expression of ABCC3 mRNA
diallyl disulfide affects the expression of ABCC3 mRNA
CTD PMID:22397993 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
decreases expression
ISO diallyl disulfide results in increased expression of ABCC4 mRNA
diallyl disulfide results in decreased expression of ABCC4 mRNA
CTD PMID:22397993 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of ABCC6 mRNA
diallyl disulfide results in increased expression of ABCC6 mRNA
CTD PMID:22397993 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of AKT1 protein CTD PMID:23663050 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO diallyl disulfide results in increased expression of ATF3 protein CTD PMID:15897233 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO diallyl disulfide results in increased expression of BAX mRNA; diallyl disulfide results in increased expression of BAX protein CTD PMID:17647244 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP
ISO
diallyl disulfide results in decreased expression of BCL2 protein
diallyl disulfide results in decreased expression of BCL2 mRNA; diallyl disulfide results in decreased expression of BCL2 protein
CTD PMID:14522920, PMID:16052692, PMID:17647244, PMID:30677442 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO diallyl disulfide results in decreased expression of BDNF protein CTD PMID:23732363 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO diallyl disulfide results in decreased expression of BIRC3 protein CTD PMID:17647244 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO diallyl disulfide results in decreased expression of BIRC5 protein CTD PMID:17647244 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO diallyl disulfide results in increased activity of CASP3 protein
diallyl disulfide results in increased cleavage of CASP3 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
CTD PMID:14522920, PMID:17647244, PMID:30677442 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases activity ISO diallyl disulfide results in increased activity of CASP4 protein CTD PMID:17647244 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]
diallyl disulfide results in increased cleavage of CASP8 protein
CTD PMID:30677442 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
ISO diallyl disulfide results in increased activity of CASP9 protein
diallyl disulfide results in increased cleavage of CASP9 protein
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]
CTD PMID:14522920, PMID:17647244, PMID:30677442 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cast calpastatin decreases expression ISO diallyl disulfide results in decreased expression of CAST mRNA; diallyl disulfide results in decreased expression of CAST protein CTD PMID:17647244 NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
JBrowse link
G Cat catalase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:24293383 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein] CTD PMID:20229525 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO diallyl disulfide results in decreased expression of CCNB1 protein
diallyl disulfide results in increased expression of CCNB1 protein
CTD PMID:16691315, PMID:19202565 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnc cyclin C multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CCNC mRNA CTD PMID:31077537 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO diallyl disulfide results in decreased expression of CDH1 mRNA; diallyl disulfide results in decreased expression of CDH1 protein CTD PMID:20600798 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdhr1 cadherin-related family member 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDHR1 mRNA CTD PMID:31077537 NCBI chr16:14,328,161...14,348,049
Ensembl chr16:14,328,160...14,348,046
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO diallyl disulfide results in decreased expression of CDK1 protein CTD PMID:16691315 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKAL1 mRNA CTD PMID:31077537 NCBI chr17:36,451,031...37,157,882
Ensembl chr17:36,451,058...37,295,069
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKN2B mRNA CTD PMID:31077537 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cldn2 claudin 2 decreases expression ISO diallyl disulfide results in decreased expression of CLDN2 mRNA; diallyl disulfide results in decreased expression of CLDN2 protein CTD PMID:20600798 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cldn3 claudin 3 decreases expression ISO diallyl disulfide results in decreased expression of CLDN3 mRNA; diallyl disulfide results in decreased expression of CLDN3 protein CTD PMID:20600798 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Cldn4 claudin 4 decreases expression ISO diallyl disulfide results in decreased expression of CLDN4 mRNA; diallyl disulfide results in decreased expression of CLDN4 protein CTD PMID:20600798 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cldn5 claudin 5 decreases expression ISO diallyl disulfide results in decreased expression of CLDN5 mRNA; diallyl disulfide results in decreased expression of CLDN5 protein CTD PMID:20600798 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO diallyl disulfide results in decreased expression of CREB1 protein modified form CTD PMID:23732363 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases phosphorylation
ISO diallyl disulfide results in increased expression of CTNNB1 mRNA; diallyl disulfide results in increased expression of CTNNB1 protein
diallyl disulfide results in decreased phosphorylation of CTNNB1 protein
CTD PMID:20600798, PMID:23663050 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
EXP
ISO
diallyl disulfide results in increased expression of CYP1A1 protein
diallyl disulfide results in decreased activity of CYP1A1 protein
CTD PMID:16000231, PMID:18339364 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP diallyl disulfide results in increased expression of CYP1A2 protein CTD PMID:16000231 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO diallyl disulfide results in increased expression of CYP2B1 mRNA; diallyl disulfide results in increased expression of CYP2B2 mRNA CTD PMID:17353348 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
decreases activity
ISO
EXP
diallyl disulfide results in decreased expression of CYP2E1 protein
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
diallyl disulfide results in decreased activity of CYP2E1 protein
[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene
CTD PMID:10774820, PMID:16000231, PMID:18339364, PMID:19325051, PMID:24293383 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP diallyl disulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dbr1 debranching RNA lariats 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of DBR1 mRNA CTD PMID:31077537 NCBI chr 8:107,826,690...107,838,186
Ensembl chr 8:107,826,424...107,838,339
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases localization ISO diallyl disulfide results in decreased localization of DIABLO protein CTD PMID:17647244 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dus2 dihydrouridine synthase 2 decreases expression
multiple interactions
EXP diallyl disulfide results in decreased expression of DUS2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of DUS2 mRNA
CTD PMID:31077537 NCBI chr19:37,990,374...38,033,590
Ensembl chr19:37,990,374...38,033,590
JBrowse link
G Exo1 exonuclease 1 increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of EXO1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of EXO1 mRNA
CTD PMID:31077537 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of FOSL1 mRNA CTD PMID:31077537 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:24293383 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO diallyl disulfide results in increased expression of GDF15 protein
TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]
CTD PMID:11925476 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24293383 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grb2 growth factor receptor bound protein 2 affects expression
decreases expression
ISO diallyl disulfide affects the expression of GRB2 protein
diallyl disulfide results in decreased expression of GRB2 protein
CTD PMID:21695758 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Grhl1 grainyhead-like transcription factor 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of GRHL1 mRNA CTD PMID:31077537 NCBI chr 6:43,734,837...43,795,757
Ensembl chr 6:43,743,702...43,794,342
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of GSK3B protein CTD PMID:23663050 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] CTD PMID:24293383 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of HES1 mRNA CTD PMID:31077537 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Carbon Tetrachloride co-treated with diallyl disulfide] results in increased expression of HMOX1 protein; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA] CTD PMID:24293383 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of HSPA1A mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNA
CTD PMID:31077537 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression
multiple interactions
EXP diallyl disulfide results in decreased expression of HSPH1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPH1 mRNA
CTD PMID:31077537 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of ID1 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID1 mRNA
CTD PMID:31077537 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions
increases expression
EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID2 mRNA
diallyl disulfide results in increased expression of ID2 mRNA
CTD PMID:31077537 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID3 mRNA CTD PMID:31077537 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of ITGB1BP1 mRNA CTD PMID:31077537 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO diallyl disulfide results in increased phosphorylation of JUN protein CTD PMID:14522920 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO diallyl disulfide results in increased expression of KIT protein CTD PMID:23663050 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klf2 Kruppel-like factor 2 increases expression
multiple interactions
EXP diallyl disulfide results in increased expression of KLF2 mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of KLF2 mRNA
CTD PMID:31077537 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Malsu1 mitochondrial assembly of ribosomal large subunit 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MALSU1 mRNA CTD PMID:31077537 NCBI chr 4:78,735,279...78,744,102
Ensembl chr 4:78,735,279...78,744,102
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 affects expression ISO diallyl disulfide affects the expression of MAP2K7 protein CTD PMID:21695758 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 affects expression ISO diallyl disulfide affects the expression of MAP3K3 protein CTD PMID:21695758 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases expression
multiple interactions
EXP
ISO
diallyl disulfide results in increased phosphorylation of MAPK1 protein
diallyl disulfide results in decreased expression of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK1 protein]
CTD PMID:17263507, PMID:21695758 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases expression
multiple interactions
EXP
ISO
diallyl disulfide results in increased phosphorylation of MAPK3 protein
diallyl disulfide results in decreased expression of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK3 protein]
CTD PMID:17263507, PMID:21695758 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO diallyl disulfide results in increased phosphorylation of MAPK8 protein
diallyl disulfide results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD PMID:14522920, PMID:17647244 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO diallyl disulfide results in decreased expression of and results in decreased activity of MMP2 protein
diallyl disulfide results in decreased expression of MMP2 mRNA; diallyl disulfide results in decreased expression of MMP2 protein
CTD PMID:20600798, PMID:21695758 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO diallyl disulfide results in decreased expression of MMP7 protein CTD PMID:21695758 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
decreases expression
ISO diallyl disulfide results in decreased expression of and results in decreased activity of MMP9 protein
diallyl disulfide affects the expression of MMP9 protein
diallyl disulfide results in decreased expression of MMP9 mRNA
CTD PMID:20600798, PMID:21695758 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MOGS mRNA CTD PMID:31077537 NCBI chr 4:113,948,328...113,951,731
Ensembl chr 4:113,948,514...113,951,847
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein] CTD PMID:24293383 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
increases expression
multiple interactions
ISO
EXP
diallyl disulfide results in increased phosphorylation of NFKBIA protein
diallyl disulfide results in increased expression of NFKBIA mRNA
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of NFKBIA mRNA
CTD PMID:23663050, PMID:31077537 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO diallyl disulfide affects the expression of NOS2 protein CTD PMID:21695758 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
increases phosphorylation
decreases degradation
ISO diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]
diallyl disulfide results in increased expression of NOS3 protein
diallyl disulfide results in decreased degradation of NOS3 protein
CTD PMID:20229525 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
EXP diallyl disulfide results in increased activity of NQO1 protein
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]
CTD PMID:8339252, PMID:24293383 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:30677442 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PMP22 mRNA CTD PMID:31077537 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA CTD PMID:31077537 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression ISO diallyl disulfide affects the expression of PTGS2 protein CTD PMID:21695758 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SESN2 mRNA CTD PMID:31077537 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sfn stratifin multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SFN mRNA CTD PMID:31077537 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO diallyl disulfide results in decreased expression of SNAI1 mRNA; diallyl disulfide results in decreased expression of SNAI1 protein CTD PMID:20600798 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA] CTD PMID:24293383 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Stag1 stromal antigen 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of STAG1 mRNA CTD PMID:31077537 NCBI chr 8:108,958,099...109,342,738
Ensembl chr 8:108,958,046...109,342,738
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SUMO1 mRNA CTD PMID:31077537 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Tfdp2 transcription factor Dp-2 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TFDP2 mRNA CTD PMID:31077537 NCBI chr 8:104,040,795...104,181,228
Ensembl chr 8:104,040,934...104,176,446
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO diallyl disulfide results in increased expression of TIMP1 mRNA CTD PMID:20600798 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO diallyl disulfide results in increased expression of TIMP2 mRNA CTD PMID:20600798 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:30677442 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein]
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TP53 mRNA
CTD PMID:11925476, PMID:19202565, PMID:31077537 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsg101 tumor susceptibility 101 multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TSG101 mRNA CTD PMID:31077537 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H multiple interactions EXP [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of UBE2H mRNA CTD PMID:31077537 NCBI chr 4:57,511,418...57,625,147
Ensembl chr 4:57,511,418...57,625,257
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity EXP diallyl disulfide results in increased activity of UGT1A1 protein CTD PMID:8339252 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO diallyl disulfide results in decreased expression of XIAP protein CTD PMID:17647244 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antifungal agent 14907
            diallyl disulfide 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organosulfur compound 15223
                                  organic disulfide 749
                                    diallyl disulfide 95
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.