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Accession:CHEBI:45735 term browser browse the term
Definition:A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.
Synonyms:exact_synonym: (3R,5R,6S,7R,8R,11R,12S,13R,14S,15S)-12-[(4-O-acetyl-2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-{[2-O-acetyl-3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-6-yl acetate
 related_synonym: Formula=C41H67NO15;   InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41+/m0/s1;   InChIKey=LQCLVBQBTUVCEQ-QTFUVMRISA-N;   Oleandocetine;   Oleandomycin triacetate;   Oleandomycin triacetyl ester;   SMILES=CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(C)=O;   Triacetyloleandomycin;   Triacetyloleandomycinum;   Tribiocillina;   Triocetin;   troleandomicina;   troleandomycine;   troleandomycinum
 alt_id: CHEBI:32267
 xref: CAS:2751-09-9 "ChemIDplus";   CAS:2751-09-9 "KEGG COMPOUND";   DrugBank:DB01361;   Drug_Central:2769 "DrugCentral";   HMDB:HMDB0015448;   KEGG:C12753;   KEGG:D01322;   LINCS:LSM-5510;   LIPID_MAPS_instance:LMPK04000042 "LIPID MAPS"
 xref_mesh: MESH:D014217
 xref: PDBeChem:TAO;   PMID:24335510 "Europe PMC";   PMID:24479850 "Europe PMC";   PMID:24889073 "Europe PMC";   PMID:24985121 "Europe PMC";   PMID:25392348 "Europe PMC";   PMID:25870103 "Europe PMC";   Reaxys:77547 "Reaxys";   Wikipedia:Troleandomycin

show annotations for term's descendants       view all columns           Sort by:
troleandomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 JBrowse link 7 12,918,352 12,922,509 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        xenobiotic 18322
          troleandomycin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic ester 13967
                                        lactone 5864
                                          macrocyclic lactone 1518
                                            macrolide 1457
                                              oleandomycins 8
                                                oleandomycin 8
                                                  troleandomycin 8
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.