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ONTOLOGY REPORT - ANNOTATIONS


Term:tacrine
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Accession:CHEBI:45980 term browser browse the term
Definition:A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Synonyms:related_synonym: 1,2,3,4-tetrahydro-9-acridinamine;   1,2,3,4-tetrahydro-9-aminoacridine;   1,2,3,4-tetrahydroacridin-9-amine;   5-amino-6,7,8,9-tetrahydroacridine;   9-amino-1,2,3,4-tetrahydroacridine;   Formula=C13H14N2;   InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15);   InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N;   SMILES=Nc1c2CCCCc2nc2ccccc12;   tetrahydroaminacrine
 alt_id: CHEBI:45978;   CHEBI:9389
 xref: Beilstein:147610 "Beilstein";   CAS:321-64-2 "ChemIDplus";   CAS:321-64-2 "KEGG COMPOUND";   CAS:321-64-2 "NIST Chemistry WebBook";   DrugBank:DB00382;   Drug_Central:2551 "DrugCentral";   KEGG:C01453;   KEGG:D08555;   LINCS:LSM-5871
 xref_mesh: MESH:D013619
 xref: PDBeChem:THA;   PMID:10817586 "Europe PMC";   PMID:24560791 "Europe PMC";   PMID:7866482 "Europe PMC";   Reaxys:147610 "Reaxys";   Wikipedia:Tacrine


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tacrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Adcyap1r1 ADCYAP receptor type I JBrowse link 4 85,662,809 85,711,696 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Chat choline O-acetyltransferase JBrowse link 16 8,576,858 8,686,131 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6480464
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:6480464
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:6480464
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:6480464
G Cspp1 centrosome and spindle pole associated protein 1 JBrowse link 5 8,761,293 8,876,205 RGD:6480464
G Cwf19l2 CWF19 like cell cycle control factor 2 JBrowse link 6 18,970,616 19,037,176 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dlg2 discs large MAGUK scaffold protein 2 JBrowse link 1 154,916,274 157,274,077 RGD:6480464
G Dnah8 dynein, axonemal, heavy chain 8 JBrowse link 20 9,301,317 9,560,805 RGD:6480464
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 JBrowse link 19 740,007 762,897 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 JBrowse link 14 39,154,072 39,230,994 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Ibsp integrin-binding sialoprotein JBrowse link 14 6,801,200 6,813,987 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnn2 potassium calcium-activated channel subfamily N member 2 JBrowse link 18 39,331,894 39,479,574 RGD:6480464
G Klk1c9 kallikrein 1-related peptidase C9 JBrowse link 1 100,086,520 100,090,406 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Mybpc1 myosin binding protein C1 JBrowse link 7 29,086,159 29,171,909 RGD:6480464
G Neurod1 neuronal differentiation 1 JBrowse link 3 66,414,314 66,417,617 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Npy5r neuropeptide Y receptor Y5 JBrowse link 16 24,796,685 24,805,730 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 JBrowse link 17 32,131,847 32,158,559 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Scn1a sodium voltage-gated channel alpha subunit 1 JBrowse link 3 52,388,811 52,533,365 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Slc6a1 solute carrier family 6 member 1 JBrowse link 4 146,258,842 146,292,176 RGD:6480464
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480464
G Syn2 synapsin II JBrowse link 4 147,037,179 147,195,096 RGD:6480464
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        refrigerant 17093
          ammonia 16691
            organic amino compound 16690
              aromatic amine 13592
                tacrine 57
                  bis(7)-tacrine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heterotricyclic compound 13728
                                      dibenzopyridine 145
                                        acridines 112
                                          tacrine 57
                                            bis(7)-tacrine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.