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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-fluorouracil
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Accession:CHEBI:46345 term browser browse the term
Definition:A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Synonyms:exact_synonym: 5-fluoropyrimidine-2,4(1H,3H)-dione
 related_synonym: 5-FU;   5-Fluoracil;   5-Fluoropyrimidine-2,4-dione;   Formula=C4H3FN2O2;   InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9);   InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N;   SMILES=Fc1c[nH]c(=O)[nH]c1=O;   fluorouracil;   fluorouracilo;   fluorouracilum
 alt_id: CHEBI:2054;   CHEBI:46343
 xref: Beilstein:127172;   CAS:51-21-8;   DrugBank:DB00544;   Drug_Central:26;   HMDB:HMDB0014684;   KEGG:C07649;   KEGG:D00584;   LINCS:LSM-4261
 xref_mesh: MESH:D005472
 xref: PDBeChem:URF;   PMID:11356943;   PMID:12520460;   PMID:14769231;   PMID:19023200;   Reaxys:127172;   Wikipedia:Fluorouracil


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5-fluorouracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of AARS1 mRNA] CTD PMID:15016801 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases expression
ISO [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Fluorouracil; ABCB1 gene SNP affects the susceptibility to [Cisplatin co-treated with Fluorouracil]; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
Fluorouracil results in increased expression of ABCB1 protein
Fluorouracil results in decreased expression of ABCB1 mRNA
CTD PMID:12576456, PMID:15239124, PMID:17287894, PMID:21332314, PMID:21833476 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression ISO Fluorouracil results in decreased expression of ABCB6 mRNA CTD PMID:20737486 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:12576456 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance ISO ABCC2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 decreases response to substance
multiple interactions
ISO ABCC5 protein results in decreased susceptibility to Fluorouracil
5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; ABCC5 protein results in increased export of and results in decreased susceptibility to Fluorouracil
CTD PMID:15897250, PMID:19077464 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects response to substance
increases expression
ISO ABCC6 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of ABCC6 protein
CTD PMID:15352031 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Fluorouracil; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Fluorouracil; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; ABCG2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] CTD PMID:12576456, PMID:21712253, PMID:21833476 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd12b abhydrolase domain containing 12B decreases expression ISO Fluorouracil results in decreased expression of ABHD12B mRNA CTD PMID:24737281 NCBI chr 6:92,568,975...92,596,327
Ensembl chr 6:92,568,975...92,596,327
JBrowse link
G Abi1 abl-interactor 1 increases expression ISO Fluorouracil results in increased expression of ABI1 mRNA CTD PMID:19272435 NCBI chr17:89,951,662...90,033,334
Ensembl chr17:89,951,752...90,033,328
JBrowse link
G Abi2 abl-interactor 2 decreases expression ISO Fluorouracil results in decreased expression of ABI2 mRNA CTD PMID:19272435 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression ISO Fluorouracil results in increased expression of ACADL protein CTD PMID:15585135, PMID:16803524 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ACKR3 mRNA] CTD PMID:15016801 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acot13 acyl-CoA thioesterase 13 affects response to substance ISO ACOT13 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:42,241,141...42,253,611
Ensembl chr17:42,241,159...42,253,649
JBrowse link
G Acot7 acyl-CoA thioesterase 7 affects response to substance ISO ACOT7 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 5:169,357,582...169,450,215
Ensembl chr 5:169,357,517...169,450,219
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of SAH mRNA] CTD PMID:15016801 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224
JBrowse link
G Actb actin, beta decreases expression ISO Fluorouracil results in decreased expression of ACTB protein CTD PMID:21296659 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 decreases expression ISO Fluorouracil results in decreased expression of ACTC1 protein CTD PMID:21296659 NCBI chr 3:105,507,403...105,512,939
Ensembl chr 3:105,507,403...105,512,939
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression ISO Fluorouracil results in decreased expression of ACTG2 mRNA CTD PMID:16709241 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Acy1 aminoacylase 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ACY1 mRNA] CTD PMID:15016801 NCBI chr 8:115,134,792...115,140,171
Ensembl chr 8:115,134,765...115,140,080
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAM10 mRNA] CTD PMID:15016801 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam3a ADAM metallopeptidase domain 3A multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAM3A mRNA] CTD PMID:15016801 NCBI chr16:72,086,878...72,136,685
Ensembl chr16:72,086,878...72,136,687
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAMTS9 mRNA] CTD PMID:15016801 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO Fluorouracil results in decreased expression of ADCY9 mRNA CTD PMID:19219653 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Add3 adducin 3 affects response to substance ISO ADD3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 affects response to substance ISO ADGRG1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr19:10,423,534...10,460,674
Ensembl chr19:10,423,501...10,460,674
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects response to substance ISO ADGRG6 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:8,593,342...8,751,540
Ensembl chr 1:8,593,075...8,751,198
JBrowse link
G Adgrl2 adhesion G protein-coupled receptor L2 affects response to substance ISO ADGRL2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 2:258,792,838...258,997,145
Ensembl chr 2:258,792,839...258,997,145
JBrowse link
G Adm adrenomedullin affects response to substance ISO ADM protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adss adenylosuccinate synthase decreases expression
increases expression
ISO Fluorouracil results in decreased expression of ADSS2 mRNA
Fluorouracil results in increased expression of ADSS2 protein
CTD PMID:15585135, PMID:16709241, PMID:16803524 NCBI chr13:95,913,426...95,943,761
Ensembl chr13:95,913,426...95,943,761
JBrowse link
G Afp alpha-fetoprotein increases expression
decreases expression
ISO Fluorouracil results in increased expression of AFP protein
Fluorouracil results in decreased expression of AFP; Fluorouracil results in decreased expression of AFP mRNA
CTD PMID:20448262, PMID:21296659, PMID:26272751 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 decreases expression ISO Fluorouracil results in decreased expression of AGAP3 mRNA CTD PMID:16709241 NCBI chr 4:7,202,330...7,253,386
Ensembl chr 4:7,202,330...7,253,072
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of AGR2 mRNA] CTD PMID:15016801 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Ahnak AHNAK nucleoprotein decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of AHNAK protein
AHNAK protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased expression of AIFM1 protein CTD PMID:16168113 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akap12 A-kinase anchoring protein 12 affects expression ISO Fluorouracil affects the expression of AKAP12 mRNA CTD PMID:16584549 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects expression ISO Fluorouracil affects the expression of AKR1B10 mRNA CTD PMID:16584549 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects response to substance ISO AKR1C2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects expression
affects response to substance
ISO Fluorouracil affects the expression of AKR1C3 mRNA
AKR1C3 protein affects the susceptibility to Fluorouracil
CTD PMID:16217747, PMID:16584549 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
increases phosphorylation
ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein; AG 1879 inhibits the reaction [Fluorouracil results in increased phosphorylation of AKT1 protein]; Fluorouracil results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]
Fluorouracil inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
CTD PMID:16724238, PMID:17918158, PMID:18794807, PMID:19885610, PMID:24095863 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression ISO Fluorouracil results in increased expression of AKT2 protein CTD PMID:16803524 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin multiple interactions ISO [Leucovorin co-treated with Cisplatin co-treated with Fluorouracil] results in decreased expression of ALB protein CTD PMID:20180123 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance
decreases expression
ISO ALCAM protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of ALCAM protein
CTD PMID:15352031 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance ISO ALDH1A1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance
decreases expression
ISO ALDH1A3 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of ALDH1A3 protein
CTD PMID:15352031 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 affects response to substance ISO ALDH3A2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Alg3 ALG3, alpha-1,3- mannosyltransferase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ALG3 mRNA] CTD PMID:15016801 NCBI chr11:83,985,484...83,991,706
Ensembl chr11:83,986,230...83,991,706
JBrowse link
G Alkbh8 alkB homolog 8, tRNA methyltransferase decreases expression ISO Fluorouracil results in decreased expression of ALKBH8 mRNA CTD PMID:16510598 NCBI chr 6:18,877,885...18,952,773
Ensembl chr 6:18,877,907...18,949,393
JBrowse link
G Amfr autocrine motility factor receptor multiple interactions ISO AMFR mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 decreases expression ISO Fluorouracil results in decreased expression of AMPD2 mRNA CTD PMID:19219653 NCBI chr 2:210,861,624...210,874,348
Ensembl chr 2:210,861,625...210,874,304
JBrowse link
G Amt aminomethyltransferase increases expression ISO Fluorouracil results in increased expression of AMT protein CTD PMID:15585135, PMID:16803524 NCBI chr 8:117,068,388...117,078,633
Ensembl chr 8:117,068,582...117,077,913
JBrowse link
G Ang angiogenin affects response to substance ISO ANG protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions
increases expression
ISO ANGPT1 protein promotes the reaction [Fluorouracil results in increased expression of IFNA1 protein]
Fluorouracil results in increased expression of ANGPT1 protein
CTD PMID:17786339 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angpt2 angiopoietin 2 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of ANGPT2 protein
ANGPT2 protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein]
CTD PMID:17786339 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Angptl2 angiopoietin-like 2 multiple interactions ISO ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
JBrowse link
G Angptl4 angiopoietin-like 4 affects response to substance ISO ANGPTL4 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Fluorouracil results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ankrd11 ankyrin repeat domain 11 increases expression
affects expression
ISO Fluorouracil results in increased expression of ANKRD11 mRNA
Fluorouracil affects the expression of ANKRD11 mRNA
CTD PMID:16510598, PMID:16584549 NCBI chr19:55,703,831...55,862,446
Ensembl chr19:55,703,824...55,737,500
JBrowse link
G Ankrd36 ankyrin repeat domain 36 increases expression ISO Fluorouracil results in increased expression of ANKRD36 mRNA CTD PMID:16510598 NCBI chr14:85,814,809...85,931,577 JBrowse link
G Anln anillin, actin binding protein decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of ANLN mRNA
TP53 protein affects the reaction [Fluorouracil results in decreased expression of ANLN mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of ANLN mRNA]
CTD PMID:15016801, PMID:17982676 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ANP32E mRNA] CTD PMID:15016801 NCBI chr 2:198,040,573...198,057,005
Ensembl chr 2:198,040,536...198,057,003
JBrowse link
G Anxa1 annexin A1 affects response to substance
decreases expression
ISO ANXA1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of ANXA1 protein
CTD PMID:15352031, PMID:16217747 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 decreases response to substance
multiple interactions
increases expression
ISO ANXA2 mRNA results in decreased susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in increased expression of ANXA2 mRNA]
CTD PMID:15152939 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa3 annexin A3 increases expression ISO Fluorouracil results in increased expression of ANXA3 mRNA CTD PMID:17039268 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Fluorouracil results in decreased expression of ANXA4 mRNA CTD PMID:15109396 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 multiple interactions ISO [Fluorouracil co-treated with irinotecan] results in decreased expression of AP2S1 mRNA CTD PMID:16391804 NCBI chr 1:78,671,238...78,682,847
Ensembl chr 1:78,671,121...78,682,871
JBrowse link
G Ap3s1 adaptor related protein complex 3 subunit sigma 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of AP3S1 mRNA] CTD PMID:15016801 NCBI chr18:40,732,472...40,798,064
Ensembl chr18:40,732,480...40,797,761
JBrowse link
G Ap4s1 adaptor related protein complex 4 subunit sigma 1 decreases expression ISO Fluorouracil results in decreased expression of AP4S1 mRNA CTD PMID:16510598 NCBI chr 6:72,461,977...72,502,717
Ensembl chr 6:72,461,977...72,503,847
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Fluorouracil results in increased expression of APAF1 mRNA CTD PMID:16557594 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apba2 amyloid beta precursor protein binding family A member 2 affects response to substance ISO APBA2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:125,367,273...125,547,741
Ensembl chr 1:125,367,280...125,548,890
JBrowse link
G Apbb2 amyloid beta precursor protein binding family B member 2 affects response to substance ISO APBB2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr14:43,205,047...43,526,968
Ensembl chr14:43,512,901...43,523,080
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Fluorouracil CTD PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoc1 apolipoprotein C1 affects response to substance ISO APOC1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Fluorouracil CTD PMID:9733774 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Areg amphiregulin affects response to substance
increases expression
ISO AREG affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of AREG mRNA
CTD PMID:15067352, PMID:16709241 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions ISO ARF1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:18927307 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arf3 ADP-ribosylation factor 3 affects response to substance ISO ARF3 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arfgap1 ADP-ribosylation factor GTPase activating protein 1 increases expression ISO Fluorouracil results in increased expression of ARFGAP1 protein CTD PMID:15331170 NCBI chr 3:176,475,847...176,490,642
Ensembl chr 3:176,475,893...176,489,925
JBrowse link
G Arid5b AT-rich interaction domain 5B affects response to substance ISO ARID5B protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr20:21,713,900...21,881,193
Ensembl chr20:21,564,975...21,880,715
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C increases expression ISO Fluorouracil results in increased expression of ARL4C mRNA CTD PMID:16510598 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 multiple interactions ISO ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]; ARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:22452940 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ARMCX1 mRNA] CTD PMID:15016801 NCBI chr  X:105,535,670...105,539,575
Ensembl chr  X:105,537,602...105,539,375
Ensembl chr  X:105,537,602...105,539,375
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO Fluorouracil results in decreased expression of ARPC3 mRNA CTD PMID:16709241 NCBI chr12:39,653,951...39,667,817
Ensembl chr12:39,653,953...39,667,849
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects response to substance
multiple interactions
ISO ASAH1 protein affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in decreased expression of ASAH1 mRNA]
CTD PMID:15016801, PMID:16217747 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Fluorouracil co-treated with irinotecan] results in decreased expression of ASS1 mRNA CTD PMID:16391804 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf3 activating transcription factor 3 affects expression
multiple interactions
increases expression
ISO Fluorouracil affects the expression of ATF3 mRNA
TP53 protein affects the reaction [Fluorouracil results in increased expression of ATF3 mRNA]
Fluorouracil results in increased expression of ATF3 mRNA; Fluorouracil results in increased expression of ATF3 protein
CTD PMID:14665630, PMID:15016801, PMID:15205334, PMID:16557594, PMID:16709241 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Fluorouracil results in increased expression of ATF4 protein CTD PMID:29879413 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg12 autophagy related 12 decreases expression ISO Fluorouracil results in decreased expression of ATG12 mRNA CTD PMID:16510598 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 affects expression ISO Fluorouracil affects the expression of ATOH8 mRNA CTD PMID:16584549 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ATP5F1D mRNA] CTD PMID:15016801 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions ISO ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Atp7b ATPase copper transporting beta increases response to substance ISO ATP7B mRNA results in increased susceptibility to Fluorouracil CTD PMID:18593893 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of ATP9A protein
ATP9A protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 3:165,405,588...165,511,104
Ensembl chr 3:165,412,803...165,477,771
JBrowse link
G Atxn10 ataxin 10 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ATXN10 mRNA] CTD PMID:15016801 NCBI chr 7:126,228,416...126,351,728
Ensembl chr 7:126,228,295...126,351,634
JBrowse link
G Aurka aurora kinase A decreases expression ISO Fluorouracil results in decreased expression of AURKA mRNA CTD PMID:15205334, PMID:16557594, PMID:16709241, PMID:17039268, PMID:19272435 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aven apoptosis and caspase activation inhibitor decreases expression
increases expression
ISO Fluorouracil results in decreased expression of AVEN mRNA
Fluorouracil results in increased expression of AVEN mRNA
CTD PMID:16510598, PMID:16709241 NCBI chr 3:103,980,612...104,117,193
Ensembl chr 3:104,042,168...104,117,192
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD mRNA] CTD PMID:31129132 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag3 BAG cochaperone 3 affects response to substance ISO BAG3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
increases response to substance
ISO Fluorouracil results in increased expression of BAK1; Fluorouracil results in increased expression of BAK1 mRNA; Fluorouracil results in increased expression of BAK1 protein
mithramycin A inhibits the reaction [Fluorouracil results in increased expression of BAK1 protein]
BAK1 mRNA results in increased susceptibility to Fluorouracil
CTD PMID:9792140, PMID:15489892, PMID:16557594, PMID:18593893 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Barx2 BARX homeobox 2 increases expression ISO Fluorouracil results in increased expression of BARX2 protein CTD PMID:15585135, PMID:16803524 NCBI chr 8:32,950,878...33,018,245
Ensembl chr 8:32,950,875...33,017,854
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression
increases response to substance
ISO
EXP
[Docosahexaenoic Acids co-treated with Fluorouracil] results in increased expression of BAX mRNA; [Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA; [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of BAX protein; [SM-1 compound co-treated with Fluorouracil] results in increased expression of BAX protein; [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein; Aspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of BAX mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of BAX mRNA]; Fluorouracil affects the reaction [rebamipide results in decreased expression of BAX protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [Plant Extracts results in increased expression of BAX protein]; IFNA1 protein promotes the reaction [Fluorouracil results in increased expression of BAX mRNA]; rebamipide inhibits the reaction [Fluorouracil results in increased expression of BAX protein]; SM-1 compound promotes the reaction [Fluorouracil results in increased expression of BAX mRNA]
Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]
Fluorouracil results in increased expression of BAX; Fluorouracil results in increased expression of BAX mRNA; Fluorouracil results in increased expression of BAX protein
[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein; IL1RN protein affects the reaction [Fluorouracil results in increased expression of BAX protein]
Fluorouracil results in decreased expression of BAX protein
BAX protein results in increased susceptibility to Fluorouracil
CTD PMID:9388485, PMID:9792140, PMID:11062132, PMID:11750847, PMID:12442003, PMID:15641988, PMID:15754201, PMID:15986848, PMID:16168113, PMID:16686938, PMID:16888818, PMID:17045692, PMID:17056233, PMID:17589894, PMID:18567086, PMID:18834353, PMID:19015929, PMID:19097688, PMID:19116755, PMID:20570612, PMID:20844880, PMID:22525470, PMID:23941782, PMID:25824412, PMID:28599477, PMID:29054700, PMID:31129132, PMID:31587439 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases response to substance
multiple interactions
increases expression
ISO BBC3 protein results in increased susceptibility to Fluorouracil
mithramycin A inhibits the reaction [Fluorouracil results in increased expression of BBC3 protein]; TP53 protein affects the reaction [Fluorouracil results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [Fluorouracil results in increased expression of BBC3 protein]
Fluorouracil results in increased expression of BBC3 mRNA; Fluorouracil results in increased expression of BBC3 protein
CTD PMID:14665630, PMID:15016801, PMID:15489892, PMID:16481741, PMID:16557594, PMID:22525470 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 multiple interactions ISO BBS4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Bbx BBX high mobility group box domain containing affects response to substance ISO BBX protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr11:52,983,286...53,228,557
Ensembl chr11:53,081,025...53,228,716
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of BCAT1 mRNA] CTD PMID:15016801 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha affects expression ISO Fluorouracil affects the expression of BCKDHA mRNA CTD PMID:16584549 NCBI chr 1:82,423,291...82,452,094
Ensembl chr 1:82,423,277...82,452,281
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
affects response to substance
decreases expression
increases expression
increases phosphorylation
decreases response to substance
ISO
EXP
[Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 mRNA; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 protein; [SM-1 compound co-treated with Fluorouracil] results in decreased expression of BCL2 mRNA; [SM-1 compound co-treated with Fluorouracil] results in decreased expression of BCL2 protein; [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein; BAY 11-7085 inhibits the reaction [[Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2 mRNA]; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of BCL2 protein]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of BCL2 mRNA]; Fluorouracil affects the reaction [rebamipide results in increased expression of BCL2 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; rebamipide inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; SM-1 compound promotes the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]
Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]
BCL2 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of BCL2 mRNA
[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein; IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]
Fluorouracil results in increased phosphorylation of BCL2 protein
Fluorouracil results in decreased expression of BCL2; Fluorouracil results in decreased expression of BCL2 mRNA; Fluorouracil results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Fluorouracil
CTD PMID:7654318, PMID:9388485, PMID:14503796, PMID:15177426, PMID:15754201, PMID:15996812, PMID:16332177, PMID:16391804, PMID:16407826, PMID:16412276, PMID:16557594, PMID:16596200, PMID:16603448, PMID:16888818, PMID:16929163, PMID:17287894, PMID:17439414, PMID:17589894, PMID:18161298, PMID:18205257, PMID:18567086, PMID:18949393, PMID:19015929, PMID:19084572, PMID:20570612, PMID:20844880, PMID:23941782, PMID:28599477, PMID:29054700, PMID:31129132, PMID:31587439 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
affects response to substance
increases expression
decreases expression
affects expression
decreases response to substance
ISO
EXP
3-methyladenine inhibits the reaction [Fluorouracil results in increased expression of BCL2L1 protein]; [Fluorouracil co-treated with IFNA1 protein] results in decreased expression of BCL2L1 mRNA; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2L1 mRNA; [Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2L1 protein; BAY 11-7085 inhibits the reaction [[Fluorouracil co-treated with RNF34 protein] results in increased expression of BCL2L1 mRNA]; BCL2L1 protein inhibits the reaction [BID protein results in increased susceptibility to Fluorouracil]; Fluorouracil affects the reaction [rebamipide results in increased expression of BCL2L1 protein]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]; IFNA1 promotes the reaction [Fluorouracil results in decreased expression of BCL2L1 mRNA]; rebamipide inhibits the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]
Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]
BCL2L1 protein affects the susceptibility to Fluorouracil
3-methyladenine inhibits the reaction [Fluorouracil results in increased expression of BCL2L1 protein]; IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]
Fluorouracil results in increased expression of BCL2L1 mRNA; Fluorouracil results in increased expression of BCL2L1 protein
Fluorouracil results in decreased expression of BCL2L1; Fluorouracil results in decreased expression of BCL2L1 mRNA; Fluorouracil results in decreased expression of BCL2L1 protein
Fluorouracil affects the expression of BCL2L1 mRNA; Fluorouracil affects the expression of BCL2L1 protein
BCL2L1 protein results in decreased susceptibility to Fluorouracil
CTD PMID:12442003, PMID:15289866, PMID:15767554, PMID:16407826, PMID:16557594, PMID:16596200, PMID:16875599, PMID:16929163, PMID:17033717, PMID:17045692, PMID:17399942, PMID:17439414, PMID:19116755, PMID:20844880, PMID:21474236, PMID:29054700, PMID:29879413, PMID:31129132 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO Fluorouracil affects the reaction [rebamipide results in decreased expression of BCL2L11 protein]; rebamipide inhibits the reaction [Fluorouracil results in increased expression of BCL2L11 protein] CTD PMID:29054700 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l12 BCL2 like 12 multiple interactions ISO [Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of BCL2L12 mRNA CTD PMID:19015929 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Fluorouracil results in decreased expression of BDH1 protein CTD PMID:15585135, PMID:16803524 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of BDKRB2 mRNA] CTD PMID:15016801 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP Fluorouracil results in decreased expression of BDNF protein CTD PMID:18702703 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bean1 brain expressed, associated with NEDD4, 1 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of BEAN1 protein
BEAN1 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr19:947,862...993,467
Ensembl chr19:949,607...983,556
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Apigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]; Fluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein]
CTD PMID:16896004, PMID:28025107 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Fluorouracil results in increased expression of BGLAP mRNA CTD PMID:16888818 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 affects response to substance ISO BHLHE41 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases response to substance
decreases expression
increases response to substance
ISO [Fluorouracil co-treated with irinotecan co-treated with vorinostat] results in increased cleavage of BID protein; BCL2L1 protein inhibits the reaction [BID protein results in increased susceptibility to Fluorouracil]; Fluorouracil results in increased cleavage of and results in increased activity of BID protein; IFNA1 promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of BID protein]
BID protein mutant form results in decreased susceptibility to Fluorouracil
Fluorouracil results in decreased expression of BID protein
CTD PMID:15095271, PMID:15289866, PMID:15754201, PMID:21474236 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Fluorouracil results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Fluorouracil results in increased expression of BIRC3 mRNA CTD PMID:16557594 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
increases expression
decreases expression
multiple interactions
affects response to substance
ISO BIRC5 protein results in decreased susceptibility to Fluorouracil; BIRC5 results in decreased susceptibility to Fluorouracil
Fluorouracil results in increased expression of BIRC5 mRNA; Fluorouracil results in increased expression of BIRC5 protein
Fluorouracil results in decreased expression of BIRC5 mRNA; Fluorouracil results in decreased expression of BIRC5 protein
[Fluorouracil co-treated with RNF34 protein] results in increased expression of BIRC5 protein; [SM-1 compound co-treated with Fluorouracil] results in decreased expression of BIRC5 mRNA; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]; SM-1 compound inhibits the reaction [Fluorouracil results in increased expression of BIRC5 mRNA]; SM-1 compound promotes the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
BIRC5 affects the susceptibility to Fluorouracil; BIRC5 protein affects the susceptibility to Fluorouracil
CTD PMID:15067352, PMID:15109396, PMID:15685548, PMID:16217747, PMID:16546719, PMID:16596200, PMID:16709241, PMID:16929163, PMID:17399942, PMID:18714155, PMID:19618606, PMID:28599477, PMID:29054700 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 affects response to substance
decreases response to substance
ISO BIRC6 protein affects the susceptibility to Fluorouracil
BIRC6 results in decreased susceptibility to Fluorouracil
CTD PMID:18239605, PMID:21542283 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 decreases response to substance ISO BIRC7 protein results in decreased susceptibility to Fluorouracil CTD PMID:17437058 NCBI chr 3:176,438,335...176,443,864
Ensembl chr 3:176,439,199...176,443,195
JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO Fluorouracil results in decreased expression of BLM mRNA CTD PMID:19272435 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Blvrb biliverdin reductase B affects response to substance ISO BLVRB protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
affects response to substance
ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of BNIP3 mRNA]
BNIP3 affects the susceptibility to Fluorouracil
CTD PMID:15016801, PMID:15067352 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like affects response to substance
decreases expression
increases expression
ISO BNIP3L affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of BNIP3L mRNA
Fluorouracil results in increased expression of BNIP3L mRNA
CTD PMID:15067352, PMID:15109396, PMID:16557594, PMID:16709241, PMID:17039268 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Boll boule homolog, RNA binding protein multiple interactions ISO BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 9:61,836,517...61,975,640
Ensembl chr 9:64,480,031...64,573,660
Ensembl chr 9:64,480,031...64,573,660
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of BOP1 mRNA] CTD PMID:15016801 NCBI chr 7:117,514,529...117,538,342
Ensembl chr 7:117,514,533...117,538,342
JBrowse link
G Bora bora, aurora kinase A activator decreases expression ISO Fluorouracil results in decreased expression of BORA mRNA CTD PMID:17374387 NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
decreases expression
multiple interactions
ISO Fluorouracil results in increased expression of BRCA1 mRNA
Fluorouracil results in decreased expression of BRCA1 mRNA
TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of BRCA1 mRNA]
CTD PMID:15607317, PMID:16101138, PMID:16557594, PMID:17982676 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brix1 biogenesis of ribosomes BRX1 decreases expression ISO Fluorouracil results in decreased expression of BRIX1 mRNA CTD PMID:16510598 NCBI chr 2:60,450,547...60,461,425
Ensembl chr 2:60,450,374...60,461,458
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of BTG2 mRNA
TP53 protein affects the reaction [Fluorouracil results in increased expression of BTG2 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of BTG2 mRNA]
CTD PMID:15016801, PMID:17982676 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg3 BTG anti-proliferation factor 3 multiple interactions ISO BTG3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Fluorouracil results in decreased expression of BUB1 mRNA CTD PMID:16709241, PMID:19272435 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO Fluorouracil results in decreased expression of BUB1B mRNA CTD PMID:16557594, PMID:16709241, PMID:19272435 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein affects response to substance
decreases expression
ISO BUB3 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of BUB3 protein
CTD PMID:15548681, PMID:15585135, PMID:16803524 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G C4bpb complement component 4 binding protein, beta affects expression ISO Fluorouracil affects the expression of C4BPB mRNA CTD PMID:16584549 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890
JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions ISO CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ca14 carbonic anhydrase 14 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CA14 mRNA] CTD PMID:15016801 NCBI chr 2:198,010,142...198,017,635
Ensembl chr 2:198,010,349...198,016,898
JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated affects response to substance ISO CABYR protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr18:4,082,175...4,096,650
Ensembl chr18:4,084,228...4,095,936
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CAD mRNA] CTD PMID:15016801 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Calb2 calbindin 2 increases response to substance
increases expression
ISO CALB2 protein results in increased susceptibility to Fluorouracil
Fluorouracil results in increased expression of CALB2 mRNA
CTD PMID:16510598 NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
JBrowse link
G Canx calnexin multiple interactions ISO CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of CANX mRNA] CTD PMID:15016801, PMID:18678097 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 affects response to substance ISO CAP2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:18,441,614...18,592,866
Ensembl chr17:18,442,127...18,592,750
JBrowse link
G Casd1 CAS1 domain containing 1 affects expression ISO Fluorouracil affects the expression of CASD1 mRNA CTD PMID:20421339 NCBI chr 4:29,638,280...29,693,151
Ensembl chr 4:29,639,154...29,691,928
JBrowse link
G Casp1 caspase 1 increases cleavage ISO Fluorouracil results in increased cleavage of CASP1 protein CTD PMID:15162350 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
decreases cleavage
increases cleavage
decreases expression
ISO
EXP
Fluorouracil results in increased expression of CASP3; Fluorouracil results in increased expression of CASP3 mRNA; Fluorouracil results in increased expression of CASP3 protein; Fluorouracil results in increased expression of CASP3 protein modified form
Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein]
Fluorouracil results in increased activity of CASP3 protein
Fluorouracil results in decreased cleavage of CASP3 protein
3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]; [10-hydroxycamptothecin co-treated with Fluorouracil co-treated with Leucovorin] results in increased activity of CASP3 protein; [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP3 protein; [Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; [Fluorouracil co-treated with Cisplatin] results in increased activity of CASP3 protein; [Fluorouracil co-treated with Cisplatin] results in increased expression of CASP3 protein; [Fluorouracil co-treated with IFNB1 protein] results in increased activity of CASP3 protein; [Fluorouracil co-treated with olaparib] results in increased cleavage of CASP3 protein; [Fluorouracil co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [S100A11 mutant form results in increased susceptibility to Fluorouracil] which results in increased activity of CASP3 protein; [SM-1 compound co-treated with Fluorouracil] results in increased cleavage of CASP3 protein; [wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [Fluorouracil results in increased cleavage of CASP3 protein]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Celecoxib inhibits the reaction [Fluorouracil results in increased expression of CASP3 protein]; Drugs, Chinese Herbal promotes the reaction [Fluorouracil results in increased cleavage of and results in increased expression of CASP3 protein]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Drugs, Chinese Herbal results in increased cleavage of and results in increased expression of CASP3 protein]; Fluorouracil promotes the reaction [gambogic acid results in decreased expression of CASP3 mRNA]; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CASP3 mRNA]; Fluorouracil promotes the reaction [temsirolimus results in increased expression of CASP3 mRNA]; Fluorouracil promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Fluorouracil results in increased activity of and results in increased cleavage of CASP3 protein; Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein; Fluorouracil results in increased cleavage of and results in increased expression of CASP3 protein; HK2 protein affects the reaction [Fluorouracil results in increased activity of CASP3 protein]; IFI6 protein inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]; IFNA1 protein promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]; Resveratrol inhibits the reaction [Fluorouracil results in decreased cleavage of CASP3 protein]; RNF34 protein inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CASP3 mRNA]; temsirolimus promotes the reaction [Fluorouracil results in increased expression of CASP3 mRNA]; TNFRSF10B mutant form inhibits the reaction [Fluorouracil results in increased cleavage of CASP3 protein]
Fluorouracil results in decreased expression of CASP3 mRNA
3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein]; Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein; IL1RN protein affects the reaction [Fluorouracil results in increased expression of CASP3 protein modified form]
CTD PMID:10891390, PMID:11300326, PMID:12414664, PMID:12934351, PMID:12941601, PMID:14503796, PMID:15120327, PMID:15282376, PMID:15585135, PMID:15685448, PMID:16080519, PMID:16168113, PMID:16407826, PMID:16803524, PMID:17016659, PMID:17056233, PMID:17219956, PMID:17399942, PMID:17461495, PMID:17498489, PMID:17589894, PMID:18161298, PMID:18205257, PMID:18608205, PMID:18772588, PMID:18830594, PMID:19084572, PMID:19097688, PMID:19116755, PMID:19764996, PMID:19815060, PMID:19816940, PMID:19885610, PMID:19928967, PMID:20570612, PMID:20844880, PMID:20876774, PMID:21036698, PMID:21461573, PMID:25940438, PMID:26310874, PMID:26544897, PMID:28025107, PMID:28599477, PMID:29678497, PMID:31129132, PMID:31288002, PMID:32634519 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of CASP4 protein
CASP4 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031, PMID:16217747 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 multiple interactions ISO Fluorouracil results in increased cleavage of and results in increased activity of CASP6 protein; resveratrol affects the reaction [Fluorouracil results in increased activity of CASP6 protein]; TP53 affects the reaction [resveratrol affects the reaction [Fluorouracil results in increased activity of CASP6 protein]] CTD PMID:18497562 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
ISO [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP7 protein
Fluorouracil results in increased cleavage of CASP7 protein
CTD PMID:16168113, PMID:26544897 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
decreases expression
increases expression
increases activity
ISO [Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein; [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein; [Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; [Fluorouracil co-treated with Cisplatin] results in increased activity of CASP8 protein; [Fluorouracil co-treated with Cisplatin] results in increased expression of CASP8 protein; [Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein]; Cadmium Chloride affects the reaction [Fluorouracil results in decreased expression of CASP8 mRNA]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP8 protein]; Fluorouracil affects the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]; Fluorouracil promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]; IFNA1 promotes the reaction [Fluorouracil results in increased expression of CASP8 protein]; IFNA1 protein promotes the reaction [Fluorouracil results in increased activity of CASP8 protein]; isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Fluorouracil results in increased activity of CASP8 protein]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of CASP8 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of CASP8 protein]
Fluorouracil results in increased cleavage of CASP8 protein
Fluorouracil results in increased expression of CASP8 mRNA; Fluorouracil results in increased expression of CASP8 protein
CTD PMID:10779637, PMID:10891390, PMID:12414664, PMID:14607657, PMID:15585135, PMID:16168113, PMID:16803524, PMID:17016659, PMID:17056233, PMID:17637740, PMID:18830594, PMID:19097688, PMID:19816940, PMID:19928967, PMID:20876774, PMID:21474236, PMID:23941782, PMID:26544897 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
decreases expression
increases expression
increases cleavage
ISO
EXP
[Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of CASP9 mRNA; [Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; [Fluorouracil co-treated with Cisplatin] results in increased activity of CASP9 protein; [Fluorouracil co-treated with Cisplatin] results in increased expression of CASP9 protein; Cadmium Chloride promotes the reaction [Fluorouracil results in decreased expression of CASP9 mRNA]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein; IFNA1 protein promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]; PTGS2 protein inhibits the reaction [Fluorouracil results in increased activity of CASP9 protein]; RNF34 protein inhibits the reaction [Fluorouracil results in increased activity of CASP9 protein]; TP53 protein inhibits the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]; TP53 protein inhibits the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP9 protein]]
Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein]
Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein]
Fluorouracil results in increased expression of CASP9 protein
Fluorouracil results in increased cleavage of CASP9 protein
CTD PMID:10779637, PMID:12414664, PMID:15546879, PMID:15996812, PMID:16168113, PMID:16407826, PMID:16803524, PMID:17016659, PMID:17056233, PMID:17498489, PMID:18830594, PMID:19015929, PMID:19097688, PMID:19816940, PMID:19928967, PMID:22963400, PMID:23941782, PMID:28025107, PMID:31129132 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Fluorouracil inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Fluorouracil promotes the reaction [Luteolin results in decreased activity of CAT protein]; Luteolin promotes the reaction [Fluorouracil results in decreased activity of CAT protein] CTD PMID:27836789, PMID:31288002 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 affects response to substance
increases expression
decreases expression
ISO CAV1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CAV1 mRNA
Fluorouracil results in decreased expression of CAV1 protein
CTD PMID:15352031, PMID:24737281 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cav2 caveolin 2 decreases expression
increases expression
ISO Fluorouracil results in decreased expression of CAV2 mRNA
Fluorouracil results in increased expression of CAV2 mRNA
CTD PMID:16510598, PMID:24737281 NCBI chr 4:44,573,264...44,580,640
Ensembl chr 4:44,573,264...44,580,638
JBrowse link
G Cbr3 carbonyl reductase 3 affects expression ISO Fluorouracil affects the expression of CBR3 mRNA CTD PMID:20421339 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Cbs cystathionine beta synthase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CBS mRNA] CTD PMID:15016801 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cbx1 chromobox 1 affects response to substance ISO CBX1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Ccdc186 coiled-coil domain containing 186 increases expression ISO Fluorouracil results in increased expression of CCDC186 mRNA CTD PMID:16510598 NCBI chr 1:277,603,601...277,635,379
Ensembl chr 1:277,606,995...277,629,196
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of CCN1 mRNA; Fluorouracil results in increased expression of CCN1 protein
CCN1 affects the susceptibility to Fluorouracil
CTD PMID:15067352, PMID:17699798, PMID:24737281 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 affects expression ISO Fluorouracil affects the expression of CCN2 mRNA CTD PMID:15205334 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn3 cellular communication network factor 3 increases expression ISO Fluorouracil results in increased expression of CCN3 mRNA CTD PMID:16510598 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccna1 cyclin A1 multiple interactions
affects expression
ISO [Cadmium Chloride co-treated with Fluorouracil] affects the expression of CCNA1 protein; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of CCNA1 mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of CCNA1 mRNA]
Fluorouracil affects the expression of CCNA1 mRNA; Fluorouracil affects the expression of CCNA1 protein
CTD PMID:23941782 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 multiple interactions
affects response to substance
affects expression
decreases expression
ISO N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNA2 protein]; TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNA2 protein]; TP53 protein inhibits the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNA2 protein]]
CCNA2 protein affects the susceptibility to Fluorouracil
Fluorouracil affects the expression of CCNA2 mRNA
Fluorouracil results in decreased expression of CCNA2 mRNA; Fluorouracil results in decreased expression of CCNA2 protein
CTD PMID:15205334, PMID:15546879, PMID:15548681, PMID:16557594, PMID:18383818 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNB1 protein]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNB1 protein]; TP53 protein inhibits the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNB1 protein]]
Fluorouracil results in decreased expression of CCNB1 mRNA; Fluorouracil results in decreased expression of CCNB1 protein
CTD PMID:15016801, PMID:15205334, PMID:15546879, PMID:16557594, PMID:17982676 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions
decreases expression
ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCNB2 mRNA]
Fluorouracil results in decreased expression of CCNB2 mRNA; Fluorouracil results in decreased expression of CCNB2 protein
CTD PMID:15016801, PMID:16557594, PMID:16709241, PMID:17982488, PMID:19272435 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnc cyclin C decreases expression ISO Fluorouracil results in decreased expression of CCNC mRNA CTD PMID:16709241 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 affects response to substance
multiple interactions
decreases expression
affects expression
ISO CCND1 protein affects the susceptibility to Fluorouracil
Fluorouracil promotes the reaction [Luteolin results in decreased expression of CCND1 protein]; Luteolin promotes the reaction [Fluorouracil results in decreased expression of CCND1 protein]
Fluorouracil affects the expression of CCND1 mRNA; Fluorouracil affects the expression of CCND1 protein
Fluorouracil results in decreased expression of CCND1 mRNA; Fluorouracil results in decreased expression of CCND1 protein
[allose co-treated with Fluorouracil] results in decreased expression of CCND1 protein; [Cadmium Chloride co-treated with Fluorouracil] affects the expression of CCND1 protein; [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA; Cadmium Chloride affects the reaction [Fluorouracil affects the expression of CCND1 mRNA]; Fluorouracil affects the reaction [Cadmium Chloride affects the expression of CCND1 mRNA]; Fluorouracil promotes the reaction [allose results in decreased expression of CCND1 mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCND1 protein]
CTD PMID:15352031, PMID:17982676, PMID:18930000, PMID:23941782, PMID:31288002, PMID:31587439 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression
decreases expression
multiple interactions
affects response to substance
ISO Fluorouracil results in increased expression of CCND2 protein
Fluorouracil results in decreased expression of CCND2 mRNA
TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCND2 mRNA]
CCND2 protein affects the susceptibility to Fluorouracil
CTD PMID:15016801, PMID:15352031, PMID:19272435 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 affects response to substance
increases expression
ISO CCND3 affects the susceptibility to Fluorouracil; CCND3 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CCND3 mRNA
CTD PMID:15067352, PMID:15548681, PMID:16709241, PMID:18383818 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
increases expression
ISO Fluorouracil results in decreased expression of CCNE1 mRNA
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA; [Leucovorin co-treated with Fluorouracil] results in increased expression of CCNE1 mRNA
Fluorouracil results in increased expression of CCNE1 mRNA; Fluorouracil results in increased expression of CCNE1 protein
CTD PMID:9930367, PMID:15342418, PMID:16101138, PMID:18930000, PMID:31587439 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 affects response to substance ISO CCNE2 affects the susceptibility to Fluorouracil CTD PMID:15067352 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnf cyclin F affects response to substance ISO CCNF affects the susceptibility to Fluorouracil CTD PMID:15067352 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 affects response to substance
increases expression
multiple interactions
decreases expression
ISO CCNG1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CCNG1 mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of CCNG1 mRNA]
Fluorouracil results in decreased expression of CCNG1 mRNA
CTD PMID:15152939, PMID:16217747, PMID:16557594, PMID:16709241, PMID:17982676, PMID:19272435, PMID:22525470 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 affects response to substance
decreases expression
increases expression
ISO CCNG2 affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CCNG2 mRNA
Fluorouracil results in increased expression of CCNG2 mRNA
CTD PMID:15067352, PMID:16510598, PMID:16557594, PMID:17039268, PMID:18754885, PMID:19272435 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccnjl cyclin J-like affects expression ISO Fluorouracil affects the expression of CCNJL mRNA CTD PMID:16584549 NCBI chr10:29,122,713...29,181,610
Ensembl chr10:29,123,273...29,182,568
JBrowse link
G Cd24 CD24 molecule increases expression ISO Fluorouracil results in increased expression of CD24 mRNA CTD PMID:16510598 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd274 CD274 molecule increases expression ISO Fluorouracil results in increased expression of CD274 protein CTD PMID:17920123 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd34 CD34 molecule increases expression ISO Fluorouracil results in increased expression of CD34 protein CTD PMID:21296659 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd38 CD38 molecule affects expression ISO Fluorouracil affects the expression of CD38 mRNA CTD PMID:16584549 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd40 CD40 molecule decreases response to substance
multiple interactions
ISO CD40 results in decreased susceptibility to Fluorouracil
Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]
CTD PMID:15611226, PMID:20188757 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]] CTD PMID:15611226 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions EXP [gimeracil co-treated with Fluorouracil] results in decreased expression of CD44 CTD PMID:12364819 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd52 CD52 molecule affects expression
multiple interactions
ISO Fluorouracil affects the expression of CD52 mRNA
TP53 protein affects the reaction [Fluorouracil results in decreased expression of CD52 mRNA]
CTD PMID:15016801, PMID:16584549 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
JBrowse link
G Cd63 Cd63 molecule decreases expression ISO Fluorouracil results in decreased expression of CD63 CTD PMID:15485462 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Cd8a CD8a molecule multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CD8A mRNA] CTD PMID:15016801 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Cd8b CD8b molecule affects response to substance
decreases expression
ISO CD8B protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CD8B protein
CTD PMID:15352031 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cd9 CD9 molecule decreases expression ISO Fluorouracil results in decreased expression of CD9 protein CTD PMID:21296659 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cda cytidine deaminase multiple interactions EXP [CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Fluorouracil CTD PMID:10811482 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CDC20 mRNA] CTD PMID:15016801 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Fluorouracil results in decreased expression of CDC25A mRNA CTD PMID:16510598 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Fluorouracil results in decreased expression of CDC25B mRNA CTD PMID:16709241, PMID:19272435 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C affects response to substance
decreases expression
ISO CDC25C protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CDC25C mRNA
CTD PMID:15548681, PMID:19272435 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme affects response to substance ISO CDC34 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc40 cell division cycle 40 increases expression ISO Fluorouracil results in increased expression of CDC40 protein CTD PMID:16803524 NCBI chr20:48,503,973...48,574,546
Ensembl chr20:48,503,973...48,574,546
JBrowse link
G Cdc42ep1 CDC42 effector protein 1 affects response to substance ISO CDC42EP1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 7:120,063,256...120,071,154
Ensembl chr 7:120,067,379...120,071,440
JBrowse link
G Cdc45 cell division cycle 45 multiple interactions
decreases expression
affects expression
ISO [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC45 mRNA
Fluorouracil results in decreased expression of CDC45 mRNA
Fluorouracil affects the expression of CDC45 mRNA
CTD PMID:15342418, PMID:16557594, PMID:19272435 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 affects expression
decreases expression
multiple interactions
increases expression
ISO Fluorouracil affects the expression of CDC6 mRNA
Fluorouracil results in decreased expression of CDC6 mRNA
[Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA
Fluorouracil results in increased expression of CDC6 mRNA
CTD PMID:15342418, PMID:16557594, PMID:16709241, PMID:17039268, PMID:19272435 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc73 cell division cycle 73 decreases expression ISO Fluorouracil results in decreased expression of CDC73 mRNA CTD PMID:16510598 NCBI chr13:60,403,771...60,496,511
Ensembl chr13:60,403,771...60,496,511
JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Fluorouracil results in increased expression of CDCA5 mRNA CTD PMID:16709241 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdca7 cell division cycle associated 7 affects expression ISO Fluorouracil affects the expression of CDCA7 mRNA CTD PMID:20421339 NCBI chr 3:59,153,281...59,163,916
Ensembl chr 3:59,153,280...59,163,913
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Fluorouracil results in decreased expression of CDCA8 mRNA CTD PMID:17374387 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdh1 cadherin 1 affects response to substance
decreases expression
multiple interactions
ISO CDH1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CDH1 protein
resveratrol inhibits the reaction [Fluorouracil results in decreased expression of CDH1 protein]
CTD PMID:15352031, PMID:26310874 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh5 cadherin 5 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of CDH5 protein
Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 mRNA]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]
CTD PMID:21296659, PMID:31404653 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cdh6 cadherin 6 decreases expression ISO Fluorouracil results in decreased expression of CDH6 mRNA CTD PMID:24737281 NCBI chr 2:63,100,723...63,246,618
Ensembl chr 2:63,101,739...63,166,509
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase affects expression ISO Fluorouracil affects the expression of CDIPT mRNA CTD PMID:16584549 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
increases expression
affects expression
ISO Fluorouracil results in decreased expression of CDK1 mRNA
[Leucovorin co-treated with Fluorouracil] results in increased expression of CDK1 mRNA
Fluorouracil results in increased expression of CDK1 mRNA
Fluorouracil affects the expression of CDK1 mRNA
CTD PMID:15152939, PMID:15205334, PMID:15342418, PMID:16557594, PMID:17039268, PMID:26272751 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects response to substance
multiple interactions
increases expression
ISO CDK2 protein affects the susceptibility to Fluorouracil; CDK2 protein modified form affects the susceptibility to Fluorouracil
[Leucovorin co-treated with Fluorouracil] results in increased expression of CDK2 mRNA
Fluorouracil results in increased expression of CDK2 mRNA
CTD PMID:15342418, PMID:15548681, PMID:16557594, PMID:18383818 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 affects expression ISO Fluorouracil affects the expression of CDK5R1 mRNA CTD PMID:15205334 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects response to substance
multiple interactions
increases expression
decreases degradation
decreases expression
decreases response to substance
increases response to substance
ISO CDKN1A affects the susceptibility to Fluorouracil; CDKN1A protein affects the susceptibility to Fluorouracil
Fluorouracil promotes the reaction [Luteolin results in increased expression of CDKN1A protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of CDKN1A protein]
Fluorouracil results in increased expression of CDKN1A mRNA; Fluorouracil results in increased expression of CDKN1A protein
Fluorouracil results in increased expression of CDKN1A; Fluorouracil results in increased expression of CDKN1A mRNA; Fluorouracil results in increased expression of CDKN1A protein
Fluorouracil results in decreased degradation of CDKN1A protein
Fluorouracil results in decreased expression of CDKN1A protein
[Fluorouracil co-treated with Genistein] results in increased expression of CDKN1A mRNA; [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of CDKN1A protein; [Fluorouracil co-treated with Plant Extracts] results in increased expression of CDKN1A protein; [Leucovorin co-treated with Fluorouracil] results in increased expression of CDKN1A mRNA; CDKN1A protein affects the reaction [Fluorouracil promotes the reaction [E2F4 protein binds to UBE2C promoter]]; CDKN1A protein affects the reaction [Fluorouracil results in decreased expression of UBE2C protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein]; Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter]; Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of CDKN1A protein]; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CDKN1A mRNA]; Fluorouracil promotes the reaction [temsirolimus results in increased expression of CDKN1A mRNA]; mithramycin A inhibits the reaction [Fluorouracil results in increased expression of CDKN1A protein]; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]; Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]; temsirolimus promotes the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of CDKN1A protein]]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of CDKN1A protein]
CDKN1A protein results in decreased susceptibility to Fluorouracil
CDKN1A protein results in increased susceptibility to Fluorouracil
CTD PMID:14646558, PMID:14665630, PMID:15016801, PMID:15067352, PMID:15205334, PMID:15331170, PMID:15342418, PMID:15375580, PMID:15489892, PMID:15546879, PMID:15625077, PMID:15754201, PMID:15896711, PMID:16168113, PMID:16434701, PMID:16557594, PMID:16584549, PMID:16686938, PMID:16709241, PMID:16949053, PMID:17039268, PMID:17207318, PMID:17355264, PMID:17699798, PMID:17982676, PMID:18834353, PMID:19098008, PMID:19764996, PMID:24211769, PMID:27129209, PMID:27163855, PMID:31288002 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects response to substance
decreases expression
ISO CDKN1B protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CDKN1B mRNA
CTD PMID:17217824, PMID:18930000 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C affects response to substance
increases expression
ISO CDKN1C affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CDKN1C mRNA
CTD PMID:15067352, PMID:19272435 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Fluorouracil results in decreased expression of CDKN2A protein CTD PMID:17982676 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2aip CDKN2A interacting protein affects response to substance ISO CDKN2AIP protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr16:47,664,864...47,670,935
Ensembl chr16:47,665,816...47,669,093
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Fluorouracil results in decreased expression of CDKN2C mRNA CTD PMID:16557594 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CDKN3 mRNA] CTD PMID:15016801 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cdx2 caudal type homeo box 2 decreases expression ISO Fluorouracil results in decreased expression of CDX2 protein
Fluorouracil results in decreased expression of CDX2 mRNA
CTD PMID:21296659, PMID:24737281 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Fluorouracil results in increased expression of CEBPB mRNA CTD PMID:16557594, PMID:16584549 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpq centromere protein Q affects response to substance
increases expression
ISO CENPQ protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CENPQ mRNA
CTD PMID:15331170 NCBI chr 9:23,352,271...23,368,774 JBrowse link
G Cenpu centromere protein U affects response to substance ISO CENPU protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr16:48,898,032...48,921,248
Ensembl chr16:48,897,982...48,921,242
JBrowse link
G Cenpx centromere protein X affects response to substance ISO CENPX protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr10:109,890,904...109,893,804 JBrowse link
G Cep55 centrosomal protein 55 decreases expression ISO Fluorouracil results in decreased expression of CEP55 mRNA CTD PMID:17039268 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist increases expression
decreases expression
ISO Fluorouracil results in increased expression of CER1 mRNA
Fluorouracil results in decreased expression of CER1 mRNA
CTD PMID:24737281, PMID:26272751 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases expression
ISO Fluorouracil promotes the reaction [TP53 protein binds to CES2 intron]; TP53 protein affects the reaction [Fluorouracil results in increased expression of CES2 mRNA] CTD PMID:15205334, PMID:16963839, PMID:17287894 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects response to substance
decreases expression
increases expression
ISO [Fluorouracil co-treated with IFNA1 protein] results in decreased expression of CFLAR protein; [Fluorouracil results in decreased expression of CFLAR protein] which results in increased susceptibility to TNFSF10 protein; CFLAR protein alternative form inhibits the reaction [Fluorouracil results in increased activity of TNFSF10 protein]; CFLAR protein inhibits the reaction [Fluorouracil results in increased susceptibility to TNFSF10 protein]; IFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of CFLAR mRNA]
CFLAR protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CFLAR mRNA; Fluorouracil results in decreased expression of CFLAR protein
Fluorouracil results in increased expression of CFLAR mRNA
CTD PMID:15152939, PMID:15548681, PMID:16217747, PMID:16373718, PMID:17045692, PMID:20876774 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chek1 checkpoint kinase 1 affects response to substance
decreases expression
increases expression
multiple interactions
ISO CHEK1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CHEK1 mRNA
Fluorouracil results in increased expression of CHEK1 protein
[CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil; Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK1 protein; TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Fluorouracil]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHEK1 mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in increased expression of CHEK1 protein]
CTD PMID:15016801, PMID:18698031, PMID:19272435, PMID:21613406, PMID:22194930 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK2 protein CTD PMID:21613406 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression ISO Fluorouracil results in increased expression of CHI3L1 mRNA CTD PMID:15205334 NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHRNA4 mRNA] CTD PMID:15016801 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chst7 carbohydrate sulfotransferase 7 affects response to substance ISO CHST7 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr  X:2,623,018...2,657,155
Ensembl chr  X:2,623,024...2,657,155
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 affects response to substance ISO CIAO1 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 3:119,671,778...119,677,324
Ensembl chr 3:119,671,779...119,678,092
JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO Fluorouracil results in increased expression of CIDEB protein CTD PMID:15585135, PMID:16803524 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 affects response to substance ISO CITED2 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Ckb creatine kinase B affects response to substance ISO CKB protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Fluorouracil results in decreased expression of CKS2 mRNA CTD PMID:17374387, PMID:19272435 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clcn3 chloride voltage-gated channel 3 affects response to substance ISO CLCN3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Cldn2 claudin 2 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of CLDN2 protein
resveratrol inhibits the reaction [Fluorouracil results in decreased expression of CLDN2 protein]
CTD PMID:26310874 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cldn4 claudin 4 affects response to substance
decreases expression
ISO CLDN4 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CLDN4 protein
CTD PMID:15352031 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Clec11a C-type lectin domain containing 11A affects response to substance
decreases expression
ISO CLEC11A protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CLEC11A protein
CTD PMID:15352031 NCBI chr 1:100,290,374...100,293,515
Ensembl chr 1:100,289,295...100,293,558
JBrowse link
G Clic1 chloride intracellular channel 1 affects response to substance ISO CLIC1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO CLTC protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of CLTC mRNA] CTD PMID:15016801, PMID:18927307 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO Fluorouracil results in decreased expression of COL12A1 mRNA CTD PMID:15205334, PMID:16510598 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Fluorouracil results in decreased expression of COL1A1 protein CTD PMID:21296659 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain affects expression ISO Fluorouracil affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO Fluorouracil results in decreased expression of COL2A1 protein
Fluorouracil results in decreased expression of COL2A1 mRNA
CTD PMID:21296659, PMID:24737281 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects response to substance ISO COL3A1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a2 collagen type IV alpha 2 chain affects response to substance
decreases expression
ISO COL4A2 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of COL4A2 protein
CTD PMID:15352031 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Col5a2 collagen type V alpha 2 chain affects response to substance ISO COL5A2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 9:52,091,088...52,238,735
Ensembl chr 9:52,092,511...52,238,564
JBrowse link
G Col6a3 collagen type VI alpha 3 chain affects response to substance
multiple interactions
ISO COL6A3 protein affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in decreased expression of COL6A3 mRNA]
CTD PMID:15016801, PMID:16217747 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546
JBrowse link
G Cp ceruloplasmin multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CP mRNA] CTD PMID:15016801 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpa4 carboxypeptidase A4 decreases expression ISO Fluorouracil results in decreased expression of CPA4 mRNA CTD PMID:16510598 NCBI chr 4:57,883,849...57,907,826
Ensembl chr 4:57,883,849...57,907,826
JBrowse link
G Cpd carboxypeptidase D affects response to substance
multiple interactions
ISO CPD protein affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in decreased expression of CPD mRNA]
CTD PMID:15016801, PMID:16217747 NCBI chr10:63,325,764...63,389,811
Ensembl chr10:63,325,199...63,389,817
JBrowse link
G Cpe carboxypeptidase E affects response to substance
increases expression
ISO CPE protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CPE protein
CTD PMID:15352031 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects response to substance ISO CPT1A protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpxm1 carboxypeptidase X (M14 family), member 1 affects expression ISO Fluorouracil affects the expression of CPXM1 mRNA CTD PMID:15205334 NCBI chr 3:122,913,886...122,920,684
Ensembl chr 3:122,913,886...122,920,684
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 affects response to substance
increases expression
ISO CRABP1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CRABP1 protein
CTD PMID:15352031 NCBI chr 8:59,344,097...59,352,135
Ensembl chr 8:59,344,083...59,352,132
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 affects expression ISO Fluorouracil affects the expression of CRABP2 protein CTD PMID:21296659 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Crhbp corticotropin releasing hormone binding protein affects expression ISO Fluorouracil affects the expression of CRHBP mRNA CTD PMID:15205334 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 affects response to substance
increases expression
decreases expression
ISO CRIM1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CRIM1 protein
Fluorouracil results in decreased expression of CRIM1 mRNA
CTD PMID:15352031, PMID:16510598 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Crk CRK proto-oncogene, adaptor protein affects response to substance ISO CRK protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Crygs crystallin, gamma S multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CRYGS mRNA] CTD PMID:15016801 NCBI chr11:81,796,891...81,802,172
Ensembl chr11:81,796,891...81,802,172
JBrowse link
G Cryl1 crystallin, lambda 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CRYL1 mRNA] CTD PMID:15016801 NCBI chr15:37,543,727...37,663,586
Ensembl chr15:37,543,727...37,663,584
JBrowse link
G Cryz crystallin zeta decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of CRYZ mRNA
TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CRYZ mRNA]
CTD PMID:17982676 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Cse1l chromosome segregation 1 like multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CSE1L mRNA] CTD PMID:15016801 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Csf1 colony stimulating factor 1 affects response to substance ISO CSF1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Fluorouracil results in increased expression of CSF2 mRNA CTD PMID:18344199 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csnk1e casein kinase 1, epsilon affects expression ISO Fluorouracil affects the expression of CSNK1E mRNA CTD PMID:16584549 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects response to substance ISO CSRP1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
JBrowse link
G Cst7 cystatin F affects response to substance
decreases expression
ISO CST7 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of CST7 protein
CTD PMID:15352031 NCBI chr 3:146,363,913...146,373,365
Ensembl chr 3:146,365,092...146,373,365
JBrowse link
G Cst8 cystatin 8 affects expression ISO Fluorouracil affects the expression of CST8 mRNA CTD PMID:16584549 NCBI chr 3:143,129,240...143,141,000
Ensembl chr 3:143,129,248...143,156,177
JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects response to substance
increases expression
ISO CSTF3 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CSTF3 mRNA
CTD PMID:15331170 NCBI chr 3:94,530,586...94,603,378
Ensembl chr 3:94,530,586...94,607,588
JBrowse link
G Ctbp2 C-terminal binding protein 2 multiple interactions ISO [Fluorouracil co-treated with irinotecan] results in decreased expression of CTBP2 mRNA; CTBP2 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:16391804, PMID:18927307 NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
JBrowse link
G Ctnnd2 catenin delta 2 multiple interactions ISO CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315
JBrowse link
G Ctps1 CTP synthase 1 decreases expression ISO Fluorouracil results in decreased expression of CTPS1 mRNA CTD PMID:19219653 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctsb cathepsin B multiple interactions
increases cleavage
ISO CA 074 methyl ester inhibits the reaction [Fluorouracil results in increased cleavage of CTSB protein] CTD PMID:19816940 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsh cathepsin H affects response to substance
increases expression
ISO CTSH protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of CTSH protein
CTD PMID:15352031 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287
JBrowse link
G Cttn cortactin decreases expression ISO Fluorouracil results in decreased expression of CTTN protein CTD PMID:15585135, PMID:16803524 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cul4a cullin 4A affects response to substance ISO CUL4A protein affects the susceptibility to Fluorouracil CTD PMID:16467204 NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
JBrowse link
G Cul4b cullin 4B increases expression ISO Fluorouracil results in increased expression of CUL4B protein CTD PMID:16803524 NCBI chr  X:124,831,391...124,870,329
Ensembl chr  X:124,832,628...124,870,329
JBrowse link
G Cul5 cullin 5 increases expression ISO Fluorouracil results in increased expression of CUL5 mRNA CTD PMID:16557594 NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
JBrowse link
G Cutc cutC copper transporter affects response to substance
multiple interactions
ISO CUTC protein affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in decreased expression of CUTC mRNA]
CTD PMID:15016801, PMID:16217747 NCBI chr 1:263,511,537...263,526,308
Ensembl chr 1:263,511,537...263,526,307
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
affects expression
ISO Fluorouracil results in increased expression of CXCL12 mRNA
Fluorouracil affects the expression of CXCL12 mRNA
CTD PMID:16337237, PMID:18344199 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Bortezomib inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; C646 compound inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA] CTD PMID:27194111 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Bortezomib inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; C646 compound inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; C646 compound inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
Fluorouracil results in increased expression of CXCL1 mRNA; Fluorouracil results in increased expression of CXCL1 protein
CTD PMID:27194111 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO CXCR1 gene SNP affects the susceptibility to [oxaliplatin co-treated with Fluorouracil] CTD PMID:16098254 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO Fluorouracil affects the expression of CXCR4 mRNA CTD PMID:16584549 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of CYC1 mRNA] CTD PMID:15016801 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 affects response to substance
multiple interactions
increases expression
ISO CYFIP2 protein affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in increased expression of CYFIP2 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of CYFIP2 mRNA]
CTD PMID:15016801, PMID:16217747, PMID:17039268, PMID:17982676 NCBI chr10:31,278,746...31,419,235
Ensembl chr10:31,278,746...31,419,235
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases response to substance ISO CYLD protein results in increased susceptibility to Fluorouracil CTD PMID:21109933 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing EXP CYP1A1 protein results in increased metabolism of Fluorouracil CTD PMID:17230597 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Fluorouracil CTD PMID:10811482 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression ISO Fluorouracil affects the expression of CYP2F1 mRNA CTD PMID:16584549 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 affects expression ISO Fluorouracil affects the expression of CYP2S1 mRNA CTD PMID:20421339 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Cyp51 cytochrome P450, family 51 affects response to substance ISO CYP51A1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyth3 cytohesin 3 decreases expression ISO Fluorouracil results in decreased expression of CYTH3 protein CTD PMID:15585135, PMID:16803524 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192
JBrowse link
G Dapk1 death associated protein kinase 1 affects expression ISO Fluorouracil affects the expression of DAPK1 mRNA CTD PMID:20421339 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 affects expression ISO Fluorouracil affects the expression of DARS1 mRNA CTD PMID:16584549 NCBI chr13:45,074,067...45,127,815
Ensembl chr13:45,074,072...45,127,815
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO Fluorouracil results in decreased expression of DBF4 mRNA CTD PMID:16510598 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dbndd2 dysbindin domain containing 2 affects response to substance ISO DBNDD2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 3:160,933,833...160,938,468
Ensembl chr 3:160,935,709...160,938,467
JBrowse link
G Dcc DCC netrin 1 receptor multiple interactions ISO DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Dck deoxycytidine kinase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DCK mRNA] CTD PMID:15016801 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Dclk1 doublecortin-like kinase 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DCLK1 mRNA] CTD PMID:15016801 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927
JBrowse link
G Dct dopachrome tautomerase affects expression ISO Fluorouracil affects the expression of DCT mRNA CTD PMID:15205334 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Dcx doublecortin decreases expression EXP Fluorouracil results in decreased expression of DCX protein CTD PMID:18702703 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DCXR mRNA] CTD PMID:15016801 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 affects response to substance ISO DDAH2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Ddb2 damage specific DNA binding protein 2 affects response to substance
increases expression
multiple interactions
ISO DDB2 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of DDB2 mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of DDB2 mRNA]
CTD PMID:15331170, PMID:16584549, PMID:17982676, PMID:22525470 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Fluorouracil results in increased expression of DDIT3 mRNA; Fluorouracil results in increased expression of DDIT3 protein CTD PMID:17355264, PMID:29879413 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Fluorouracil results in increased expression of DDIT4 mRNA CTD PMID:16510598, PMID:16557594, PMID:17039268 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx39b DExD-box helicase 39B increases expression ISO Fluorouracil results in increased expression of DDX39B mRNA CTD PMID:16510598 NCBI chr20:4,806,103...4,818,600
Ensembl chr20:4,806,108...4,818,568
JBrowse link
G Ddx4 DEAD-box helicase 4 increases expression ISO Fluorouracil results in increased expression of DDX4 protein CTD PMID:21296659 NCBI chr 2:44,447,610...44,504,263
Ensembl chr 2:44,447,573...44,504,354
JBrowse link
G Dennd2c DENN domain containing 2C affects expression ISO Fluorouracil affects the expression of DENND2C mRNA CTD PMID:20421339 NCBI chr 2:205,592,348...205,660,619
Ensembl chr 2:205,592,182...205,660,611
JBrowse link
G Depdc7 DEP domain containing 7 affects expression ISO Fluorouracil affects the expression of DEPDC7 mRNA CTD PMID:20421339 NCBI chr 3:94,665,714...94,687,013
Ensembl chr 3:94,665,717...94,686,989
JBrowse link
G Des desmin decreases expression ISO Fluorouracil results in decreased expression of DES protein CTD PMID:21296659 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dhfr dihydrofolate reductase affects expression
increases expression
ISO Fluorouracil affects the expression of DHFR mRNA
Fluorouracil results in increased expression of DHFR mRNA
CTD PMID:15109396, PMID:16557594, PMID:21814787 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Dhx15 DEAH-box helicase 15 increases expression ISO Fluorouracil results in increased expression of DHX15 mRNA CTD PMID:16584549 NCBI chr14:61,136,740...61,174,880
Ensembl chr14:61,136,746...61,174,880
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases response to substance
increases expression
ISO DIABLO protein results in increased susceptibility to Fluorouracil
Fluorouracil results in increased expression of DIABLO mRNA
CTD PMID:16557594, PMID:18031615 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dicer1 dicer 1 ribonuclease III decreases expression ISO Fluorouracil results in decreased expression of DICER1 mRNA CTD PMID:16510598 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Dimt1 DIMT1 rRNA methyltransferase and ribosome maturation factor multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DIMT1 mRNA] CTD PMID:15016801 NCBI chr 2:38,120,562...38,144,871
Ensembl chr 2:38,120,592...38,144,327
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of DKK1 protein
DKK1 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031, PMID:16217747 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 increases expression ISO Fluorouracil results in increased expression of DKK4 mRNA CTD PMID:16584549 NCBI chr16:74,260,551...74,264,142
Ensembl chr16:74,260,551...74,264,142
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DLC1 mRNA] CTD PMID:15016801 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions ISO DLG1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:18927307 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 multiple interactions
increases expression
ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of DLK1 mRNA]
Fluorouracil results in increased expression of DLK1 mRNA
CTD PMID:15016801, PMID:24737281 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Dnah2 dynein, axonemal, heavy chain 2 decreases expression ISO Fluorouracil results in decreased expression of DNAH2 mRNA CTD PMID:24737281 NCBI chr10:56,029,022...56,154,602
Ensembl chr10:56,029,029...56,154,548
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO Fluorouracil results in increased expression of DNER mRNA CTD PMID:16510598 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO Fluorouracil results in decreased expression of DNMT3B protein CTD PMID:21296659 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 affects response to substance ISO DPAGT1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 8:48,657,779...48,664,531
Ensembl chr 8:48,657,795...48,664,860
JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 affects response to substance ISO DPY19L1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 8:25,582,938...25,669,394
Ensembl chr 8:25,582,938...25,669,394
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases response to substance
decreases expression
increases metabolic processing
decreases response to substance
increases activity
increases expression
affects activity
increases degradation
decreases metabolic processing
affects degradation
affects response to substance
affects metabolic processing
multiple interactions
ISO DPYD gene mutant form results in increased susceptibility to Fluorouracil; DPYD gene polymorphism results in increased susceptibility to Fluorouracil; DPYD mRNA results in increased susceptibility to Fluorouracil
Fluorouracil results in decreased expression of DPYD mRNA
DPYD protein results in increased metabolism of Fluorouracil
DPYD mRNA results in decreased susceptibility to Fluorouracil; DPYD protein results in decreased susceptibility to Fluorouracil
Fluorouracil results in increased activity of DPYD protein
Fluorouracil results in increased expression of DPYD mRNA; Fluorouracil results in increased expression of DPYD protein
Fluorouracil metabolite affects the activity of DPYD protein
DPYD protein results in increased degradation of Fluorouracil
DPYD gene polymorphism results in decreased metabolism of Fluorouracil; DPYD protein mutant form results in decreased metabolism of Fluorouracil
DPYD protein affects the degradation of Fluorouracil
DPYD gene polymorphism affects the susceptibility to Fluorouracil; DPYD gene SNP affects the susceptibility to Fluorouracil; DPYD intron polymorphism affects the susceptibility to Fluorouracil; DPYD mRNA affects the susceptibility to Fluorouracil; DPYD promoter modified form affects the susceptibility to Fluorouracil; DPYD protein affects the susceptibility to Fluorouracil; DPYD protein mutant form affects the susceptibility to Fluorouracil
DPYD affects the metabolism of Fluorouracil; DPYD protein affects the metabolism of Fluorouracil
[Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNA; [docetaxel co-treated with Fluorouracil] results in decreased expression of DPYD mRNA; [Leucovorin co-treated with Fluorouracil] results in decreased activity of DPYD protein; Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]; Cisplatin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]; docetaxel inhibits the reaction [Fluorouracil results in increased activity of DPYD protein]; DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin]; DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil]; Fluorouracil inhibits the reaction [docetaxel results in increased expression of DPYD protein]; gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in decreased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]
CTD PMID:3335642, PMID:7503095, PMID:8680084, PMID:9470816, PMID:9816193, PMID:10099659, PMID:11148247, PMID:12044515, PMID:12562666, PMID:12635664, PMID:14689231, PMID:15017333, PMID:15109396, PMID:15239142, PMID:15246190, PMID:15591715, PMID:15655543, PMID:15737843, PMID:15858133, PMID:15865071, PMID:15890242, PMID:15930747, PMID:15949589, PMID:15993511, PMID:16033824, PMID:16115930, PMID:16282729, PMID:16361556, PMID:16525674, PMID:16557585, PMID:16568373, PMID:16646564, PMID:16761622, PMID:17046731, PMID:17064846, PMID:17121937, PMID:17330233, PMID:17377791, PMID:18075467, PMID:18197934, PMID:18225548, PMID:18299612, PMID:18383874, PMID:18443386, PMID:18600527, PMID:18619742, PMID:18846242, PMID:18986760, PMID:19020767, PMID:19093184, PMID:19104657, PMID:19105824, PMID:19219653 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 affects expression ISO Fluorouracil affects the expression of DPYSL3 mRNA CTD PMID:15205334 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 multiple interactions
increases expression
ISO TP53 protein promotes the reaction [Fluorouracil results in increased expression of DRAM1 mRNA]
Fluorouracil promotes the reaction [Luteolin results in increased expression of DRAM1 protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of DRAM1 protein]
CTD PMID:17982676, PMID:31288002 NCBI chr 7:28,898,647...28,932,641
Ensembl chr 7:28,898,649...28,932,641
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Dst dystonin affects response to substance ISO DST protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dtymk deoxythymidylate kinase affects response to substance
multiple interactions
increases expression
ISO DTYMK affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in decreased expression of DTYMK mRNA]
Fluorouracil results in increased expression of DTYMK mRNA
CTD PMID:15016801, PMID:15067352, PMID:15109396 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp14 dual specificity phosphatase 14 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of DUSP14 mRNA] CTD PMID:15016801 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of DUSP5 mRNA] CTD PMID:15016801 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Fluorouracil results in increased expression of DUSP6 mRNA CTD PMID:16510598 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dut deoxyuridine triphosphatase decreases response to substance
decreases expression
ISO DUT protein results in decreased susceptibility to Fluorouracil
Fluorouracil results in decreased expression of DUT mRNA
CTD PMID:16557594, PMID:19015155 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Fluorouracil results in decreased expression of E2F2 CTD PMID:11300326 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO E2F3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO CDKN1A protein affects the reaction [Fluorouracil promotes the reaction [E2F4 protein binds to UBE2C promoter]]; Fluorouracil promotes the reaction [E2F4 protein binds to UBE2C promoter]; TP53 protein affects the reaction [Fluorouracil promotes the reaction [E2F4 protein binds to UBE2C promoter]] CTD PMID:27129209 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G E2f8 E2F transcription factor 8 affects expression ISO Fluorouracil affects the expression of E2F8 mRNA CTD PMID:16584549 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Ebp EBP, cholestenol delta-isomerase affects response to substance ISO EBP protein affects the susceptibility to Fluorouracil CTD PMID:15548681, PMID:16217747 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 affects response to substance ISO ECHDC3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression ISO Fluorouracil results in increased expression of ECHS1 mRNA CTD PMID:15152939 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Ect2 epithelial cell transforming 2 multiple interactions
decreases expression
ISO TP53 protein promotes the reaction [Fluorouracil results in decreased expression of ECT2 mRNA] CTD PMID:17982676 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 affects response to substance ISO EDIL3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 2:17,616,116...18,128,514
Ensembl chr 2:17,616,401...18,128,512
JBrowse link
G Edn1 endothelin 1 increases expression ISO Fluorouracil results in increased expression of EDN1 mRNA; Fluorouracil results in increased expression of EDN1 protein CTD PMID:1606078, PMID:19098008 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A affects response to substance ISO EDNRA protein affects the susceptibility to Fluorouracil CTD PMID:17032313 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B decreases expression ISO Fluorouracil results in decreased expression of EDNRB mRNA CTD PMID:24737281 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects expression
multiple interactions
increases expression
ISO Fluorouracil affects the expression of EEF1A1 protein
TP53 protein inhibits the reaction [Fluorouracil results in increased expression of EEF1A1 mRNA]
CTD PMID:17982676, PMID:21296659 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Fluorouracil results in increased expression of EFEMP1 mRNA CTD PMID:24737281 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Efhd1 EF-hand domain family, member D1 affects response to substance ISO EFHD1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 9:94,362,249...94,408,884
Ensembl chr 9:94,362,299...94,408,885
JBrowse link
G Efhd2 EF-hand domain family, member D2 decreases expression ISO Fluorouracil results in decreased expression of EFHD2 mRNA CTD PMID:16510598 NCBI chr 5:160,407,777...160,423,811
Ensembl chr 5:160,407,778...160,423,811
JBrowse link
G Efnb2 ephrin B2 affects response to substance
decreases expression
ISO EFNB2 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of EFNB2 protein
CTD PMID:15352031, PMID:16217747 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance
decreases expression
increases phosphorylation
affects response to substance
multiple interactions
ISO EGFR gene polymorphism results in decreased susceptibility to Fluorouracil
Fluorouracil results in decreased expression of EGFR protein
Fluorouracil results in increased phosphorylation of EGFR protein
EGFR protein affects the susceptibility to Fluorouracil
[Cisplatin co-treated with Fluorouracil] results in decreased expression of EGFR mRNA; EGFR gene polymorphism affects the susceptibility to [oxaliplatin co-treated with Fluorouracil]; EGFR protein affects the susceptibility to [Cyclophosphamide co-treated with Doxorubicin co-treated with Fluorouracil]; EGFR results in increased susceptibility to [Cisplatin co-treated with docetaxel co-treated with Fluorouracil]; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Fluorouracil results in decreased phosphorylation of and results in decreased activity of EGFR protein; TP53 protein affects the reaction [Fluorouracil results in decreased expression of EGFR protein]
CTD PMID:15737843, PMID:15981280, PMID:16098254, PMID:16836928, PMID:17169374, PMID:17918158, PMID:17982676, PMID:18794807, PMID:19217205, PMID:21947696 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions
affects expression
affects localization
increases expression
decreases expression
ISO EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 mRNA]; EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 protein]; Fluorouracil promotes the reaction [EGR1 protein binds to THBS1 promoter]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 protein]
Fluorouracil affects the expression of EGR1 mRNA
Fluorouracil affects the localization of EGR1 protein
Fluorouracil results in decreased expression of EGR1 mRNA
CTD PMID:15205334, PMID:16557594, PMID:17039268, PMID:18757417 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehd2 EH-domain containing 2 affects response to substance ISO EHD2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870
JBrowse link
G Ehf ets homologous factor multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of EHF mRNA] CTD PMID:15016801 NCBI chr 3:93,176,257...93,216,484
Ensembl chr 3:93,178,163...93,216,495
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO Fluorouracil results in increased phosphorylation of EIF2AK3 protein CTD PMID:29879413 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta decreases expression ISO Fluorouracil results in decreased expression of EIF2B2 protein CTD PMID:15585135, PMID:16803524 NCBI chr 6:109,044,830...109,051,254
Ensembl chr 6:109,043,880...109,051,253
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Fluorouracil results in increased phosphorylation of EIF2S1 protein CTD PMID:29879413 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H increases expression ISO Fluorouracil results in increased expression of EIF3H protein CTD PMID:15585135, PMID:16803524 NCBI chr 6:10,151,732...10,236,677 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases expression
multiple interactions
ISO Fluorouracil results in increased expression of EIF4E mRNA
Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of EIF4E mRNA]
CTD PMID:15016801, PMID:15611226, PMID:16584549 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]] CTD PMID:15611226 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H increases expression ISO Fluorouracil results in increased expression of EIF4H protein CTD PMID:15585135, PMID:16803524 NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 increases expression ISO Fluorouracil results in increased expression of EIF5 mRNA CTD PMID:17039268 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Eipr1 EARP complex and GARP complex interacting protein 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of EIPR1 mRNA] CTD PMID:15016801 NCBI chr 6:48,021,771...48,135,241
Ensembl chr 6:48,021,771...48,135,241
JBrowse link
G Elmo2 engulfment and cell motility 2 increases expression ISO Fluorouracil results in increased expression of ELMO2 protein CTD PMID:16803524 NCBI chr 3:161,812,474...161,850,006
Ensembl chr 3:161,812,474...162,003,588
JBrowse link
G Eln elastin affects expression ISO Fluorouracil affects the expression of ELN mRNA CTD PMID:15205334 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Eloa elongin A affects expression ISO Fluorouracil affects the expression of ELOA mRNA CTD PMID:15205334 NCBI chr 5:154,348,167...154,363,324
Ensembl chr 5:154,347,391...154,363,329
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 affects response to substance ISO ELOVL5 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Emc1 ER membrane protein complex subunit 1 affects expression ISO Fluorouracil affects the expression of EMC1 mRNA CTD PMID:16584549 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Eml2 EMAP like 2 multiple interactions ISO EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Fluorouracil results in increased expression of EMP3 mRNA CTD PMID:19272435 NCBI chr 1:101,900,731...101,903,948
Ensembl chr 1:101,900,733...101,903,910
JBrowse link
G Enah ENAH, actin regulator affects response to substance ISO ENAH protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr13:100,297,421...100,415,335
Ensembl chr13:100,300,054...100,414,226
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 decreases expression ISO Fluorouracil results in decreased expression of ENTPD1 mRNA CTD PMID:19219653 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Eomes eomesodermin decreases expression ISO Fluorouracil results in decreased expression of EOMES protein CTD PMID:21296659 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Fluorouracil promotes the reaction [EP300 protein binds to UBE2C promoter] CTD PMID:27129209 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ep400 E1A binding protein p400 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of EP400 mRNA] CTD PMID:15016801 NCBI chr12:51,948,650...52,055,274
Ensembl chr12:51,948,650...52,055,271
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO Fluorouracil results in increased expression of EPAS1 mRNA CTD PMID:16557594 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 affects expression ISO Fluorouracil affects the expression of EPB41L3 mRNA CTD PMID:20421339 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
JBrowse link
G Epha2 Eph receptor A2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of EPHA2 mRNA] CTD PMID:15016801 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Ephx1 epoxide hydrolase 1 affects response to substance
increases expression
ISO EPHX1 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of EPHX1 mRNA
CTD PMID:15205334, PMID:16217747 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Epo erythropoietin increases response to substance
increases expression
ISO
EXP
EPO protein results in increased susceptibility to Fluorouracil
Fluorouracil results in increased expression of EPO protein
CTD PMID:2206997, PMID:16103069, PMID:20020992 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor affects response to substance ISO EPOR gene mutant form affects the susceptibility to Fluorouracil CTD PMID:16511603 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Eppk1 epiplakin 1 increases expression ISO Fluorouracil results in increased expression of EPPK1 mRNA CTD PMID:16510598 NCBI chr 7:117,163,383...117,173,741 JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase decreases expression ISO Fluorouracil results in decreased expression of EPRS1 mRNA CTD PMID:16709241 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Epyc epiphycan affects expression ISO Fluorouracil affects the expression of EPYC mRNA CTD PMID:15205334 NCBI chr 7:38,897,278...38,934,989
Ensembl chr 7:38,897,278...38,934,985
JBrowse link
G Eras ES cell expressed Ras decreases expression ISO Fluorouracil results in decreased expression of ERAS protein CTD PMID:21296659 NCBI chr  X:15,318,215...15,322,601
Ensembl chr  X:15,419,028...15,423,414
Ensembl chr  X:15,419,028...15,423,414
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
affects expression
decreases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein; [Cisplatin co-treated with Fluorouracil] results in decreased expression of ERBB2 mRNA; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Fluorouracil; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; ERBB2 protein affects the susceptibility to [Cyclophosphamide co-treated with pirarubicin co-treated with Fluorouracil]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; ERBB2 protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; Fluorouracil results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
Fluorouracil affects the expression of ERBB2 mRNA
ERBB2 mRNA results in decreased susceptibility to Fluorouracil; ERBB2 results in decreased susceptibility to Fluorouracil
CTD PMID:9816327, PMID:15205334, PMID:15737843, PMID:15940066, PMID:16446318, PMID:16682728, PMID:17918158, PMID:18337622, PMID:19885610, PMID:21712253 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Fluorouracil results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein CTD PMID:17918158 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO [Cisplatin co-treated with Fluorouracil] results in decreased expression of ERCC1 mRNA; ERCC1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with Oxaliplatin]; ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Oxaliplatin]; ERCC1 gene SNP results in increased susceptibility to [Cisplatin co-treated with Fluorouracil]; ERCC1 mRNA affects the susceptibility to [Cisplatin co-treated with Fluorouracil]
Fluorouracil results in decreased expression of ERCC1 mRNA
CTD PMID:15173087, PMID:15213713, PMID:15737843, PMID:17016597, PMID:17401013, PMID:18448328, PMID:21286668 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit multiple interactions ISO ERCC2 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]; ERCC2 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:15213713, PMID:17401013 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ereg epiregulin decreases expression ISO Fluorouracil results in decreased expression of EREG mRNA CTD PMID:16510598 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Fluorouracil results in decreased expression of ERP29 protein CTD PMID:15585135, PMID:16803524 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase affects response to substance ISO ESPL1 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 7:143,896,890...143,923,868
Ensembl chr 7:143,897,014...143,923,868
JBrowse link
G Etf1 eukaryotic translation termination factor 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ETF1 mRNA] CTD PMID:15016801 NCBI chr18:27,698,693...27,725,694
Ensembl chr18:27,698,695...27,725,694
JBrowse link
G Etfb electron transfer flavoprotein subunit beta affects response to substance ISO ETFB protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ETS1 mRNA] CTD PMID:15016801 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 mRNA]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN mRNA]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:89,091,239...89,094,570
Ensembl chr 1:89,091,239...89,094,530
JBrowse link
G Exo1 exonuclease 1 affects response to substance ISO HEXO1 protein affects the susceptibility to Fluorouracil CTD PMID:16477629 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Exosc10 exosome component 10 affects response to substance
increases metabolic processing
ISO EXOSC10 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased metabolism of EXOSC10 protein
CTD PMID:18567802 NCBI chr 5:165,374,964...165,398,195
Ensembl chr 5:165,374,951...165,398,217
JBrowse link
G F12 coagulation factor XII affects response to substance
decreases expression
ISO F12 protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of F12 protein
CTD PMID:15352031 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G F2 coagulation factor II decreases expression ISO Fluorouracil results in decreased expression of F2 mRNA CTD PMID:16709241 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of F3 mRNA
F3 affects the susceptibility to Fluorouracil
CTD PMID:15067352, PMID:16510598 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G F8 coagulation factor VIII multiple interactions ISO F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan] CTD PMID:17327601 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression ISO Fluorouracil results in decreased expression of FABP7 mRNA CTD PMID:24737281 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fads1 fatty acid desaturase 1 affects response to substance ISO FADS1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fah fumarylacetoacetate hydrolase multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of FAH mRNA] CTD PMID:15016801 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Fam102a family with sequence similarity 102, member A affects expression ISO Fluorouracil affects the expression of FAM102A mRNA CTD PMID:16584549 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
JBrowse link
G Fam107b family with sequence similarity 107, member B multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of FAM107B mRNA] CTD PMID:15016801 NCBI chr17:78,489,667...78,689,933
Ensembl chr17:78,489,668...78,561,613
JBrowse link
G Fam114a1 family with sequence similarity 114, member A1 affects expression ISO Fluorouracil affects the expression of FAM114A1 mRNA CTD PMID:16584549 NCBI chr14:44,941,705...45,012,299
Ensembl chr14:44,943,172...45,002,719
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 affects response to substance ISO FAM171A1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:79,030,150...79,149,480
Ensembl chr17:79,031,423...79,085,076
JBrowse link
G Fam189b family with sequence similarity 189, member B affects response to substance ISO FAM189B protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 2:188,495,237...188,501,444
Ensembl chr 2:188,495,629...188,501,444
JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase affects expression ISO Fluorouracil affects the expression of FAM20C mRNA CTD PMID:16584549 NCBI chr12:17,913,771...17,972,733
Ensembl chr12:17,913,767...17,972,737
JBrowse link
G Fam234b family with sequence similarity 234, member B multiple interactions ISO FAM234B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:168,976,797...169,052,750
Ensembl chr 4:168,976,859...169,019,561
JBrowse link
G Fam76b family with sequence similarity 76, member B decreases expression ISO Fluorouracil results in decreased expression of FAM76B mRNA CTD PMID:16510598 NCBI chr 8:12,355,767...12,378,040
Ensembl chr 8:12,355,767...12,374,689
JBrowse link
G Fancc FA complementation group C decreases expression ISO Fluorouracil results in decreased expression of FANCC mRNA CTD PMID:16557594 NCBI chr17:826,512...955,703
Ensembl chr17:833,509...955,615
JBrowse link
G Fancg FA complementation group G increases expression
affects response to substance
ISO Fluorouracil results in increased expression of FANCG mRNA
FANCG affects the susceptibility to Fluorouracil; FANCG protein affects the susceptibility to Fluorouracil
CTD PMID:15067352, PMID:15109396, PMID:15548681 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819
JBrowse link
G Fanci FA complementation group I affects response to substance ISO FANCI protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial decreases expression ISO Fluorouracil results in decreased expression of FARS2 mRNA CTD PMID:16101138 NCBI chr17:29,006,981...29,438,906
Ensembl chr17:29,006,988...29,438,668
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [Docosahexaenoic Acids co-treated with Fluorouracil] results in decreased expression of FAS mRNA; [Fluorouracil co-treated with RNF34 protein] results in increased expression of FAS protein; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP3 protein]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP8 protein]; FAS protein affects the reaction [Fluorouracil results in increased activity of CASP9 protein]; N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased expression of FAS protein]; TP53 protein affects the reaction [Fluorouracil results in increased expression of FAS mRNA]; TP53 protein affects the reaction [Fluorouracil results in increased expression of FAS protein]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of FAS protein]; TP53 protein promotes the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in increased expression of FAS protein]]
Fluorouracil results in increased expression of FAS; Fluorouracil results in increased expression of FAS mRNA; Fluorouracil results in increased expression of FAS protein
CTD PMID:11300326, PMID:14665630, PMID:15016801, PMID:15034078, PMID:15152939, PMID:15161716, PMID:15546879, PMID:15585135, PMID:16557594, PMID:16596200, PMID:16709241, PMID:16957513, PMID:17039268, PMID:17045692, PMID:17056233, PMID:17982676, PMID:18074150, PMID:19015929, PMID:22525470 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases response to substance
increases expression
ISO FASL results in increased susceptibility to Fluorouracil
Fluorouracil results in increased expression of FASL
CTD PMID:11196169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbln1 fibulin 1 affects expression
increases expression
ISO Fluorouracil affects the expression of FBLN1 mRNA
Fluorouracil results in increased expression of FBLN1 mRNA
CTD PMID:15205334, PMID:17039268 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO Fluorouracil results in decreased expression of FBXO5 mRNA CTD PMID:16557594, PMID:19272435 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fdxr ferredoxin reductase multiple interactions
increases expression
ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of FDXR mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of FDXR mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of FDXR protein]
Fluorouracil results in increased expression of FDXR mRNA; Fluorouracil results in increased expression of FDXR mRNA alternative form; Fluorouracil results in increased expression of FDXR protein
CTD PMID:14665630, PMID:15016801, PMID:15205334, PMID:16557594, PMID:17982676, PMID:22966307 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
JBrowse link
G Fen1 flap structure-specific endonuclease 1 affects response to substance
increases expression
ISO FEN1 affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of FEN1 mRNA
CTD PMID:15067352, PMID:15109396 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fermt2 fermitin family member 2 affects response to substance ISO FERMT2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Fgd6 FYVE, RhoGEF and PH domain containing 6 affects response to substance ISO FGD6 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 7:34,951,878...35,063,006
Ensembl chr 7:34,952,011...35,063,929
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Fluorouracil results in decreased expression of FGF2 mRNA CTD PMID:16510598 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf4 fibroblast growth factor 4 affects expression ISO Fluorouracil affects the expression of FGF4 protein CTD PMID:21296659 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fgf5 fibroblast growth factor 5 decreases expression ISO Fluorouracil results in decreased expression of FGF5 protein CTD PMID:21296659 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgf7 fibroblast growth factor 7 decreases response to substance
multiple interactions
ISO FGF7 protein results in decreased susceptibility to Fluorouracil; FGF7 results in decreased susceptibility to Fluorouracil
FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Fluorouracil]; FGFR2 protein alternative form inhibits the reaction [FGF7 protein results in decreased susceptibility to Fluorouracil]
CTD PMID:18575591 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Fluorouracil]; FGFR2 protein alternative form inhibits the reaction [FGF7 protein results in decreased susceptibility to Fluorouracil] CTD PMID:18575591 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgg fibrinogen gamma chain decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of FGG mRNA
FGG protein affects the susceptibility to Fluorouracil
CTD PMID:16217747, PMID:17039268 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fhl2 four and a half LIM domains 2 affects response to substance ISO FHL2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fhl3 four and a half LIM domains 3 increases expression ISO Fluorouracil results in increased expression of FHL3 mRNA CTD PMID:17039268 NCBI chr 5:142,688,962...142,696,330
Ensembl chr 5:142,689,026...142,696,383
JBrowse link
G Filip1l filamin A interacting protein 1-like affects response to substance
increases expression
ISO FILIP1L protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of FILIP1L protein
CTD PMID:15352031 NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 affects response to substance ISO FKBP11 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B affects response to substance ISO FKBP1B protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of FKBP5 mRNA] CTD PMID:15016801 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO Fluorouracil results in increased expression of FKBPL mRNA CTD PMID:14503796 NCBI chr20:4,411,890...4,413,360
Ensembl chr20:4,411,876...4,413,366
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 affects response to substance ISO FLRT2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 6:119,518,459...119,613,534
Ensembl chr 6:119,519,714...119,609,296
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of FLT1 protein
IFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of FLT1 protein]
CTD PMID:18157009 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fmod fibromodulin multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of FMOD mRNA] CTD PMID:15016801 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Fluorouracil results in decreased expression of FN1 protein CTD PMID:21296659 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fnbp1 formin binding protein 1 affects response to substance ISO FNBP1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 3:9,865,657...9,936,333
Ensembl chr 3:9,861,237...9,936,405
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of FNDC3B mRNA
FNDC3B protein affects the susceptibility to Fluorouracil
CTD PMID:16217747, PMID:16510598 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Folr1 folate receptor alpha decreases expression ISO Fluorouracil results in decreased expression of FOLR1 mRNA CTD PMID:16510598 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression
ISO Fluorouracil results in increased expression of FOS mRNA
Fluorouracil affects the expression of FOS mRNA
CTD PMID:15205334, PMID:17039268 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Fluorouracil results in decreased expression of FOXA2 protein CTD PMID:21296659 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Foxc1 forkhead box C1 affects expression ISO Fluorouracil affects the expression of FOXC1 mRNA CTD PMID:16584549 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Foxd3 forkhead box D3 decreases expression ISO Fluorouracil results in decreased expression of FOXD3 protein CTD PMID:21296659 NCBI chr 5:118,346,283...118,349,120 JBrowse link
G Foxg1 forkhead box G1 decreases expression ISO Fluorouracil results in decreased expression of FOXG1 mRNA CTD PMID:30518710 NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037
JBrowse link
G Foxn3 forkhead box N3 decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of FOXN3 protein
FOXN3 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 6:123,183,720...123,577,719
Ensembl chr 6:123,187,726...123,577,695
JBrowse link
G Foxo3 forkhead box O3 affects response to substance ISO FOXO3 affects the susceptibility to Fluorouracil CTD PMID:15067352 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fpgs folylpolyglutamate synthase increases response to substance ISO FPGS protein results in increased susceptibility to Fluorouracil CTD PMID:15542523 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
G Fut1 fucosyltransferase 1 affects response to substance ISO FUT1 protein affects the susceptibility to Fluorouracil CTD PMID:15649251 NCBI chr 1:101,599,018...101,602,440
Ensembl chr 1:101,599,018...101,602,436
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Fluorouracil results in increased expression of FXYD3 mRNA CTD PMID:15152939 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects response to substance ISO FYN protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Fzd2 frizzled class receptor 2 affects response to substance ISO FZD2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G G0s2 G0/G1switch 2 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of G0S2 protein
G0S2 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression ISO Fluorouracil results in increased expression of GABRB3 protein CTD PMID:21296659 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases expression
affects response to substance
increases response to substance
multiple interactions
ISO Fluorouracil results in increased expression of GADD45A mRNA; Fluorouracil results in increased expression of GADD45A protein
Fluorouracil results in decreased expression of GADD45A mRNA
GADD45A protein affects the susceptibility to Fluorouracil
GADD45A protein results in increased susceptibility to Fluorouracil
GADD45A affects the susceptibility to Fluorouracil
TP53 protein affects the reaction [Fluorouracil results in increased expression of GADD45A mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of GADD45A mRNA]
CTD PMID:15016801, PMID:15067352, PMID:15205334, PMID:16709241, PMID:16732331, PMID:17982676, PMID:19003803, PMID:19098008, PMID:19272435, PMID:22525470 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases response to substance
affects response to substance
multiple interactions
ISO GADD45B protein results in decreased susceptibility to Fluorouracil
GADD45B protein affects the susceptibility to Fluorouracil
IFNG protein inhibits the reaction [GADD45B protein results in decreased susceptibility to Fluorouracil]
CTD PMID:16732331, PMID:17711513 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Fluorouracil results in increased expression of GADD45G mRNA CTD PMID:19272435 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Fluorouracil results in decreased expression of GAL protein CTD PMID:21296659 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 affects response to substance ISO GALNT3 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 3:52,174,469...52,212,395
Ensembl chr 3:52,175,547...52,212,412
JBrowse link
G Gamt guanidinoacetate N-methyltransferase increases expression
affects response to substance
multiple interactions
ISO Fluorouracil results in increased expression of GAMT protein
GAMT protein affects the susceptibility to Fluorouracil
GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of GAMT mRNA]
CTD PMID:15016801, PMID:15352031, PMID:16896004 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects splicing
decreases expression
ISO Fluorouracil affects the splicing of GAPDH mRNA
Fluorouracil results in decreased expression of GAPDH protein
CTD PMID:17169984, PMID:21296659 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase increases expression ISO Fluorouracil results in increased expression of GART mRNA CTD PMID:19219653 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Gast gastrin decreases response to substance ISO GAST protein modified form results in decreased susceptibility to Fluorouracil CTD PMID:16618411 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 mRNA]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN mRNA]; Fluorouracil inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gata4 GATA binding protein 4 affects expression ISO Fluorouracil affects the expression of GATA4 protein CTD PMID:21296659 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gata6 GATA binding protein 6 affects expression ISO Fluorouracil affects the expression of GATA6 protein CTD PMID:21296659 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects response to substance ISO GCLM protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gcsh glycine cleavage system protein H multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of GCSH mRNA] CTD PMID:15016801 NCBI chr19:49,522,054...49,532,811
Ensembl chr19:49,522,054...49,532,811
JBrowse link
G Gdf1 growth differentiation factor 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of GDF1 mRNA] CTD PMID:15016801 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,767
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of GDF15 mRNA; Fluorouracil results in increased expression of GDF15 protein
TP53 protein affects the reaction [Fluorouracil results in increased expression of GDF15 mRNA]
CTD PMID:14665630, PMID:15016801, PMID:15205334, PMID:24737281 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf3 growth differentiation factor 3 affects expression ISO Fluorouracil affects the expression of GDF3 protein CTD PMID:21296659 NCBI chr 4:155,417,667...155,422,014
Ensembl chr 4:155,417,004...155,421,998
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle affects expression ISO Fluorouracil affects the expression of GEM mRNA CTD PMID:15205334 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Fluorouracil results in increased expression of GFAP protein CTD PMID:21296659 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Gins1 GINS complex subunit 1 increases response to substance ISO GINS1 gene mutant form results in increased susceptibility to Fluorouracil CTD PMID:18984863 NCBI chr 3:146,695,366...146,716,787
Ensembl chr 3:146,695,344...146,716,816
JBrowse link
G Gins2 GINS complex subunit 2 affects expression ISO Fluorouracil affects the expression of GINS2 mRNA CTD PMID:16584549 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608
JBrowse link
G Gja1 gap junction protein, alpha 1 affects response to substance ISO GJA1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747, PMID:16531325 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjc1 gap junction protein, gamma 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of GJC1 mRNA] CTD PMID:15016801 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287
JBrowse link
G Gla galactosidase, alpha affects response to substance ISO GLA protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of GLI1 mRNA
GLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein]
CTD PMID:18776995 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Fluorouracil results in increased expression of GLIPR1 mRNA CTD PMID:24737281 NCBI chr 7:54,767,828...54,778,823
Ensembl chr 7:54,767,827...54,778,848
JBrowse link
G Gnb2 G protein subunit beta 2 decreases expression ISO Fluorouracil results in decreased expression of GNB2 mRNA CTD PMID:16709241 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096
JBrowse link
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of GNE protein
GNE protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 5:59,511,738...59,553,421
Ensembl chr 5:59,512,872...59,553,416
JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta affects expression ISO Fluorouracil affects the expression of GP1BB mRNA CTD PMID:16584549 NCBI chr11:86,520,992...86,522,169
Ensembl chr11:86,520,992...86,522,169
JBrowse link
G Gpr132 G protein-coupled receptor 132 increases expression ISO Fluorouracil results in increased expression of GPR132 mRNA CTD PMID:16584549 NCBI chr 6:137,652,213...137,671,658
Ensembl chr 6:137,652,213...137,664,133
JBrowse link
G Gpr137c G protein-coupled receptor 137C affects expression ISO Fluorouracil affects the expression of GPR137C mRNA CTD PMID:16584549 NCBI chr15:19,547,783...19,615,717
Ensembl chr15:19,547,871...19,614,805
JBrowse link
G Gpr35 G protein-coupled receptor 35 affects response to substance
increases expression
ISO GPR35 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of GPR35 mRNA
CTD PMID:15331170 NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
JBrowse link
G Gpr87 G protein-coupled receptor 87 increases expression ISO Fluorouracil results in increased expression of GPR87 mRNA CTD PMID:24737281 NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO
EXP
Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Fluorouracil results in increased activity of GPT protein
CTD PMID:27836789, PMID:29678497, PMID:31129132 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of GPX1 mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of GPX1 mRNA]
CTD PMID:17982676 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of GPX2 mRNA] CTD PMID:15016801 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gramd4 GRAM domain containing 4 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of GRAMD4 mRNA
TP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA]
CTD PMID:21127500 NCBI chr 7:126,939,819...127,013,455
Ensembl chr 7:126,939,925...127,013,486
JBrowse link
G Grb7 growth factor receptor bound protein 7 increases expression ISO Fluorouracil results in increased expression of GRB7 protein CTD PMID:21296659 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Grhl3 grainyhead-like transcription factor 3 affects expression ISO Fluorouracil affects the expression of GRHL3 mRNA CTD PMID:16584549 NCBI chr 5:153,893,039...153,925,045
Ensembl chr 5:153,893,039...153,924,896
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 affects expression ISO Fluorouracil affects the expression of GRINA mRNA CTD PMID:16584549 NCBI chr 7:117,304,742...117,307,916
Ensembl chr 7:117,304,742...117,307,916
JBrowse link
G Gspt1 G1 to S phase transition 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of GSPT1 mRNA] CTD PMID:15016801 NCBI chr10:4,313,100...4,347,661
Ensembl chr10:4,312,863...4,446,200
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects response to substance ISO GSTA4 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO Fluorouracil results in increased expression of GSTP1 mRNA
[Cisplatin co-treated with Fluorouracil] results in decreased expression of GSTP1 mRNA; GSTP1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]; GSTP1 gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]
CTD PMID:15205334, PMID:15213713, PMID:15737843, PMID:16622263 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO Fluorouracil results in increased expression of GSTT1 protein CTD PMID:15585135, PMID:16803524 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gtpbp4 GTP binding protein 4 affects response to substance ISO GTPBP4 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:63,111,086...63,145,618
Ensembl chr17:63,110,254...63,145,577
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 decreases expression ISO Fluorouracil results in decreased expression of GUCY1B1 mRNA CTD PMID:19219653 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G H1f0 H1 histone family, member 0 affects expression ISO Fluorouracil affects the expression of H1F0 mRNA CTD PMID:20421339 NCBI chr 7:120,260,776...120,262,636 JBrowse link
G H2ax H2A.X variant histone affects expression
multiple interactions
increases phosphorylation
ISO Fluorouracil affects the expression of H2AX mRNA
[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein; [S100A11 mutant form results in increased susceptibility to Fluorouracil] which results in increased expression of H2AX protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein]; TP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein]]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of H2AX mRNA]
Fluorouracil results in increased phosphorylation of H2AX protein
CTD PMID:15016801, PMID:16584549, PMID:25940438, PMID:26544897 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression
affects response to substance
increases expression
ISO Fluorouracil results in decreased expression of H2BC12 mRNA
H2BC12 protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of H2BC12 protein
CTD PMID:15352031, PMID:16101138, PMID:16217747 NCBI chr17:44,527,421...44,527,801
Ensembl chr17:44,527,421...44,527,801
JBrowse link
G H4f3 H1.3 linker histone, cluster member increases expression ISO Fluorouracil results in increased expression of H1-3 protein CTD PMID:15585135 NCBI chr17:43,797,711...43,798,450
Ensembl chr17:43,797,721...43,798,383
JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 affects response to substance ISO HACD1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:81,173,238...81,196,012
Ensembl chr17:81,173,713...81,187,739
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HAND1 mRNA] CTD PMID:15016801 NCBI chr10:43,250,729...43,253,296
Ensembl chr10:43,250,745...43,253,296
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 increases expression ISO Fluorouracil results in increased expression of HAND2 mRNA CTD PMID:24737281 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 affects expression ISO Fluorouracil affects the expression of HAPLN2 mRNA CTD PMID:16584549 NCBI chr 2:187,395,104...187,402,076
Ensembl chr 2:187,396,349...187,401,786
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HBA1 mRNA] CTD PMID:15016801 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta affects splicing ISO Fluorouracil affects the splicing of HBB mRNA CTD PMID:17169984 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hbe1 hemoglobin subunit epsilon 1 decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of HBE1 protein
HBE1 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 1:169,003,904...169,005,184
Ensembl chr 1:169,003,788...169,005,190
JBrowse link
G Hbz hemoglobin subunit zeta decreases expression ISO Fluorouracil results in decreased expression of HBZ protein CTD PMID:21296659 NCBI chr10:15,609,348...15,610,826
Ensembl chr10:15,609,358...15,610,826
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]; [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]; Fluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC1 protein] CTD PMID:25178657 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions ISO [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]; [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]; Fluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC2 protein] CTD PMID:25178657 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO Fluorouracil results in decreased expression of HDAC3 mRNA CTD PMID:19272435 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac4 histone deacetylase 4 decreases expression ISO Fluorouracil results in decreased expression of HDAC4 mRNA CTD PMID:16557594 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hdac7 histone deacetylase 7 decreases expression ISO Fluorouracil results in decreased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO Fluorouracil results in increased expression of HDAC9 mRNA CTD PMID:24737281 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hdgfl3 HDGF like 3 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HDGFL3 mRNA] CTD PMID:15016801 NCBI chr 1:143,702,864...143,752,060
Ensembl chr 1:143,702,853...143,751,789
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HERPUD1 mRNA] CTD PMID:15016801 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases activity ISO Fluorouracil results in increased activity of HES1 protein CTD PMID:19147571 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Fluorouracil results in increased expression of HGF mRNA CTD PMID:24737281 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hic2 HIC ZBTB transcriptional repressor 2 affects response to substance ISO HIC2 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr11:87,988,213...88,016,825
Ensembl chr11:87,988,213...88,016,825
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects localization
decreases expression
decreases uptake
affects response to substance
decreases response to substance
multiple interactions
ISO Fluorouracil affects the localization of HIF1A protein
Fluorouracil results in decreased expression of HIF1A protein
HIF1A protein results in decreased uptake of Fluorouracil
HIF1A protein affects the susceptibility to Fluorouracil
Fluorouracil results in decreased susceptibility to HIF1A protein; HIF1A results in decreased susceptibility to Fluorouracil
Acetylcysteine inhibits the reaction [Fluorouracil affects the localization of HIF1A protein]; Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Fluorouracil]
CTD PMID:16628086, PMID:17066447, PMID:17219956, PMID:27163855 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Fluorouracil results in increased expression of HINT1 protein CTD PMID:15585135, PMID:16803524 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of H4C2 mRNA
TP53 protein affects the reaction [Fluorouracil results in decreased expression of H4C2 mRNA]
CTD PMID:15016801, PMID:17039268 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
JBrowse link
G Hk2 hexokinase 2 decreases expression
affects response to substance
multiple interactions
ISO Fluorouracil results in decreased expression of HK2 protein
HK2 protein affects the susceptibility to Fluorouracil
HK2 protein affects the reaction [Fluorouracil results in increased activity of CASP3 protein]
CTD PMID:16595493, PMID:18772588 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hm13 histocompatibility minor 13 affects expression ISO Fluorouracil affects the expression of HM13 mRNA CTD PMID:16584549 NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623
JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific affects response to substance ISO HMCES protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 4:119,841,088...119,864,115
Ensembl chr 4:119,815,139...119,864,114
JBrowse link
G Hmg20b high mobility group 20 B decreases expression ISO Fluorouracil results in decreased expression of HMG20B mRNA CTD PMID:16709241 NCBI chr 7:11,238,594...11,243,312
Ensembl chr 7:11,238,630...11,243,310
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HMG1 mRNA] CTD PMID:15016801 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 increases expression ISO Fluorouracil results in increased expression of HMGN5 mRNA CTD PMID:16510598 NCBI chr  X:80,134,557...80,142,902
Ensembl chr  X:80,134,557...80,142,902
JBrowse link
G Hmmr hyaluronan-mediated motility receptor multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HMMR mRNA] CTD PMID:15016801 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
ISO
EXP
Fluorouracil results in increased expression of HMOX1
Fluorouracil affects the expression of HMOX1 mRNA
CTD PMID:20722640, PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression
multiple interactions
ISO Fluorouracil results in decreased expression of HNRNPA1 mRNA
TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPA1 mRNA]
CTD PMID:15016801, PMID:16101138 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPA2B1 mRNA] CTD PMID:15016801 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C increases expression ISO Fluorouracil results in increased expression of HNRNPC protein CTD PMID:15585135, PMID:16803524 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPF mRNA] CTD PMID:15016801 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPH1 mRNA] CTD PMID:15016801 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPL mRNA] CTD PMID:15016801 NCBI chr 1:86,994,090...87,006,776
Ensembl chr 1:86,996,093...87,006,776
JBrowse link
G Hoxa1 homeobox A1 decreases expression ISO Fluorouracil results in decreased expression of HOXA1 mRNA CTD PMID:24737281 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hoxb3 homeo box B3 decreases expression ISO Fluorouracil results in decreased expression of HOXB3 mRNA CTD PMID:24737281 NCBI chr10:84,170,629...84,196,823
Ensembl chr10:84,182,118...84,195,796
JBrowse link
G Hoxc11 homeobox C11 affects expression
affects response to substance
ISO Fluorouracil affects the expression of HOXC11 protein
HOXC11 protein affects the susceptibility to Fluorouracil
CTD PMID:15331170 NCBI chr 7:144,565,392...144,568,580
Ensembl chr 7:144,565,392...144,567,580
JBrowse link
G Hoxd1 homeo box D1 decreases expression ISO Fluorouracil results in decreased expression of HOXD1 mRNA CTD PMID:24737281 NCBI chr 3:61,685,619...61,687,758
Ensembl chr 3:61,685,619...61,687,758
JBrowse link
G Hpx hemopexin multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of HPX mRNA] CTD PMID:15016801 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Fluorouracil results in increased expression of HRAS mRNA CTD PMID:16557594 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 decreases expression ISO Fluorouracil results in decreased expression of HS6ST2 mRNA CTD PMID:16510598 NCBI chr  X:138,675,326...138,972,774
Ensembl chr  X:138,677,580...138,972,684
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects expression ISO Fluorouracil affects the expression of HSD17B2 mRNA CTD PMID:16584549 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of HSPA1B protein
HSPA1B protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of HSPA2 mRNA
HSPA2 protein affects the susceptibility to Fluorouracil
CTD PMID:16101138, PMID:16217747 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of HSPA4 protein
HSPA4 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Fluorouracil results in decreased expression of HSPA5 protein CTD PMID:29879413 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects response to substance ISO HSPA8 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
decreases response to substance
ISO HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin]
HSPB1 protein results in decreased susceptibility to Fluorouracil
CTD PMID:18949417, PMID:19088045 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 increases phosphorylation
multiple interactions
ISO Fluorouracil results in increased phosphorylation of HSPB2 protein
SB 203580 inhibits the reaction [Fluorouracil results in increased phosphorylation of HSPB2 protein]
CTD PMID:18757417 NCBI chr 8:55,176,648...55,178,227
Ensembl chr 8:55,176,847...55,177,818
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Fluorouracil results in increased expression of HSPB8 mRNA CTD PMID:16557594 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Fluorouracil results in increased expression of HSPE1 mRNA CTD PMID:15152939 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions
increases response to substance
ISO [Fluorouracil co-treated with irinotecan] results in increased expression of HTATIP2 mRNA
HTATIP2 protein results in increased susceptibility to Fluorouracil
CTD PMID:16391804, PMID:16799960 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects expression ISO Fluorouracil affects the expression of HTR7 mRNA CTD PMID:16584549 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of HTRA1 protein
HTRA1 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Iapp islet amyloid polypeptide decreases expression ISO Fluorouracil results in decreased expression of IAPP protein CTD PMID:21296659 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression
multiple interactions
ISO Fluorouracil results in increased expression of ID1 mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of ID1 mRNA]
CTD PMID:16557594 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression
increases expression
multiple interactions
affects response to substance
ISO Fluorouracil results in decreased expression of ID2 protein
Fluorouracil results in increased expression of ID2 mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of ID2 mRNA]
ID2 protein affects the susceptibility to Fluorouracil
CTD PMID:15016739, PMID:15352031, PMID:16557594, PMID:25178657 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Fluorouracil results in increased expression of ID3 mRNA CTD PMID:15205334, PMID:16557594 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 affects response to substance ISO IDI1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ier5 immediate early response 5 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of IER5 mRNA] CTD PMID:15016801 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
G Ifi27l2b interferon, alpha-inducible protein 27 like 2B multiple interactions ISO [Fluorouracil co-treated with irinotecan] results in increased expression of IFI27L2 mRNA CTD PMID:16391804 NCBI chr 6:127,336,305...127,337,791
Ensembl chr 6:127,336,305...127,337,791
JBrowse link
G Ifi35 interferon-induced protein 35 increases expression ISO Fluorouracil results in increased expression of IFI35 mRNA CTD PMID:16101138 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Fluorouracil results in increased expression of IFIT2 mRNA CTD PMID:16101138 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO Fluorouracil results in decreased expression of IFITM1 protein CTD PMID:21296659 NCBI chr 1:213,765,825...213,767,841
Ensembl chr 1:213,766,758...213,767,815
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Fluorouracil results in increased expression of IFITM2 protein CTD PMID:21296659 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 increases expression ISO Fluorouracil results in increased expression of IFNAR1 mRNA; Fluorouracil results in increased expression of IFNAR1 protein CTD PMID:17088986 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 increases expression ISO Fluorouracil results in increased expression of IFNAR2 mRNA; Fluorouracil results in increased expression of IFNAR2 protein CTD PMID:16101138, PMID:17088986 NCBI chr11:31,527,790...31,559,834
Ensembl chr11:31,539,016...31,558,851
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions
increases response to substance
ISO [Fluorouracil co-treated with IFNB1 protein] results in increased activity of CASP3 protein
IFNB1 protein results in increased susceptibility to Fluorouracil
CTD PMID:15937643, PMID:16101138, PMID:18608205, PMID:18695887 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases abundance
ISO [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to Fluorouracil; Fluorouracil promotes the reaction [IL18 protein modified form results in increased expression of IFNG protein]; IFNG protein inhibits the reaction [GADD45B protein results in decreased susceptibility to Fluorouracil]
Fluorouracil results in decreased expression of IFNG protein
LCS101 inhibits the reaction [Fluorouracil results in decreased expression of IFNG protein]
IFNG protein results in increased abundance of Fluorouracil
CTD PMID:15162350, PMID:15301717, PMID:15754409, PMID:16568373, PMID:17711513, PMID:23637542 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Fluorouracil results in increased expression of IGF1 mRNA CTD PMID:16888818 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Fluorouracil results in decreased phosphorylation of and results in decreased activity of IGF1R protein CTD PMID:17918158 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Fluorouracil results in increased expression of IGFBP2 protein CTD PMID:21296659 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Fluorouracil results in decreased expression of IGFBP5 mRNA CTD PMID:16557594 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 decreases expression
affects response to substance
ISO Fluorouracil results in decreased expression of IGFBP6 protein
IGFBP6 protein affects the susceptibility to Fluorouracil
CTD PMID:15352031 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Ihh Indian hedgehog signaling molecule decreases expression ISO Fluorouracil results in decreased expression of IHH mRNA; Fluorouracil results in decreased expression of IHH protein CTD PMID:25190613 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Ikbip IKBKB interacting protein increases expression
multiple interactions
ISO Fluorouracil results in increased expression of IKBIP mRNA
TP53 protein promotes the reaction [Fluorouracil results in increased expression of IKBIP mRNA]
CTD PMID:17982676 NCBI chr 7:31,784,390...31,803,200
Ensembl chr 7:31,784,438...31,803,194
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 protein CTD PMID:31651976 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression ISO Fluorouracil results in decreased expression of IL12B protein CTD PMID:15754409 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il18 interleukin 18 multiple interactions
affects expression
ISO [Fluorouracil co-treated with irinotecan] results in decreased expression of IL18 mRNA; Fluorouracil promotes the reaction [IL18 protein modified form results in increased expression of IFNG protein]; Fluorouracil results in increased cleavage of and results in increased secretion of IL18 protein
Fluorouracil affects the expression of IL18 mRNA
CTD PMID:15162350, PMID:16391804, PMID:20421339 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1A protein CTD PMID:31651976 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions
ISO
EXP
Fluorouracil results in increased expression of IL1B mRNA; Fluorouracil results in increased expression of IL1B protein
Fluorouracil results in increased secretion of IL1B protein
[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1B protein; Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]
IL1B promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]
CTD PMID:16820919, PMID:18523641, PMID:18535404, PMID:19528421, PMID:20844880, PMID:31651976, PMID:32314717 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO IL1RN protein affects the reaction [Fluorouracil results in increased expression of BAX protein]; IL1RN protein affects the reaction [Fluorouracil results in increased expression of CASP3 protein modified form]; IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2L1 protein] CTD PMID:20844880 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il27ra interleukin 27 receptor subunit alpha affects response to substance ISO IL27RA protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086
JBrowse link
G Il3 interleukin 3 multiple interactions ISO [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL3 protein CTD PMID:31651976 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
IL6 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]
Fluorouracil inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]
Fluorouracil results in increased expression of IL6 mRNA
CTD PMID:16820919, PMID:18344199, PMID:18523641, PMID:25824412 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7 interleukin 7 affects expression ISO Fluorouracil affects the expression of IL7 mRNA CTD PMID:18344199 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Impa2 inositol monophosphatase 2 increases expression ISO Fluorouracil results in increased expression of IMPA2 mRNA CTD PMID:16510598 NCBI chr18:63,016,577...63,050,123
Ensembl chr18:63,016,577...63,047,781
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression ISO Fluorouracil results in increased expression of IMPDH2 mRNA CTD PMID:19219653 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Inka2 inka box actin regulator 2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in increased expression of INKA2 mRNA] CTD PMID:15016801 NCBI chr 2:208,170,652...208,187,088
Ensembl chr 2:208,170,652...208,185,965
JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of INPP5E mRNA] CTD PMID:15016801 NCBI chr 3:3,843,307...3,856,154
Ensembl chr 3:3,843,307...3,855,981
JBrowse link
G Ins2 insulin 2 decreases expression ISO Fluorouracil results in decreased expression of INS2 protein CTD PMID:21296659 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Fluorouracil results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of IQGAP2 mRNA] CTD PMID:15016801 NCBI chr 2:26,161,628...26,439,067
Ensembl chr 2:26,167,199...26,438,790
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression
affects response to substance
ISO Fluorouracil results in increased expression of IRAK1 mRNA
IRAK1 affects the susceptibility to Fluorouracil
CTD PMID:15067352, PMID:15109396 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression ISO Fluorouracil results in increased expression of IREB2 mRNA CTD PMID:16584549 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Fluorouracil results in increased expression of IRF9 mRNA CTD PMID:16101138, PMID:17039268 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Irgm immunity-related GTPase M affects response to substance ISO IRGM1 protein affects the susceptibility to Fluorouracil CTD PMID:18371424 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Fluorouracil results in increased expression of ISG15 mRNA CTD PMID:16101138, PMID:16557594 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO Fluorouracil results in decreased expression of ISL1 protein CTD PMID:21296659 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Itgav integrin subunit alpha V affects response to substance ISO ITGAV protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression ISO Fluorouracil results in decreased expression of ITGB2 CTD PMID:15485462 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Fluorouracil results in decreased expression of ITGB4 mRNA CTD PMID:15205334 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of ITPR1 mRNA] CTD PMID:15016801 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itsn1 intersectin 1 affects response to substance ISO ITSN1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 NCBI chr11:31,943,119...32,069,249
Ensembl chr11:31,893,489...32,069,249
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Fluorouracil results in increased expression of JAG1 mRNA CTD PMID:16510598 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression
ISO Fluorouracil affects the expression of JUN mRNA
Fluorouracil results in increased expression of JUN mRNA
CTD PMID:15205334, PMID:16557594, PMID:17355264 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Fluorouracil results in increased expression of JUNB mRNA
JUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]
CTD PMID:16557594, PMID:18678097 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kansl1 KAT8 regulatory NSL complex subunit 1 multiple interactions ISO KANSL1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:18927307 NCBI chr10:92,388,045...92,517,449
Ensembl chr10:92,389,530...92,476,109
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases response to substance ISO KCNA5 protein results in increased susceptibility to Fluorouracil CTD PMID:17428690 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of KCNQ2 mRNA] CTD PMID:15016801 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Fluorouracil results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kdm4b lysine demethylase 4B multiple interactions
affects expression
ISO KDM4B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Fluorouracil affects the expression of KDM4B mRNA
CTD PMID:16896004, PMID:20421339 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Kdm5a lysine demethylase 5A decreases expression ISO Fluorouracil results in decreased expression of KDM5A mRNA CTD PMID:16557594 NCBI chr 4:152,892,388...152,972,196
Ensembl chr 4:152,892,388...152,972,201
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Fluorouracil results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance ISO KEAP1 protein affects the susceptibility to Fluorouracil CTD PMID:18692501 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Khk ketohexokinase affects response to substance
increases expression
ISO KHK protein affects the susceptibility to Fluorouracil
Fluorouracil results in increased expression of KHK protein
CTD PMID:15352031 NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959
JBrowse link
G Kif15 kinesin family member 15 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of KIF15 mRNA] CTD PMID:15016801 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Kif23 kinesin family member 23 multiple interactions ISO TP53 protein affects the reaction [Fluorouracil results in decreased expression of KIF23 mRNA] CTD PMID:15016801 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kif2c kinesin family member 2C affects response to substance ISO KIF2C protein affects the susceptibility to Fluorouracil CTD PMID:15548681 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Kif3a kinesin family member 3a multiple interactions ISO KIF3A mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:38,918,705...38,953,958
Ensembl chr10:38,918,748...38,952,785
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance
decreases expression
ISO KIT protein mutant form affects the susceptibility to Fluorouracil
Fluorouracil results in decreased expression of KIT protein
CTD PMID:19100679, PMID:21296659 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G