Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:465284 term browser browse the term
Definition:An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections.
Synonyms:exact_synonym: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
 related_synonym: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol;   2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol;   2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone;   9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine;   9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE;   9-[(1,3-dihydroxy-2-propoxy)methyl]guanine;   Formula=C9H13N5O4;   GA2;   InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);   InChIKey=IRSCQMHQWWYFCW-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1;   ganciclovirum;   gancyclovir
 alt_id: CHEBI:42659;   CHEBI:5273
 xref: Beilstein:3654487;   CAS:82410-32-0;   DrugBank:DB01004;   Drug_Central:1277;   HMDB:HMDB0015139;   KEGG:D00333;   LINCS:LSM-5382
 xref_mesh: MESH:D015774
 xref: PDBeChem:GA2;   PMID:10197958;   PMID:10377226;   PMID:10411487;   PMID:10447945;   PMID:10560739;   PMID:10691698;   PMID:10882370;   PMID:10882372;   PMID:10882374;   PMID:10882375;   PMID:10888336;   PMID:10966740;   PMID:10966745;   PMID:10999475;   PMID:11229780;   PMID:11262090;   PMID:11412988;   PMID:11454465;   PMID:11472207;   PMID:11495586;   PMID:11585457;   PMID:11677126;   PMID:11708924;   PMID:11708929;   PMID:11754587;   PMID:11814776;   PMID:11858989;   PMID:11985471;   PMID:12408716;   PMID:12459010;   PMID:12723951;   PMID:1310744;   PMID:1319491;   PMID:1323678;   PMID:14521407;   PMID:14584954;   PMID:14643328;   PMID:14643358;   PMID:14736238;   PMID:15027877;   PMID:15081019;   PMID:15481985;   PMID:15509173;   PMID:15509174;   PMID:15509175;   PMID:15509176;   PMID:15615545;   PMID:15634003;   PMID:15658858;   PMID:15658861;   PMID:15658873;   PMID:15689173;   PMID:15745823;   PMID:15801851;   PMID:16134946;   PMID:16392791;   PMID:16392824;   PMID:16420056;   PMID:16480257;   PMID:1652016;   PMID:16759112;   PMID:16814545;   PMID:17004726;   PMID:17043128;   PMID:17092728;   PMID:17161946;   PMID:17181158;   PMID:17181162;   PMID:17188402;   PMID:17239594;   PMID:17298047;   PMID:17329103;   PMID:17402726;   PMID:17434304;   PMID:17438061;   PMID:17513108;   PMID:17518459;   PMID:17539622;   PMID:17622128;   PMID:17672445;   PMID:17869124;   PMID:17948980;   PMID:17960926;   PMID:18082410;   PMID:1849998;   PMID:2157013;   PMID:2160539;   PMID:2163453;   PMID:2163454;   PMID:2165163;   PMID:2175356;   PMID:2329551;   PMID:2329561;   PMID:2391689;   PMID:2500527;   PMID:2544723;   PMID:2822928;   PMID:2826784;   PMID:2840500;   PMID:2842505;   PMID:2846837;   PMID:2848125;   PMID:2913300;   PMID:2989523;   PMID:2993615;   PMID:3009811;   PMID:3016263;   PMID:3871860;   PMID:7562929;   PMID:7562946;   PMID:7562947;   PMID:7752205;   PMID:7877148;   PMID:7932543;   PMID:8071942;   PMID:8176714;   PMID:8254613;   PMID:8394933;   PMID:8632412;   PMID:8709116;   PMID:8765514;   PMID:8784444;   PMID:8784445;   PMID:8941388;   PMID:9046339;   PMID:9057866;   PMID:9057867;   PMID:9057868;   PMID:9216836;   PMID:9438017;   PMID:9548814;   PMID:9575044;   PMID:9836613;   PMID:9836626;   PMID:9871553;   PMID:9925738;   PMID:9934470;   PMID:9934471;   Patent:US4355032;   Reaxys:3654487;   Wikipedia:Ganciclovir

show annotations for term's descendants           Sort by:
ganciclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ganciclovir results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Ganciclovir results in increased secretion of TNF protein
Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
CTD PMID:17143539 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Ganciclovir results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antiinfective agent 13140
              ganciclovir 4
                valganciclovir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          aminopurine 4398
                                            2-aminopurines 4008
                                              guanine 3972
                                                ganciclovir 4
                                                  valganciclovir 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.