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ONTOLOGY REPORT - ANNOTATIONS


Term:ganciclovir
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Accession:CHEBI:465284 term browser browse the term
Definition:An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections.
Synonyms:exact_synonym: 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
 related_synonym: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol;   2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one;   2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol;   2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone;   9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine;   9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE;   9-[(1,3-dihydroxy-2-propoxy)methyl]guanine;   Formula=C9H13N5O4;   GA2;   InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);   InChIKey=IRSCQMHQWWYFCW-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1;   ganciclovirum;   gancyclovir
 alt_id: CHEBI:42659;   CHEBI:5273
 xref: Beilstein:3654487 "Beilstein";   CAS:82410-32-0 "ChemIDplus";   CAS:82410-32-0 "DrugBank";   CAS:82410-32-0 "KEGG COMPOUND";   CAS:82410-32-0 "KEGG DRUG";   DrugBank:DB01004;   Drug_Central:1277 "DrugCentral";   HMDB:HMDB0015139;   KEGG:D00333;   LINCS:LSM-5382
 xref_mesh: MESH:D015774
 xref: PDBeChem:GA2;   PMID:10197958 "ChEMBL";   PMID:10377226 "ChEMBL";   PMID:10411487 "ChEMBL";   PMID:10447945 "ChEMBL";   PMID:10560739 "ChEMBL";   PMID:10691698 "ChEMBL";   PMID:10882370 "ChEMBL";   PMID:10882372 "ChEMBL";   PMID:10882374 "ChEMBL";   PMID:10882375 "ChEMBL";   PMID:10888336 "ChEMBL";   PMID:10966740 "ChEMBL";   PMID:10966745 "ChEMBL";   PMID:10999475 "ChEMBL";   PMID:11229780 "ChEMBL";   PMID:11262090 "ChEMBL";   PMID:11412988 "ChEMBL";   PMID:11454465 "ChEMBL";   PMID:11472207 "ChEMBL";   PMID:11495586 "ChEMBL";   PMID:11585457 "ChEMBL";   PMID:11677126 "ChEMBL";   PMID:11708924 "ChEMBL";   PMID:11708929 "ChEMBL";   PMID:11754587 "ChEMBL";   PMID:11814776 "ChEMBL";   PMID:11858989 "ChEMBL";   PMID:11985471 "ChEMBL";   PMID:12408716 "ChEMBL";   PMID:12459010 "ChEMBL";   PMID:12723951 "ChEMBL";   PMID:1310744 "ChEMBL";   PMID:1319491 "ChEMBL";   PMID:1323678 "ChEMBL";   PMID:14521407 "ChEMBL";   PMID:14584954 "ChEMBL";   PMID:14643328 "ChEMBL";   PMID:14643358 "ChEMBL";   PMID:14736238 "ChEMBL";   PMID:15027877 "ChEMBL";   PMID:15081019 "ChEMBL";   PMID:15481985 "ChEMBL";   PMID:15509173 "ChEMBL";   PMID:15509174 "ChEMBL";   PMID:15509175 "ChEMBL";   PMID:15509176 "ChEMBL";   PMID:15615545 "ChEMBL";   PMID:15634003 "ChEMBL";   PMID:15658858 "ChEMBL";   PMID:15658861 "ChEMBL";   PMID:15658873 "ChEMBL";   PMID:15689173 "ChEMBL";   PMID:15745823 "ChEMBL";   PMID:15801851 "ChEMBL";   PMID:16134946 "ChEMBL";   PMID:16392791 "ChEMBL";   PMID:16392824 "ChEMBL";   PMID:16420056 "ChEMBL";   PMID:16480257 "ChEMBL";   PMID:1652016 "ChEMBL";   PMID:16759112 "ChEMBL";   PMID:16814545 "ChEMBL";   PMID:17004726 "ChEMBL";   PMID:17043128 "ChEMBL";   PMID:17092728 "ChEMBL";   PMID:17161946 "ChEMBL";   PMID:17181158 "ChEMBL";   PMID:17181162 "ChEMBL";   PMID:17188402 "ChEMBL";   PMID:17239594 "ChEMBL";   PMID:17298047 "ChEMBL";   PMID:17329103 "ChEMBL";   PMID:17402726 "ChEMBL";   PMID:17434304 "ChEMBL";   PMID:17438061 "ChEMBL";   PMID:17513108 "ChEMBL";   PMID:17518459 "ChEMBL";   PMID:17539622 "ChEMBL";   PMID:17622128 "ChEMBL";   PMID:17672445 "ChEMBL";   PMID:17869124 "ChEMBL";   PMID:17948980 "ChEMBL";   PMID:17960926 "ChEMBL";   PMID:18082410 "ChEMBL";   PMID:1849998 "ChEMBL";   PMID:2157013 "ChEMBL";   PMID:2160539 "ChEMBL";   PMID:2163453 "ChEMBL";   PMID:2163454 "ChEMBL";   PMID:2165163 "ChEMBL";   PMID:2175356 "ChEMBL";   PMID:2329551 "ChEMBL";   PMID:2329561 "ChEMBL";   PMID:2391689 "ChEMBL";   PMID:2500527 "ChEMBL";   PMID:2544723 "ChEMBL";   PMID:2822928 "ChEMBL";   PMID:2826784 "ChEMBL";   PMID:2840500 "ChEMBL";   PMID:2842505 "ChEMBL";   PMID:2846837 "ChEMBL";   PMID:2848125 "ChEMBL";   PMID:2913300 "ChEMBL";   PMID:2989523 "ChEMBL";   PMID:2993615 "ChEMBL";   PMID:3009811 "ChEMBL";   PMID:3016263 "ChEMBL";   PMID:3871860 "ChEMBL";   PMID:7562929 "ChEMBL";   PMID:7562946 "ChEMBL";   PMID:7562947 "ChEMBL";   PMID:7752205 "ChEMBL";   PMID:7877148 "ChEMBL";   PMID:7932543 "ChEMBL";   PMID:8071942 "ChEMBL";   PMID:8176714 "ChEMBL";   PMID:8254613 "ChEMBL";   PMID:8394933 "ChEMBL";   PMID:8632412 "ChEMBL";   PMID:8709116 "ChEMBL";   PMID:8765514 "ChEMBL";   PMID:8784444 "ChEMBL";   PMID:8784445 "ChEMBL";   PMID:8941388 "ChEMBL";   PMID:9046339 "ChEMBL";   PMID:9057866 "ChEMBL";   PMID:9057867 "ChEMBL";   PMID:9057868 "ChEMBL";   PMID:9216836 "ChEMBL";   PMID:9438017 "ChEMBL";   PMID:9548814 "ChEMBL";   PMID:9575044 "ChEMBL";   PMID:9836613 "ChEMBL";   PMID:9836626 "ChEMBL";   PMID:9871553 "ChEMBL";   PMID:9925738 "ChEMBL";   PMID:9934470 "ChEMBL";   PMID:9934471 "ChEMBL";   Patent:US4355032;   Reaxys:3654487 "Reaxys";   Wikipedia:Ganciclovir


show annotations for term's descendants       view all columns           Sort by:
 
ganciclovir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            antiinfective agent 12918
              ganciclovir 4
                valganciclovir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteropolycyclic compound 17500
                                    organic heterobicyclic compound 15910
                                      imidazopyrimidine 5415
                                        purines 5413
                                          aminopurine 4372
                                            2-aminopurines 3998
                                              guanine 3962
                                                ganciclovir 4
                                                  valganciclovir 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.