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Accession:CHEBI:4659 term browser browse the term
Definition:An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Synonyms:exact_synonym: 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
 related_synonym: 1,1'-dithiobis(N,N-diethylthioformamide);   Antabuse;   Formula=C10H20N2S4;   InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3;   InChIKey=AUZONCFQVSMFAP-UHFFFAOYSA-N;   N,N,N',N'-tetraethylthiuram disulfide;   SMILES=S(SC(N(CC)CC)=S)C(N(CC)CC)=S;   bis(diethylthiocarbamoyl) disulfide;   tetraethylthioperoxydicarbonic diamide;   tetraethylthiuram disulfide;   tetraethylthiuram disulphide
 xref: CAS:97-77-8 "ChemIDplus";   CAS:97-77-8 "KEGG COMPOUND";   CAS:97-77-8 "NIST Chemistry WebBook";   DrugBank:DB00822;   Drug_Central:928 "DrugCentral";   HMDB:HMDB0014960;   KEGG:C01692;   KEGG:D00131;   LINCS:LSM-5467
 xref_mesh: MESH:D004221
 xref: PMID:10841824 "Europe PMC";   PMID:11005259 "Europe PMC";   PMID:11716515 "Europe PMC";   PMID:14978246 "Europe PMC";   PMID:15325261 "Europe PMC";   PMID:15709459 "Europe PMC";   PMID:16426571 "Europe PMC";   PMID:16661923 "Europe PMC";   PMID:16666414 "Europe PMC";   PMID:16880974 "Europe PMC";   PMID:17079463 "Europe PMC";   PMID:17579916 "Europe PMC";   PMID:17667894 "Europe PMC";   PMID:18579431 "Europe PMC";   PMID:19720750 "Europe PMC";   PMID:19782464 "Europe PMC";   PMID:19787200 "Europe PMC";   PMID:21471244 "Europe PMC";   PMID:24496638 "Europe PMC";   PMID:25133664 "Europe PMC";   PMID:25445071 "Europe PMC";   PMID:25464072 "Europe PMC";   PMID:25476326 "Europe PMC";   PMID:25495604 "Europe PMC";   PMID:25557293 "Europe PMC";   PMID:25565438 "Europe PMC";   PMID:25657800 "Europe PMC";   PMID:25777347 "Europe PMC";   PMID:26033731 "Europe PMC";   PMID:26224731 "Europe PMC";   PMID:26235918 "Europe PMC";   PMID:26239994 "Europe PMC";   PMID:26314552 "Europe PMC";   PMID:26517513 "Europe PMC";   PMID:26550292 "Europe PMC";   PMID:8442800 "Europe PMC";   PMID:8572926 "Europe PMC";   Reaxys:1712560 "Reaxys";   Wikipedia:Disulfiram

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disulfiram term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 JBrowse link 14 141,690,737 141,703,078 RGD:6480464
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 836
    role 813
      biological role 813
        inhibitor 480
          NF-kappaB inhibitor 2
            disulfiram 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 836
    subatomic particle 820
      composite particle 820
        hadron 820
          baryon 820
            nucleon 820
              atomic nucleus 820
                atom 820
                  main group element atom 808
                    p-block element atom 805
                      carbon group element atom 776
                        carbon atom 772
                          organic molecular entity 772
                            heteroorganic entity 530
                              organochalcogen compound 494
                                organosulfur compound 182
                                  organic disulfide 5
                                    disulfiram 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.