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ONTOLOGY REPORT - ANNOTATIONS


Term:N-acetylsphingosine
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Accession:CHEBI:46979 term browser browse the term
Definition:A N-acylsphingosine that has an acetamido group at position 2.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide
 related_synonym: (2S,3R,4E)-2-(acetylamino)-4-octadecene-1,3-diol;   C2-ceramide;   Formula=C20H39NO3;   InChI=1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m0/s1;   InChIKey=BLTCBVOJNNKFKC-QUDYQQOWSA-N;   N-(acetyl)-sphing-4-enine;   N-[(2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide;   N-acetoyl-D-erythro-sphingosine;   N-acetyl-D-erythro-sphingosine;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)NC(C)=O
 xref: CAS:3102-57-6 "ChemIDplus"
 xref_mesh: MESH:C064769
 xref: PMID:25656578 "Europe PMC";   PMID:27043542 "Europe PMC";   PMID:27807662 "Europe PMC";   PMID:28288862 "Europe PMC";   PMID:28572944 "Europe PMC";   Reaxys:1728870 "Reaxys"


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N-acetylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Clk1 CDC-like kinase 1 JBrowse link 9 65,296,777 65,308,017 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Dapk1 death associated protein kinase 1 JBrowse link 17 4,297,038 4,454,941 RGD:6480464
G Dffb DNA fragmentation factor subunit beta JBrowse link 5 171,250,559 171,261,875 RGD:6480464
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6480464
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Mir15b microRNA 15b JBrowse link 2 165,605,923 165,606,020 RGD:6480464
G Mir20a microRNA 20a JBrowse link 15 100,180,334 100,180,418 RGD:6480464
G Mir25 microRNA 25 JBrowse link 12 19,307,340 19,307,423 RGD:6480464
G Mir93 microRNA 93 JBrowse link 12 19,307,543 19,307,629 RGD:6480464
G Mirlet7b microRNA let-7b JBrowse link 7 126,590,627 126,590,711 RGD:6480464
G Mirlet7d microRNA let-7d JBrowse link 17 16,419,980 16,420,077 RGD:6480464
G Mirlet7i microRNA let-7i JBrowse link 7 66,802,731 66,802,815 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6480464
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Tfe3 transcription factor binding to IGHM enhancer 3 JBrowse link X 15,574,579 15,587,826 RGD:6480464
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 9 119,181,079 119,190,698 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          metabolite 19162
            eukaryotic metabolite 18779
              animal metabolite 18514
                mammalian metabolite 18497
                  human metabolite 18133
                    N-acylsphingosine 76
                      N-acetylsphingosine 62
                        1-O-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl]-N-acetylsphingosine 0
                        1-O-arachidonoyl-N-acetylsphingosine 0
                        1-O-linoleoyl-N-acetylsphingosine 0
                        1-O-oleoyl-N-acetylsphingosine 0
                        1-O-palmitoyl-N-acetylsphingosine 0
                        1-O-stearoyl-N-acetylsphingosine 0
                        N-acetylsphingosine 1-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    main group molecular entity 19622
                      s-block molecular entity 19388
                        hydrogen molecular entity 19377
                          hydrides 18283
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17001
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        amino alcohol 865
                                          aminodiol 151
                                            2-aminooctadecene-1,3-diol 111
                                              2-aminooctadec-4-ene-1,3-diol 111
                                                sphing-4-enine 111
                                                  sphingosine 111
                                                    sphingosine-based sphingolipid 76
                                                      N-acylsphingosine 76
                                                        N-acetylsphingosine 62
                                                          1-O-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl]-N-acetylsphingosine 0
                                                          1-O-arachidonoyl-N-acetylsphingosine 0
                                                          1-O-linoleoyl-N-acetylsphingosine 0
                                                          1-O-oleoyl-N-acetylsphingosine 0
                                                          1-O-palmitoyl-N-acetylsphingosine 0
                                                          1-O-stearoyl-N-acetylsphingosine 0
                                                          N-acetylsphingosine 1-phosphate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.