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ONTOLOGY REPORT - ANNOTATIONS


Term:dorzolamide
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Accession:CHEBI:4702 term browser browse the term
Definition:5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:related_synonym: (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide;   (4S,6S)-4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide;   (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide;   4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide;   4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide;   4S,6S-dorzolamide;   Formula=C10H16N2O4S3;   InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1;   InChIKey=IAVUPMFITXYVAF-XPUUQOCRSA-N;   SMILES=CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
 alt_id: CHEBI:101089;   CHEBI:105798;   CHEBI:42295
 xref: Beilstein:5910880 "Beilstein";   CAS:120279-96-1 "ChemIDplus";   CAS:120279-96-1 "KEGG COMPOUND";   DrugBank:DB00869;   Drug_Central:949 "DrugCentral";   KEGG:C06969;   KEGG:D07871;   LINCS:LSM-5597;   PDBeChem:ETS;   PMID:10762051 "ChEMBL";   PMID:11229775 "ChEMBL";   PMID:11425561 "ChEMBL";   PMID:11906288 "ChEMBL";   PMID:14611846 "ChEMBL";   PMID:14684332 "ChEMBL";   Patent:EP296879;   Patent:US4797413;   Wikipedia:Dorzolamide


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dorzolamide hydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ca3 carbonic anhydrase 3 JBrowse link 2 88,126,519 88,136,063 RGD:6480464
G Car2 carbonic anhydrase 2 JBrowse link 2 88,097,740 88,112,868 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            cardiovascular drug 7567
              antihypertensive agent 1642
                dorzolamide 2
                  dorzolamide hydrochloride 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      chalcogen 19322
                        oxygen atom 19283
                          oxygen molecular entity 19283
                            hydroxides 19042
                              oxoacid 18106
                                chalcogen oxoacid 11403
                                  sulfur oxoacid 10994
                                    sulfonic acid 7253
                                      sulfonic acid derivative 7253
                                        sulfonamide 3125
                                          dorzolamide 2
                                            dorzolamide hydrochloride 2
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