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ONTOLOGY REPORT - ANNOTATIONS


Term:ouabain
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Accession:CHEBI:472805 term browser browse the term
Definition:A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Synonyms:exact_synonym: 3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide
 related_synonym: 3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide;   Formula=C29H44O12;   G-Strophanthin;   InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1;   InChIKey=LPMXVESGRSUGHW-HBYQJFLCSA-N;   Ouabagenin L-Rhamnoside;   Ouabagenin-L-rhamnosid;   Ouabain anhydrous;   Ouabaine;   Oubain;   SMILES=[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   Strodival
 alt_id: CHEBI:44461;   CHEBI:7805
 xref: Beilstein:101712 "Beilstein";   CAS:630-60-4 "ChemIDplus";   CAS:630-60-4 "KEGG COMPOUND";   DrugBank:DB01092;   Drug_Central:2004 "DrugCentral";   HMDB:HMDB0015224;   KEGG:C01443;   KEGG:D00112;   KNApSAcK:C00003633;   LINCS:LSM-2781;   LIPID_MAPS_instance:LMST01120022 "LIPID MAPS"
 xref_mesh: MESH:D010042
 xref: PDBeChem:OBN;   PMID:10438974 "Europe PMC";   PMID:1316269 "Europe PMC";   PMID:16529963 "Europe PMC";   PMID:20372980 "Europe PMC";   PMID:9872395 "Europe PMC";   Reaxys:101712 "Reaxys";   Wikipedia:Ouabain
 cyclic_relationship: is_conjugate_acid_of CHEBI:145798


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ouabain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2M alpha-2-macroglobulin JBrowse link 12 9,067,708 9,116,229 RGD:6480464
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:6480464
G ACAA2 acetyl-CoA acyltransferase 2 JBrowse link 18 49,782,164 49,813,533 RGD:6480464
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:6480464
G ACTA2 actin alpha 2, smooth muscle JBrowse link 10 88,935,074 88,991,397 RGD:6480464
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide JBrowse link 4 99,336,497 99,352,746 RGD:6480464
G AGT angiotensinogen JBrowse link 1 230,702,523 230,714,122 RGD:6480464
G AGTR1 angiotensin II receptor type 1 JBrowse link 3 148,697,871 148,743,003 RGD:6480464
G ANXA1 annexin A1 JBrowse link 9 73,151,865 73,170,393 RGD:6480464
G ANXA2 annexin A2 JBrowse link 15 60,347,151 60,398,025 RGD:6480464
G ARAF A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 47,561,100 47,571,921 RGD:6480464
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 15 72,474,330 72,602,987 RGD:6480464
G ARPC5 actin related protein 2/3 complex subunit 5 JBrowse link 1 183,620,846 183,635,783 RGD:6480464
G ARRB1 arrestin beta 1 JBrowse link 11 75,260,122 75,351,662 RGD:6480464
G ASAH1 N-acylsphingosine amidohydrolase 1 JBrowse link 8 18,055,992 18,084,961 RGD:6480464
G ATP12A ATPase H+/K+ transporting non-gastric alpha2 subunit JBrowse link 13 24,680,408 24,712,493 RGD:6480464
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 1 116,372,986 116,410,259 RGD:6480464
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 JBrowse link 1 160,115,759 160,143,591 RGD:6480464
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 19 41,966,582 41,994,230 RGD:6480464
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 1 169,106,690 169,132,719 RGD:6480464
G ATP4B ATPase H+/K+ transporting subunit beta JBrowse link 13 113,648,804 113,658,198 RGD:6480464
G ATP5F1A ATP synthase F1 subunit alpha JBrowse link 18 46,080,248 46,104,233 RGD:6480464
G BAHD1 bromo adjacent homology domain containing 1 JBrowse link 15 40,439,757 40,468,237 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BDNF brain derived neurotrophic factor JBrowse link 11 27,654,893 27,722,030 RGD:6480464
G CALB1 calbindin 1 JBrowse link 8 90,058,608 90,082,879 RGD:6480464
G CALML5 calmodulin like 5 JBrowse link 10 5,498,697 5,499,570 RGD:6480464
G CANX calnexin JBrowse link 5 179,678,646 179,731,641 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:6480464
G CAV1 caveolin 1 JBrowse link 7 116,525,009 116,561,185 RGD:6480464
G CCDC14 coiled-coil domain containing 14 JBrowse link 3 123,887,383 123,961,412 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CCNA1 cyclin A1 JBrowse link 13 36,430,488 36,442,882 RGD:6480464
G CCNA2 cyclin A2 JBrowse link 4 121,816,444 121,823,883 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CDH1 cadherin 1 JBrowse link 16 68,737,292 68,835,537 RGD:6480464
G CDH2 cadherin 2 JBrowse link 18 27,932,878 28,177,130 RGD:6480464
G CDK2 cyclin dependent kinase 2 JBrowse link 12 55,966,830 55,972,789 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G CKB creatine kinase B JBrowse link 14 103,519,667 103,522,833 RGD:6480464
G CLDN1 claudin 1 JBrowse link 3 190,305,707 190,322,446 RGD:6480464
G CNPY2 canopy FGF signaling regulator 2 JBrowse link 12 56,309,844 56,316,348 RGD:6480464
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 50,184,096 50,201,649 RGD:6480464
G CS citrate synthase JBrowse link 12 56,271,699 56,300,330 RGD:6480464
G CYC1 cytochrome c1 JBrowse link 8 144,095,076 144,097,525 RGD:6480464
G DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit JBrowse link 1 20,651,777 20,661,369 RGD:6480464
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 16 4,425,805 4,456,775 RGD:6480464
G DRD1 dopamine receptor D1 JBrowse link 5 175,440,036 175,444,182 RGD:6480464
G DSG1 desmoglein 1 JBrowse link 18 31,318,160 31,359,246 RGD:6480464
G DUT deoxyuridine triphosphatase JBrowse link 15 48,329,991 48,343,373 RGD:6480464
G ECE1 endothelin converting enzyme 1 JBrowse link 1 21,217,250 21,345,504 RGD:6480464
G ECHS1 enoyl-CoA hydratase, short chain 1 JBrowse link 10 133,362,480 133,373,396 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G EDNRA endothelin receptor type A JBrowse link 4 147,480,917 147,544,954 RGD:6480464
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:6480464
G EIF3K eukaryotic translation initiation factor 3 subunit K JBrowse link 19 38,619,188 38,636,954 RGD:6480464
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 16 13,920,137 13,952,348 RGD:6480464
G ETS1 ETS proto-oncogene 1, transcription factor JBrowse link 11 128,458,761 128,587,593 RGD:6480464
G FANCD2 FA complementation group D2 JBrowse link 3 10,026,437 10,101,932 RGD:6480464
G FANCF FA complementation group F JBrowse link 11 22,622,533 22,625,823 RGD:6480464
G FANCI FA complementation group I JBrowse link 15 89,243,973 89,317,259 RGD:6480464
G FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial JBrowse link 6 5,261,007 5,771,583 RGD:6480464
G FBXO32 F-box protein 32 JBrowse link 8 123,497,887 123,541,206 RGD:6480464
G FH fumarate hydratase JBrowse link 1 241,497,603 241,519,755 RGD:6480464
G FKBP7 FKBP prolyl isomerase 7 JBrowse link 2 178,463,664 178,480,817 RGD:6480464
G FN1 fibronectin 1 JBrowse link 2 215,360,440 215,436,167 RGD:6480464
G GC GC vitamin D binding protein JBrowse link 4 71,741,693 71,805,520 RGD:6480464
G GLRB glycine receptor beta JBrowse link 4 157,076,125 157,172,090 RGD:6480464
G GRB2 growth factor receptor bound protein 2 JBrowse link 17 75,318,076 75,405,709 RGD:6480464
G GTPBP6 GTP binding protein 6 (putative) JBrowse link X
Y
303,352
303,352
318,819
318,819
RGD:6480464
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 JBrowse link 8 79,764,010 79,767,863 RGD:6480464
G HGF hepatocyte growth factor JBrowse link 7 81,699,006 81,770,438 RGD:6480464
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 61,695,513 61,748,259 RGD:6480464
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 7 26,189,920 26,200,775 RGD:6480464
G HNRNPDL heterogeneous nuclear ribonucleoprotein D like JBrowse link 4 82,422,564 82,430,225 RGD:6480464
G HPCAL1 hippocalcin like 1 JBrowse link 2 10,302,124 10,427,617 RGD:6480464
G HRG histidine rich glycoprotein JBrowse link 3 186,665,975 186,678,235 RGD:6480464
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2 197,486,584 197,500,274 RGD:6480464
G ID2 inhibitor of DNA binding 2 JBrowse link 2 8,682,056 8,684,461 RGD:6480464
G IL2RA interleukin 2 receptor subunit alpha JBrowse link 10 6,010,689 6,062,367 RGD:6480464
G IL2RB interleukin 2 receptor subunit beta JBrowse link 22 37,125,838 37,175,118 RGD:6480464
G ILK integrin linked kinase JBrowse link 11 6,603,708 6,610,874 RGD:6480464
G ITGAV integrin subunit alpha V JBrowse link 2 186,590,056 186,680,902 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 1 58,780,791 58,784,047 RGD:6480464
G KCND2 potassium voltage-gated channel subfamily D member 2 JBrowse link 7 120,273,175 120,750,337 RGD:6480464
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 7 150,944,956 150,978,321 RGD:6480464
G LEF1 lymphoid enhancer binding factor 1 JBrowse link 4 108,047,545 108,168,956 RGD:6480464
G LGALS1 galectin 1 JBrowse link 22 37,675,636 37,679,802 RGD:6480464
G LIMK1 LIM domain kinase 1 JBrowse link 7 74,083,804 74,122,525 RGD:6480464
G LSS lanosterol synthase JBrowse link 21 46,188,446 46,228,824 RGD:6480464
G MAP2K6 mitogen-activated protein kinase kinase 6 JBrowse link 17 69,414,697 69,553,865 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MAPK7 mitogen-activated protein kinase 7 JBrowse link 17 19,377,721 19,383,544 RGD:6480464
G MDH2 malate dehydrogenase 2 JBrowse link 7 76,048,106 76,067,508 RGD:6480464
G MIR29B1 microRNA 29b-1 JBrowse link 7 130,877,459 130,877,539 RGD:6480464
G MMP13 matrix metallopeptidase 13 JBrowse link 11 102,942,995 102,955,732 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MRAS muscle RAS oncogene homolog JBrowse link 3 138,347,648 138,405,535 RGD:6480464
G MRTFA myocardin related transcription factor A JBrowse link 22 40,410,289 40,636,719 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464
G MYL12A myosin light chain 12A JBrowse link 18 3,247,482 3,256,237 RGD:6480464
G MYLK myosin light chain kinase JBrowse link 3 123,610,049 123,884,332 RGD:6480464
G NECTIN3 nectin cell adhesion molecule 3 JBrowse link 3 111,071,764 111,201,444 RGD:6480464
G NECTIN4 nectin cell adhesion molecule 4 JBrowse link 1 161,070,998 161,089,566 RGD:6480464
G NEFL neurofilament light JBrowse link 8 24,950,955 24,956,612 RGD:6480464
G NOS1 nitric oxide synthase 1 JBrowse link 12 117,208,142 117,361,802 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:6480464
G NPC2 NPC intracellular cholesterol transporter 2 JBrowse link 14 74,479,935 74,493,512 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:6480464
G NRAS NRAS proto-oncogene, GTPase JBrowse link 1 114,704,469 114,716,771 RGD:6480464
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,505 RGD:6480464
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 1 226,360,691 226,408,093 RGD:6480464
G PCNA proliferating cell nuclear antigen JBrowse link 20 5,114,953 5,126,622 RGD:6480464
G PDCD6 programmed cell death 6 JBrowse link 5 271,621 314,974 RGD:6480464
G PFDN5 prefoldin subunit 5 JBrowse link 12 53,295,451 53,299,450 RGD:6480464
G PFN1 profilin 1 JBrowse link 17 4,945,652 4,948,530 RGD:6480464
G PLAUR plasminogen activator, urokinase receptor JBrowse link 19 43,646,095 43,670,346 RGD:6480464
G PLCG1 phospholipase C gamma 1 JBrowse link 20 41,137,519 41,177,626 RGD:6480464
G PPT2 palmitoyl-protein thioesterase 2 JBrowse link 6 32,153,528 32,163,675 RGD:6480464
G PSMB6 proteasome 20S subunit beta 6 JBrowse link 17 4,796,144 4,798,503 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G PTPN2 protein tyrosine phosphatase non-receptor type 2 JBrowse link 18 12,785,478 12,884,351 RGD:6480464
G RAB11B RAB11B, member RAS oncogene family JBrowse link 19 8,390,360 8,404,434 RGD:6480464
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 3 12,583,601 12,664,201 RGD:6480464
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 JBrowse link 15 78,959,947 79,090,780 RGD:6480464
G RGS2 regulator of G protein signaling 2 JBrowse link 1 192,809,039 192,812,275 RGD:6480464
G RHOH ras homolog family member H JBrowse link 4 40,191,080 40,246,967 RGD:6480464
G ROCK1 Rho associated coiled-coil containing protein kinase 1 JBrowse link 18 20,946,906 21,111,813 RGD:6480464
G ROCK2 Rho associated coiled-coil containing protein kinase 2 JBrowse link 2 11,179,759 11,345,437 RGD:6480464
G RPA3 replication protein A3 JBrowse link 7 7,636,518 7,718,607 RGD:6480464
G RPGRIP1L RPGRIP1 like JBrowse link 16 53,598,153 53,703,938 RGD:6480464
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:6480464
G RYR2 ryanodine receptor 2 JBrowse link 1 237,042,184 237,833,988 RGD:6480464
G S100A13 S100 calcium binding protein A13 JBrowse link 1 153,618,799 153,634,361 RGD:6480464
G S100B S100 calcium binding protein B JBrowse link 21 46,598,604 46,605,243 RGD:6480464
G SGK1 serum/glucocorticoid regulated kinase 1 JBrowse link 6 134,169,246 134,318,112 RGD:6480464
G SGK2 serum/glucocorticoid regulated kinase 2 JBrowse link 20 43,559,027 43,585,633 RGD:6480464
G SGK3 serum/glucocorticoid regulated kinase family member 3 JBrowse link 8 66,712,781 66,862,022 RGD:6480464
G SHC3 SHC adaptor protein 3 JBrowse link 9 89,005,771 89,182,402 RGD:6480464
G SLC16A1 solute carrier family 16 member 1 JBrowse link 1 112,911,847 112,956,196 RGD:6480464
G SLC22A12 solute carrier family 22 member 12 JBrowse link 11 64,590,810 64,603,250 RGD:6480464
G SLC5A5 solute carrier family 5 member 5 JBrowse link 19 17,871,394 17,895,175 RGD:6480464
G SLC5A6 solute carrier family 5 member 6 JBrowse link 2 27,199,587 27,212,342 RGD:6480464
G SLC8A1 solute carrier family 8 member A1 JBrowse link 2 40,094,523 40,512,452 RGD:6480464
G SLC9A1 solute carrier family 9 member A1 JBrowse link 1 27,098,809 27,155,125 RGD:6480464
G SMAD4 SMAD family member 4 JBrowse link 18 51,030,213 51,085,042 RGD:6480464
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 2 38,981,549 39,124,959 RGD:6480464
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 14 50,117,130 50,231,578 RGD:6480464
G SPHK1 sphingosine kinase 1 JBrowse link 17 76,383,204 76,387,855 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TGFB2 transforming growth factor beta 2 JBrowse link 1 218,345,284 218,444,619 RGD:6480464
G TGFB3 transforming growth factor beta 3 JBrowse link 14 75,958,061 75,983,011 RGD:6480464
G TGFBR3 transforming growth factor beta receptor 3 JBrowse link 1 91,680,343 91,906,002 RGD:6480464
G TLN1 talin 1 JBrowse link 9 35,696,948 35,732,195 RGD:6480464
G TLN2 talin 2 JBrowse link 15 62,390,523 62,844,631 RGD:6480464
G TPI1 triosephosphate isomerase 1 JBrowse link 12 6,866,834 6,870,948 RGD:6480464
G TPT1 tumor protein, translationally-controlled 1 JBrowse link 13 45,333,471 45,341,284 RGD:6480464
G TRIM63 tripartite motif containing 63 JBrowse link 1 26,051,304 26,067,634 RGD:6480464
G TRPC1 transient receptor potential cation channel subfamily C member 1 JBrowse link 3 142,724,034 142,807,888 RGD:6480464
G TRPC6 transient receptor potential cation channel subfamily C member 6 JBrowse link 11 101,451,470 101,584,007 RGD:6480464
G TXN thioredoxin JBrowse link 9 110,243,810 110,256,507 RGD:6480464
G ZFHX3 zinc finger homeobox 3 JBrowse link 16 72,782,885 73,891,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23758
    role 23647
      biological role 23610
        molecular messenger 18824
          hormone 18476
            steroid hormone 8264
              ouabain 165
Path 2
Term Annotations click to browse term
  CHEBI ontology 23758
    subatomic particle 23707
      composite particle 23707
        hadron 23707
          baryon 23707
            nucleon 23707
              atomic nucleus 23707
                atom 23707
                  main group element atom 23527
                    p-block element atom 23527
                      carbon group element atom 23238
                        carbon atom 23215
                          organic molecular entity 23215
                            heteroorganic entity 22857
                              organochalcogen compound 22341
                                organooxygen compound 22264
                                  carbohydrates and carbohydrate derivatives 12936
                                    carbohydrate 12936
                                      carbohydrate derivative 12559
                                        glycosyl compound 11599
                                          glycoside 9737
                                            deoxy hexoside 7962
                                              rhamnoside 431
                                                alpha-L-rhamnoside 431
                                                  ouabain 165
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.