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ONTOLOGY REPORT - ANNOTATIONS


Term:entecavir (anhydrous)
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Accession:CHEBI:473990 term browser browse the term
Definition:Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.
Synonyms:exact_synonym: 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
 related_synonym: Formula=C12H15N5O3;   InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1;   InChIKey=QDGZDCVAUDNJFG-FXQIFTODSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](CO)C1=C;   entecavir
 xref: Beilstein:7692760 "Beilstein";   CAS:142217-69-4 "ChemIDplus";   DrugBank:DB00442;   Drug_Central:1019 "DrugCentral";   KEGG:D07896;   LINCS:LSM-5258


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Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        antimicrobial agent 17216
          antiviral agent 3710
            antiviral drug 1777
              entecavir (anhydrous) 0
                entecavir hydrate 0
Path 2
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  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic molecule 19418
                              organic cyclic compound 19189
                                organic heterocyclic compound 18267
                                  organic heteropolycyclic compound 17572
                                    organic heterobicyclic compound 16245
                                      imidazopyrimidine 5417
                                        purines 5415
                                          aminopurine 4372
                                            2-aminopurines 3998
                                              entecavir (anhydrous) 0
                                                entecavir hydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.