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ONTOLOGY REPORT - ANNOTATIONS


Term:entecavir (anhydrous)
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Accession:CHEBI:473990 term browser browse the term
Definition:Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.
Synonyms:exact_synonym: 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
 related_synonym: Formula=C12H15N5O3;   InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1;   InChIKey=QDGZDCVAUDNJFG-FXQIFTODSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](CO)C1=C;   entecavir
 xref: Beilstein:7692760 "Beilstein";   CAS:142217-69-4 "ChemIDplus";   DrugBank:DB00442;   Drug_Central:1019 "DrugCentral";   KEGG:D07896;   LINCS:LSM-5258


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  CHEBI ontology 0
    role 0
      biological role 0
        antimicrobial agent 0
          antiviral agent 0
            antiviral drug 0
              entecavir (anhydrous) 0
                entecavir hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            organic molecule 0
                              organic cyclic compound 0
                                organic heterocyclic compound 0
                                  organic heteropolycyclic compound 0
                                    organic heterobicyclic compound 0
                                      imidazopyrimidine 0
                                        purines 0
                                          aminopurine 0
                                            2-aminopurines 0
                                              entecavir (anhydrous) 0
                                                entecavir hydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.