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ONTOLOGY REPORT - ANNOTATIONS


Term:cefazolin
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Accession:CHEBI:474053 term browser browse the term
Definition:A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.
Synonyms:exact_synonym: 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEZ;   Cefamezin;   Cephamezine;   Cephazolidin;   Cephazolin;   Cephazoline;   Formula=C14H14N8O4S3;   InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1;   InChIKey=MLYYVTUWGNIJIB-BXKDBHETSA-N;   SMILES=[C@]12(N(C(=C(CS1)CSC3=NN=C(S3)C)C(=O)O)C([C@H]2NC(=O)CN4C=NN=N4)=O)[H];   cefazolina;   cefazoline;   cefazolinum
 alt_id: CHEBI:3482
 xref: Beilstein:4169371 "Beilstein";   CAS:25953-19-9 "ChemIDplus";   CAS:25953-19-9 "DrugBank";   CAS:25953-19-9 "KEGG COMPOUND";   CAS:25953-19-9 "KEGG DRUG";   DrugBank:DB01327;   Drug_Central:530 "DrugCentral";   HMDB:HMDB0015422;   KEGG:C06880;   KEGG:D02299;   LINCS:LSM-34744
 xref_mesh: MESH:D002437
 xref: PMID:12569987 "Europe PMC";   PMID:2083978 "Europe PMC";   PMID:22011388 "Europe PMC";   PMID:23702270 "Europe PMC";   PMID:24462449 "Europe PMC";   PMID:28543395 "Europe PMC";   PMID:29017833 "Europe PMC";   PMID:6176550 "Europe PMC";   Patent:US3516997;   Reaxys:4169371 "Reaxys";   VSDB:1910;   Wikipedia:Cefazolin
 cyclic_relationship: is_conjugate_acid_of CHEBI:53657


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cefazolin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G RT1-DOa RT1 class II, locus DOa JBrowse link 20 3,889,106 3,892,360 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        antimicrobial agent 17215
          antibacterial agent 12930
            antibacterial drug 3089
              cefazolin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        carboacyl group 17073
                                          univalent carboacyl group 17073
                                            carbamoyl group 16800
                                              carboxamide 16800
                                                lactam 7679
                                                  beta-lactam 784
                                                    beta-lactam antibiotic 772
                                                      cephem 538
                                                        cephalosporin 537
                                                          cefazolin 4
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