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ONTOLOGY REPORT - ANNOTATIONS


Term:furosemide
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Accession:CHEBI:47426 term browser browse the term
Definition:A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Synonyms:exact_synonym: 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
 related_synonym: 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid;   4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid;   4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid;   4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid;   Formula=C12H11ClN2O5S;   Frusemide;   InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);   InChIKey=ZZUFCTLCJUWOSV-UHFFFAOYSA-N;   Lasix (TN);   SMILES=NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
 alt_id: CHEBI:47425;   CHEBI:5198
 xref: CAS:54-31-9;   DrugBank:DB00695;   Drug_Central:1258;   HMDB:HMDB0001933;   KEGG:D00331;   LINCS:LSM-5847
 xref_mesh: MESH:D005665
 xref: PMID:15286542;   PMID:18701232;   Reaxys:1399731;   VSDB:1770;   Wikipedia:Furosemide


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furosemide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 JBrowse link 11 94,343,295 94,393,017 RGD:6480464
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 JBrowse link 14 118,482,692 118,707,856 RGD:6480464
G Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 JBrowse link 16 85,793,827 85,803,113 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Alb albumin JBrowse link 5 90,460,870 90,476,602 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 JBrowse link 19 20,492,583 20,643,463 RGD:6480464
G Ang angiogenin, ribonuclease, RNase A family, 5 JBrowse link 14 51,091,077 51,102,009 RGD:6480464
G Angpt2 angiopoietin 2 JBrowse link 8 18,690,263 18,741,562 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 10 90,989,311 91,082,743 RGD:6480464
G Aqp2 aquaporin 2 JBrowse link 15 99,579,056 99,584,545 RGD:6480464
G Arc activity regulated cytoskeletal-associated protein JBrowse link 15 74,669,081 74,672,570 RGD:6480464
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 7 113,178,471 113,314,126 RGD:6480464
G Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:6480464
G Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 JBrowse link 6 83,743,017 83,758,855 RGD:6480464
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 73,891,765 73,894,428 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 19 6,941,861 6,951,905 RGD:6480464
G Bak1 BCL2-antagonist/killer 1 JBrowse link 17 27,019,812 27,028,627 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl10 B cell leukemia/lymphoma 10 JBrowse link 3 145,924,262 145,934,366 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bcl2l10 Bcl2-like 10 JBrowse link 9 75,347,758 75,351,640 RGD:6480464
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) JBrowse link 2 128,126,038 128,162,547 RGD:6480464
G Bcl2l2 BCL2-like 2 JBrowse link 14 54,883,366 54,898,927 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 6 120,893,119 120,917,062 RGD:6480464
G Bik BCL2-interacting killer JBrowse link 15 83,526,790 83,544,635 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 9 7,818,226 7,837,131 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 11 117,849,237 117,855,743 RGD:6480464
G Birc6 baculoviral IAP repeat-containing 6 JBrowse link 17 74,528,254 74,703,356 RGD:6480464
G Bok BCL2-related ovarian killer JBrowse link 1 93,685,575 93,695,770 RGD:6480464
G Bsnd barttin CLCNK type accessory beta subunit JBrowse link 4 106,483,456 106,492,243 RGD:6480464
G Calb1 calbindin 1 JBrowse link 4 15,881,264 15,906,709 RGD:6480464
G Car2 carbonic anhydrase 2 JBrowse link 3 14,886,269 14,900,770 RGD:6480464
G Casp1 caspase 1 JBrowse link 9 5,298,517 5,307,281 RGD:6480464
G Casp12 caspase 12 JBrowse link 9 5,345,442 5,373,034 RGD:6480464
G Casp14 caspase 14 JBrowse link 10 78,711,995 78,718,347 RGD:6480464
G Casp2 caspase 2 JBrowse link 6 42,264,902 42,282,508 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp4 caspase 4, apoptosis-related cysteine peptidase JBrowse link 9 5,308,823 5,336,791 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Cd40 CD40 antigen JBrowse link 2 165,055,614 165,071,654 RGD:6480464
G Cd70 CD70 antigen JBrowse link 17 57,145,997 57,149,777 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 8 104,101,613 104,144,504 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 9 36,708,482 36,726,658 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 5 110,839,800 110,874,140 RGD:6480464
G Chga chromogranin A JBrowse link 12 102,554,941 102,565,027 RGD:6480464
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A JBrowse link 18 67,343,564 67,367,794 RGD:6480464
G Cideb cell death-inducing DNA fragmentation factor, alpha subunit-like effector B JBrowse link 14 55,754,052 55,758,424 RGD:6480464
G Clcnka chloride channel, voltage-sensitive Ka JBrowse link 4 141,384,611 141,398,706 RGD:6480464
G Col18a1 collagen, type XVIII, alpha 1 JBrowse link 10 77,052,178 77,166,530 RGD:6480464
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 10 95,174,739 95,324,138 RGD:6480464
G Csf3 colony stimulating factor 3 (granulocyte) JBrowse link 11 98,700,183 98,703,631 RGD:6480464
G Dapk2 death-associated protein kinase 2 JBrowse link 9 66,158,226 66,272,242 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Dffa DNA fragmentation factor, alpha subunit JBrowse link 4 149,104,142 149,120,653 RGD:6480464
G Efna5 ephrin A5 JBrowse link 17 62,602,957 62,881,317 RGD:6480464
G Fadd Fas (TNFRSF6)-associated via death domain JBrowse link 7 144,578,323 144,582,441 RGD:6480464
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6480464
G Fgf16 fibroblast growth factor 16 JBrowse link X 105,764,477 105,776,532 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 3 37,348,477 37,410,106 RGD:6480464
G Fgf4 fibroblast growth factor 4 JBrowse link 7 144,861,386 144,865,245 RGD:6480464
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 13 55,152,818 55,168,759 RGD:6480464
G Flt1 FMS-like tyrosine kinase 1 JBrowse link 5 147,561,604 147,726,438 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G G6pdx glucose-6-phosphate dehydrogenase X-linked JBrowse link X 74,409,483 74,428,880 RGD:6480464
G Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 JBrowse link 5 71,569,734 71,658,308 RGD:6480464
G Gad1 glutamate decarboxylase 1 JBrowse link 2 70,561,303 70,602,014 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Gclm glutamate-cysteine ligase, modifier subunit JBrowse link 3 122,245,487 122,267,215 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G H2-M2 histocompatibility 2, M region locus 2 JBrowse link 17 37,480,851 37,483,554 RGD:6480464
G Hmgb1 high mobility group box 1 JBrowse link 5 149,046,702 149,053,057 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) JBrowse link 5 118,169,764 118,189,478 RGD:6480464
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 1 193,221,640 193,264,049 RGD:6480464
G Hus1 HUS1 checkpoint clamp component JBrowse link 11 8,993,137 9,011,236 RGD:6480464
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 2 152,736,251 152,737,410 RGD:6480464
G Id3 inhibitor of DNA binding 3 JBrowse link 4 136,143,822 136,145,392 RGD:6480464
G Ifna16 interferon alpha 16 JBrowse link 4 88,676,287 88,676,856 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Itga5 integrin alpha 5 (fibronectin receptor alpha) JBrowse link 15 103,344,286 103,366,791 RGD:6480464
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:6480464
G Lta lymphotoxin A JBrowse link 17 35,203,165 35,205,578 RGD:6480464
G Ltbr lymphotoxin B receptor JBrowse link 6 125,306,571 125,313,885 RGD:6480464
G Mdk midkine JBrowse link 2 91,929,805 91,932,297 RGD:6480464
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:6480464
G Msr1 macrophage scavenger receptor 1 JBrowse link 8 39,543,232 39,642,750 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 8 94,178,883 94,180,327 RGD:6480464
G Naip2 NLR family, apoptosis inhibitory protein 2 JBrowse link 13 100,144,063 100,202,122 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:6480464
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) JBrowse link 8 105,276,145 105,281,939 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Pdgfra platelet derived growth factor receptor, alpha polypeptide JBrowse link 5 75,151,322 75,198,206 RGD:6480464
G Pdgfrb platelet derived growth factor receptor, beta polypeptide JBrowse link 18 61,045,127 61,085,067 RGD:6480464
G Pecam1 platelet/endothelial cell adhesion molecule 1 JBrowse link 11 106,654,213 106,715,281 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 5 90,772,435 90,773,383 RGD:6480464
G Pgd phosphogluconate dehydrogenase JBrowse link 4 149,149,991 149,166,705 RGD:6480464
G Pgf placental growth factor JBrowse link 12 85,166,637 85,177,785 RGD:6480464
G Pink1 PTEN induced putative kinase 1 JBrowse link 4 138,313,409 138,326,296 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 17 10,840,359 12,063,370 RGD:6480464
G Ptger4 prostaglandin E receptor 4 (subtype EP4) JBrowse link 15 5,233,399 5,244,187 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 2 36,216,742 36,258,593 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Pth parathyroid hormone JBrowse link 7 113,385,576 113,388,672 RGD:6480464
G Ptn pleiotrophin JBrowse link 6 36,714,924 36,810,179 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 JBrowse link 13 34,002,225 34,035,170 RGD:6480464
G Rpa3 replication protein A3 JBrowse link 6 8,255,936 8,259,141 RGD:6480464
G S100b S100 protein, beta polypeptide, neural JBrowse link 10 76,253,836 76,261,319 RGD:6480464
G S100g S100 calcium binding protein G JBrowse link X 162,961,992 162,964,599 RGD:6480464
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 3 115,710,433 115,715,055 RGD:6480464
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 JBrowse link 1 106,861,175 106,883,348 RGD:6480464
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 JBrowse link 11 75,410,029 75,422,623 RGD:6480464
G Slc12a1 solute carrier family 12, member 1 JBrowse link 2 125,152,510 125,230,002 RGD:6480464
G Slc12a2 solute carrier family 12, member 2 JBrowse link 18 57,878,512 57,946,821 RGD:6480464
G Slc12a5 solute carrier family 12, member 5 JBrowse link 2 164,960,846 164,999,731 RGD:6480464
G Slc12a7 solute carrier family 12, member 7 JBrowse link 13 73,733,052 73,816,754 RGD:6480464
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 JBrowse link 19 8,617,996 8,628,299 RGD:6480464
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 JBrowse link 17 46,432,185 46,438,477 RGD:6480464
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 JBrowse link 19 8,591,254 8,611,835 RGD:6480464
G Slc26a4 solute carrier family 26, member 4 JBrowse link 12 31,519,814 31,560,055 RGD:6480464
G Sparc secreted acidic cysteine rich glycoprotein JBrowse link 11 55,394,159 55,420,080 RGD:6480464
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link 18 43,728,069 43,737,237 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 11 50,200,152 50,210,820 RGD:6480464
G Tek TEK receptor tyrosine kinase JBrowse link 4 94,739,086 94,874,976 RGD:6480464
G Tgfa transforming growth factor alpha JBrowse link 6 86,195,038 86,275,743 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor I JBrowse link 4 47,353,222 47,414,926 RGD:6480464
G Tgfbr2 transforming growth factor, beta receptor II JBrowse link 9 116,087,695 116,175,363 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 2 118,111,876 118,127,133 RGD:6480464
G Thbs2 thrombospondin 2 JBrowse link 17 14,665,500 14,694,262 RGD:6480464
G Thbs3 thrombospondin 3 JBrowse link 3 89,215,180 89,226,841 RGD:6480464
G Thbs4 thrombospondin 4 JBrowse link 13 92,751,586 92,794,818 RGD:6480464
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 JBrowse link 4 118,471,191 118,489,849 RGD:6480464
G Timp2 tissue inhibitor of metalloproteinase 2 JBrowse link 11 118,301,061 118,355,411 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator JBrowse link 1 105,780,673 105,849,444 RGD:6480464
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a JBrowse link 6 125,349,723 125,362,483 RGD:6480464
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b JBrowse link 4 145,212,368 145,246,870 RGD:6480464
G Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 JBrowse link 4 152,115,528 152,120,119 RGD:6480464
G Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 JBrowse link 4 145,267,132 145,315,164 RGD:6480464
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 JBrowse link 4 150,920,155 150,946,104 RGD:6480464
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 JBrowse link 3 27,317,077 27,339,665 RGD:6480464
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 JBrowse link 14 78,277,446 78,308,043 RGD:6480464
G Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 JBrowse link 11 69,686,240 69,696,098 RGD:6480464
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 JBrowse link 11 69,682,577 69,685,554 RGD:6480464
G Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 JBrowse link 4 63,831,202 63,861,508 RGD:6480464
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 JBrowse link 17 57,105,287 57,107,758 RGD:6480464
G Tpmt thiopurine methyltransferase JBrowse link 13 47,021,987 47,043,338 RGD:6480464
G Traf5 TNF receptor-associated factor 5 JBrowse link 1 191,997,203 192,092,599 RGD:6480464
G Traf6 TNF receptor-associated factor 6 JBrowse link 2 101,678,420 101,701,668 RGD:6480464
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 JBrowse link 6 41,651,661 41,681,224 RGD:6480464
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 JBrowse link 6 41,620,619 41,636,405 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 JBrowse link 1 88,211,959 88,220,002 RGD:6480464
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 JBrowse link 1 88,055,411 88,220,002 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 1 88,200,611 88,220,002 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 3 116,110,020 116,129,688 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464
G Vegfc vascular endothelial growth factor C JBrowse link 8 54,077,532 54,186,454 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 42,059,613 42,109,664 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      biological role 21242
        xenobiotic 18868
          furosemide 168
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21122
                    p-block element atom 21122
                      carbon group element atom 20893
                        carbon atom 20784
                          organic molecular entity 20784
                            organic group 19177
                              organic divalent group 19167
                                organodiyl group 19167
                                  carbonyl group 19137
                                    carbonyl compound 19137
                                      carboxylic acid 18818
                                        aromatic carboxylic acid 10871
                                          benzoic acids 10837
                                            chlorobenzoic acid 168
                                              furosemide 168
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.