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ONTOLOGY REPORT - ANNOTATIONS


Term:ecothiopate
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Accession:CHEBI:4753 term browser browse the term
Definition:The phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Synonyms:exact_synonym: 2-[(diethoxyphosphoryl)sulfanyl]-N,N,N-trimethylethanaminium
 related_synonym: (2-diethoxyphosphinylthioethyl)trimethylammonium;   Echothiophate;   Formula=C9H23NO3PS;   InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1;   InChIKey=BJOLKYGKSZKIGU-UHFFFAOYSA-N;   SMILES=CCOP(=O)(OCC)SCC[N+](C)(C)C;   ecothiopatum
 xref: Beilstein:1794025 "Beilstein";   CAS:6736-03-4 "ChemIDplus";   CAS:6736-03-4 "KEGG COMPOUND";   DrugBank:DB01057;   Drug_Central:982 "DrugCentral";   KEGG:C06975;   Wikipedia:Echothiophate


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ecothiopate iodide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Nceh1 neutral cholesterol ester hydrolase 1 JBrowse link 2 112,868,834 112,932,622 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          neurotransmitter agent 16396
            miotic 65
              ecothiopate 4
                ecothiopate iodide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  ammonium 8213
                                    ammonium ion derivative 8208
                                      quaternary ammonium ion 5058
                                        cholines 4766
                                          choline 3508
                                            choline ester 123
                                              phosphocholines 123
                                                ecothiopate 4
                                                  ecothiopate iodide 4
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