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ONTOLOGY REPORT - ANNOTATIONS


Term:ecothiopate
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Accession:CHEBI:4753 term browser browse the term
Definition:The phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.
Synonyms:exact_synonym: 2-[(diethoxyphosphoryl)sulfanyl]-N,N,N-trimethylethanaminium
 related_synonym: (2-diethoxyphosphinylthioethyl)trimethylammonium;   Echothiophate;   Formula=C9H23NO3PS;   InChI=1S/C9H23NO3PS/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5/h6-9H2,1-5H3/q+1;   InChIKey=BJOLKYGKSZKIGU-UHFFFAOYSA-N;   SMILES=CCOP(=O)(OCC)SCC[N+](C)(C)C;   ecothiopatum
 xref: Beilstein:1794025 "Beilstein";   CAS:6736-03-4 "ChemIDplus";   CAS:6736-03-4 "KEGG COMPOUND";   DrugBank:DB01057;   Drug_Central:982 "DrugCentral";   KEGG:C06975;   Wikipedia:Echothiophate


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ecothiopate iodide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 5 137,288,247 137,294,466 RGD:6480464
G Alb albumin JBrowse link 5 90,460,870 90,476,602 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 3 73,635,805 73,708,436 RGD:6480464
G Nceh1 neutral cholesterol ester hydrolase 1 JBrowse link 3 27,183,004 27,245,266 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21264
    role 21247
      biological role 21245
        pharmacological role 19163
          neurotransmitter agent 16854
            miotic 65
              ecothiopate 4
                ecothiopate iodide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 21264
    subatomic particle 21260
      composite particle 21260
        hadron 21260
          baryon 21260
            nucleon 21260
              atomic nucleus 21260
                atom 21260
                  main group element atom 21128
                    main group molecular entity 21128
                      s-block molecular entity 20600
                        hydrogen molecular entity 20513
                          hydrides 19480
                            inorganic hydride 17587
                              pnictogen hydride 17538
                                nitrogen hydride 17352
                                  ammonium 8068
                                    ammonium ion derivative 8063
                                      quaternary ammonium ion 5196
                                        cholines 4880
                                          choline 3628
                                            choline ester 124
                                              phosphocholines 124
                                                ecothiopate 4
                                                  ecothiopate iodide 4
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