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ONTOLOGY REPORT - ANNOTATIONS


Term:ergothioneine
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Accession:CHEBI:4828 term browser browse the term
Definition:A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs.
Synonyms:exact_synonym: (2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate
 related_synonym: (2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylammonio)propanoate;   (S)-(1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethylammonium hydroxide;   (alphaS)-alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt;   2-mercaptohistidine trimethylbetaine;   3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-trimethylammonio-propanoate;   Formula=C9H15N3O2S;   InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1;   InChIKey=SSISHJJTAXXQAX-ZETCQYMHSA-N;   L-ergothioneine;   L-thioneine;   SMILES=C[N+](C)(C)[C@@H](Cc1c[nH]c(S)n1)C([O-])=O;   ergothioneine thiol;   ergothionine;   erythrothioneine;   sympectothion;   thiolhistidine-betaine;   thiolhistidinebetaine
 xref: Beilstein:5755696 "Beilstein";   CAS:497-30-3 "ChemIDplus";   CAS:497-30-3 "KEGG COMPOUND";   HMDB:HMDB0003045;   KEGG:C05570
 xref_mesh: MESH:D004880
 xref: MetaCyc:CPD-15276;   PMID:15030958 "Europe PMC";   PMID:15744438 "Europe PMC";   PMID:17616140 "Europe PMC";   PMID:18670092 "Europe PMC";   PMID:18841979 "Europe PMC";   PMID:19660151 "Europe PMC";   PMID:19911007 "Europe PMC";   PMID:20420449 "Europe PMC";   PMID:23418129 "Europe PMC";   PMID:23494799 "Europe PMC";   PMID:23922985 "Europe PMC";   PMID:24392160 "Europe PMC";   PMID:25154712 "Europe PMC";   PMID:25736892 "Europe PMC";   PMID:26079795 "Europe PMC";   PMID:26149121 "Europe PMC";   PMID:26229105 "Europe PMC";   PMID:26338495 "Europe PMC";   PMID:26412552 "Europe PMC";   PMID:26542137 "Europe PMC";   PMID:26579093 "Europe PMC";   PMID:26634964 "Europe PMC";   PMID:26713511 "Europe PMC";   PMID:26772879 "Europe PMC";   PMID:26774486 "Europe PMC";   PMID:26921894 "Europe PMC";   PMID:26994919 "Europe PMC";   PMID:27101740 "Europe PMC";   PMID:27134772 "Europe PMC";   PMID:27306320 "Europe PMC";   PMID:27444382 "Europe PMC";   PMID:7144630 "Europe PMC";   Reaxys:5755696 "Reaxys";   Reaxys:8411606 "Reaxys";   Wikipedia:Ergothioneine
 cyclic_relationship: is_conjugate_base_of CHEBI:134344;   is_tautomer_of CHEBI:82707


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ergothioneine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      chemical role 19114
        antioxidant 14059
          ergothioneine 1
            2-sulfenohercynine 0
            S-methyl-L-ergothioneine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        amino acid 12306
                                          alpha-amino acid 7423
                                            L-alpha-amino acid 7080
                                              L-histidine 1
                                                L-histidine derivative 1
                                                  ergothioneine 1
                                                    2-sulfenohercynine 0
                                                    S-methyl-L-ergothioneine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.