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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triclocarban
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Accession:CHEBI:48347 term browser browse the term
Definition:A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Synonyms:related_synonym: 1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea;   3,4,4'-trichloro carbanilide;   3,4,4'-trichlorocarbanilide;   3,4,4'-trichlorodiphenylurea;   Cutisan;   Formula=C13H9Cl3N2O;   InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19);   InChIKey=ICUTUKXCWQYESQ-UHFFFAOYSA-N;   N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea;   Nobacter;   SMILES=Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1;   Solubacter;   TCC;   triclocarbanum
 xref: Beilstein:2814890;   CAS:101-20-2;   DrugBank:DB11155;   Drug_Central:3630;   KEGG:D06223
 xref_mesh: MESH:C009540
 xref: PMID:18048496;   PMID:24461429;   PMID:24464075;   PMID:24562054;   PMID:30033524;   Patent:GB769273;   Patent:US2818390;   Reaxys:2814890;   Wikipedia:Triclocarban


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triclocarban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases expression EXP triclocarban results in increased expression of ACACA mRNA CTD PMID:31576746 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO
EXP
AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of AHR mRNA; triclocarban results in increased expression of AHR protein
CTD PMID:23524099, PMID:31576746 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions ISO triclocarban analog promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; triclocarban promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Trenbolone Acetate results in increased activity of AR protein] CTD PMID:18795164, PMID:20821581, PMID:20943248 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO triclocarban results in increased expression of ATF4 protein CTD PMID:30592132 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO triclocarban results in increased expression of ATF6 mRNA; triclocarban results in increased expression of ATF6 protein CTD PMID:30592132 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Cers2 ceramide synthase 2 increases expression EXP triclocarban results in increased expression of CERS2 mRNA CTD PMID:31576746 NCBI chr 2:196,487,656...196,495,930
Ensembl chr 2:196,487,656...196,496,986
JBrowse link
G Cers6 ceramide synthase 6 increases expression EXP triclocarban results in increased expression of CERS6 mRNA CTD PMID:31576746 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[bisphenol A co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [butylparaben co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Genistein co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of CYP1A1 mRNA
CTD PMID:23524099, PMID:31576746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [Genistein results in increased expression of CYP1B1 mRNA] CTD PMID:22761658, PMID:23524099, PMID:31576746 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]
triclocarban results in increased expression of CYP2B10 mRNA; triclocarban results in increased expression of CYP2B10 protein
CTD PMID:22761658 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA] CTD PMID:22761658 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO triclocarban results in increased expression of EIF2AK3 protein modified form CTD PMID:30592132 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO triclocarban results in increased expression of EIF2S1 protein modified form CTD PMID:30592132 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]; triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein]; triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein]
triclocarban results in decreased expression of ESR1 mRNA; triclocarban results in decreased expression of ESR1 protein
CTD PMID:18795164, PMID:22761658, PMID:23524099, PMID:24740835 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fasn fatty acid synthase increases expression EXP triclocarban results in increased expression of FASN mRNA CTD PMID:31576746 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression EXP triclocarban results in increased expression of FFAR2 mRNA CTD PMID:31576746 NCBI chr 1:89,268,197...89,271,942
Ensembl chr 1:89,268,938...89,269,930
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression EXP triclocarban results in increased expression of GPER1 mRNA CTD PMID:31576746 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO triclocarban results in increased expression of HSPA5 mRNA; triclocarban results in increased expression of HSPA5 protein CTD PMID:30592132 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il10 interleukin 10 increases response to substance ISO IL10 gene mutant form results in increased susceptibility to triclocarban CTD PMID:31868902 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression EXP triclocarban results in increased expression of IL1B mRNA CTD PMID:31576746 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
triclocarban results in increased expression of IL6 mRNA
CTD PMID:21741984, PMID:31576746 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mir193b microRNA 193b increases expression ISO triclocarban results in increased expression of MIR193B mRNA CTD PMID:24740835 NCBI chr14:30,331,049...30,331,131
Ensembl chr14:30,331,049...30,331,131
JBrowse link
G Mir206 microRNA 206 increases expression ISO triclocarban results in increased expression of MIR206 mRNA CTD PMID:24740835 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mir22 microRNA 22 increases expression ISO triclocarban results in increased expression of MIR22 mRNA CTD PMID:24740835 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]
CTD PMID:22761658 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP triclocarban results in increased expression of SCD mRNA CTD PMID:31576746 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc5a5 solute carrier family 5 member 5 decreases activity
multiple interactions
EXP
ISO
triclocarban results in decreased activity of SLC5A5 protein
triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
CTD PMID:26827900, PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression EXP triclocarban results in increased expression of SPTLC2 mRNA CTD PMID:31576746 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO triclocarban results in increased expression of TFF1 mRNA; triclocarban results in increased expression of TFF1 protein CTD PMID:24740835 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:21741984 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP triclocarban results in decreased activity of TPO protein CTD PMID:26827900 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]
CTD PMID:22761658 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA] CTD PMID:22761658 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] CTD PMID:22761658 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A6 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]
CTD PMID:22761658 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A9 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]
CTD PMID:22761658 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
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  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          triclocarban 36
Path 2
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  urea 4989
                                                    ureas 4987
                                                      phenylureas 1981
                                                        1,3-diphenylurea 36
                                                          triclocarban 36
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