Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:esmolol
go back to main search page
Accession:CHEBI:4856 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure.
Synonyms:exact_synonym: rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate
 related_synonym: 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester;   Formula=C16H25NO4;   Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate;   esmololum;   methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
 alt_id: CHEBI:143354
 xref: Beilstein:5287174 "Beilstein";   CAS:103598-03-4 "ChemIDplus";   CAS:103598-03-4 "KEGG COMPOUND";   CAS:81147-92-4 "ChemIDplus";   DrugBank:DB00187;   HMDB:HMDB0014333;   KEGG:C06980;   KEGG:D07916
 xref_mesh: MESH:C036604
 xref: PMID:16118074 "Europe PMC";   PMID:24500140 "Europe PMC";   PMID:25105423 "Europe PMC";   PMID:25575405 "Europe PMC";   PMID:26073350 "Europe PMC";   PMID:26137757 "Europe PMC";   PMID:26316443 "Europe PMC";   Patent:EP41491;   Patent:EP53435;   Patent:US4593119;   Reaxys:5287174 "Reaxys";   Wikipedia:Esmolol


show annotations for term's descendants       view all columns           Sort by:
 
esmolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    chemical entity 19677
      chemical substance 10728
        mixture 9933
          racemate 8662
            esmolol 3
              esmolol hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    main group molecular entity 19555
                      s-block molecular entity 19336
                        hydrogen molecular entity 19325
                          hydrides 18249
                            inorganic hydride 17113
                              pnictogen hydride 17071
                                nitrogen hydride 16891
                                  azane 16568
                                    ammonia 16565
                                      organic amino compound 16564
                                        amino alcohol 862
                                          ethanolamines 754
                                            3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoic acid 3
                                              methyl 3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoate 3
                                                (S)-esmolol 3
                                                  esmolol 3
                                                    esmolol hydrochloride 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.