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Accession:CHEBI:4877 term browser browse the term
Definition:An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.
Synonyms:exact_synonym: (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
 related_synonym: (+)-2,2'-(ethylenediimino)di-1-butanol;   (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine;   (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol;   EMB;   Formula=C10H24N2O2;   InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1;   InChIKey=AEUTYOVWOVBAKS-UWVGGRQHSA-N;   S,S-Ethambutol;   SMILES=CC[C@@H](CO)NCCN[C@@H](CC)CO;   etambutol;   ethambutolum
 alt_id: CHEBI:133410;   CHEBI:659237;   CHEBI:678172
 xref: Beilstein:6312870 "Beilstein";   CAS:74-55-5 "ChemIDplus";   CAS:74-55-5 "KEGG COMPOUND";   DrugBank:DB00330;   Drug_Central:1073 "DrugCentral";   KEGG:C06984;   KEGG:D07925
 xref_mesh: MESH:D004977
 xref: PMID:10649975 "ChEMBL";   PMID:10891117 "ChEMBL";   PMID:10966749 "ChEMBL";   PMID:12182855 "ChEMBL";   PMID:14695841 "ChEMBL";   PMID:14698152 "ChEMBL";   PMID:15225698 "ChEMBL";   PMID:16005211 "ChEMBL";   PMID:16759086 "ChEMBL";   PMID:16870429 "ChEMBL";   PMID:17210775 "ChEMBL";   PMID:17239593 "ChEMBL";   PMID:17276683 "ChEMBL";   PMID:17315960 "ChEMBL";   PMID:17331717 "ChEMBL";   PMID:17562368 "ChEMBL";   PMID:17851083 "ChEMBL";   PMID:17888665 "ChEMBL";   PMID:19524332 "ChEMBL";   PMID:19648006 "ChEMBL";   PMID:3934384 "ChEMBL";   Reaxys:6312870 "Reaxys";   Wikipedia:Ethambutol

show annotations for term's descendants       view all columns           Sort by:
ethambutol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        xenobiotic 18165
          ethambutol 16
            ethambutol dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        polyamine 8072
                                          diamine 8000
                                            primary diamine 5604
                                              alkane-alpha,omega-diamine 3715
                                                ethylenediamine 3699
                                                  ethylenediamine derivative 3536
                                                    ethambutol 16
                                                      ethambutol dihydrochloride 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.