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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bisanthene
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Accession:CHEBI:49267 term browser browse the term
Definition:An ortho- and peri-fused polycyclic arene that has formula C28H14.
Synonyms:exact_synonym: phenanthro[1,10,9,8-opqra]perylene
 related_synonym: Bisanthen;   Formula=C28H14;   InChI=1S/C28H14/c1-5-15-13-16-6-3-11-21-22-12-4-8-18-14-17-7-2-10-20-19(9-1)23(15)27(25(16)21)28(24(17)20)26(18)22/h1-14H;   InChIKey=RYQHWGXLBQHJST-UHFFFAOYSA-N;   SMILES=c1cc2cc3cccc4c5cccc6cc7cccc8c(c1)c2c(c34)c(c78)c56
 xref: Beilstein:2059422;   CAS:190-39-6


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hypericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
hypericin results in increased expression of ABCB1
CTD PMID:15266218, PMID:16005588 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO hypericin results in increased expression of ABCC1 protein CTD PMID:24994473 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Alb albumin affects binding ISO hypericin binds to ALB protein CTD PMID:15461448 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO hypericin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hypericin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO hypericin binds to and results in decreased activity of GSTA1 protein CTD PMID:15461448 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO
EXP
hypericin binds to and results in decreased activity of GSTP1 protein
hypericin results in decreased activity of GSTP1 protein
CTD PMID:15461448, PMID:20637187 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO hypericin results in decreased activity of TOP2A protein CTD PMID:11597574 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            polycyclic arene 16889
              ortho- and peri-fused polycyclic arene 16155
                bisanthene 7
                  hypericin + 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho- and peri-fused polycyclic arene 16155
                                          bisanthene 7
                                            hypericin + 7
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