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ONTOLOGY REPORT - ANNOTATIONS


Term:exemestane
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Accession:CHEBI:4953 term browser browse the term
Definition:A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
Synonyms:exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
 related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione;   Formula=C20H24O2;   InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1;   InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N;   SMILES=[H][C@@]12CC(=C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   exemestano;   exemestanum
 xref: CAS:107868-30-4 "ChemIDplus";   CAS:107868-30-4 "KEGG COMPOUND";   DrugBank:DB00990;   Drug_Central:1122 "DrugCentral";   KEGG:C08162;   KEGG:D00963
 xref_mesh: MESH:C056516
 xref: PMID:10882163 "Europe PMC";   Reaxys:6609645 "Reaxys";   Wikipedia:Exemestane


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exemestane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg4 ATP binding cassette subfamily G member 4 JBrowse link 8 48,604,915 48,626,219 RGD:6480464
G Adcyap1r1 ADCYAP receptor type I JBrowse link 4 85,662,809 85,711,696 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:6480464
G Cd83 CD83 molecule JBrowse link 17 24,416,651 24,435,790 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:6480464
G Ebf1 EBF transcription factor 1 JBrowse link 10 23,654,849 24,051,627 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gpc2 glypican 2 JBrowse link 12 19,593,041 19,599,374 RGD:6480464
G Hoxd11 homeobox D11 JBrowse link 3 61,604,256 61,606,874 RGD:6480464
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:6480464
G Ints4 integrator complex subunit 4 JBrowse link 1 162,447,692 162,511,350 RGD:6480464
G Kif13b kinesin family member 13B JBrowse link 15 48,030,837 48,192,932 RGD:6480464
G Klk7 kallikrein-related peptidase 7 JBrowse link 1 99,749,991 99,754,723 RGD:6480464
G Metrn meteorin, glial cell differentiation regulator JBrowse link 10 15,164,439 15,166,457 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mybl2 MYB proto-oncogene like 2 JBrowse link 3 159,421,638 159,450,087 RGD:6480464
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:6480464
G Ostm1 osteoclastogenesis associated transmembrane protein 1 JBrowse link 20 47,394,979 47,430,304 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6480464
G RGD1565616 RGD1565616 JBrowse link 3 123,243,873 123,376,458 RGD:6480464
G Rnf123 ring finger protein 123 JBrowse link 8 116,829,050 116,857,050 RGD:6480464
G Rrp12 ribosomal RNA processing 12 homolog JBrowse link 1 261,106,768 261,140,416 RGD:6480464
G Slc13a4 solute carrier family 13 member 4 JBrowse link 4 62,796,732 62,841,053 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tbc1d17 TBC1 domain family, member 17 JBrowse link 1 100,836,993 100,845,216 RGD:6480464
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:6480464
G Tnfrsf14 TNF receptor superfamily member 14 JBrowse link 5 172,328,259 172,337,221 RGD:6480464
G Triobp TRIO and F-actin binding protein JBrowse link 7 120,173,892 120,237,145 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        xenobiotic 18261
          exemestane 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      ketone 15909
                                        oxo steroid 9263
                                          3-oxo steroid 8787
                                            3-oxo-Delta(1) steroid 5089
                                              3-oxo-Delta(1),Delta(4)-steroid 5089
                                                exemestane 31
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.