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ONTOLOGY REPORT - ANNOTATIONS


Term:lapatinib
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Accession:CHEBI:49603 term browser browse the term
Definition:A furan that has formula C29H26ClFN4O4S.
Synonyms:exact_synonym: N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
 related_synonym: Formula=C29H26ClFN4O4S;   GW 572016;   InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);   InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N;   N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine;   N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE;   SMILES=CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1;   Tykerb
 alt_id: CHEBI:38636;   CHEBI:49602;   MESH:C490728
 xref: Beilstein:10502247 "Beilstein";   CAS:231277-92-2 "ChemIDplus";   DrugBank:DB01259;   Drug_Central:1548 "DrugCentral";   LINCS:LSM-1051
 xref_mesh: MESH:C490728
 xref: PDBeChem:FMM;   Wikipedia:Lapatinib


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lapatinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 JBrowse link 2 69,238,282 69,342,616 RGD:6480464
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 JBrowse link 5 8,893,614 8,959,226 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 6 58,584,491 58,692,451 RGD:6480464
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 JBrowse link 19 20,492,583 20,643,463 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 11 117,849,237 117,855,743 RGD:6480464
G Bnip3 BCL2/adenovirus E1B interacting protein 3 JBrowse link 7 138,890,836 138,909,506 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 3 36,564,865 36,573,038 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 7 38,097,984 38,107,490 RGD:6480464
G Cd24a CD24a antigen JBrowse link 10 43,579,169 43,584,265 RGD:6480464
G Cd44 CD44 antigen JBrowse link 2 102,811,141 102,901,669 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 8 106,603,350 106,670,247 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 16,588,877 16,809,246 RGD:6480464
G Cdk2 cyclin-dependent kinase 2 JBrowse link 10 128,697,938 128,705,051 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 JBrowse link 5 137,892,933 137,925,610 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 11 98,412,484 98,437,716 RGD:6480464
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 10 128,567,523 128,589,635 RGD:6480464
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:6480464
G Gpt glutamic pyruvic transaminase, soluble JBrowse link 15 76,696,726 76,699,675 RGD:6480464
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 15 89,130,584 89,141,577 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 5 138,164,583 138,172,111 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 4 148,448,582 148,557,685 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 JBrowse link 4 57,190,841 57,339,040 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Snai1 snail family zinc finger 1 JBrowse link 2 167,538,195 167,542,814 RGD:6480464
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Sox2 SRY (sex determining region Y)-box 2 JBrowse link 3 34,649,995 34,652,461 RGD:6480464
G Src Rous sarcoma oncogene JBrowse link 2 157,423,906 157,471,838 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 1 88,200,611 88,220,002 RGD:6480464
G Vim vimentin JBrowse link 2 13,574,311 13,582,826 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      application 20373
        pharmaceutical 19971
          drug 19971
            antineoplastic agent 17297
              lapatinib 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic molecule 20371
                              organic cyclic compound 20047
                                carbocyclic compound 18211
                                  benzenoid aromatic compound 17489
                                    benzenes 17091
                                      fluorobenzenes 1640
                                        monofluorobenzenes 1310
                                          monofluorobenzene 86
                                            lapatinib 50
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.