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ONTOLOGY REPORT - ANNOTATIONS


Term:indometacin
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Accession:CHEBI:49662 term browser browse the term
Definition:A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Synonyms:exact_synonym: [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
 related_synonym: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid;   Aconip;   Formula=C19H16ClNO4;   InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23);   InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N;   Indocin;   Indomethacin;   SMILES=COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1;   indometacina;   indometacine;   indometacinum;   {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
 alt_id: CHEBI:49660;   CHEBI:5918
 xref: Beilstein:497341 "Beilstein";   CAS:53-86-1 "ChemIDplus";   CAS:53-86-1 "KEGG COMPOUND";   CAS:53-86-1 "NIST Chemistry WebBook";   DrugBank:DB00328;   Drug_Central:1440 "DrugCentral";   Gmelin:1446006 "Gmelin";   HMDB:HMDB0014473;   KEGG:C01926;   KEGG:D00141;   KNApSAcK:C00030512;   LINCS:LSM-3275
 xref_mesh: MESH:D007213
 xref: MetaCyc:CPD-10545;   PDBeChem:IMN;   PMID:22931205 "Europe PMC";   PMID:23992308 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:5952296 "Europe PMC";   PMID:6039425 "Europe PMC";   Patent:BE379378;   Patent:US3161654;   Reaxys:497341 "Reaxys";   Wikipedia:Indometacin


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23757
    role 23646
      biological role 23609
        xenobiotic 19314
          indometacin 3407
            acemetacin 1
            oxametacin 0
            proglumetacin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23757
    subatomic particle 23706
      composite particle 23706
        hadron 23706
          baryon 23706
            nucleon 23706
              atomic nucleus 23706
                atom 23706
                  main group element atom 23525
                    p-block element atom 23525
                      carbon group element atom 23236
                        carbon atom 23213
                          organic molecular entity 23213
                            organic group 21896
                              organic divalent group 21868
                                organodiyl group 21868
                                  carbonyl group 21840
                                    carbonyl compound 21840
                                      carboxylic acid 20888
                                        carboacyl group 18982
                                          univalent carboacyl group 18982
                                            carbamoyl group 18369
                                              carboxamide 18369
                                                N-acylindole 3407
                                                  indometacin 3407
                                                    acemetacin 1
                                                    oxametacin 0
                                                    proglumetacin + 0
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