Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:gefitinib
go back to main search page
Accession:CHEBI:49668 term browser browse the term
Definition:A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.
Synonyms:exact_synonym: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
 related_synonym: 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline;   Formula=C22H24ClFN4O3;   InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27);   InChIKey=XGALLCVXEZPNRQ-UHFFFAOYSA-N;   Iressa;   Irressat;   N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine;   SMILES=C1=C(C(=CC=2C1=NC=NC2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4)OC;   ZD 1839;   ZD1839;   gefitinibum
 alt_id: CHEBI:38917;   CHEBI:49667
 xref: CAS:184475-35-2 "ChemIDplus";   DrugBank:DB00317;   Drug_Central:1282 "DrugCentral";   HMDB:HMDB0014462;   KEGG:D01977;   LINCS:LSM-1098
 xref_mesh: MESH:C419708
 xref: PDBeChem:IRE;   PMID:14981586 "Europe PMC";   PMID:15068398 "Europe PMC";   PMID:20573926 "Europe PMC";   PMID:20949670 "Europe PMC";   PMID:27396387 "Europe PMC";   PMID:28968167 "Europe PMC";   PMID:29332330 "Europe PMC";   PMID:29493460 "Europe PMC";   PMID:29579334 "Europe PMC";   PMID:29668619 "Europe PMC";   PMID:30068310 "Europe PMC";   PMID:30069771 "Europe PMC";   PMID:30214852 "Europe PMC";   Reaxys:8949523 "Reaxys";   Wikipedia:Gefitinib


show annotations for term's descendants       view all columns           Sort by:
 
gefitinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:6480464
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:6480464
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:6480464
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:6480464
G Aven apoptosis and caspase activation inhibitor JBrowse link 3 103,980,612 104,117,193 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:6480464
G Cert1 ceramide transporter 1 JBrowse link 2 27,365,145 27,469,797 RGD:6480464
G Cgrrf1 cell growth regulator with ring finger domain 1 JBrowse link 15 23,619,176 23,639,622 RGD:6480464
G Cldn2 claudin 2 JBrowse link X 111,122,552 111,133,188 RGD:6480464
G Coro1c coronin 1C JBrowse link 12 48,481,741 48,554,054 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 JBrowse link 1 83,933,974 83,947,804 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:6480464
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:6480464
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link 5 128,923,809 129,022,268 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fgf6 fibroblast growth factor 6 JBrowse link 4 159,563,798 159,572,333 RGD:6480464
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:6480464
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6480464
G Gars glycyl-tRNA synthetase JBrowse link 4 85,235,122 85,276,085 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gnb2 G protein subunit beta 2 JBrowse link 12 22,229,079 22,234,096 RGD:6480464
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gucy2d guanylate cyclase 2D, retinal JBrowse link 10 55,835,695 55,851,235 RGD:6480464
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:6480464
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Marveld1 MARVEL domain containing 1 JBrowse link 1 261,389,804 261,393,736 RGD:6480464
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:6480464
G Micb MHC class I polypeptide-related sequence B JBrowse link 1 79,754,587 79,772,092 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mr1 major histocompatibility complex, class I-related JBrowse link 13 72,771,992 72,789,861 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Mug1 murinoglobulin 1 JBrowse link 4 154,676,382 154,729,288 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:6480464
G Ndufaf4 NADH:ubiquinone oxidoreductase complex assembly factor 4 JBrowse link 5 39,251,370 39,256,542 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Nptx2 neuronal pentraxin 2 JBrowse link 12 12,014,638 12,025,547 RGD:6480464
G Nrl neural retina leucine zipper JBrowse link 15 34,197,115 34,201,408 RGD:6480464
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pcnt pericentrin JBrowse link 20 12,943,523 13,038,615 RGD:6480464
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6480464
G Pgrmc1 progesterone receptor membrane component 1 JBrowse link X 123,205,869 123,213,880 RGD:6480464
G Phlda2 pleckstrin homology-like domain, family A, member 2 JBrowse link 1 216,701,345 216,704,479 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Plbd1 phospholipase B domain containing 1 JBrowse link 4 170,564,387 170,620,681 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Pttg1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 10 29,014,332 29,026,088 RGD:6480464
G Qsox1 quiescin sulfhydryl oxidase 1 JBrowse link 13 73,423,396 73,460,890 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rbm7 RNA binding motif protein 7 JBrowse link 8 52,823,094 52,828,134 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Rrm1 ribonucleotide reductase catalytic subunit M1 JBrowse link 1 167,538,387 167,562,688 RGD:6480464
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:6480464
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:6480464
G RT1-DOa RT1 class II, locus DOa JBrowse link 20 3,889,106 3,892,360 RGD:6480464
G S100a6 S100 calcium binding protein A6 JBrowse link 2 190,007,013 190,008,512 RGD:6480464
G S100a8 S100 calcium binding protein A8 JBrowse link 2 190,073,239 190,074,333 RGD:6480464
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:6480464
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6480464
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:6480464
G Slc10a3 solute carrier family 10, member 3 JBrowse link X 156,335,385 156,340,256 RGD:6480464
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:6480464
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Synpo synaptopodin JBrowse link 18 55,863,081 55,921,412 RGD:6480464
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:6480464
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trim23 tripartite motif-containing 23 JBrowse link 2 34,255,300 34,288,140 RGD:6480464
G Tsc22d1 TSC22 domain family, member 1 JBrowse link 15 58,554,358 58,658,156 RGD:6480464
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
G Zc3h3 zinc finger CCCH type containing 3 JBrowse link 7 116,787,762 116,872,536 RGD:6480464
G Zfp35 zinc finger protein 35 JBrowse link 18 15,883,182 15,898,803 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            antineoplastic agent 16550
              gefitinib 140
                linkable gefitinib analogue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        secondary amino compound 6362
                                          gefitinib 140
                                            linkable gefitinib analogue 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.