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Accession:CHEBI:49960 term browser browse the term
Definition:A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Synonyms:exact_synonym: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
 related_synonym: 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE;   Formula=C22H24BrFN4O2;   InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27);   InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N;   SMILES=COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1;   ZD 6474;   ZD6474;   Zactima;   caprelsa
 alt_id: CHEBI:38942;   CHEBI:49959;   MESH:C452423
 xref: CAS:443913-73-3 "ChemIDplus";   DrugBank:DB08764;   Drug_Central:4178 "DrugCentral";   KEGG:D06407;   LINCS:LSM-1199
 xref_mesh: MESH:C452423
 xref: PDBeChem:ZD6;   PMID:12684431 "Europe PMC";   PMID:14760102 "Europe PMC";   PMID:15305185 "Europe PMC";   PMID:15367698 "Europe PMC";   PMID:15596048 "Europe PMC";   PMID:15604279 "Europe PMC";   PMID:15623642 "Europe PMC";   PMID:15623658 "Europe PMC";   PMID:15928657 "Europe PMC";   PMID:16140331 "Europe PMC";   PMID:16179094 "Europe PMC";   PMID:16299247 "Europe PMC";   PMID:16361567 "Europe PMC";   PMID:16377413 "Europe PMC";   PMID:16688779 "Europe PMC";   PMID:16783964 "Europe PMC";   PMID:16843002 "Europe PMC";   PMID:17136225 "Europe PMC";   PMID:17393165 "Europe PMC";   PMID:17409986 "Europe PMC";   PMID:17631646 "Europe PMC";   PMID:17878479 "Europe PMC";   PMID:17912240 "Europe PMC";   PMID:18228115 "Europe PMC";   PMID:18698025 "Europe PMC";   PMID:18936474 "Europe PMC";   PMID:19002384 "Europe PMC";   PMID:19088171 "Europe PMC";   PMID:19211364 "Europe PMC";   PMID:19220256 "Europe PMC";   PMID:19332730 "Europe PMC";   PMID:19349511 "Europe PMC";   PMID:19394692 "Europe PMC";   PMID:19512898 "Europe PMC";   PMID:19622715 "Europe PMC";   PMID:19687425 "Europe PMC";   PMID:19881951 "Europe PMC";   PMID:19883226 "Europe PMC";   PMID:19946413 "Europe PMC";   PMID:20371720 "Europe PMC";   PMID:21046425 "Europe PMC";   PMID:21353546 "Europe PMC";   PMID:21718364 "Europe PMC";   PMID:22075979 "Europe PMC";   PMID:22158569 "Europe PMC";   PMID:22169262 "Europe PMC";   PMID:22184381 "Europe PMC";   PMID:22245891 "Europe PMC";   PMID:22307735 "Europe PMC";   PMID:22343387 "Europe PMC";   PMID:22346266 "Europe PMC";   PMID:22370318 "Europe PMC";   PMID:22500115 "Europe PMC";   PMID:22505191 "Europe PMC";   PMID:22608542 "Europe PMC";   PMID:22611027 "Europe PMC";   PMID:22633931 "Europe PMC";   PMID:22665903 "Europe PMC";   PMID:22667325 "Europe PMC";   PMID:22701615 "Europe PMC";   PMID:22781612 "Europe PMC";   PMID:22830347 "Europe PMC";   PMID:22898678 "Europe PMC";   PMID:22938056 "Europe PMC";   Patent:US2006135486;   Patent:US2008032989;   Patent:US2008199480;   Patent:WO2005115145;   Patent:WO2006005915;   Patent:WO2007036713;   Patent:WO2008001101;   Patent:WO2008007113;   Patent:WO2009024825;   Patent:WO2012055015;   Reaxys:9161676 "Reaxys";   Wikipedia:Vandetanib

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vandetanib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:6480464
G Calb1 calbindin 1 JBrowse link 5 29,538,380 29,562,774 RGD:6480464
G Col4a3 collagen type IV alpha 3 chain JBrowse link 9 88,357,528 88,484,735 RGD:6480464
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Eno2 enolase 2 JBrowse link 4 157,285,192 157,294,090 RGD:6480464
G Fam13a family with sequence similarity 13, member A JBrowse link 4 89,183,180 89,281,282 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G H1f2 H1.2 linker histone, cluster member JBrowse link 17 43,638,938 43,640,445 RGD:6480464
G Hilpda hypoxia inducible lipid droplet-associated JBrowse link 4 56,547,600 56,550,584 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6480464
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:6480464
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kdm3a lysine demethylase 3A JBrowse link 4 99,503,160 99,547,315 RGD:6480464
G Msh3 mutS homolog 3 JBrowse link 2 21,790,048 21,931,791 RGD:6480464
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:6480464
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:6480464
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:6480464
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 JBrowse link 8 99,977,334 100,059,736 RGD:6480464
G Ptma prothymosin alpha JBrowse link 9 93,545,396 93,549,436 RGD:6480464
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:6480464
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            antineoplastic agent 16873
              vandetanib 29
                linkable vandetanib analogue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    main group molecular entity 19622
                      s-block molecular entity 19388
                        hydrogen molecular entity 19377
                          hydrides 18283
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17001
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        secondary amino compound 6365
                                          secondary amine 1656
                                            vandetanib 29
                                              linkable vandetanib analogue 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.