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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zinc dichloride
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Accession:CHEBI:49976 term browser browse the term
Definition:A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Synonyms:exact_synonym: zinc(2+) chloride;   zinc(II) chloride
 related_synonym: Formula=Cl2Zn;   InChI=1S/2ClH.Zn/h2*1H;/q;;+2/p-2;   InChIKey=JIAARYAFYJHUJI-UHFFFAOYSA-L;   SMILES=[Cl-].[Cl-].[Zn++];   Zinkchlorid;   ZnCl2;   butter of zinc;   chlorure de zinc;   dichlorozinc;   zinc chloride;   zinc chloride, anhydrous
 xref: CAS:7646-85-7;   Gmelin:430396;   KEGG:D02058
 xref_mesh: MESH:C016837
 xref: MolBase:1125;   PMID:23021350;   PMID:23399499;   PMID:23471775;   PMID:23514640;   PMID:23546181;   PMID:23574241;   PMID:23739012;   PMID:23761032;   PMID:23763136;   PMID:29079364;   PMID:7615984;   PMID:9730919;   Wikipedia:Zinc_Chloride


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zinc dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ABCB1 mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
CTD PMID:19714248 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ABCB6 mRNA] CTD PMID:22202117 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein] CTD PMID:19429256 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in decreased activity of ACO2 protein CTD PMID:16624386 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Actb actin, beta multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of ACTB mRNA CTD PMID:31588059 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 decreases expression ISO zinc chloride results in decreased expression of ADAM2 mRNA CTD PMID:16870260 NCBI chr15:42,708,536...42,751,281
Ensembl chr15:42,708,387...42,751,330
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein] CTD PMID:18509044 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Adm adrenomedullin multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ADM mRNA] CTD PMID:22202117 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP zinc chloride inhibits the reaction [N(6)-cyclohexyladenosine binds to ADORA1 protein] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO zinc chloride results in decreased expression of AFP mRNA CTD PMID:18947441 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein CTD PMID:22415087 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ak4 adenylate kinase 4 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of AK4 mRNA] CTD PMID:22202117 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO zinc chloride results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]
CTD PMID:11340092 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO
EXP
[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury; zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]
lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]; zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of ALAD protein]
CTD PMID:2061546, PMID:14615064, PMID:22413763, PMID:24619859, PMID:24679358 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA] CTD PMID:22202117 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOC mRNA] CTD PMID:22202117 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases activity
ISO
EXP
[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA
zinc chloride results in increased activity of ALPL protein
Cadmium inhibits the reaction [zinc chloride results in increased activity of ALPL protein]; zinc chloride inhibits the reaction [Cadmium results in decreased activity of ALPL protein]
CTD PMID:19913120, PMID:26214600 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ang angiogenin multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANG mRNA] CTD PMID:22202117 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANGPTL4 mRNA] CTD PMID:22202117 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ankrd37 ankyrin repeat domain 37 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANKRD37 mRNA] CTD PMID:22202117 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANKZF1 mRNA] CTD PMID:22202117 NCBI chr 9:82,393,619...82,400,537
Ensembl chr 9:82,393,672...82,400,530
JBrowse link
G Ar androgen receptor multiple interactions EXP Androgens inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]; zinc chloride inhibits the reaction [Androgens binds to AR protein] CTD PMID:6323860 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg2 arginase 2 increases expression ISO zinc chloride results in increased expression of ARG2 mRNA CTD PMID:18947441 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arrb2 arrestin, beta 2 affects localization ISO zinc chloride affects the localization of ARRB2 protein CTD PMID:16959833 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO [[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein] CTD PMID:30768131 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO zinc chloride results in decreased expression of ATF4 mRNA CTD PMID:18947441 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression ISO zinc chloride results in decreased expression of ATP6V1B2 mRNA CTD PMID:18947441 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Atp7b ATPase copper transporting beta decreases expression
increases expression
ISO zinc chloride results in decreased expression of ATP7B mRNA
zinc chloride results in increased expression of ATP7B mRNA
CTD PMID:18947441 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bag3 BAG cochaperone 3 increases expression
multiple interactions
ISO zinc chloride results in increased expression of BAG3 mRNA
zinc chloride results in increased expression of and affects the localization of BAG3 protein
CTD PMID:12706811, PMID:16870260 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
[Citric Acid co-treated with zinc chloride] results in increased expression of BAX protein
zinc chloride affects the reaction [Cadmium Chloride results in increased expression of BAX protein]
zinc chloride promotes the reaction [Doxorubicin results in increased expression of BAX mRNA]
CTD PMID:16624386, PMID:19714248, PMID:28390674 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO zinc chloride promotes the reaction [Doxorubicin results in increased expression of BBC3 mRNA] CTD PMID:19714248 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in decreased expression of BCL2 protein; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 mRNA]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 protein]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BCL2 mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of BCL2 mRNA]
CTD PMID:16624386, PMID:17786326, PMID:19714248 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO zinc chloride results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in decreased expression of BCL2L1 protein CTD PMID:16624386 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP zinc chloride affects the reaction [Cadmium Chloride affects the expression of BDNF mRNA] CTD PMID:29548726 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO [zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA CTD PMID:19913120 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BHLHE40 mRNA] CTD PMID:22202117 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BNIP3L mRNA] CTD PMID:22202117 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BOP1 mRNA] CTD PMID:22202117 NCBI chr 7:117,514,529...117,538,342
Ensembl chr 7:117,514,533...117,538,342
JBrowse link
G C3 complement C3 increases expression ISO zinc chloride results in increased expression of C3 mRNA CTD PMID:19428942 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Ca13 carbonic anhydrase 13 increases expression ISO zinc chloride results in increased expression of CAR13 mRNA CTD PMID:19000923 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA] CTD PMID:22202117 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Cald1 caldesmon 1 increases expression ISO zinc chloride results in increased expression of CALD1 mRNA CTD PMID:16870260 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in increased activity of CASP12 protein CTD PMID:16624386 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in increased activity of CASP3 protein CTD PMID:16624386 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA] CTD PMID:28390674 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity
EXP
ISO
zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
zinc chloride results in increased expression of CAT mRNA
zinc chloride results in increased activity of CAT protein
CTD PMID:9330853, PMID:19429256, PMID:23726800 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO zinc chloride results in increased expression of CCL11 mRNA CTD PMID:19428942 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO zinc chloride results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO zinc chloride results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO zinc chloride results in increased expression of CCL20 mRNA CTD PMID:19428942, PMID:21540303, PMID:27427241 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO zinc chloride results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 increases expression ISO zinc chloride results in increased expression of CCL26 mRNA CTD PMID:19428942 NCBI chr12:24,157,182...24,161,870
Ensembl chr12:24,158,766...24,161,869
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO zinc chloride results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO zinc chloride affects the reaction [Cadmium Chloride results in increased expression of CCNG1 mRNA] CTD PMID:16842966 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CCNG2 mRNA] CTD PMID:22202117 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO zinc chloride results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO zinc chloride results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Cd86 CD86 molecule decreases expression ISO zinc chloride results in decreased expression of CD86 protein CTD PMID:24284788 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd9 CD9 molecule increases expression ISO zinc chloride results in increased expression of CD9 mRNA CTD PMID:16870260 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO zinc chloride results in decreased expression of CDH17 mRNA CTD PMID:18947441 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in increased expression of CDKN1A protein CTD PMID:16624386 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO zinc chloride results in decreased expression of CDKN1B mRNA CTD PMID:21540303 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B decreases expression ISO zinc chloride results in decreased expression of CDKN2B mRNA CTD PMID:21540303 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdr1 cerebellar degeneration related protein 1 decreases expression ISO zinc chloride results in decreased expression of CDR1 mRNA CTD PMID:16870260 NCBI chr  X:144,326,497...144,330,364 JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 increases expression ISO zinc chloride results in increased expression of CEACAM6 mRNA CTD PMID:18947441 NCBI chr 1:81,683,500...81,701,230
Ensembl chr 1:81,683,463...81,701,317
JBrowse link
G Cftr CF transmembrane conductance regulator increases expression ISO zinc chloride results in increased expression of CFTR mRNA CTD PMID:16870260 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO zinc chloride results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CITED2 mRNA] CTD PMID:22202117 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of COL1A1 mRNA CTD PMID:19913120 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Commd1 copper metabolism domain containing 1 multiple interactions EXP [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein CTD PMID:25007851 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO zinc chloride results in decreased expression of COX17 mRNA CTD PMID:18947441 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cp ceruloplasmin increases expression ISO zinc chloride results in increased expression of CP mRNA CTD PMID:18947441 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 increases expression ISO zinc chloride results in increased expression of CPS1 mRNA CTD PMID:16870260 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Crp C-reactive protein increases expression ISO zinc chloride results in increased expression of CRP mRNA CTD PMID:19428942 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 increases expression
multiple interactions
ISO zinc chloride results in increased expression of CSF2 mRNA
zinc chloride results in increased expression of CSF2 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]
CTD PMID:18509044, PMID:21540303, PMID:27427241 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CSRP2 mRNA] CTD PMID:22202117 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO zinc chloride results in increased expression of CXCL1 mRNA CTD PMID:19428942 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO zinc chloride results in increased expression of CXCL11 mRNA CTD PMID:19428942 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO zinc chloride results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO zinc chloride results in increased expression of CXCL14 mRNA CTD PMID:19428942 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO zinc chloride results in increased expression of CXCL1 mRNA CTD PMID:19428942 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO zinc chloride results in decreased expression of CXCL6 mRNA CTD PMID:19428942 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases stability
multiple interactions
ISO zinc chloride results in increased stability of CYP1A1 mRNA; zinc chloride results in increased stability of CYP1A1 protein
zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
CTD PMID:19896525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcp1b decapping mRNA 1B multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA CTD PMID:22415087 NCBI chr 4:151,249,654...151,287,018
Ensembl chr 4:151,250,041...151,285,702
JBrowse link
G Ddx21 DExD-box helicase 21 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of DDX21 mRNA] CTD PMID:22202117 NCBI chr20:32,213,147...32,232,632
Ensembl chr20:32,213,148...32,232,632
JBrowse link
G Dennd2b DENN domain containing 2B increases expression ISO zinc chloride results in increased expression of DENND2B mRNA CTD PMID:16870260 NCBI chr 1:174,137,120...174,290,533
Ensembl chr 1:174,137,120...174,289,647
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO zinc chloride results in increased expression of DHRS2 mRNA CTD PMID:16870260 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Dicer1 dicer 1 ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein CTD PMID:22415087 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Dll4 delta like canonical Notch ligand 4 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in decreased expression of DLL4 mRNA CTD PMID:31588059 NCBI chr 3:111,135,011...111,146,746
Ensembl chr 3:111,135,021...111,145,986
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP zinc chloride inhibits the reaction [ecopipam binds to DRD1 protein]; zinc chloride inhibits the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:9109525 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP zinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein] CTD PMID:9109525 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein CTD PMID:22415087 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Duox1 dual oxidase 1 multiple interactions ISO DUOX1 protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein] CTD PMID:27427241 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO zinc chloride results in increased phosphorylation of EGFR protein CTD PMID:21540303 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EGLN1 mRNA]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein] CTD PMID:16579968, PMID:22202117 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein CTD PMID:22415087 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases activity
EXP zinc chloride results in increased phosphorylation of and results in increased activity of ELK1 protein
zinc chloride results in increased activity of ELK1 protein
CTD PMID:16960431, PMID:20412391 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eno2 enolase 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ENO2 mRNA] CTD PMID:22202117 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Epo erythropoietin multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:11090055 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 decreases expression ISO zinc chloride results in decreased expression of F2RL2 mRNA CTD PMID:16870260 NCBI chr 2:26,240,385...26,245,533
Ensembl chr 2:26,240,385...26,245,533
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO zinc chloride results in decreased expression of FABP1 mRNA CTD PMID:18947441 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fam162a family with sequence similarity 162, member A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of FAM162A mRNA] CTD PMID:22202117 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Fasn fatty acid synthase decreases expression ISO zinc chloride results in decreased expression of FASN mRNA CTD PMID:21540303 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of FOS mRNA] CTD PMID:22202117 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO zinc chloride results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO zinc chloride results in decreased expression of FOXA2 mRNA CTD PMID:21540303 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Foxd1 forkhead box D1 increases expression ISO zinc chloride results in increased expression of FOXD1 mRNA CTD PMID:16870260 NCBI chr 2:28,460,068...28,462,488
Ensembl chr 2:28,460,068...28,462,488
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions EXP zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of G6PC protein] CTD PMID:22413763 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:18972399 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GBE1 mRNA] CTD PMID:22202117 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA] CTD PMID:18385089 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLM mRNA] CTD PMID:18385089 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO zinc chloride results in increased expression of GPX2 mRNA CTD PMID:18947441 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO zinc chloride results in increased expression of GRIK2 mRNA CTD PMID:16870260 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2A protein]; zinc chloride results in increased expression of and results in increased phosphorylation of GRIN2A protein CTD PMID:12211081 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2B protein]; zinc chloride results in increased expression of and results in increased phosphorylation of GRIN2B protein CTD PMID:12211081 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
increases expression
EXP Copper inhibits the reaction [zinc chloride results in increased expression of GRM5 protein] CTD PMID:25007851 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride
zinc chloride inhibits the reaction [Cadmium Chloride results in increased activity of GSR protein]; zinc chloride inhibits the reaction [Copper results in decreased activity of GSR protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD PMID:12632252, PMID:19429256, PMID:20600438, PMID:23726800 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP [Cadmium Chloride co-treated with zinc chloride] results in increased expression of GSTP1 protein CTD PMID:15602745 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gys1 glycogen synthase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA] CTD PMID:22202117 NCBI chr 1:101,427,195...101,447,092
Ensembl chr 1:101,427,195...101,447,092
JBrowse link
G H2ax H2A.X variant histone increases expression ISO zinc chloride results in increased expression of H2AX mRNA CTD PMID:18947441 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hcfc1r1 host cell factor C1 regulator 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HCFC1R1 mRNA] CTD PMID:22202117 NCBI chr10:12,994,229...12,995,674
Ensembl chr10:12,994,683...12,995,457
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA CTD PMID:31588059 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO zinc chloride results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Heph hephaestin decreases expression ISO zinc chloride results in decreased expression of HEPH mRNA CTD PMID:18947441 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [bitertanol results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Butylated Hydroxyanisole results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [butylparaben results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [EPN oxon results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Permethrin results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [salinomycin results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [terbufos results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
affects splicing
ISO Cycloheximide inhibits the reaction [zinc chloride results in increased expression of HIF1A protein alternative form]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
[Doxorubicin co-treated with zinc chloride] results in decreased expression of HIF1A mRNA
zinc chloride results in increased expression of HIF1A mRNA; zinc chloride results in increased expression of HIF1A mRNA alternative form; zinc chloride results in increased expression of HIF1A protein alternative form
zinc chloride affects the splicing of HIF1A mRNA
CTD PMID:11090055, PMID:11739637, PMID:16579968, PMID:19714248 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HILPDA mRNA] CTD PMID:22202117 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in decreased expression of HIPK2 protein]
[Doxorubicin co-treated with zinc chloride] results in increased expression of HIPK2 mRNA
CTD PMID:19714248 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HK2 mRNA] CTD PMID:22202117 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO zinc chloride results in increased expression of HMOX1 mRNA; zinc chloride results in increased expression of HMOX1 protein
HMOX1 enhancer affects the reaction [zinc chloride results in increased expression of HMOX1 mRNA]
zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]
CTD PMID:7538129, PMID:16870260, PMID:22202117, PMID:27427241 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO zinc chloride results in increased expression of HSPA1A mRNA CTD PMID:12085988, PMID:16870260 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO zinc chloride results in increased expression of HSPA1B mRNA CTD PMID:12085988 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP zinc chloride results in increased expression of HSPD1 protein CTD PMID:19429256 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in decreased expression of IFNG mRNA; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]] CTD PMID:8975779, PMID:31588059 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO zinc chloride results in decreased expression of IKBKB mRNA CTD PMID:21540303 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 increases expression ISO zinc chloride results in increased expression of IL10 mRNA CTD PMID:24284788 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO zinc chloride results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il12b interleukin 12B decreases expression ISO zinc chloride results in decreased expression of IL12B mRNA CTD PMID:24284788 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il18r1 interleukin 18 receptor 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of IL18R1 mRNA] CTD PMID:22202117 NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO zinc chloride results in increased expression of IL1A protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]
CTD PMID:18509044 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
zinc chloride results in increased expression of IL1B mRNA
zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:9138684, PMID:18509044, PMID:19130485, PMID:27427241 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO zinc chloride results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO zinc chloride results in increased expression of IL1RN mRNA CTD PMID:19428942 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il3 interleukin 3 multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein] CTD PMID:18509044 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO zinc chloride results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO zinc chloride results in increased secretion of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; RELA protein affects the reaction [zinc chloride results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]
zinc chloride results in increased expression of IL6 mRNA
CTD PMID:21842098, PMID:27427241 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of INSIG2 mRNA] CTD PMID:22202117 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Insr insulin receptor increases phosphorylation ISO zinc chloride results in increased phosphorylation of INSR protein CTD PMID:11340092 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression ISO zinc chloride results in increased expression of IREB2 mRNA CTD PMID:18947441 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Itgb6 integrin subunit beta 6 increases expression ISO zinc chloride results in increased expression of ITGB6 mRNA CTD PMID:16870260 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO zinc chloride results in increased expression of JUN mRNA
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [zinc chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]
CTD PMID:11306679, PMID:19000923, PMID:21540303, PMID:30768131 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO zinc chloride results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions ISO zinc chloride affects the reaction [4-aminophenylarsenoxide binds to KAT5 protein] CTD PMID:28837777 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
JBrowse link
G Kdm3a lysine demethylase 3A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of KDM3A mRNA] CTD PMID:22202117 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905
JBrowse link
G Kdm4b lysine demethylase 4B multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of KDM4B mRNA] CTD PMID:22202117 NCBI chr 9:10,656,035...10,734,127
Ensembl chr 9:10,653,216...10,734,073
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects folding
multiple interactions
ISO zinc chloride affects the folding of KEAP1 protein
zinc chloride promotes the reaction [KEAP1 protein binds to KEAP1 protein]
CTD PMID:30261176 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kif5a kinesin family member 5A multiple interactions
decreases activity
ISO Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Magnesium Chloride affects the reaction [zinc chloride results in decreased activity of KIF5A protein] CTD PMID:28122263 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Lep leptin increases expression ISO zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Limch1 LIM and calponin homology domains 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of LIMCH1 mRNA] CTD PMID:22202117 NCBI chr14:42,760,363...43,072,976
Ensembl chr14:42,762,587...43,072,843
JBrowse link
G Lta lymphotoxin alpha decreases expression
increases expression
ISO zinc chloride results in decreased expression of LTA mRNA
zinc chloride results in increased expression of LTA mRNA
CTD PMID:19428942, PMID:21540303 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltb4r leukotriene B4 receptor decreases expression ISO zinc chloride results in decreased expression of LTB4R mRNA CTD PMID:19428942 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of MAFF mRNA] CTD PMID:22202117 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO zinc chloride results in increased expression of MAFG mRNA CTD PMID:11162468 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of MAML1 mRNA CTD PMID:31588059 NCBI chr10:35,765,196...35,801,375
Ensembl chr10:35,765,719...35,800,120
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases activity ISO zinc chloride results in increased activity of MAP2K4 protein CTD PMID:11306679 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein] CTD PMID:11306679 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
increases phosphorylation
EXP
ISO
N,N'-diphenyl-4-phenylenediamine inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK1 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein
zinc chloride results in increased activity of MAPK1 protein
CTD PMID:11306679, PMID:11551972, PMID:16960431, PMID:20412391 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; N,N'-diphenyl-4-phenylenediamine inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; Vanadates promotes the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16960431, PMID:20412391, PMID:21575692 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]; [[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]; RAC1 protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]; zinc chloride inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:11306679, PMID:20423716, PMID:30768131 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO zinc chloride inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein] CTD PMID:20423716 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO zinc chloride results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mif macrophage migration inhibitory factor decreases expression ISO zinc chloride results in decreased expression of MIF mRNA CTD PMID:18947441 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir130a microRNA 130a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA CTD PMID:22415087 NCBI chr 3:72,141,037...72,141,124
Ensembl chr 3:72,141,037...72,141,124
JBrowse link
G Mir223 microRNA 223 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA CTD PMID:22415087 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir29a microRNA 29a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA CTD PMID:22415087 NCBI chr 4:58,343,931...58,344,018 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein] CTD PMID:21573219 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO zinc chloride results in decreased expression of MMP7 mRNA CTD PMID:21540303 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mt1 metallothionein 1 affects binding
increases expression
multiple interactions
affects response to substance
decreases expression
ISO
EXP
zinc chloride binds to MT1 protein
zinc chloride results in increased expression of MT1A mRNA; zinc chloride results in increased expression of MT1A protein
zinc chloride promotes the reaction [Glucose results in increased expression of MT1A mRNA]
MT1 affects the susceptibility to zinc chloride
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; bisindolylmaleimide I inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]]; Genistein inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Sodium Selenite inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]
zinc chloride results in increased expression of MT1 mRNA; zinc chloride results in increased expression of MT1 protein
zinc chloride results in decreased expression of MT1 protein
CTD PMID:3422486, PMID:8928928, PMID:11551972, PMID:14998373, PMID:15288509, PMID:16987576, PMID:17637929, PMID:17910954, PMID:19835899, PMID:23056475, PMID:24284788 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions
affects binding
affects response to substance
increases expression
ISO
EXP
[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA; Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]
zinc chloride promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]
zinc chloride binds to MT2 protein
MT2 affects the susceptibility to zinc chloride
zinc chloride results in increased expression of MT2 mRNA; zinc chloride results in increased expression of MT2 protein
zinc chloride results in increased expression of MT2A mRNA; zinc chloride results in increased expression of MT2A protein
zinc chloride promotes the reaction [Glucose results in increased expression of MT2A mRNA]
CTD PMID:9138684, PMID:15288509, PMID:16842966, PMID:16870260, PMID:16987576, PMID:17234632, PMID:17637929, PMID:18947441, PMID:19835899, PMID:20471814, PMID:20801194, PMID:23056475 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 increases expression ISO zinc chloride results in increased expression of MT3 mRNA CTD PMID:18947441 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO zinc chloride results in decreased expression of MTA2 mRNA CTD PMID:16870260 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
affects localization
decreases expression
ISO zinc chloride results in increased phosphorylation of and results in increased activity of MTF1 protein
zinc chloride affects the localization of MTF1 protein
zinc chloride results in decreased expression of MTF1 mRNA
CTD PMID:11551972, PMID:16423564, PMID:18947441 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtf2 metal response element binding transcription factor 2 decreases expression ISO zinc chloride results in decreased expression of MTF2 mRNA CTD PMID:18947441 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases response to substance
ISO NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]
NCF1 results in increased susceptibility to zinc chloride
CTD PMID:18509044 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of NDRG1 mRNA] CTD PMID:22202117 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Ndufaf5 NADH:ubiquinone oxidoreductase complex assembly factor 5 decreases expression ISO zinc chloride results in decreased expression of NDUFAF5 mRNA CTD PMID:16870260 NCBI chr 3:133,232,412...133,261,932
Ensembl chr 3:133,232,432...133,261,973
JBrowse link
G Nf2 neurofibromin 2 decreases expression ISO zinc chloride results in decreased expression of NF2 mRNA CTD PMID:16870260 NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance
multiple interactions
ISO [NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to zinc chloride
zinc chloride promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein]
CTD PMID:18385089, PMID:19303893 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity ISO zinc chloride results in increased activity of NFKB1 protein CTD PMID:21842098 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nip7 nucleolar pre-rRNA processing protein NIP7 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of NIP7 mRNA] CTD PMID:22202117 NCBI chr19:39,257,586...39,259,728
Ensembl chr19:39,257,586...39,259,728
JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of NMNAT1 mRNA CTD PMID:31588059 NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]] CTD PMID:8975779 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO zinc chloride results in increased expression of NOX4 mRNA CTD PMID:16870260 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Ntn3 netrin 3 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of NTN3 mRNA CTD PMID:31588059 NCBI chr10:13,577,725...13,580,821
Ensembl chr10:13,577,725...13,580,821
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO zinc chloride results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:16190872 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA] CTD PMID:22202117 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA2 mRNA] CTD PMID:22202117 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO zinc chloride results in decreased expression of PAIP1 mRNA CTD PMID:18947441 NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases activity
increases response to substance
ISO zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; zinc chloride inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]
zinc chloride results in increased expression of PARP1 protein
zinc chloride results in increased activity of PARP1 protein
PARP1 results in increased susceptibility to zinc chloride
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; Cibacron Blue F 3GA inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; coomassie Brilliant Blue inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; periodate-oxidized adenosine 5'-triphosphate inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
CTD PMID:18509044, PMID:19056730, PMID:19714248, PMID:22253048 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 increases expression ISO zinc chloride results in increased expression of PCBD1 mRNA CTD PMID:18947441 NCBI chr20:30,689,690...30,696,465
Ensembl chr20:30,690,810...30,696,476
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Cadmium Chloride co-treated with zinc chloride] results in increased expression of PCNA protein CTD PMID:15602745 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdap1 PDGFA associated protein 1 multiple interactions ISO zinc chloride promotes the reaction [Cadmium Chloride results in increased expression of PDAP1 mRNA] CTD PMID:16842966 NCBI chr12:11,240,775...11,251,002
Ensembl chr12:11,240,761...11,251,004
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PDK1 mRNA] CTD PMID:22202117 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Peg3 paternally expressed 3 decreases expression ISO zinc chloride results in decreased expression of PEG3 mRNA CTD PMID:16870260 NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB3 mRNA] CTD PMID:22202117 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB4 mRNA] CTD PMID:22202117 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Pgf placental growth factor increases expression ISO zinc chloride results in increased expression of PGF mRNA CTD PMID:16870260 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA] CTD PMID:22202117 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pgm1 phosphoglucomutase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PGM1 mRNA] CTD PMID:22202117 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO zinc chloride results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein] CTD PMID:11306679 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 increases expression ISO zinc chloride results in increased expression of PIK3R4 mRNA CTD PMID:16870260 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO zinc chloride results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO zinc chloride results in increased expression of PMP22 mRNA CTD PMID:18947441 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization
EXP 1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]; 1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of PRKCA protein]; Glucose promotes the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]; Vanadates promotes the reaction [zinc chloride affects the localization of PRKCA protein]; zinc chloride affects the localization of and results in increased activity of PRKCA protein CTD PMID:20800666, PMID:21575692 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of PTH1R mRNA CTD PMID:19913120 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Rab20 RAB20, member RAS oncogene family multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RAB20 mRNA] CTD PMID:22202117 NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO RAC1 protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein] CTD PMID:11306679 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO zinc chloride results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO zinc chloride results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
increases phosphorylation
EXP 1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein] CTD PMID:21575692 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rangap1 RAN GTPase activating protein 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RANGAP1 mRNA] CTD PMID:22202117 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA] CTD PMID:22202117 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions ISO zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]; zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein] CTD PMID:21573219 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO zinc chloride results in increased phosphorylation of RELA protein
RELA protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]; RELA protein affects the reaction [zinc chloride results in increased secretion of IL6 protein]
CTD PMID:27427241 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO zinc chloride results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
JBrowse link
G Riok3 RIO kinase 3 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RIOK3 mRNA] CTD PMID:22202117 NCBI chr18:3,565,166...3,590,739
Ensembl chr18:3,565,166...3,590,739
JBrowse link
G Rora RAR-related orphan receptor A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RORA mRNA] CTD PMID:22202117 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rpl11 ribosomal protein L11 decreases expression ISO zinc chloride results in decreased expression of RPL11 mRNA CTD PMID:18947441 NCBI chr 5:154,390,809...154,394,412
Ensembl chr 5:154,388,140...154,394,328
JBrowse link
G Rrp15 ribosomal RNA processing 15 homolog multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RRP15 mRNA] CTD PMID:22202117 NCBI chr13:105,155,824...105,178,907
Ensembl chr13:105,155,441...105,179,095
JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RRS1 mRNA] CTD PMID:22202117 NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of RUNX2 protein; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 protein CTD PMID:19913120 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RUVBL1 mRNA] CTD PMID:22202117 NCBI chr 4:120,411,917...120,447,458
Ensembl chr 4:120,411,991...120,447,455
JBrowse link
G Sall1 spalt-like transcription factor 1 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of SALL1 mRNA CTD PMID:31588059 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
G Sap30 Sin3A associated protein 30 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SAP30 mRNA] CTD PMID:22202117 NCBI chr16:36,115,942...36,121,310
Ensembl chr16:36,116,258...36,121,097
JBrowse link
G Sbno1 strawberry notch homolog 1 increases expression ISO zinc chloride results in increased expression of SBNO1 mRNA CTD PMID:16870260 NCBI chr12:37,593,692...37,650,761
Ensembl chr12:37,593,874...37,649,036
JBrowse link
G Scara3 scavenger receptor class A, member 3 decreases expression ISO zinc chloride results in decreased expression of SCARA3 mRNA CTD PMID:16870260 NCBI chr15:42,605,505...42,638,409
Ensembl chr15:42,605,473...42,638,392
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO zinc chloride results in increased expression of SCARB1 mRNA CTD PMID:19000923 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SCD mRNA] CTD PMID:22202117 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Selplg selectin P ligand increases expression ISO zinc chloride results in increased expression of SELPLG mRNA CTD PMID:21540303 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
JBrowse link
G Sertad2 SERTA domain containing 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SERTAD2 mRNA] CTD PMID:22202117 NCBI chr14:104,786,649...104,890,022
Ensembl chr14:104,821,215...104,886,197
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 multiple interactions
increases expression
EXP [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; Copper inhibits the reaction [zinc chloride results in increased expression of SHANK2 protein] CTD PMID:25007851 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions
increases expression
EXP [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein; Copper inhibits the reaction [zinc chloride results in increased expression of SHANK3 protein] CTD PMID:25007851 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases transport ISO SLC11A2 protein results in increased transport of zinc chloride CTD PMID:22736759 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SLC16A3 mRNA] CTD PMID:22202117 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions ISO [Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein CTD PMID:19061913 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO zinc chloride results in decreased expression of SLC1A5 mRNA CTD PMID:18947441 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc25a15 solute carrier family 25 member 15 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SLC25A15 mRNA] CTD PMID:22202117 NCBI chr16:74,505,318...74,554,523
Ensembl chr16:74,531,564...74,554,529
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression
ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA]
zinc chloride results in increased expression of SLC2A1 mRNA
CTD PMID:19000923, PMID:22202117 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression
ISO
EXP
epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of SLC30A1 mRNA]; zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in decreased expression of SLC30A1 mRNA]
zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A1 mRNA]; zinc chloride promotes the reaction [Glucose results in increased expression of SLC30A1 mRNA]
CTD PMID:18947441, PMID:20392624, PMID:20471814, PMID:23056475, PMID:25653005 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc30a2 solute carrier family 30 member 2 increases expression
multiple interactions
EXP zinc chloride results in increased expression of SLC30A2 mRNA
zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A2 mRNA]
CTD PMID:20392624, PMID:25653005 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799
JBrowse link
G Slc30a4 solute carrier family 30 member 4 multiple interactions EXP zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A4 mRNA] CTD PMID:25653005 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154
JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression
multiple interactions
ISO zinc chloride results in decreased expression of SLC30A5 mRNA
Dactinomycin inhibits the reaction [zinc chloride results in decreased expression of SLC30A5 mRNA]
CTD PMID:17234632, PMID:20392624 NCBI chr 2:30,815,683...30,845,796
Ensembl chr 2:30,815,703...30,846,149
JBrowse link
G Slc30a7 solute carrier family 30 member 7 increases expression
decreases expression
ISO zinc chloride results in increased expression of SLC30A7 mRNA
zinc chloride results in decreased expression of SLC30A7 mRNA
CTD PMID:20392624 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030
JBrowse link
G Slc31a2 solute carrier family 31 member 2 increases expression
decreases expression
ISO zinc chloride results in increased expression of SLC31A2 mRNA
zinc chloride results in decreased expression of SLC31A2 mRNA
CTD PMID:18947441 NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114
JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions ISO zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in increased expression of SLC39A1 mRNA] CTD PMID:20471814 NCBI chr 2:189,609,766...189,615,367
Ensembl chr 2:189,609,800...189,615,366
JBrowse link
G Slc39a2 solute carrier family 39 member 2 multiple interactions
increases expression
ISO [SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione; zinc chloride promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein]; zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA]; zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLM mRNA]
zinc chloride results in increased expression of SLC39A2 mRNA
CTD PMID:18385089 NCBI chr15:28,295,044...28,297,688
Ensembl chr15:28,295,368...28,297,684
JBrowse link
G Slc39a3 solute carrier family 39 member 3 multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A3 mRNA] CTD PMID:25653005 NCBI chr 7:11,545,073...11,551,074
Ensembl chr 7:11,545,024...11,553,370
JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions
decreases expression
ISO
EXP
zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in increased expression of SLC39A4 mRNA]
zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A4 mRNA]
zinc chloride results in decreased expression of SLC39A4 mRNA
CTD PMID:20471814, PMID:25653005 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A8 mRNA] CTD PMID:25653005 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
G Slc48a1 solute carrier family 48 member 1 increases expression ISO zinc chloride results in increased expression of SLC48A1 mRNA CTD PMID:16870260 NCBI chr 7:139,271,698...139,279,499
Ensembl chr 7:139,271,698...139,279,499
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]; zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of SLC5A1 mRNA] CTD PMID:20060848 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Slc5a2 solute carrier family 5 member 2 multiple interactions ISO zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]]; zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of SLC5A2 mRNA] CTD PMID:20060848 NCBI chr 1:199,682,688...199,688,809
Ensembl chr 1:199,682,688...199,688,809
JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases expression ISO zinc chloride results in increased expression of SLC9A1 mRNA CTD PMID:18947441 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein] CTD PMID:18972399 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases activity
ISO zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]
zinc chloride results in increased activity of SP1 protein
CTD PMID:9330853, PMID:20060848 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp110 SP110 nuclear body protein multiple interactions ISO zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]] CTD PMID:20060848 NCBI chr 9:92,593,909...92,618,867
Ensembl chr 9:92,593,910...92,616,165
JBrowse link
G Spag4 sperm associated antigen 4 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SPAG4 mRNA] CTD PMID:22202117 NCBI chr 3:151,609,602...151,613,946
Ensembl chr 3:151,609,602...151,613,942
JBrowse link
G Spice1 spindle and centriole associated protein 1 decreases expression ISO zinc chloride results in decreased expression of SPICE1 mRNA CTD PMID:16870260 NCBI chr11:61,250,649...61,294,116
Ensembl chr11:61,251,696...61,294,022
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression ISO zinc chloride results in decreased expression of SPINK1 mRNA CTD PMID:18947441 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SPOCK1 mRNA] CTD PMID:22202117 NCBI chr17:7,675,531...7,797,863
Ensembl chr17:7,675,531...7,797,863
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression
multiple interactions
ISO zinc chloride results in decreased expression of SPP1 mRNA
[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SPP1 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SPP1 mRNA; zinc chloride promotes the reaction [Calcitriol results in increased activity of SPP1 promoter]
CTD PMID:10777672, PMID:19428942, PMID:19913120 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
EXP 1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of SRC protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of SRC protein]; Vanadates promotes the reaction [zinc chloride results in increased phosphorylation of SRC protein] CTD PMID:12211081, PMID:21575692 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srm spermidine synthase multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SRM mRNA] CTD PMID:22202117 NCBI chr 5:165,405,168...165,408,325
Ensembl chr 5:165,405,168...165,408,320
JBrowse link
G Stbd1 starch binding domain 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of STBD1 mRNA] CTD PMID:22202117 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760
JBrowse link
G Stmn1 stathmin 1 increases expression ISO zinc chloride results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Citric Acid co-treated with zinc chloride] results in decreased activity of TERT protein CTD PMID:16624386 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tf transferrin multiple interactions
increases expression
ISO zinc chloride inhibits the reaction [TF protein results in increased uptake of Iron]
zinc chloride results in increased expression of TF mRNA
CTD PMID:11335103, PMID:18947441 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO zinc chloride results in increased expression of TFPI2 mRNA CTD PMID:16870260 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
JBrowse link
G Tfrc transferrin receptor increases expression ISO zinc chloride results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tmem45a transmembrane protein 45A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of TMEM45A mRNA] CTD PMID:22202117 NCBI chr11:46,009,216...46,093,969
Ensembl chr11:46,009,322...46,093,973
JBrowse link
G Tnf tumor necrosis factor increases expression ISO zinc chloride results in increased expression of TNF mRNA CTD PMID:19428942, PMID:21540303, PMID:24284788 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of TNFRSF11B protein] CTD PMID:23726800 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein] CTD PMID:23726800 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnfsf14 TNF superfamily member 14 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of TNFSF14 mRNA CTD PMID:31588059 NCBI chr 9:9,761,363...9,765,461
Ensembl chr 9:9,761,536...9,765,186
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]] CTD PMID:19714248 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tra2a transformer 2 alpha homolog decreases expression ISO zinc chloride results in decreased expression of TRA2A mRNA CTD PMID:16870260 NCBI chr 4:78,905,380...78,924,203
Ensembl chr 4:78,905,380...78,924,181
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO [zinc chloride results in increased abundance of Zinc] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:29957541 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Ttr transthyretin multiple interactions ISO [zinc chloride results in increased abundance of Zinc] which results in increased expression of TTR mRNA CTD PMID:31588059 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression ISO zinc chloride results in increased expression of TUBA1B mRNA CTD PMID:18947441 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO zinc chloride promotes the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; zinc chloride results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 increases expression ISO zinc chloride results in increased expression of UBE2E2 mRNA CTD PMID:18947441 NCBI chr15:7,402,210...7,928,320
Ensembl chr15:7,871,497...7,927,939
JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO zinc chloride results in increased expression of UNC5B mRNA CTD PMID:18947441 NCBI chr20:30,339,680...30,406,593
Ensembl chr20:30,339,673...30,406,295
JBrowse link
G Use1 unconventional SNARE in the ER 1 increases expression ISO zinc chloride results in increased expression of USE1 mRNA CTD PMID:16870260 NCBI chr16:19,762,202...19,765,781
Ensembl chr16:19,762,938...19,765,782
JBrowse link
G Utrn utrophin affects binding ISO zinc chloride binds to UTRN protein CTD PMID:17009962 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of VEGFA mRNA]
CTD PMID:19714248 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdr4 WD repeat domain 4 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of WDR4 mRNA] CTD PMID:22202117 NCBI chr20:10,240,571...10,264,818
Ensembl chr20:10,239,154...10,257,044
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of WSB1 mRNA] CTD PMID:22202117 NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO zinc chloride results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110
JBrowse link
G Yeats2 YEATS domain containing 2 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of YEATS2 mRNA] CTD PMID:22202117 NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542
JBrowse link
G Zfp292 zinc finger protein 292 multiple interactions ISO zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ZNF292 mRNA] CTD PMID:22202117 NCBI chr 5:50,282,084...50,362,344
Ensembl chr 5:50,282,084...50,362,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        acceptor 16968
          Lewis acid 1799
            zinc dichloride 304
              fast blue salt B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      halogen 18011
                        chlorine atom 17793
                          chlorine molecular entity 17793
                            elemental chlorine 8373
                              monoatomic chlorine 8354
                                chloride 8354
                                  chloride salt 8354
                                    inorganic chloride 8227
                                      zinc dichloride 304
                                        fast blue salt B 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.