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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methyl-N-nitrosourea
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Accession:CHEBI:50102 term browser browse the term
Definition:A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Synonyms:exact_synonym: 1-methyl-1-nitrosourea
 related_synonym: 1-(aminocarbonyl)-1-methyl-2-oxohydrazine;   1-nitroso-1-methylurea;   Formula=C2H5N3O2;   InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6);   InChIKey=ZRKWMRDKSOPRRS-UHFFFAOYSA-N;   MNU;   Methylnitrosoharnstoff;   Methylnitrosourea;   N-Methyl-N-nitrosoharnstoff;   N-Nitroso-N-methylharnstoff;   N-methyl-N-nitrosocarbamide;   N-methyl-N-nitrosouree;   N-nitroso-N-methylcarbamide;   N-nitroso-N-methylurea;   N-nitroso-N-methyluree;   N-nitrosomethylurea;   NMH;   NMU;   SMILES=CN(N=O)C(N)=O;   methylnitrosouree;   nitrosomethylurea
 alt_id: CHEBI:25565;   CHEBI:34843;   CHEBI:50101
 xref: Beilstein:1756040;   CAS:684-93-5;   KEGG:C14595
 xref_mesh: MESH:D008770
 xref: PMID:11479921;   PMID:12767522;   PMID:15990165;   PMID:19181008;   PMID:24441676;   PMID:6243984;   PMID:8098217;   PMID:8603364;   Wikipedia:N-Methyl-N-nitrosourea


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N-methyl-N-nitrosourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Methylnitrosourea results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Acly ATP citrate lyase increases expression EXP Methylnitrosourea results in increased expression of ACLY mRNA CTD PMID:16525678 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Actb actin, beta increases mutagenesis EXP Methylnitrosourea results in increased mutagenesis of ACTB gene CTD PMID:10767621 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Methylnitrosourea results in increased expression of ADAMTS1 mRNA CTD PMID:17412507 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Afp alpha-fetoprotein decreases response to substance EXP AFP protein modified form results in decreased susceptibility to Methylnitrosourea CTD PMID:16322315 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Methylnitrosourea results in increased expression of AGTR1B mRNA CTD PMID:16525678 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylnitrosourea results in increased expression of AKR1B10 mRNA CTD PMID:25270620 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Methylnitrosourea results in increased expression of AKR1B8 protein CTD PMID:11565795 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of AKT1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of AKT1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:15581186, PMID:22465879, PMID:25164625 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Methylnitrosourea results in decreased expression of ALDH1A1 mRNA CTD PMID:25922126 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Methylnitrosourea results in increased expression of ANGPTL4 mRNA CTD PMID:17412507 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ap3s1 adaptor related protein complex 3 subunit sigma 1 increases expression ISO Methylnitrosourea results in increased expression of AP3S1 mRNA CTD PMID:25270620 NCBI chr18:40,732,472...40,798,064
Ensembl chr18:40,732,480...40,797,761
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Methylnitrosourea results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apc APC regulator of WNT signaling pathway increases response to substance ISO APC gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Methylnitrosourea results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Areg amphiregulin multiple interactions EXP [Methylnitrosourea co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of AREG mRNA CTD PMID:20732338 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Asip agouti signaling protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of A gene CTD PMID:10517996, PMID:17174358 NCBI chr 3:150,492,010...150,579,870
Ensembl chr 3:150,574,473...150,579,870
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Methylnitrosourea results in decreased expression of ASNS mRNA CTD PMID:17412507 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf1 activating transcription factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of ATF1 mRNA CTD PMID:25270620 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656
JBrowse link
G Atr ATR serine/threonine kinase affects localization
multiple interactions
ISO Methylnitrosourea affects the localization of ATR protein
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]
CTD PMID:21285353 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Aurka aurora kinase A multiple interactions
decreases expression
increases expression
EXP
ISO
[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]
Methylnitrosourea results in decreased expression of AURKA mRNA
CTD PMID:12124350, PMID:27233451 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B decreases phosphorylation ISO Methylnitrosourea results in decreased phosphorylation of AURKB protein CTD PMID:27233451 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression EXP Methylnitrosourea results in increased expression of B3GALT1 mRNA CTD PMID:17412507 NCBI chr 3:53,699,409...54,269,612
Ensembl chr 3:54,253,949...54,267,292
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAD mRNA CTD PMID:20732338 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of BAX mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]
Methylnitrosourea results in increased expression of BAX mRNA; Methylnitrosourea results in increased expression of BAX protein
CTD PMID:16011256, PMID:16047940, PMID:16168987, PMID:20732338, PMID:22465879, PMID:28688903 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression EXP Methylnitrosourea results in increased expression of BCL10 mRNA CTD PMID:17412507 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of BCL2 protein; [Methylnitrosourea co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of BCL2 mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]
Methylnitrosourea results in increased expression of BCL2 mRNA
CTD PMID:15240709, PMID:16011256, PMID:16047940, PMID:20732338, PMID:22465879, PMID:24463056 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methylnitrosourea results in increased expression of BDNF mRNA CTD PMID:28688903 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Methylnitrosourea results in increased expression of BIRC5 mRNA CTD PMID:25270620 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmp5 bone morphogenetic protein 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BMP5 gene CTD PMID:10517996, PMID:17174358 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:103,268,045...103,292,848
Ensembl chr13:103,268,068...103,292,854
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Methylnitrosourea results in increased expression of BTG2 mRNA CTD PMID:21382384 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Methylnitrosourea results in increased expression of BUB1 mRNA CTD PMID:25270620 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Capn1 calpain 1 decreases activity EXP Methylnitrosourea results in decreased activity of CAPN1 protein CTD PMID:17069801 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 increases activity EXP Methylnitrosourea results in increased activity of CAPN2 protein CTD PMID:17069801 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Methylnitrosourea results in increased expression of CAR2 mRNA CTD PMID:17341692 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP3 protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of CASP3 mRNA
CTD PMID:13679151, PMID:20732338, PMID:22465879 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases expression EXP Methylnitrosourea results in increased expression of CASP6 mRNA CTD PMID:28688903 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA
Methylnitrosourea results in increased expression of CASP8 mRNA
CTD PMID:20732338, PMID:22465879, PMID:28688903 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP9 mRNA CTD PMID:20732338 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP Methylnitrosourea results in increased expression of CBR1 mRNA CTD PMID:16525678 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
EXP
ISO
Methylnitrosourea results in increased expression of CCL2 mRNA
Methylnitrosourea results in increased expression of CCL2 protein
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
CTD PMID:16822543, PMID:17412507 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Methylnitrosourea results in increased expression of CCL20 mRNA CTD PMID:25270620 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Methylnitrosourea results in increased expression of CCL3 mRNA CTD PMID:17412507 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP Methylnitrosourea results in increased expression of CCL4 mRNA CTD PMID:17412507 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Methylnitrosourea results in increased expression of CCL5 mRNA CTD PMID:15240709 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Methylnitrosourea results in decreased expression of CCN2 mRNA CTD PMID:16525678 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
ISO Methylnitrosourea results in increased expression of CCNA2 mRNA; Methylnitrosourea results in increased expression of CCNA2 protein
Methylnitrosourea results in decreased expression of CCNA2
CTD PMID:15870882, PMID:18593901, PMID:25270620 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Methylnitrosourea results in increased expression of CCNB1 mRNA CTD PMID:25270620 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP Methylnitrosourea results in increased expression of CCND1 protein
[Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein]
CTD PMID:18155124, PMID:20732338, PMID:25164625 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Methylnitrosourea results in increased expression of CCND3 protein CTD PMID:18155124 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cd59 CD59 molecule multiple interactions
decreases lipidation
EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
Methylnitrosourea results in decreased lipidation of CD59 protein
CTD PMID:19965957, PMID:20202993, PMID:27931811 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
EXP
ISO
[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA; [Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]
Methylnitrosourea results in decreased expression of CDH1 mRNA
CTD PMID:25164625, PMID:27221058 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein] CTD PMID:25164625 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh22 cadherin 22 decreases expression EXP Methylnitrosourea results in decreased expression of CDH22 mRNA CTD PMID:17341692 NCBI chr 3:161,574,993...161,971,102
Ensembl chr 3:161,575,631...161,917,285
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
increases expression
ISO
EXP
Methylnitrosourea results in decreased expression of CDK1
Methylnitrosourea results in increased expression of CDK1 protein
Methylnitrosourea results in increased expression of CDK1 mRNA
CTD PMID:15870882, PMID:16525678, PMID:18593901 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity EXP Methylnitrosourea results in increased activity of CDK2 protein CTD PMID:15581186 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of CDK5R1 protein CTD PMID:17069801 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:149,835,953...149,870,429
Ensembl chr 3:149,703,848...149,870,413
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO
EXP
Methylnitrosourea results in increased expression of CDKN1A mRNA
Methylnitrosourea results in decreased expression of CDKN1A protein
CTD PMID:15581186, PMID:18593901, PMID:28688903, PMID:29110037 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Methylnitrosourea results in increased expression of CEL mRNA CTD PMID:15240709 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Cela2a chymotrypsin like elastase 2A increases expression ISO Methylnitrosourea results in increased expression of CELA2A mRNA CTD PMID:15240709 NCBI chr 5:160,374,031...160,383,782
Ensembl chr 5:160,374,031...160,383,782
JBrowse link
G Cenpa centromere protein A decreases expression ISO Methylnitrosourea results in decreased expression of CENPA mRNA CTD PMID:27233451 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cenpe centromere protein E increases expression ISO Methylnitrosourea results in increased expression of CENPE mRNA CTD PMID:25270620 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cep290 centrosomal protein 290 decreases expression EXP Methylnitrosourea results in decreased expression of CEP290 mRNA CTD PMID:17412507 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO Methylnitrosourea results in increased phosphorylation of CHEK2 protein
MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]
CTD PMID:21285353 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Methylnitrosourea results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:80,424,320...80,526,583
Ensembl chr 3:80,468,154...80,526,593
JBrowse link
G Cldn7 claudin 7 decreases expression EXP Methylnitrosourea results in decreased expression of CLDN7 mRNA CTD PMID:16525678 NCBI chr10:56,576,326...56,578,632
Ensembl chr10:56,576,428...56,578,626
JBrowse link
G Clu clusterin increases expression EXP Methylnitrosourea results in increased expression of CLU mRNA CTD PMID:17412507 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col4a3 collagen type IV alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL4A3 mRNA CTD PMID:16525678 NCBI chr 9:88,357,528...88,484,735
Ensembl chr 9:88,357,556...88,485,830
JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL5A3 mRNA CTD PMID:17341692 NCBI chr 8:21,786,324...21,831,751
Ensembl chr 8:21,786,324...21,831,668
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression ISO Methylnitrosourea results in increased expression of CPT1C mRNA CTD PMID:25270620 NCBI chr 1:100,955,094...100,970,579
Ensembl chr 1:100,955,095...100,969,560
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Methylnitrosourea results in increased expression of CREM mRNA CTD PMID:17412507 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crip2 cysteine-rich protein 2 increases expression ISO Methylnitrosourea results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctcf CCCTC-binding factor decreases expression ISO Methylnitrosourea results in decreased expression of CTCF mRNA CTD PMID:25270620 NCBI chr19:37,600,151...37,649,674
Ensembl chr19:37,600,148...37,649,673
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Methylnitrosourea results in increased expression of CTNNB1 protein CTD PMID:12096346 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin decreases expression ISO Methylnitrosourea results in decreased expression of CWC27 mRNA CTD PMID:25270620 NCBI chr 2:34,716,420...34,923,060
Ensembl chr 2:34,719,344...34,923,024
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP Methylnitrosourea results in increased expression of CYP27B1 mRNA CTD PMID:21843606 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP Methylnitrosourea results in decreased expression of CYP2J9 mRNA CTD PMID:17412507 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Methylnitrosourea results in increased expression of DAPK1 mRNA CTD PMID:25270620 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression EXP Methylnitrosourea results in increased expression of DBI mRNA CTD PMID:16525678 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Methylnitrosourea results in decreased expression of DBP mRNA CTD PMID:16525678 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 increases expression ISO Methylnitrosourea results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr 6:107,001,763...107,027,466
Ensembl chr 6:107,001,763...107,027,456
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Methylnitrosourea results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Depdc7 DEP domain containing 7 increases expression EXP Methylnitrosourea results in increased expression of DEPDC7 mRNA CTD PMID:17412507 NCBI chr 3:94,665,714...94,687,013
Ensembl chr 3:94,665,717...94,686,989
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions EXP Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA] CTD PMID:15922087 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:118,277,046...119,159,807
Ensembl chr 9:118,586,179...119,158,196
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression ISO Methylnitrosourea results in increased expression of DMBT1 mRNA CTD PMID:15240709 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression ISO Methylnitrosourea results in increased expression of DNAJB5 mRNA CTD PMID:25270620 NCBI chr 5:58,393,197...58,402,162
Ensembl chr 5:58,393,233...58,401,870
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression ISO Methylnitrosourea results in decreased expression of DNAJC7 mRNA CTD PMID:25270620 NCBI chr10:88,498,271...88,533,730
Ensembl chr10:88,498,238...88,533,829
JBrowse link
G Dnpep aspartyl aminopeptidase decreases activity EXP Methylnitrosourea results in decreased activity of DNPEP protein CTD PMID:16537183 NCBI chr 9:82,505,529...82,514,399
Ensembl chr 9:82,505,530...82,514,399
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression EXP Methylnitrosourea results in decreased expression of DPYSL3 mRNA CTD PMID:28688903 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP Methylnitrosourea results in increased expression of DUSP5 mRNA CTD PMID:17412507 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dym dymeclin increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:70,996,074...71,313,033
Ensembl chr18:70,996,044...71,313,084
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Edf1 endothelial differentiation-related factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of EDF1 mRNA CTD PMID:25270620 NCBI chr 3:2,781,169...2,785,474
Ensembl chr 3:2,781,169...2,785,474
JBrowse link
G Ednrb endothelin receptor type B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of EDNRB gene CTD PMID:17174358 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Eed embryonic ectoderm development affects response to substance ISO EED protein affects the susceptibility to Methylnitrosourea CTD PMID:11803473 NCBI chr 1:154,189,252...154,216,340
Ensembl chr 1:154,189,260...154,216,340
JBrowse link
G Efna3 ephrin A3 increases expression ISO Methylnitrosourea results in increased expression of EFNA3 mRNA CTD PMID:25270620 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Efs embryonal Fyn-associated substrate increases expression ISO Methylnitrosourea results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr15:33,579,952...33,590,217
Ensembl chr15:33,578,381...33,589,522
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; Methylnitrosourea results in increased phosphorylation of and results in decreased expression of EGFR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein] CTD PMID:22245120, PMID:25164625 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of EGLN3 mRNA CTD PMID:25270620 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO Methylnitrosourea results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of EIF4EBP1 protein CTD PMID:22465879 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Methylnitrosourea results in increased expression of ELOVL6 mRNA CTD PMID:16525678 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Eomes eomesodermin decreases expression ISO Methylnitrosourea results in decreased expression of EOMES mRNA CTD PMID:25270620 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Methylnitrosourea results in increased expression of EPHX1 mRNA CTD PMID:21382384 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression
increases expression
ISO Methylnitrosourea results in decreased expression of ERCC4 mRNA
Methylnitrosourea results in increased expression of ERCC4 mRNA
CTD PMID:16616109 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Ergic3 ERGIC and golgi 3 increases expression ISO Methylnitrosourea results in increased expression of ERGIC3 mRNA CTD PMID:25270620 NCBI chr 3:151,553,567...151,563,318
Ensembl chr 3:151,553,578...151,563,364
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases phosphorylation
increases response to substance
EXP [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
ESR1 protein results in increased susceptibility to Methylnitrosourea
CTD PMID:15528971, PMID:16891317, PMID:22245120 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ezr ezrin increases expression EXP Methylnitrosourea results in increased expression of EZR mRNA CTD PMID:17412507 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Methylnitrosourea results in increased expression of F3 mRNA CTD PMID:17412507 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Methylnitrosourea results in increased expression of FABP3 mRNA CTD PMID:17341692 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression EXP Methylnitrosourea results in increased expression of FAIM2 mRNA CTD PMID:17412507 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fam187b family with sequence similarity 187, member B decreases expression ISO Methylnitrosourea results in decreased expression of FAM187B mRNA CTD PMID:25270620 NCBI chr 1:89,408,718...89,416,629
Ensembl chr 1:89,408,935...89,416,745
JBrowse link
G Fasn fatty acid synthase increases expression EXP Methylnitrosourea results in increased expression of FASN mRNA CTD PMID:16525678 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbp2 fructose-bisphosphatase 2 increases expression ISO Methylnitrosourea results in increased expression of FBP2 mRNA CTD PMID:25270620 NCBI chr17:372,554...389,918
Ensembl chr17:372,551...389,967
JBrowse link
G Fbxo15 F-box protein 15 decreases expression ISO Methylnitrosourea results in decreased expression of FBXO15 mRNA CTD PMID:25270620 NCBI chr18:81,785,408...81,882,796
Ensembl chr18:81,821,127...81,882,796
JBrowse link
G Fbxo5 F-box protein 5 increases expression ISO Methylnitrosourea results in increased expression of FBXO5 mRNA CTD PMID:25270620 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein] CTD PMID:16011256 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR1 protein CTD PMID:15581186 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR2 protein CTD PMID:15581186 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR4 protein CTD PMID:15581186 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases methylation
decreases expression
EXP Methylnitrosourea results in increased methylation of FHIT intron; Methylnitrosourea results in increased methylation of FHIT promoter
Methylnitrosourea results in decreased expression of FHIT mRNA; Methylnitrosourea results in decreased expression of FHIT protein
CTD PMID:15937960, PMID:17412507 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Methylnitrosourea results in increased expression of FOS mRNA; Methylnitrosourea results in increased expression of FOS protein
[tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of FOS protein]
CTD PMID:16168987, PMID:16268501, PMID:17412507 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxa1 forkhead box A1 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA1 mRNA CTD PMID:27221058 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA2 mRNA CTD PMID:27221058 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein] CTD PMID:22245120 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 increases expression ISO Methylnitrosourea results in increased expression of GALNT6 mRNA CTD PMID:25270620 NCBI chr 7:142,322,172...142,364,281
Ensembl chr 7:142,322,172...142,352,382
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Methylnitrosourea results in increased expression of GBP2 mRNA CTD PMID:17412507 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression
EXP Methylnitrosourea results in increased expression of GFAP protein
Methylnitrosourea results in decreased expression of GFAP mRNA
CTD PMID:18155124, PMID:28688903 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gh1 growth hormone 1 decreases response to substance EXP GH1 gene mutant form results in decreased susceptibility to Methylnitrosourea CTD PMID:12082019 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases response to substance ISO GJB1 protein results in decreased susceptibility to Methylnitrosourea CTD PMID:17463168 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Glipr1l2 GLIPR1 like 2 decreases expression ISO Methylnitrosourea results in decreased expression of GLIPR1L2 mRNA CTD PMID:25270620 NCBI chr 7:54,794,793...54,824,256
Ensembl chr 7:54,795,260...54,823,956
JBrowse link
G Gmcl1 germ cell-less 1, spermatogenesis associated increases expression ISO Methylnitrosourea results in increased expression of GMCL1 mRNA CTD PMID:25270620 NCBI chr 4:118,494,997...118,534,301
Ensembl chr 4:118,478,075...118,534,280
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Methylnitrosourea results in increased expression of GPX2 mRNA; Methylnitrosourea results in increased expression of GPX2 protein CTD PMID:18056462 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein CTD PMID:22465879 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
increases expression
EXP Methylnitrosourea results in decreased expression of GRIN2A mRNA
Methylnitrosourea results in increased expression of GRIN2A mRNA
CTD PMID:28688903 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein] CTD PMID:25164625 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Methylnitrosourea results in increased expression of H2AX protein modified form CTD PMID:27233451 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBA1 protein CTD PMID:15655799 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBB protein CTD PMID:15655799 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,616,538...2,636,708
Ensembl chr16:2,634,603...2,636,708
JBrowse link
G Hgf hepatocyte growth factor decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of HGF mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA]
CTD PMID:18675455 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Methylnitrosourea results in decreased expression of H2BC4 mRNA CTD PMID:25270620 NCBI chr17:44,736,184...44,738,393
Ensembl chr17:44,737,950...44,738,330
Ensembl chr17:44,737,950...44,738,330
JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression EXP Methylnitrosourea results in increased expression of HIVEP2 mRNA CTD PMID:17412507 NCBI chr 1:8,129,354...8,333,890
Ensembl chr 1:8,310,577...8,333,885
JBrowse link
G Hmgb2 high mobility group box 2 increases expression EXP Methylnitrosourea results in increased expression of HMGB2 mRNA; Methylnitrosourea results in increased expression of HMGB2 protein CTD PMID:16525678, PMID:29877212 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgb3 high mobility group box 3 decreases expression ISO Methylnitrosourea results in decreased expression of HMGB3 mRNA CTD PMID:25270620 NCBI chr17:36,690,190...36,694,329
Ensembl chr17:36,690,249...36,694,325
Ensembl chr14:36,690,249...36,694,325
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Methylnitrosourea results in increased expression of HMOX1 mRNA CTD PMID:17412507 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis
increases expression
EXP
ISO
Methylnitrosourea results in increased mutagenesis of HPRT1 gene
Methylnitrosourea results in increased expression of HPRT mRNA
CTD PMID:18249417, PMID:25270620 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases response to substance
increases mutagenesis
decreases response to substance
ISO
EXP
limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]
Methylnitrosourea results in increased mutagenesis of HRAS gene
HRAS protein results in decreased susceptibility to Methylnitrosourea
CTD PMID:10767621, PMID:11182032, PMID:11376698, PMID:11802805, PMID:11973638, PMID:12117780, PMID:15688392, PMID:28421967 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Methylnitrosourea results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ier3 immediate early response 3 increases expression EXP Methylnitrosourea results in increased expression of IER3 mRNA CTD PMID:17412507 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifng interferon gamma multiple interactions
decreases response to substance
ISO
EXP
IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
IFNG protein results in decreased susceptibility to Methylnitrosourea
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein
CTD PMID:14736494, PMID:15240709, PMID:16080182, PMID:16822543 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IFRD1 mRNA] CTD PMID:18675455 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igdcc4 immunoglobulin superfamily, DCC subclass, member 4 increases expression ISO Methylnitrosourea results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr 8:70,591,561...70,627,329
Ensembl chr 8:70,603,249...70,624,925
JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance ISO IGF1 protein results in increased susceptibility to Methylnitrosourea CTD PMID:15528971 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein; Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein] CTD PMID:16237195, PMID:22465879 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Methylnitrosourea results in decreased expression of IGFBP2 mRNA CTD PMID:25270620 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 decreases expression ISO Methylnitrosourea results in decreased expression of IKZF1 mRNA CTD PMID:16616109 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
decreases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]
Methylnitrosourea results in increased expression of IL10 mRNA; Methylnitrosourea results in increased expression of IL10 protein
CTD PMID:14999141, PMID:16822543 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17b interleukin 17B increases expression EXP Methylnitrosourea results in increased expression of IL17B mRNA CTD PMID:17341692 NCBI chr18:57,011,575...57,016,009
Ensembl chr18:57,011,575...57,016,009
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Methylnitrosourea results in increased expression of IL1B mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IL1B mRNA]
CTD PMID:17412507, PMID:18675455 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]
[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IL2 protein
CTD PMID:14736494, PMID:16822543 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Insr insulin receptor increases expression EXP Methylnitrosourea results in increased expression of INSR protein CTD PMID:16237195 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf1 interferon regulatory factor 1 decreases response to substance
increases expression
ISO
EXP
IRF1 protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased expression of IRF1 mRNA
CTD PMID:15240709, PMID:17412507 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Jam2 junctional adhesion molecule 2 decreases expression ISO Methylnitrosourea results in decreased expression of JAM2 mRNA CTD PMID:25270620 NCBI chr11:24,235,310...24,285,279
Ensembl chr11:24,266,345...24,285,275
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
increases phosphorylation
EXP Methylnitrosourea results in increased expression of JUN protein
[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of JUN protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of JUN protein]
CTD PMID:16168987, PMID:16268501 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylnitrosourea results in increased expression of JUNB mRNA CTD PMID:17412507 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of KITL mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of KITL mRNA]
CTD PMID:18675455 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klhl22 kelch-like family member 22 increases expression ISO Methylnitrosourea results in increased expression of KLHL22 mRNA CTD PMID:25270620 NCBI chr11:87,646,489...87,718,808
Ensembl chr11:87,677,966...87,718,826
JBrowse link
G Klk1 kallikrein 1 increases expression ISO Methylnitrosourea results in increased expression of KLK1 mRNA CTD PMID:15240709 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
increases mutagenesis
EXP
ISO
KRAS protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased mutagenesis of KRAS gene
CTD PMID:11973638, PMID:12483526, PMID:18062963 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Methylnitrosourea results in increased expression of LCN2 mRNA CTD PMID:17412507 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lep leptin multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals3 galectin 3 decreases expression ISO Methylnitrosourea results in decreased expression of LGALS3 mRNA CTD PMID:25270620 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G LOC103694381 lymphotoxin-beta decreases response to substance ISO LTB protein results in decreased susceptibility to Methylnitrosourea CTD PMID:15240709 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Methylnitrosourea results in decreased expression of MACROD2 mRNA CTD PMID:25270620 NCBI chr 3:135,729,839...136,422,082 JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 increases expression ISO Methylnitrosourea results in increased expression of MADCAM1 mRNA CTD PMID:15240709 NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases response to substance
multiple interactions
EXP MAPK1 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK1 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK1 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein]
CTD PMID:12693035, PMID:15528971, PMID:22465879, PMID:25164625 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:12693035 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases response to substance
multiple interactions
EXP MAPK3 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK3 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK3 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK3 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein]
CTD PMID:12693035, PMID:15528971, PMID:22465879, PMID:25164625 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases activity
decreases response to substance
ISO
EXP
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
Methylnitrosourea results in increased phosphorylation of MAPK8 protein
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK8 protein; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of MAPK8 protein]
MAPK8 gene mutant form results in decreased susceptibility to Methylnitrosourea
CTD PMID:12693035, PMID:16168987, PMID:18593901 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Methylnitrosourea results in increased expression of MAPKAPK3 mRNA CTD PMID:25270620 NCBI chr 8:116,012,126...116,046,012
Ensembl chr 8:116,012,121...116,045,954
JBrowse link
G Mbp myelin basic protein decreases expression EXP Methylnitrosourea results in decreased expression of MBP mRNA CTD PMID:17341692 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO Methylnitrosourea results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Methylnitrosourea results in increased expression of ME1 mRNA CTD PMID:16525678 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases alkylation
increases expression
decreases response to substance
multiple interactions
ISO
EXP
Methylnitrosourea results in increased alkylation of MGMT protein
Methylnitrosourea results in increased expression of MGMT mRNA
MGMT protein results in decreased susceptibility to Methylnitrosourea
MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]
CTD PMID:8823159, PMID:11276365, PMID:11536039, PMID:12663516, PMID:13679151, PMID:15870882, PMID:17507295, PMID:23288051, PMID:28688903 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:78,172,842...78,506,232
Ensembl chr 6:78,172,790...78,499,599
JBrowse link
G Mir185 microRNA 185 increases expression EXP Methylnitrosourea results in increased expression of MIR185 mRNA CTD PMID:30336191 NCBI chr11:86,812,702...86,812,781
Ensembl chr11:86,812,702...86,812,781
JBrowse link
G Mir96 microRNA 96 increases expression EXP Methylnitrosourea results in increased expression of MIR96 mRNA CTD PMID:30336191 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Methylnitrosourea results in increased expression of MKI67 mRNA CTD PMID:25270620 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mlf1 myeloid leukemia factor 1 increases expression EXP Methylnitrosourea results in increased expression of MLF1 mRNA CTD PMID:17412507 NCBI chr 2:164,549,423...164,582,645
Ensembl chr 2:164,549,455...164,582,643
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
MLH1 protein affects the susceptibility to Methylnitrosourea
MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
CTD PMID:12967659, PMID:13679151, PMID:16204460 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mlx MAX dimerization protein MLX increases expression ISO Methylnitrosourea results in increased expression of MLX mRNA CTD PMID:25270620 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Methylnitrosourea results in increased expression of MMP3 mRNA CTD PMID:17412507 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 increases expression EXP Methylnitrosourea results in increased expression of MPC1 mRNA CTD PMID:16525678 NCBI chr 1:53,026,608...53,038,229
Ensembl chr 1:53,026,608...53,038,229
JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases response to substance
increases response to substance
ISO MPG protein results in decreased susceptibility to Methylnitrosourea
MPG protein results in increased susceptibility to Methylnitrosourea
CTD PMID:15299078, PMID:16288039, PMID:17674369 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 decreases expression ISO Methylnitrosourea results in decreased expression of MRPL47 mRNA CTD PMID:25270620 NCBI chr 2:119,128,311...119,139,451
Ensembl chr 2:119,128,309...119,139,451
JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression ISO Methylnitrosourea results in decreased expression of MRPS31 mRNA CTD PMID:25270620 NCBI chr16:74,467,874...74,504,834
Ensembl chr16:74,467,851...74,496,731
JBrowse link
G Msc musculin decreases expression ISO Methylnitrosourea results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 5:3,954,902...3,956,974
Ensembl chr 5:3,955,227...3,956,572
JBrowse link
G Msh2 mutS homolog 2 multiple interactions
increases response to substance
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]; Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
MSH2 protein results in increased susceptibility to Methylnitrosourea
MSH2 protein affects the susceptibility to Methylnitrosourea
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
CTD PMID:12185594, PMID:16204460, PMID:21285353 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein] CTD PMID:16204460 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
ISO [Methylnitrosourea co-treated with Carrageenan] results in increased expression of MT1 protein
Methylnitrosourea results in increased expression of MT1 protein
CTD PMID:15928667 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP Methylnitrosourea results in decreased expression of MTHFD2 mRNA CTD PMID:17412507 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein] CTD PMID:22465879, PMID:25164625 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO
EXP
Methylnitrosourea results in increased expression of MYC mRNA
Methylnitrosourea results in decreased expression of MYC mRNA
CTD PMID:16616109, PMID:17412507, PMID:25270620 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myo5a myosin VA increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MYO5A gene CTD PMID:10517996, PMID:17174358 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects expression EXP Methylnitrosourea affects the expression of NCOR2 mRNA CTD PMID:21843606 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 decreases expression EXP Methylnitrosourea results in decreased expression of NECTIN1 mRNA CTD PMID:16525678 NCBI chr 8:48,094,233...48,198,499
Ensembl chr 8:48,094,673...48,157,305
JBrowse link
G Nes nestin increases expression
increases methylation
EXP
ISO
Methylnitrosourea results in increased expression of NES protein
Methylnitrosourea results in increased methylation of NES gene
CTD PMID:18155124, PMID:25922126 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
EXP [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein] CTD PMID:15960898, PMID:16098260, PMID:16762860 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nme5 NME/NM23 family member 5 decreases expression ISO Methylnitrosourea results in decreased expression of NME5 mRNA CTD PMID:25270620 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nnat neuronatin decreases expression EXP Methylnitrosourea results in decreased expression of NNAT mRNA CTD PMID:16525678 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Methylnitrosourea results in increased expression of NOS2 protein CTD PMID:16052507 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrxn3 neurexin 3 decreases expression EXP Methylnitrosourea results in decreased expression of NRXN3 mRNA CTD PMID:17412507 NCBI chr 6:112,133,204...114,069,589
Ensembl chr 6:112,133,204...114,067,564
JBrowse link
G Ntm neurotrimin decreases expression ISO Methylnitrosourea results in decreased expression of NTM mRNA CTD PMID:25922126 NCBI chr 8:30,039,332...31,041,755
Ensembl chr 8:30,039,408...30,222,036
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression ISO Methylnitrosourea results in increased expression of NUSAP1 mRNA CTD PMID:25270620 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Oaf out at first homolog increases expression EXP Methylnitrosourea results in increased expression of OAF mRNA CTD PMID:17412507 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of OCA2 gene CTD PMID:10517996, PMID:17174358 NCBI chr 1:114,661,970...114,987,433
Ensembl chr 1:114,679,537...114,987,433
JBrowse link
G Ogfrl1 opioid growth factor receptor-like 1 increases expression EXP Methylnitrosourea results in increased expression of OGFRL1 mRNA CTD PMID:17412507 NCBI chr 9:29,634,178...29,647,903
Ensembl chr 9:29,634,179...29,647,903
JBrowse link
G Opn4 opsin 4 decreases expression EXP Methylnitrosourea results in decreased expression of OPN4 mRNA; Methylnitrosourea results in decreased expression of OPN4 protein CTD PMID:16580133 NCBI chr16:10,943,353...10,966,602
Ensembl chr16:10,943,341...10,952,549
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 increases expression ISO Methylnitrosourea results in increased expression of PAFAH2 mRNA CTD PMID:25270620 NCBI chr 5:152,606,850...152,635,956
Ensembl chr 5:152,606,847...152,634,803
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases response to substance ISO PARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15282315 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases response to substance
multiple interactions
increases activity
affects response to substance
ISO
EXP
PARP1 gene mutant form results in increased susceptibility to Methylnitrosourea
Niacinamide inhibits the reaction [Methylnitrosourea results in increased activity of PARP1 protein]
PARP1 protein affects the susceptibility to Methylnitrosourea
PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]; PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein]
CTD PMID:11850828, PMID:15282315, PMID:16052507, PMID:16168987 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases response to substance ISO PARP2 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12727891 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Patj PATJ, crumbs cell polarity complex component increases expression ISO Methylnitrosourea results in increased expression of PATJ mRNA CTD PMID:15240709 NCBI chr 5:117,038,548...117,340,308
Ensembl chr 5:117,052,260...117,340,336
JBrowse link
G Pbk PDZ binding kinase increases expression ISO Methylnitrosourea results in increased expression of PBK mRNA CTD PMID:25270620 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Pc pyruvate carboxylase increases expression EXP Methylnitrosourea results in increased expression of PC mRNA CTD PMID:16525678 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO
EXP
Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein]
Methylnitrosourea results in increased expression of PCNA protein
CTD PMID:16204460, PMID:18155124, PMID:25164625 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression EXP Methylnitrosourea results in increased expression of PDK1 mRNA CTD PMID:16525678 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein] CTD PMID:25164625 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Methylnitrosourea results in increased expression of PERP mRNA CTD PMID:21382384, PMID:25270620 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Methylnitrosourea results in decreased expression of PFKP mRNA CTD PMID:25270620 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Methylnitrosourea results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 increases expression ISO Methylnitrosourea results in increased expression of PIAS2 mRNA CTD PMID:25270620 NCBI chr18:73,479,863...73,524,956
Ensembl chr18:73,378,662...73,524,956
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 increases expression EXP Methylnitrosourea results in increased expression of PIEZO1 mRNA CTD PMID:17412507 NCBI chr19:55,305,494...55,367,680
Ensembl chr19:55,305,496...55,367,353
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein; Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein
Methylnitrosourea results in increased mutagenesis of PIGA; Methylnitrosourea results in increased mutagenesis of PIGA gene
CTD PMID:19965957, PMID:20202993, PMID:22923490, PMID:27931811 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 decreases expression ISO Methylnitrosourea results in decreased expression of PINX1 mRNA CTD PMID:25270620 NCBI chr15:47,211,682...47,270,343
Ensembl chr15:47,211,583...47,270,317
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta increases expression EXP Methylnitrosourea results in increased expression of PKIB mRNA CTD PMID:17341692 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Methylnitrosourea results in increased expression of PMAIP1 mRNA CTD PMID:18593901 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component multiple interactions
increases response to substance
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
PMS2 protein results in increased susceptibility to Methylnitrosourea
PMS2 protein affects the susceptibility to Methylnitrosourea
CTD PMID:12967659, PMID:16204460, PMID:16426742 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641
JBrowse link
G Polb DNA polymerase beta increases response to substance ISO POLB gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:17166880 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases response to substance ISO PPARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15930296 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Methylnitrosourea results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO Methylnitrosourea results in increased expression of PRAF2 mRNA CTD PMID:25270620 NCBI chr  X:15,618,324...15,620,992
Ensembl chr  X:15,618,991...15,620,841
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Methylnitrosourea results in increased expression of PRC1 mRNA CTD PMID:25270620 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prdm14 PR/SET domain 14 decreases expression ISO Methylnitrosourea results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 5:5,710,076...5,730,560
Ensembl chr 5:5,710,392...5,730,560
JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:196,427,714...196,457,105
Ensembl chr 2:196,427,710...196,456,481
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO Methylnitrosourea results in decreased expression of PTEN mRNA CTD PMID:16616109 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Methylnitrosourea results in increased expression of PTGS2 CTD PMID:28688903 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO Methylnitrosourea results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr13:108,689,916...108,841,593
Ensembl chr13:108,696,336...108,841,511
JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis
increases expression
multiple interactions
ISO
EXP
Methylnitrosourea results in increased mutagenesis of RARA gene
Methylnitrosourea results in increased expression of RARA mRNA
Cholecalciferol inhibits the reaction [Methylnitrosourea results in increased expression of RARA mRNA]
CTD PMID:16868089, PMID:21843606 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation EXP Methylnitrosourea results in increased phosphorylation of RB1 protein CTD PMID:15581186 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 increases expression ISO Methylnitrosourea results in increased expression of RBCK1 mRNA CTD PMID:25270620 NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919
JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:220,038,403...220,049,756
Ensembl chr 1:220,039,734...220,048,966
JBrowse link
G Rbm43 RNA binding motif protein 43 decreases expression ISO Methylnitrosourea results in decreased expression of RBM43 mRNA CTD PMID:25270620 NCBI chr 3:37,434,616...37,446,777
Ensembl chr 3:37,434,620...37,445,907
JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP Methylnitrosourea results in increased expression of RBP4 mRNA CTD PMID:16525678 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Reg1a regenerating family member 1 alpha increases expression ISO Methylnitrosourea results in increased expression of REG1 mRNA CTD PMID:15240709 NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
JBrowse link
G Reg3b regenerating family member 3 beta increases expression ISO Methylnitrosourea results in increased expression of REG3B mRNA CTD PMID:15240709 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
decreases expression
affects localization
affects activity
EXP 3-aminobenzamide inhibits the reaction [Methylnitrosourea results in decreased expression of RELA protein modified form]; [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
Methylnitrosourea results in increased expression of RELA protein
Methylnitrosourea results in decreased expression of RELA protein; Methylnitrosourea results in decreased expression of RELA protein modified form
Methylnitrosourea affects the activity of RELA protein
CTD PMID:15960898, PMID:16098260, PMID:16762860, PMID:17137578 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:25,831,358...25,909,976
Ensembl chr 7:25,808,419...25,907,849
JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 increases expression ISO Methylnitrosourea results in increased expression of RHBDF2 mRNA CTD PMID:25270620 NCBI chr10:105,573,759...105,600,885
Ensembl chr10:105,573,752...105,600,913
JBrowse link
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 (pancreatic) increases expression ISO Methylnitrosourea results in increased expression of RNASE1 mRNA CTD PMID:15240709 NCBI chr15:28,043,491...28,045,098
Ensembl chr15:28,043,758...28,044,210
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of RPS6KB1 protein CTD PMID:22465879 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression EXP Methylnitrosourea results in increased expression of RT1-A2 mRNA CTD PMID:17412507 NCBI chr20:5,374,990...5,378,536
Ensembl chr20:5,374,985...5,378,539
JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP Methylnitrosourea results in increased expression of RT1-EC2 mRNA CTD PMID:17341692
G Rxrg retinoid X receptor gamma affects expression EXP Methylnitrosourea affects the expression of RXRG mRNA CTD PMID:21843606 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression EXP Methylnitrosourea results in increased expression of S100A3 mRNA CTD PMID:17412507 NCBI chr 2:189,955,619...189,996,029
Ensembl chr 2:189,955,836...189,996,029
JBrowse link
G Scg2 secretogranin II increases expression EXP Methylnitrosourea results in increased expression of SCG2 mRNA CTD PMID:17412507 NCBI chr 9:85,237,460...85,243,024
Ensembl chr 9:85,237,458...85,243,001
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 decreases expression EXP Methylnitrosourea results in decreased expression of SCN10A mRNA CTD PMID:16525678 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Methylnitrosourea results in increased expression of SERPINE2 mRNA CTD PMID:25270620 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Methylnitrosourea results in increased expression of SGK1 mRNA CTD PMID:29110037 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:252,976,071...253,054,500
Ensembl chr 1:252,976,644...253,000,760
JBrowse link
G Slc25a53 solute carrier family 25, member 53 increases expression ISO Methylnitrosourea results in increased expression of SLC25A53 mRNA CTD PMID:15240709 NCBI chr  X:107,622,504...107,632,594 JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions EXP Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA] CTD PMID:15922087 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression ISO Methylnitrosourea results in decreased expression of SLC4A1AP mRNA CTD PMID:25270620 NCBI chr 6:26,214,083...26,241,337
Ensembl chr 6:26,214,335...26,241,337
JBrowse link
G Smad4 SMAD family member 4 increases response to substance ISO SMAD4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Methylnitrosourea results in decreased expression of SMAD7 mRNA CTD PMID:25270620 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor decreases expression ISO Methylnitrosourea results in decreased expression of SMG6 mRNA CTD PMID:25270620 NCBI chr10:61,526,024...61,542,583
NCBI chr10:61,771,912...62,007,030
Ensembl chr10:61,772,449...62,007,030
Ensembl chr10:61,772,449...62,007,030
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA] CTD PMID:25164625 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression
EXP
ISO
[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]
Methylnitrosourea results in decreased expression of SNAI2 mRNA
CTD PMID:25164625, PMID:27221058 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Snrnp35 small nuclear ribonucleoprotein U11/U12 subunit 35 decreases expression ISO Methylnitrosourea results in decreased expression of SNRNP35 mRNA CTD PMID:25270620 NCBI chr12:37,531,082...37,538,823
Ensembl chr12:37,531,095...37,538,403
JBrowse link
G Snrpc small nuclear ribonucleoprotein polypeptide C decreases expression ISO Methylnitrosourea results in decreased expression of SNRPC mRNA CTD PMID:25270620 NCBI chr20:7,409,401...7,427,581
Ensembl chr20:7,409,401...7,427,581
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Methylnitrosourea results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 affects metabolic processing
multiple interactions
ISO Methylnitrosourea affects the metabolism of SOD2 protein
PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein]
CTD PMID:16052507 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SOS1 mRNA CTD PMID:22465879 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sphk1 sphingosine kinase 1 increases expression EXP Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:57,238,221...57,252,654
Ensembl chr 5:57,239,086...57,250,662
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Methylnitrosourea results in decreased expression of SPP1 mRNA CTD PMID:16525678 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 increases expression EXP Methylnitrosourea results in increased expression of SPRY2 mRNA CTD PMID:17412507 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of SPTAN1 protein CTD PMID:17069801 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases expression
EXP Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; Methylnitrosourea results in increased phosphorylation of and results in increased expression of SRC protein
Methylnitrosourea results in increased expression of SRC protein
CTD PMID:22245120 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat4 signal transducer and activator of transcription 4 increases response to substance ISO STAT4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:11418001 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stmn1 stathmin 1 increases expression EXP Methylnitrosourea results in increased expression of STMN1 mRNA CTD PMID:16525678 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stmn2 stathmin 2 decreases expression ISO Methylnitrosourea results in decreased expression of STMN2 mRNA CTD PMID:25270620 NCBI chr 2:95,424,251...95,471,900
Ensembl chr 2:95,424,251...95,472,115
JBrowse link
G Syp synaptophysin affects expression EXP Methylnitrosourea affects the expression of SYP protein CTD PMID:18155124 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Terc telomerase RNA component affects response to substance ISO TERC protein affects the susceptibility to Methylnitrosourea CTD PMID:14612493 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110
JBrowse link
G Tff2 trefoil factor 2 increases expression ISO Methylnitrosourea results in increased expression of TFF2 mRNA CTD PMID:15240709 NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP Methylnitrosourea results in increased expression of TGIF1 mRNA CTD PMID:17412507 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Thpo thrombopoietin multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Thra thyroid hormone receptor alpha affects expression EXP Methylnitrosourea affects the expression of THRA mRNA CTD PMID:21843606 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta affects expression EXP Methylnitrosourea affects the expression of THRB mRNA CTD PMID:21843606 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Thrsp thyroid hormone responsive decreases expression
increases expression
EXP Methylnitrosourea results in decreased expression of THRSP mRNA
Methylnitrosourea results in increased expression of THRSP mRNA
CTD PMID:16525678, PMID:17341692 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Thumpd3 THUMP domain containing 3 decreases expression ISO Methylnitrosourea results in decreased expression of THUMPD3 mRNA CTD PMID:25270620 NCBI chr 4:144,985,850...145,010,164
Ensembl chr 4:144,985,880...145,008,831
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Methylnitrosourea results in increased expression of TIMP1 mRNA CTD PMID:17412507 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression EXP Methylnitrosourea results in increased expression of TINAGL1 mRNA CTD PMID:17412507 NCBI chr 5:148,382,702...148,392,729
Ensembl chr 5:148,382,706...148,392,697
JBrowse link
G Tkt transketolase increases expression EXP Methylnitrosourea results in increased expression of TKT mRNA CTD PMID:16525678 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:135,394,013...135,397,591
Ensembl chr 5:135,394,016...135,397,591
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Methylnitrosourea results in increased expression of TNF mRNA
CTD PMID:16822543, PMID:28688903 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Methylnitrosourea results in decreased expression of TNFRSF11B mRNA CTD PMID:17341692 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Methylnitrosourea results in increased expression of TNFRSF12A mRNA CTD PMID:17412507 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 increases expression EXP Methylnitrosourea results in increased expression of TNIP2 mRNA CTD PMID:17412507 NCBI chr14:81,487,934...81,505,889
Ensembl chr14:81,488,008...81,504,686
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO Methylnitrosourea results in increased expression of TOP2A mRNA CTD PMID:25270620 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top3b DNA topoisomerase III beta decreases expression
increases expression
ISO Methylnitrosourea results in decreased expression of TOP3B mRNA
Methylnitrosourea results in increased expression of TOP3B mRNA
CTD PMID:16616109, PMID:25270620 NCBI chr11:88,346,305...88,374,896
Ensembl chr11:88,346,313...88,374,679
JBrowse link
G Tor1b torsin family 1, member B decreases expression ISO Methylnitrosourea results in decreased expression of TOR1B mRNA CTD PMID:25270620 NCBI chr 3:9,792,818...9,798,924
Ensembl chr 3:9,792,899...9,798,923
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases stability
affects response to substance
increases response to substance
increases phosphorylation
increases expression
EXP
ISO
[Estradiol co-treated with Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TP53 protein]
Methylnitrosourea results in increased stability of TP53 protein
Methylnitrosourea results in increased expression of and results in increased phosphorylation of TP53 protein; TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein]
TRP53 protein affects the susceptibility to Methylnitrosourea
TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased phosphorylation of TRP53 protein
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]
Methylnitrosourea results in increased expression of TP53 mRNA
CTD PMID:11536039, PMID:11850828, PMID:12185594, PMID:17412507, PMID:18593901, PMID:20732338, PMID:21285353, PMID:27233451, PMID:28688903, PMID:29110037 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Methylnitrosourea results in increased expression of TP53BP1 protein CTD PMID:27233451 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Methylnitrosourea results in increased expression of TRP53INP1 mRNA CTD PMID:25270620 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Trip6 thyroid hormone receptor interactor 6 decreases expression ISO Methylnitrosourea results in decreased expression of TRIP6 mRNA CTD PMID:25270620 NCBI chr12:22,451,596...22,456,003
Ensembl chr12:22,451,596...22,456,003
JBrowse link
G Tspo translocator protein increases expression EXP Methylnitrosourea results in increased expression of TSPO mRNA CTD PMID:17412507 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Ttk Ttk protein kinase increases expression ISO Methylnitrosourea results in increased expression of TTK mRNA CTD PMID:25270620 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA] CTD PMID:25164625 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Tyr tyrosinase increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYR gene CTD PMID:17174358 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYRP1 gene CTD PMID:17174358 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:108,286,407...108,433,531
Ensembl chr15:108,286,453...108,433,529
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression ISO Methylnitrosourea results in increased expression of UBE2C mRNA CTD PMID:25270620 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 increases expression EXP Methylnitrosourea results in increased expression of UBE2J1 mRNA CTD PMID:17412507 NCBI chr 5:48,274,387...48,292,699
Ensembl chr 5:48,274,477...48,290,658
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression
decreases expression
EXP
ISO
Methylnitrosourea results in increased expression of UPP1 mRNA
Methylnitrosourea results in decreased expression of UPP1 mRNA
CTD PMID:17412507, PMID:25270620 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
[Methylnitrosourea co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of VEGFA mRNA
CTD PMID:16822543, PMID:20732338 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein] CTD PMID:25164625 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vrk1 VRK serine/threonine kinase 1 decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of VRK1 protein
TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein]
CTD PMID:27233451 NCBI chr 6:129,835,788...129,902,839
Ensembl chr 6:129,835,919...129,902,793
JBrowse link
G Wdr35 WD repeat domain 35 increases expression ISO Methylnitrosourea results in increased expression of WDR35 mRNA CTD PMID:25270620 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link
G Wnt5a Wnt family member 5A increases expression EXP Methylnitrosourea results in increased expression of WNT5A mRNA CTD PMID:17341692 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases response to substance ISO XIAP protein results in decreased susceptibility to Methylnitrosourea CTD PMID:12766084 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of XRCC5 gene CTD PMID:16868089 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Methylnitrosourea results in increased expression of ZEB1 mRNA CTD PMID:27221058 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Methylnitrosourea results in increased expression of ZFP365 mRNA CTD PMID:25270620 NCBI chr20:22,060,160...22,083,766
Ensembl chr20:22,060,224...22,086,108
JBrowse link
G Zscan22 zinc finger and SCAN domain containing 22 increases expression EXP Methylnitrosourea results in increased expression of ZFP128 mRNA CTD PMID:16525678 NCBI chr 1:65,675,932...65,702,955
Ensembl chr 1:65,677,621...65,681,440
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            N-methyl-N-nitrosourea 354
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  urea 4989
                                                    ureas 4987
                                                      N-nitrosoureas 1928
                                                        N-methyl-N-nitrosourea 354
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.