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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
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Accession:CHEBI:50218 term browser browse the term
Definition:An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*).
Synonyms:related_synonym: EC 3.1.4.* (phosphoric diester hydrolase) inhibitors;   phosphodiesterase inhibitor;   phosphodiesterase inhibitors;   phosphoric diester hydrolase inhibitor;   phosphoric diester hydrolase inhibitors
 alt_id: CHEBI:76774


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1D-myo-inositol 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO inositol 1-phosphate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases response to substance
EXP
ISO
8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060, PMID:15641640, PMID:18608257, PMID:19966059, PMID:21195062 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
multiple interactions
ISO DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368, PMID:10199625 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nts neurotensin multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
aminophylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein CTD PMID:15645133 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO [Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein] CTD PMID:30776357 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gcg glucagon increases secretion EXP Aminophylline results in increased secretion of GCG protein CTD PMID:1248788 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline CTD PMID:16129921 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
amrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Amrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:9004165 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Amrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:9004165 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acan aggrecan decreases expression EXP Caffeine results in decreased expression of ACAN mRNA CTD PMID:29966748, PMID:32663519 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Caffeine results in decreased expression of ACAT2 mRNA CTD PMID:11793227 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Ace angiotensin I converting enzyme increases expression
decreases methylation
EXP Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein
Caffeine results in decreased methylation of ACE promoter
CTD PMID:30423288 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] CTD PMID:28465162 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression ISO Caffeine results in increased expression of ACIN1 mRNA CTD PMID:11793227 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
JBrowse link
G Acly ATP citrate lyase increases expression EXP Caffeine results in increased expression of ACLY mRNA CTD PMID:30776459 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO Caffeine results in increased expression of ACSL3 mRNA CTD PMID:11793227 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Caffeine results in decreased expression of ACSL4 protein CTD PMID:31195006 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression EXP Caffeine results in increased expression of ACTA2 mRNA CTD PMID:29055810 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta decreases expression ISO Caffeine results in decreased expression of ACTB protein CTD PMID:31195006 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Caffeine results in increased expression of ACTBL2 protein CTD PMID:31195006 NCBI chr 2:42,829,413...42,832,160
Ensembl chr 2:42,829,413...42,832,160
JBrowse link
G Actl6b actin-like 6B increases expression ISO Caffeine results in increased expression of ACTL6B protein CTD PMID:31195006 NCBI chr12:22,194,595...22,211,107
Ensembl chr12:22,194,618...22,211,080
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:266,123,864...266,142,621
Ensembl chr 1:266,123,870...266,142,538
JBrowse link
G Ada adenosine deaminase increases expression EXP Caffeine results in increased expression of ADA protein CTD PMID:6149265 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 increases expression EXP Caffeine results in increased expression of ADAMTS5 mRNA CTD PMID:31874197 NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression EXP Caffeine results in decreased expression of ADARB1 mRNA CTD PMID:20864626 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
JBrowse link
G Adcy5 adenylate cyclase 5 decreases expression EXP Caffeine results in decreased expression of ADCY5 mRNA CTD PMID:26367767 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Caffeine results in increased expression of ADIPOR2 mRNA CTD PMID:22583948 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA
Caffeine deficiency results in decreased expression of ADORA1 mRNA
Caffeine results in decreased activity of ADORA1 protein
Caffeine results in decreased expression of ADORA1 mRNA
Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]
Caffeine results in increased expression of ADORA1 protein
CTD PMID:3003150, PMID:7996441, PMID:10401785, PMID:12153486, PMID:15708489, PMID:22164264, PMID:23611293, PMID:29107002, PMID:29882086 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance
affects binding
ISO
EXP
ADORA2A protein affects the susceptibility to Caffeine
Caffeine results in decreased expression of ADORA2A mRNA
Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]
ADORA2A polymorphism affects the susceptibility to Caffeine
Caffeine results in decreased activity of ADORA2A protein
ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine
Caffeine analog binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to ADORA2A protein
ADORA2A protein results in increased susceptibility to Caffeine
CTD PMID:10214707, PMID:11172060, PMID:12077927, PMID:12825092, PMID:15452191, PMID:16221767, PMID:16470403, PMID:16771831, PMID:18305461, PMID:20520601, PMID:21950736, PMID:23611293, PMID:26367767, PMID:30555576, PMID:30825513 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor multiple interactions
decreases expression
ISO
EXP
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
Caffeine results in decreased expression of ADORA2B mRNA
CTD PMID:22701600, PMID:26367767 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Agt angiotensinogen increases expression EXP Caffeine results in increased expression of AGT protein CTD PMID:30423288 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
decreases expression
EXP Caffeine results in increased expression of AGTR1A
Caffeine results in decreased expression of AGTR1A mRNA
CTD PMID:25986755, PMID:30423288 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755, PMID:30423288 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Caffeine results in decreased expression of AHCY protein CTD PMID:31195006 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression ISO Caffeine results in decreased expression of AKAP9 protein CTD PMID:31195006 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects expression
decreases expression
decreases phosphorylation
increases phosphorylation
decreases response to substance
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]
Caffeine affects the expression of AKT1 mRNA
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form
Caffeine results in decreased phosphorylation of AKT1 protein
AKT1 results in decreased susceptibility to Caffeine
CTD PMID:15126379, PMID:18201823, PMID:21081844, PMID:21561856, PMID:22974838, PMID:29966748, PMID:30528684 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO Caffeine results in decreased expression of ALDH18A1 mRNA CTD PMID:11793227 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] CTD PMID:20230807 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression EXP Caffeine results in increased expression of ALDH9A1 mRNA CTD PMID:20864626 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases expression EXP Caffeine results in decreased expression of ALMS1 mRNA CTD PMID:25868845 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Caffeine results in decreased expression of ALPL mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ang angiogenin decreases expression ISO Caffeine results in decreased expression of ANG mRNA CTD PMID:11793227 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Caffeine results in decreased expression of ANKRD37 mRNA CTD PMID:20864626 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anxa11 annexin A11 decreases expression ISO Caffeine results in decreased expression of ANXA11 protein CTD PMID:31195006 NCBI chr16:3,867,193...3,912,043
Ensembl chr16:3,867,208...3,912,148
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Caffeine results in decreased expression of ANXA4 protein CTD PMID:31195006 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
Caffeine results in decreased expression of APOA1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
Caffeine results in decreased expression of APOA2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apob apolipoprotein B multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
[Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA
Caffeine results in decreased expression of APOB mRNA
CTD PMID:16324916, PMID:25868845, PMID:29800656 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc1 apolipoprotein C1 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
Caffeine results in decreased expression of APOC1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Apoc2 apolipoprotein C2 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
Caffeine results in decreased expression of APOC2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apom apolipoprotein M decreases expression EXP Caffeine results in decreased expression of APOM mRNA CTD PMID:25868845 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
JBrowse link
G Arcn1 archain 1 decreases expression ISO Caffeine results in decreased expression of ARCN1 protein CTD PMID:31195006 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 increases expression ISO Caffeine results in increased expression of ARL6IP1 mRNA CTD PMID:11793227 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
JBrowse link
G Arrb2 arrestin, beta 2 increases expression EXP Caffeine results in increased expression of ARRB2 mRNA CTD PMID:20864626 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Caffeine results in decreased expression of ASNS mRNA CTD PMID:18444173 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atg7 autophagy related 7 increases response to substance ISO ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine CTD PMID:21081844 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
decreases activity
ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:10531013, PMID:11507241, PMID:15975956, PMID:18347191, PMID:19028473, PMID:19038232, PMID:20734998, PMID:20888899, PMID:22927544, PMID:23274516, PMID:31168028 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance ISO ATP2A2 protein affects the susceptibility to Caffeine CTD PMID:19328205 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Caffeine results in decreased expression of ATP5MF mRNA CTD PMID:11793227 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] CTD PMID:20230807 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] CTD PMID:20230807 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression EXP Caffeine results in decreased expression of ATPAF1 mRNA CTD PMID:20864626 NCBI chr 5:134,641,618...134,667,079
Ensembl chr 5:134,641,608...134,667,084
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
affects activity
ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
Caffeine affects the activity of ATR protein
CTD PMID:11507241, PMID:15975956, PMID:18158334, PMID:20734998 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atrn attractin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Caffeine results in increased expression of BASP1 protein CTD PMID:31195006 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Caffeine results in increased expression of BAX protein
[Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA
CTD PMID:12811820, PMID:12907610, PMID:31756439 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] CTD PMID:19028473 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA CTD PMID:31756439 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] CTD PMID:26339337 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein]
CTD PMID:30555576 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Caffeine results in decreased expression of BGLAP mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form CTD PMID:21670593 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G C1r complement C1r multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829
JBrowse link
G C1s complement C1s multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
JBrowse link
G C2cd5 C2 calcium-dependent domain containing 5 increases expression EXP Caffeine results in increased expression of C2CD5 mRNA CTD PMID:20864626 NCBI chr 4:177,245,868...177,331,910
Ensembl chr 4:177,245,868...177,331,915
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression EXP Caffeine results in increased expression of CAD protein CTD PMID:6149265 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calu calumenin decreases expression ISO Caffeine results in decreased expression of CALU mRNA CTD PMID:11793227 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Cand1 cullin-associated and neddylation-dissociated 1 decreases expression ISO Caffeine results in decreased expression of CAND1 protein CTD PMID:31195006 NCBI chr 7:62,124,362...62,162,451
Ensembl chr 7:62,124,362...62,162,453
JBrowse link
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 decreases expression ISO Caffeine results in decreased expression of CAPN2 protein CTD PMID:31195006 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp2 caspase 2 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] CTD PMID:16777994 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
affects cleavage
ISO
EXP
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein
Caffeine results in decreased expression of CASP3 protein modified form
Caffeine results in increased expression of CASP3 mRNA
Caffeine results in increased cleavage of CASP3 protein
Caffeine results in increased activity of CASP3 protein
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Caffeine affects the cleavage of CASP3 protein
CTD PMID:12378022, PMID:12395097, PMID:12907610, PMID:15537744, PMID:16522534, PMID:16777994, PMID:18201823, PMID:18283038, PMID:19242509, PMID:19490937, PMID:19815060, PMID:21081844, PMID:21229324, PMID:31874197 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
CTD PMID:16522534, PMID:16777994, PMID:20230807 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression
ISO
EXP
Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein]
Caffeine results in decreased expression of CAT mRNA
Caffeine results in increased expression of CAT protein
[Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein
CTD PMID:22154906, PMID:23099337, PMID:25868845 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 increases expression ISO Caffeine results in increased expression of CAV1 protein CTD PMID:31195006 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cav3 caveolin 3 decreases expression EXP Caffeine results in decreased expression of CAV3 mRNA CTD PMID:25868845 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583
JBrowse link
G Ccdc124 coiled-coil domain containing 124 increases expression ISO Caffeine results in increased expression of CCDC124 protein CTD PMID:31195006 NCBI chr16:20,317,446...20,323,265
Ensembl chr16:20,317,446...20,323,265
JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression EXP Caffeine results in decreased expression of CCDC174 mRNA CTD PMID:20864626 NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
decreases expression
ISO Caffeine results in increased expression of CCL3 mRNA
Caffeine results in decreased expression of CCL3 mRNA
CTD PMID:28089782 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
ISO Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein]
Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]
Caffeine results in increased expression of CCNB1 protein
CTD PMID:9098629, PMID:19038232, PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnf cyclin F multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] CTD PMID:20230807 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Caffeine results in decreased expression of CCT8 protein CTD PMID:31195006 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Ccz1b CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated decreases expression EXP Caffeine results in decreased expression of CCZ1 mRNA CTD PMID:20864626 NCBI chr12:12,638,849...12,662,371
Ensembl chr12:12,638,864...12,662,371
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd59 CD59 molecule increases expression ISO Caffeine results in increased expression of CD59 protein CTD PMID:31195006 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd9 CD9 molecule decreases expression ISO Caffeine results in decreased expression of CD9 protein CTD PMID:31195006 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:1,709,703...1,797,732
Ensembl chr17:1,703,943...1,797,750
JBrowse link
G Cdc25b cell division cycle 25B increases expression EXP Caffeine results in increased expression of CDC25B mRNA CTD PMID:20864626 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C decreases expression
multiple interactions
ISO Caffeine results in decreased expression of CDC25C protein
Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]
CTD PMID:11835680, PMID:15975956 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 increases expression EXP Caffeine results in increased expression of CDH1 mRNA CTD PMID:20864626 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein
Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]
CTD PMID:9098629, PMID:11835680, PMID:15975956, PMID:19038232 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Caffeine results in decreased activity of CDK2 protein CTD PMID:11835680 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein]
Caffeine results in decreased expression of CDK4 mRNA
CTD PMID:11793227, PMID:15126379 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]
CTD PMID:17977830, PMID:18223691, PMID:18347191, PMID:19735649, PMID:21840268, PMID:22927544, PMID:23274516, PMID:30555576 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
affects expression
increases expression
EXP Caffeine results in decreased expression of CEBPA mRNA
Caffeine affects the expression of CEBPA mRNA
Caffeine results in increased expression of CEBPA mRNA
CTD PMID:23727198, PMID:30423288, PMID:30528684, PMID:30776459 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP Caffeine results in decreased expression of CEBPB mRNA CTD PMID:30528684 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:239,397,322...239,474,931
Ensembl chr 1:239,398,043...239,474,931
JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:12,101,473...12,115,009
Ensembl chr 2:12,102,487...12,115,009
JBrowse link
G Cfd complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
ISO Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]
Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
Caffeine results in decreased expression of CHEK1 protein modified form
Caffeine results in decreased phosphorylation of CHEK1 protein
CTD PMID:15975956, PMID:18158334, PMID:19261750, PMID:21505179, PMID:21561856, PMID:22403396, PMID:29074359 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases activity
ISO Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
Caffeine results in decreased activity of CHEK2 protein
CTD PMID:10531013, PMID:15975956, PMID:16777994, PMID:18158334, PMID:19038232, PMID:23274516 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression ISO Caffeine results in increased expression of CLIC1 protein CTD PMID:31195006 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:166,533,262...166,601,686
Ensembl chr 5:166,533,181...166,601,684
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:12,782,459...12,787,977
Ensembl chr 7:12,782,491...12,787,750
JBrowse link
G Cobl cordon-bleu WH2 repeat protein affects expression EXP Caffeine affects the expression of COBL mRNA CTD PMID:20864626 NCBI chr14:92,341,949...92,497,169
Ensembl chr14:92,342,957...92,577,936
JBrowse link
G Coch cochlin decreases expression EXP Caffeine results in decreased expression of COCH mRNA CTD PMID:20864626 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]
Caffeine results in decreased expression of COL1A1 mRNA
CTD PMID:20230807, PMID:24275088 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748, PMID:32663519 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Coq8a coenzyme Q8A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] CTD PMID:20230807 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
JBrowse link
G Cort cortistatin decreases expression EXP Caffeine results in decreased expression of CORT protein CTD PMID:25868845 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Caffeine results in decreased expression of CPT1A mRNA CTD PMID:30776459 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO
EXP
Caffeine results in decreased expression of CREB1 mRNA CTD PMID:26367767 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases expression ISO Caffeine results in decreased expression of CRTC2 protein CTD PMID:31195006 NCBI chr 2:189,615,928...189,625,646
Ensembl chr 2:189,615,948...189,626,051
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 decreases expression EXP Caffeine results in decreased expression of CSNK2A2 mRNA CTD PMID:20864626 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA CTD PMID:29447158 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis
multiple interactions
EXP Caffeine results in increased mutagenesis of CTNNB1 gene
Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]
CTD PMID:18283038, PMID:30377735 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA]
CTD PMID:19490937, PMID:20230807 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D increases expression ISO Caffeine results in increased expression of CTSD protein CTD PMID:31195006 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog decreases expression ISO Caffeine results in decreased expression of CWC25 protein CTD PMID:31195006 NCBI chr10:85,684,898...85,709,568
Ensembl chr10:85,684,898...85,709,568
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyc1 cytochrome c-1 decreases expression ISO Caffeine results in decreased expression of CYC1 mRNA CTD PMID:11793227 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Caffeine results in decreased expression of CYP11A1 mRNA CTD PMID:24717552, PMID:25868845 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Caffeine results in decreased expression of CYP11B1 mRNA CTD PMID:25868845, PMID:29343424, PMID:30528684 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Caffeine results in decreased expression of CYP11B2 mRNA CTD PMID:25868845, PMID:29343424 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP17A1 mRNA CTD PMID:25868845 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein CTD PMID:28111094 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
increases activity
decreases methylation
ISO
EXP
CYP1A2 protein binds to Caffeine
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]
Caffeine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine
Caffeine results in increased activity of CYP1A2 protein
CTD PMID:1302044, PMID:9334905, PMID:11145498, PMID:11376689, PMID:11465391, PMID:11907490, PMID:12433797, PMID:12706856, PMID:14586384, PMID:14586387, PMID:15022032, PMID:15199075, PMID:15286053, PMID:15327588, PMID:15619608, PMID:15659567, PMID:15822860, PMID:15856409, PMID:15980104, PMID:16934051, PMID:18420780, PMID:19215233, PMID:20716633, PMID:24211539, PMID:26599973, PMID:28843594, PMID:31132250 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression
decreases expression
EXP Caffeine results in increased expression of CYP21A1 mRNA
Caffeine results in decreased expression of CYP21A1 mRNA; Caffeine results in decreased expression of CYP21A2 mRNA
CTD PMID:24717552, PMID:25868845, PMID:30528684 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of Caffeine CTD PMID:1302044, PMID:14586387 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP4B1 mRNA CTD PMID:18444173 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Caffeine results in decreased expression of CYP7B1 mRNA CTD PMID:20864626 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dad1 defender against cell death 1 decreases expression ISO Caffeine results in decreased expression of DAD1 mRNA CTD PMID:11793227 NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 decreases expression EXP Caffeine results in decreased expression of DCAF11 mRNA CTD PMID:20864626 NCBI chr15:34,233,840...34,244,512
Ensembl chr15:34,234,193...34,244,504
JBrowse link
G Dct dopachrome tautomerase increases expression ISO Caffeine results in increased expression of DCT mRNA CTD PMID:18444173 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] CTD PMID:20230807 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression EXP Caffeine results in increased expression of DDHD1 mRNA CTD PMID:20864626 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP Caffeine results in decreased expression of DDX31 mRNA CTD PMID:20864626 NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617
JBrowse link
G Ddx39a DExD-box helicase 39A decreases expression ISO Caffeine results in decreased expression of DDX39A protein CTD PMID:31195006 NCBI chr19:24,846,530...24,854,886
Ensembl chr19:24,846,938...24,854,953
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR24 mRNA CTD PMID:20864626 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR7 mRNA CTD PMID:25868845 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP Caffeine results in increased expression of DHODH protein CTD PMID:6149265 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression ISO Caffeine results in increased expression of DNAJC12 protein CTD PMID:31195006 NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression EXP Caffeine results in increased expression of DNMT1 mRNA CTD PMID:24717552 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression EXP Caffeine results in increased expression of DNMT3A mRNA CTD PMID:24717552 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression EXP Caffeine results in increased expression of DNMT3B mRNA CTD PMID:25868845, PMID:30423288 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
increases response to substance
multiple interactions
ISO
EXP
DRD2 polymorphism affects the susceptibility to Caffeine
DRD2 protein results in increased susceptibility to Caffeine
Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]
CTD PMID:11172060, PMID:16889759, PMID:18305461 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression EXP Caffeine results in decreased expression of DTX4 mRNA CTD PMID:20864626 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression EXP Caffeine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] CTD PMID:22403396 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP Caffeine results in increased expression of EBP mRNA CTD PMID:25868845 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Ebpl EBP like decreases expression EXP Caffeine results in decreased expression of EBPL mRNA CTD PMID:20864626 NCBI chr15:41,668,119...41,691,518
Ensembl chr15:41,668,119...41,691,518
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of ECI1 mRNA CTD PMID:20864626 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Edn1 endothelin 1 increases activity EXP Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA]
Caffeine results in increased expression of EEF1A1 protein
CTD PMID:20230807, PMID:31195006 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Caffeine results in decreased expression of EEF1D protein CTD PMID:31195006 NCBI chr 7:116,928,264...116,942,981
Ensembl chr 7:116,928,265...116,936,674
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma increases expression ISO Caffeine results in increased expression of EEF1G protein CTD PMID:31195006 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] CTD PMID:20230807 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] CTD PMID:20230807 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:56,161,431...56,168,819
Ensembl chr10:56,161,432...56,167,426
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Caffeine results in increased expression of EGR1 mRNA
Caffeine results in decreased expression of EGR1 mRNA
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]
[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA
CTD PMID:10971643, PMID:16771831 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO Caffeine results in increased expression of EHBP1 protein CTD PMID:31195006 NCBI chr14:106,871,426...107,160,224
Ensembl chr14:106,871,430...107,160,334
JBrowse link
G Ehd1 EH-domain containing 1 decreases expression ISO Caffeine results in decreased expression of EHD1 protein CTD PMID:31195006 NCBI chr 1:221,644,867...221,667,242
Ensembl chr 1:221,644,867...221,667,239
JBrowse link
G Ehd2 EH-domain containing 2 decreases expression ISO Caffeine results in decreased expression of EHD2 protein CTD PMID:31195006 NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Caffeine results in increased expression of EIF1 mRNA CTD PMID:11793227 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B decreases expression ISO Caffeine results in decreased expression of EIF3B protein CTD PMID:31195006 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] CTD PMID:20230807 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
increases expression
ISO
EXP
Caffeine results in decreased expression of EIF4EBP1 protein modified form
Caffeine results in increased expression of EIF4EBP1 protein
CTD PMID:21081844 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Ell elongation factor for RNA polymerase II decreases expression EXP Caffeine results in decreased expression of ELL mRNA CTD PMID:20864626 NCBI chr16:20,594,129...20,641,441
Ensembl chr16:20,594,072...20,641,908
JBrowse link
G Emc6 ER membrane protein complex subunit 6 decreases expression EXP Caffeine results in decreased expression of EMC6 mRNA CTD PMID:20864626 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression EXP Caffeine results in decreased expression of ENDOD1 mRNA CTD PMID:20864626 NCBI chr 8:12,898,430...12,928,156 JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eppk1 epiplakin 1 decreases expression ISO Caffeine results in decreased expression of EPPK1 protein CTD PMID:31195006 NCBI chr 7:117,163,383...117,173,741 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
JBrowse link
G Esyt2 extended synaptotagmin 2 decreases expression EXP Caffeine results in decreased expression of ESYT2 mRNA CTD PMID:20864626 NCBI chr 6:144,156,021...144,248,374
Ensembl chr 6:144,156,175...144,245,545
JBrowse link
G Etv3 ETS variant transcription factor 3 increases expression ISO Caffeine results in increased expression of ETV3 protein CTD PMID:31195006 NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Caffeine results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Ezr ezrin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] CTD PMID:20230807 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO
EXP
Caffeine results in decreased expression of FABP4 mRNA CTD PMID:23727198 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Farsa phenylalanyl-tRNA synthetase subunit alpha increases expression ISO Caffeine results in increased expression of FARSA protein CTD PMID:31195006 NCBI chr19:25,969,255...25,978,777
Ensembl chr19:25,969,255...25,978,776
JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP Caffeine results in decreased expression of FAS mRNA CTD PMID:29343424 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
ISO
EXP
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA
Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein
CTD PMID:28843594, PMID:30776459 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fastkd3 FAST kinase domains 3 decreases expression EXP Caffeine results in decreased expression of FASTKD3 mRNA CTD PMID:20864626 NCBI chr 1:37,734,400...37,742,932
Ensembl chr 1:37,734,403...37,742,932
JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion increases expression ISO Caffeine results in increased expression of FAU protein CTD PMID:31195006 NCBI chr 1:221,420,312...221,421,827
Ensembl chr 1:221,420,271...221,421,842
JBrowse link
G Fbln2 fibulin 2 increases expression EXP Caffeine results in increased expression of FBLN2 mRNA CTD PMID:20864626 NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
JBrowse link
G Fbrs fibrosin increases expression EXP Caffeine results in increased expression of FBRS mRNA CTD PMID:20864626 NCBI chr 1:198,925,265...198,938,939
Ensembl chr 1:198,932,870...198,937,750
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:21,656,636...21,662,755
Ensembl chr 8:21,656,639...21,661,259
JBrowse link
G Fbxl19 F-box and leucine-rich repeat protein 19 decreases expression ISO Caffeine results in decreased expression of FBXL19 protein CTD PMID:31195006 NCBI chr 1:199,196,126...199,217,147
Ensembl chr 1:199,196,059...199,216,391
JBrowse link
G Fcsk fucose kinase increases expression EXP Caffeine results in increased expression of FCSK mRNA CTD PMID:20864626 NCBI chr19:43,338,146...43,357,826
Ensembl chr19:43,338,166...43,357,822
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression
increases expression
EXP Caffeine results in decreased expression of FDFT1 mRNA
Caffeine results in increased expression of FDFT1 mRNA
CTD PMID:20864626, PMID:25868845 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdx1 ferredoxin 1 decreases expression EXP Caffeine results in decreased expression of FDX1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Caffeine results in increased expression of FHL1 mRNA CTD PMID:20864626 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression EXP Caffeine results in increased expression of FILIP1L mRNA CTD PMID:20864626 NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Caffeine results in increased expression of FOS mRNA
[Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]
CTD PMID:10971643 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] CTD PMID:20230807 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gale UDP-galactose-4-epimerase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] CTD PMID:20230807 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO Caffeine results in decreased expression of GANAB protein CTD PMID:31195006 NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gast gastrin increases secretion EXP Caffeine results in increased secretion of GAST protein CTD PMID:19208342 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf10 growth differentiation factor 10 decreases expression EXP Caffeine results in decreased expression of GDF10 mRNA CTD PMID:20864626 NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO
EXP
Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein]
Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein]
CTD PMID:19882200, PMID:26339337 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:14,370,269...14,382,647
Ensembl chr16:14,371,531...14,382,641
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Caffeine results in decreased expression of GJA1 mRNA CTD PMID:28087314 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glrx glutaredoxin decreases expression ISO Caffeine results in decreased expression of GLRX mRNA CTD PMID:11793227 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 decreases expression ISO Caffeine results in decreased expression of GLT8D1 mRNA CTD PMID:11793227 NCBI chr16:7,082,450...7,097,405
Ensembl chr16:7,082,450...7,097,401
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Caffeine results in decreased expression of GLUD1 mRNA CTD PMID:11793227 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression
increases expression
EXP Caffeine results in decreased expression of GNAI1 protein
Caffeine results in increased expression of GNAI1 mRNA
CTD PMID:15708489 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Caffeine results in decreased expression of GNAI2 protein CTD PMID:15708489 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnal G protein subunit alpha L increases response to substance ISO GNAL protein results in increased susceptibility to Caffeine CTD PMID:11404425 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Gnaq G protein subunit alpha q decreases expression EXP Caffeine results in decreased expression of GNAQ protein CTD PMID:15998294 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnas GNAS complex locus decreases expression EXP Caffeine results in decreased expression of GNAS protein CTD PMID:15708489 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:176,606,669...176,617,884
Ensembl chr 4:176,606,649...176,619,710
JBrowse link
G Gosr1 golgi SNAP receptor complex member 1 decreases expression EXP Caffeine results in decreased expression of GOSR1 mRNA CTD PMID:20864626 NCBI chr10:63,405,526...63,442,257
Ensembl chr10:63,405,586...63,442,250
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression ISO Caffeine results in decreased expression of GOT2 protein CTD PMID:31195006 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpc3 glypican 3 affects expression EXP Caffeine affects the expression of GPC3 mRNA CTD PMID:20864626 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gpi glucose-6-phosphate isomerase decreases expression ISO Caffeine results in decreased expression of GPI protein CTD PMID:31195006 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Caffeine results in increased activity of GPT protein
CTD PMID:11394713, PMID:30776459 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] CTD PMID:31756439 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Caffeine results in decreased expression of GRM1 protein CTD PMID:15998294 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grpr gastrin releasing peptide receptor decreases expression EXP Caffeine results in decreased expression of GRPR mRNA CTD PMID:20864626 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359
JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 decreases expression EXP Caffeine results in decreased expression of GRWD1 mRNA CTD PMID:20864626 NCBI chr 1:101,813,356...101,819,058
Ensembl chr 1:101,813,684...101,819,478
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression EXP Caffeine results in increased expression of GSK3A mRNA CTD PMID:25868845 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Caffeine results in increased phosphorylation of GSK3B protein
Caffeine results in decreased phosphorylation of GSK3B protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]
CTD PMID:15126379, PMID:21229324 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Caffeine results in decreased expression of GSTO1 mRNA CTD PMID:11793227 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G H1f0 H1 histone family, member 0 decreases expression ISO Caffeine results in decreased expression of H1F0 protein CTD PMID:31195006 NCBI chr 7:120,260,776...120,262,636 JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-4 protein CTD PMID:31195006 NCBI chr17:43,734,461...43,735,120
Ensembl chr17:43,734,461...43,735,120
JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-5 protein CTD PMID:31195006 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
JBrowse link
G H1f6 H1.6 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-6 protein CTD PMID:31195006 NCBI chr17:43,675,190...43,675,934
Ensembl chr17:43,675,190...43,675,934
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP
Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein
CTD PMID:15537744, PMID:15975956, PMID:16777994, PMID:20888899, PMID:24069304, PMID:26231820 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 decreases expression EXP Caffeine results in decreased expression of HACD1 mRNA CTD PMID:20864626 NCBI chr17:81,173,238...81,196,012
Ensembl chr17:81,173,713...81,187,739
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP Caffeine results in increased expression of HDAC2 mRNA CTD PMID:24717552 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac7 histone deacetylase 7 increases expression EXP Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein CTD PMID:31306741 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdlbp high density lipoprotein binding protein decreases expression EXP Caffeine results in decreased expression of HDLBP mRNA CTD PMID:25868845 NCBI chr 9:100,554,574...100,624,707
Ensembl chr 9:100,554,563...100,624,638
JBrowse link
G Heca hdc homolog, cell cycle regulator increases expression EXP Caffeine results in increased expression of HECA mRNA CTD PMID:20864626 NCBI chr 1:13,036,909...13,050,644
Ensembl chr 1:13,036,909...13,050,644
JBrowse link
G Hells helicase, lymphoid specific multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]
Caffeine results in increased expression of HELLS protein
CTD PMID:20025956, PMID:20230807 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hhipl2 HHIP like 2 decreases expression ISO Caffeine results in decreased expression of HHIPL2 protein CTD PMID:31195006 NCBI chr13:101,814,574...101,835,144
Ensembl chr13:101,814,574...101,834,584
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA CTD PMID:31756439 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] CTD PMID:20230807 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Caffeine results in increased expression of H4C9 protein CTD PMID:31195006 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Caffeine results in decreased expression of HMGA1 protein CTD PMID:31195006 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO Caffeine results in decreased expression of HMGA2 protein CTD PMID:31195006 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
EXP
ISO
[Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]
Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]
CTD PMID:29800656, PMID:29958987, PMID:30825513 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of HMGCS1 mRNA
Caffeine results in increased expression of HMGCS1 mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]
CTD PMID:20864626, PMID:25868845, PMID:30825513 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Caffeine results in decreased expression of HNRNPDL protein CTD PMID:31195006 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO Caffeine results in decreased expression of HNRNPF protein CTD PMID:31195006 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Caffeine results in decreased expression of HNRNPH1 protein CTD PMID:31195006 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of HNRNPK mRNA
Caffeine results in increased expression of HNRNPK protein
CTD PMID:25868845, PMID:31195006 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Caffeine results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] CTD PMID:20230807 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Caffeine results in increased expression of HSD11B1 mRNA CTD PMID:22583948, PMID:30423288, PMID:30528684 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of HSD11B2 mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
CTD PMID:22583948, PMID:22701600, PMID:30423288, PMID:30528684 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Caffeine results in decreased expression of HSD17B7 mRNA CTD PMID:20864626 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
decreases expression
EXP Caffeine results in increased expression of HSD3B1 mRNA
Caffeine results in decreased expression of HSD3B1 mRNA
CTD PMID:25868845, PMID:30528684
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] CTD PMID:20230807 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Caffeine results in decreased expression of HSP90B1 mRNA CTD PMID:25868845 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Caffeine results in increased expression of HSPA4 protein CTD PMID:31195006 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Caffeine results in decreased expression of HSPA9 protein CTD PMID:31195006 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
decreases expression
EXP
ISO
Caffeine results in increased expression of HSPB1 mRNA
Caffeine results in decreased expression of HSPB1 protein
CTD PMID:20864626, PMID:31195006 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb6 heat shock protein family B (small) member 6 increases expression EXP Caffeine results in increased expression of HSPB6 mRNA CTD PMID:20864626 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Caffeine results in decreased expression of IBSP mRNA CTD PMID:31874197 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Caffeine results in decreased expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression EXP Caffeine results in increased expression of ID3 mRNA CTD PMID:20864626 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of IDI1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Igf1 insulin-like growth factor 1 decreases secretion
multiple interactions
affects expression
decreases activity
decreases expression
ISO
EXP
Caffeine results in decreased secretion of IGF1 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA
Caffeine affects the expression of IGF1 protein
Caffeine results in decreased activity of IGF1 protein
Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein
CTD PMID:1995187, PMID:22583948, PMID:24239806, PMID:29343424, PMID:29966748, PMID:30528684, PMID:31756439 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
EXP Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein
Caffeine affects the expression of IGF1R mRNA
CTD PMID:22583948, PMID:29343424, PMID:29966748, PMID:30528684 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Caffeine results in increased expression of IGFBP1 mRNA CTD PMID:11793227 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases expression EXP Caffeine results in increased expression of IKBKB mRNA CTD PMID:20864626 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 increases expression ISO Caffeine results in increased expression of IL10 mRNA CTD PMID:28089782 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression EXP Caffeine results in increased expression of IL10RB mRNA CTD PMID:20864626 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il12a interleukin 12A decreases expression ISO Caffeine results in decreased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:26852703 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
ISO
EXP
Caffeine results in decreased expression of IL1B mRNA
Caffeine results in increased expression of IL1B mRNA
CTD PMID:28089782, PMID:29055810, PMID:30776459 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Caffeine results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] CTD PMID:26852703 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4r interleukin 4 receptor increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of IL4RA mRNA
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA]
CTD PMID:20230807, PMID:20864626 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 increases expression ISO Caffeine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of IL6 mRNA
Caffeine results in increased expression of IL6 mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
CTD PMID:23727198, PMID:26852703, PMID:29055810, PMID:30776459 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 increases expression ISO Caffeine results in increased expression of ILF3 protein CTD PMID:31195006 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of IMPDH2 protein CTD PMID:31195006 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Ino80c INO80 complex subunit C decreases expression EXP Caffeine results in decreased expression of INO80C mRNA CTD PMID:20864626 NCBI chr18:15,995,005...16,009,639
Ensembl chr18:15,995,000...16,009,710
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP Caffeine results in decreased expression of INSIG1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insr insulin receptor decreases expression EXP Caffeine results in decreased expression of INSR mRNA CTD PMID:22583948 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:15,838,714...15,842,135
Ensembl chr19:15,838,714...15,840,990
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] CTD PMID:19882200 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Caffeine results in decreased expression of ITPR1 mRNA CTD PMID:18444173 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation
increases expression
ISO Caffeine results in decreased phosphorylation of JUN protein
Caffeine results in increased expression of JUN protein
CTD PMID:17145898, PMID:20025956 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd14 potassium channel tetramerization domain containing 14 decreases expression EXP Caffeine results in decreased expression of KCTD14 mRNA CTD PMID:20864626 NCBI chr 1:162,418,389...162,424,322
Ensembl chr 1:162,419,262...162,424,825
JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression ISO Caffeine results in increased expression of KHSRP protein CTD PMID:31195006 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Kidins220 kinase D-interacting substrate 220 increases expression EXP Caffeine results in increased expression of KIDINS220 mRNA CTD PMID:20864626 NCBI chr 6:44,225,142...44,322,938
Ensembl chr 6:44,225,233...44,322,938
JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein
CTD PMID:20230807, PMID:31306741 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Krt1 keratin 1 decreases expression ISO Caffeine results in decreased expression of KRT1 protein CTD PMID:31195006 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt18 keratin 18 decreases expression ISO Caffeine results in decreased expression of KRT18 protein CTD PMID:31195006 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt36 keratin 36 decreases expression ISO Caffeine results in decreased expression of KRT36 protein CTD PMID:31195006 NCBI chr10:88,016,602...88,019,967
Ensembl chr10:88,016,602...88,019,967
JBrowse link
G Krt84 keratin 84 decreases expression ISO Caffeine results in decreased expression of KRT84 protein CTD PMID:31195006 NCBI chr 7:143,180,212...143,187,684
Ensembl chr 7:143,179,835...143,187,648
JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Caffeine results in increased expression of LAMB1 protein CTD PMID:31195006 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Caffeine results in decreased expression of LDHA mRNA CTD PMID:11793227 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP [Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] CTD PMID:29800656 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin decreases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of LEP mRNA
Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
CTD PMID:23727198, PMID:26367767 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Caffeine results in increased expression of LEPR mRNA
Caffeine results in decreased expression of LEPR mRNA
CTD PMID:22583948, PMID:26367767 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Caffeine results in decreased expression of LMNB1 protein CTD PMID:31195006 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G LOC100361854 ribosomal protein S26-like increases expression ISO Caffeine results in increased expression of RPS26 protein CTD PMID:31195006 NCBI chr  X:115,495,660...115,496,062
Ensembl chr  X:115,495,698...115,496,045
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347
JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of LPL mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA
CTD PMID:23727198, PMID:28843594 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Lysmd2 LysM domain containing 2 decreases expression EXP Caffeine results in decreased expression of LYSMD2 mRNA CTD PMID:20864626 NCBI chr 8:82,560,363...82,576,662
Ensembl chr 8:82,560,761...82,577,019
JBrowse link
G Mael maelstrom spermatogenic transposon silencer decreases expression ISO Caffeine results in decreased expression of MAEL protein CTD PMID:31195006 NCBI chr13:84,412,569...84,452,140
Ensembl chr13:84,383,670...84,452,181
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases cleavage
multiple interactions
ISO Caffeine results in increased cleavage of MAP1LC3B protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
CTD PMID:30555576 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] CTD PMID:20230807 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation
ISO Caffeine results in increased expression of MAPK1 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Caffeine results in decreased phosphorylation of MAPK1 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 increases expression EXP Caffeine results in increased expression of MAPK15 mRNA CTD PMID:20864626 NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation
ISO Caffeine results in increased expression of MAPK3 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Caffeine results in decreased phosphorylation of MAPK3 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marchf11 membrane associated ring-CH-type finger 11 decreases expression EXP Caffeine results in decreased expression of MARCHF11 mRNA CTD PMID:20864626 NCBI chr 2:78,825,053...78,926,402
Ensembl chr 2:78,825,074...78,926,395
JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] CTD PMID:20230807 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Caffeine results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of MDH2 protein CTD PMID:31195006 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression
multiple interactions
EXP Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]
CTD PMID:25093688 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression
EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein
CTD PMID:25093688 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Caffeine results in decreased expression of MGST1 mRNA CTD PMID:11793227 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Micb MHC class I polypeptide-related sequence B multiple interactions ISO Caffeine inhibits the reaction [[Decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] CTD PMID:18395517 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092
JBrowse link
G Mill1 MHC I like leukocyte 1 multiple interactions ISO Caffeine inhibits the reaction [Resveratrol results in increased expression of MICA protein] CTD PMID:23445485 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941
JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515
JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein]
Caffeine results in decreased expression of MKI67 protein
CTD PMID:26339337, PMID:30528684 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Caffeine results in increased expression of MMP13 mRNA CTD PMID:31874197 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] CTD PMID:20230807 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 decreases expression EXP Caffeine results in decreased expression of MOGAT1 mRNA CTD PMID:20864626 NCBI chr 9:84,405,481...84,418,657
Ensembl chr 9:84,405,477...84,418,591
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression ISO Caffeine results in increased expression of MOS protein CTD PMID:31195006 NCBI chr 5:16,746,085...16,747,392
Ensembl chr 5:16,746,197...16,747,222
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of MRM3 mRNA CTD PMID:20864626 NCBI chr10:64,398,308...64,406,193
Ensembl chr10:64,398,339...64,405,017
JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 decreases expression EXP Caffeine results in decreased expression of MRPL19 mRNA CTD PMID:20864626 NCBI chr 4:112,703,041...112,707,270
Ensembl chr 4:112,703,041...112,707,270
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:173,248,245...173,252,775
Ensembl chr 5:173,248,245...173,252,775
JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:195,684,750...195,689,470
Ensembl chr 2:195,684,210...195,689,052
JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 increases expression ISO Caffeine results in increased expression of MRPS5 protein CTD PMID:31195006 NCBI chr 3:120,165,953...120,182,536
Ensembl chr 3:120,165,913...120,182,536
JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Caffeine results in decreased expression of MSH2 mRNA CTD PMID:12706856 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression EXP Caffeine results in decreased expression of MSMO1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:6,937,341...6,961,165
Ensembl chr20:6,937,347...6,961,162
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like decreases expression EXP Caffeine results in decreased expression of MTHFD2L mRNA CTD PMID:20864626 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity ISO Caffeine results in decreased activity of MTOR protein CTD PMID:21081844 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase decreases expression EXP Caffeine results in decreased expression of MTRR mRNA CTD PMID:20864626 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
G Mutyh mutY DNA glycosylase increases expression EXP Caffeine results in increased expression of MUTYH mRNA CTD PMID:20864626 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344
JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression EXP Caffeine results in decreased expression of MVD mRNA CTD PMID:25868845 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mvk mevalonate kinase increases expression EXP Caffeine results in increased expression of MVK mRNA CTD PMID:25868845 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] CTD PMID:18283038 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions
EXP Caffeine results in increased expression of MYH7 mRNA
Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]
CTD PMID:25093688 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl6b myosin light chain 6B decreases expression ISO Caffeine results in decreased expression of MYL6B protein CTD PMID:31195006 NCBI chr  X:43,831,778...43,833,044 JBrowse link
G Myof myoferlin increases expression ISO Caffeine results in increased expression of MYOF protein CTD PMID:31195006 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects metabolic processing
ISO NAT2 protein results in increased acetylation of Caffeine
NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine
CTD PMID:14586384, PMID:14586387, PMID:14747882, PMID:15199075, PMID:15327588, PMID:15558239, PMID:15980104, PMID:24221535 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ncl nucleolin increases expression ISO Caffeine results in increased expression of NCL protein CTD PMID:31195006 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:119,139,717...119,153,753
Ensembl chr 2:119,139,717...119,153,753
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] CTD PMID:20230807 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nefh neurofilament heavy affects expression EXP Caffeine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Caffeine results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:22974838 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:26852703 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nisch nischarin multiple interactions EXP Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22974838, PMID:26852703 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA CTD PMID:29447158 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin decreases expression EXP Caffeine results in decreased expression of NPHS2 mRNA CTD PMID:25986755, PMID:31306741 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:70,938,073...70,981,179
Ensembl chr13:70,938,082...70,980,913
JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression
EXP Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:15452191, PMID:25093688 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions
EXP Caffeine results in increased expression of NPPB mRNA
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]
CTD PMID:25093688 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein CTD PMID:22583948, PMID:30423288, PMID:30528684, PMID:30776459, PMID:31306741, PMID:32663519 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Caffeine results in increased expression of NR3C2 mRNA CTD PMID:22959462 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases methylation
decreases expression
EXP Caffeine results in increased methylation of NR5A1 promoter
Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein
CTD PMID:24717552 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression EXP Caffeine results in decreased expression of NRF1 mRNA CTD PMID:20864626 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
JBrowse link
G Nt5e 5' nucleotidase, ecto decreases activity
multiple interactions
EXP Caffeine results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]
CTD PMID:28465162 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oat ornithine aminotransferase increases expression ISO Caffeine results in increased expression of OAT mRNA CTD PMID:11793227 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Caffeine results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Caffeine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 increases expression EXP Caffeine results in increased expression of OXSR1 mRNA CTD PMID:20864626 NCBI chr 8:127,920,349...128,009,951
Ensembl chr 8:127,920,349...128,009,951
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:157,359,331...157,375,186
Ensembl chr 4:157,359,332...157,372,861
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 decreases expression EXP Caffeine results in decreased expression of PAK1 mRNA CTD PMID:29343424 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions
increases activity
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]
Caffeine results in increased activity of PAK2 protein
CTD PMID:19325779, PMID:20230807 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects cleavage
decreases response to substance
multiple interactions
increases cleavage
ISO
EXP
Caffeine affects the cleavage of PARP1 protein
PARP1 protein results in decreased susceptibility to Caffeine
Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein
Caffeine results in increased cleavage of PARP1 protein
CTD PMID:16522534, PMID:19242509, PMID:19490937, PMID:21229324, PMID:21840268, PMID:22226932, PMID:30377735 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pax3 paired box 3 decreases expression ISO Caffeine results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Pcare photoreceptor cilium actin regulator decreases expression ISO Caffeine results in decreased expression of PCARE protein CTD PMID:31195006 NCBI chr 6:23,337,507...23,346,232
Ensembl chr 6:23,337,571...23,346,173
JBrowse link
G Pcna proliferating cell nuclear antigen affects expression EXP Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein CTD PMID:29343424 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression EXP Caffeine results in decreased expression of PCSK9 mRNA CTD PMID:25868845 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pde11a phosphodiesterase 11A decreases expression EXP Caffeine results in decreased expression of PDE11A mRNA CTD PMID:20864626 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Caffeine results in decreased expression of PDE5A mRNA CTD PMID:20864626 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression EXP Caffeine results in decreased expression of PDHX mRNA CTD PMID:20864626 NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:29,233,987...29,290,447
Ensembl chr18:29,233,987...29,290,447
JBrowse link
G Pfkm phosphofructokinase, muscle affects expression ISO Caffeine affects the expression of PFKM protein CTD PMID:25486098 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Pgk2 phosphoglycerate kinase 2 decreases expression ISO Caffeine results in decreased expression of PGK2 protein CTD PMID:31195006 NCBI chr 9:24,095,774...24,097,340
Ensembl chr 9:24,095,751...24,097,337
JBrowse link
G Pgr progesterone receptor increases expression EXP Caffeine results in increased expression of PGR mRNA CTD PMID:20864626 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phb prohibitin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] CTD PMID:20230807 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Caffeine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] CTD PMID:20230807 NCBI chr 2:206,452,115...206,518,387
Ensembl chr 2:206,454,208...206,493,030
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:79,886,832...79,889,305
Ensembl chr13:79,886,832...79,889,304
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:11,267,207...11,294,291
Ensembl chr 7:11,267,218...11,294,249
JBrowse link
G Pitx2 paired-like homeodomain 2 decreases expression EXP Caffeine results in decreased expression of PITX2 mRNA CTD PMID:20864626 NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting multiple interactions
affects response to substance
ISO PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]
PKD1 protein affects the susceptibility to Caffeine
CTD PMID:18679710 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions
decreases expression
EXP Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Caffeine results in decreased expression of PLCB1 protein
CTD PMID:15998294 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plec plectin decreases expression ISO Caffeine results in decreased expression of PLEC protein CTD PMID:31195006 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
JBrowse link
G Plg plasminogen decreases expression EXP Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Caffeine results in increased expression of PLP1 mRNA CTD PMID:18444173 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Pls1 plastin 1 increases expression ISO Caffeine results in increased expression of PLS1 protein CTD PMID:31195006 NCBI chr 8:103,557,361...103,659,625
Ensembl chr 8:103,557,364...103,608,913
JBrowse link
G Pls3 plastin 3 decreases expression ISO Caffeine results in decreased expression of PLS3 protein CTD PMID:31195006 NCBI chr  X:119,030,311...119,124,268
Ensembl chr  X:119,030,419...119,124,250
JBrowse link
G Pnp purine nucleoside phosphorylase increases expression EXP Caffeine results in increased expression of PNP protein CTD PMID:6149265 NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Caffeine results in decreased expression of PPARA mRNA CTD PMID:30776459 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO
EXP
Caffeine results in decreased expression of PPARG mRNA CTD PMID:23727198 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Caffeine results in increased expression of PPARGC1A mRNA CTD PMID:17516843 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO Caffeine results in increased expression of PPFIBP1 protein CTD PMID:31195006 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppial4g peptidylprolyl isomerase A like 4G decreases expression ISO Caffeine results in decreased expression of PPIAL4G protein CTD PMID:31195006 NCBI chr15:81,576,690...81,577,379
Ensembl chr15:81,576,888...81,577,379
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Caffeine results in decreased expression of PPP2R2B mRNA CTD PMID:18444173 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:76,056,585...76,079,755
Ensembl chr 6:76,056,499...76,079,664
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO Caffeine results in increased expression of PRDX2 protein CTD PMID:31195006 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prelid1 PRELI domain containing 1 decreases expression ISO Caffeine results in decreased expression of PRELID1 mRNA CTD PMID:11793227 NCBI chr17:9,834,245...9,837,285
Ensembl chr17:9,834,242...9,837,303
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Caffeine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Caffeine results in increased expression of PRKAA2 mRNA CTD PMID:22583948 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression ISO
EXP
Caffeine results in decreased expression of PRKACA protein CTD PMID:30825513 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression EXP Caffeine results in decreased expression of PRKAR1A mRNA CTD PMID:29343424 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkcsh protein kinase C substrate 80K-H increases expression ISO Caffeine results in increased expression of PRKCSH protein CTD PMID:31195006 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
PRKDC protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:18158334, PMID:20888899 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prmt3 protein arginine methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of PRMT3 mRNA CTD PMID:20864626 NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470
JBrowse link
G Prnp prion protein decreases expression ISO Caffeine results in decreased expression of PRNP mRNA CTD PMID:18444173 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Prorsd1 prolyl-tRNA synthetase associated domain containing 1 decreases expression EXP Caffeine results in decreased expression of PRORSD1 mRNA CTD PMID:20864626 NCBI chr14:113,938,061...113,940,330
Ensembl chr14:113,938,061...113,940,330
JBrowse link
G Prph peripherin decreases expression ISO Caffeine results in decreased expression of PRPH protein CTD PMID:31195006 NCBI chr 7:140,742,406...140,746,197
Ensembl chr 7:140,742,418...140,746,197
JBrowse link
G Psma2 proteasome 20S subunit alpha 2 decreases expression ISO Caffeine results in decreased expression of PSMA2 protein CTD PMID:31195006 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression ISO Caffeine results in increased expression of PSMA5 protein CTD PMID:31195006 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression ISO Caffeine results in decreased expression of PSMC3 protein CTD PMID:31195006 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO Caffeine results in increased expression of PSMC4 protein CTD PMID:31195006 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:94,445,877...94,451,811
Ensembl chr10:94,445,877...94,451,811
JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO Caffeine results in decreased expression of PSME3 mRNA CTD PMID:11793227 NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041
JBrowse link
G Ptgfrn prostaglandin F2 receptor inhibitor increases expression EXP Caffeine results in increased expression of PTGFRN mRNA CTD PMID:20864626 NCBI chr 2:203,423,143...203,494,391
Ensembl chr 2:203,423,143...203,494,391
JBrowse link
G Ptgr1 prostaglandin reductase 1 decreases expression EXP Caffeine results in decreased expression of PTGR1 mRNA CTD PMID:25868845 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO Caffeine results in decreased expression of PTGS2 protein
Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:21561856, PMID:22974838, PMID:26852703 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pwp2 PWP2, small subunit processome component decreases expression EXP Caffeine results in decreased expression of PWP2 mRNA CTD PMID:20864626 NCBI chr20:11,228,892...11,243,204
Ensembl chr20:11,228,844...11,243,205
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression EXP Caffeine results in increased expression of QARS1 mRNA CTD PMID:20864626 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702
JBrowse link
G Qrsl1 glutaminyl-tRNA amidotransferase subunit QRSL1 decreases expression EXP Caffeine results in decreased expression of QRSL1 mRNA CTD PMID:20864626 NCBI chr20:48,855,839...48,881,112
Ensembl chr20:48,855,914...48,881,119
JBrowse link
G Rab3ip RAB3A interacting protein increases expression EXP Caffeine results in increased expression of RAB3IP mRNA CTD PMID:20864626 NCBI chr 7:59,927,486...59,971,518
Ensembl chr 7:59,928,426...59,957,232
JBrowse link
G Rab5c RAB5C, member RAS oncogene family decreases expression ISO Caffeine results in decreased expression of RAB5C protein CTD PMID:31195006 NCBI chr10:88,621,924...88,645,364
Ensembl chr10:88,621,925...88,645,364
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 decreases expression EXP Caffeine results in decreased expression of RABGEF1 mRNA CTD PMID:20864626 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 decreases expression EXP Caffeine results in decreased expression of RABL3 mRNA CTD PMID:20864626 NCBI chr11:66,049,635...66,078,669
Ensembl chr11:66,049,635...66,078,669
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Caffeine results in increased expression of RAC2 protein CTD PMID:31195006 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAD50 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA] CTD PMID:20230807 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Caffeine results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Ralgapb Ral GTPase activating protein non-catalytic subunit beta decreases expression ISO Caffeine results in decreased expression of RALGAPB protein CTD PMID:31195006 NCBI chr 3:154,910,291...154,983,021
Ensembl chr 3:154,905,141...154,983,021
JBrowse link
G Ran RAN, member RAS oncogene family increases expression ISO Caffeine results in increased expression of RAN protein CTD PMID:31195006 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:81,320,090...81,434,239
Ensembl chr16:81,318,633...81,434,363
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Caffeine results in decreased phosphorylation of RB1 protein CTD PMID:15126379, PMID:21229324 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:49,250,301...49,277,152
Ensembl chr13:49,250,301...49,277,152
JBrowse link
G Rbm12 RNA binding motif protein 12 decreases expression EXP Caffeine results in decreased expression of RBM12 mRNA CTD PMID:20864626 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Rbmx RNA binding motif protein, X-linked decreases expression ISO Caffeine results in decreased expression of RBMX protein CTD PMID:31195006 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:22974838, PMID:26852703 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases expression
increases secretion
increases activity
EXP
ISO
Caffeine results in increased expression of REN protein
Caffeine results in increased secretion of REN protein
Caffeine results in increased activity of REN protein
CTD PMID:1860718, PMID:3020089, PMID:3044993, PMID:8244516, PMID:10803761 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RGS2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA] CTD PMID:20230807 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhebl1 RHEB like 1 increases expression EXP Caffeine results in increased expression of RHEBL1 mRNA CTD PMID:20864626 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 decreases expression EXP Caffeine results in decreased expression of RIMS2 mRNA CTD PMID:20864626 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
JBrowse link
G Rnf166 ring finger protein 166 increases expression EXP Caffeine results in increased expression of RNF166 mRNA CTD PMID:20864626 NCBI chr19:55,290,563...55,300,403
Ensembl chr19:55,290,563...55,300,403
JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 decreases expression ISO Caffeine results in decreased expression of RNH1 protein CTD PMID:31195006 NCBI chr 1:214,151,341...214,163,807
Ensembl chr 1:214,151,338...214,163,808
JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Caffeine results in decreased expression of RPIA mRNA CTD PMID:20864626 NCBI chr 4:98,568,028...98,593,664
Ensembl chr 4:98,568,028...98,593,664
JBrowse link
G Rpl10a ribosomal protein L10A decreases expression ISO Caffeine results in decreased expression of RPL10A protein CTD PMID:31195006 NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867
JBrowse link
G Rpl13 ribosomal protein L13 decreases expression ISO Caffeine results in decreased expression of RPL13 protein CTD PMID:31195006 NCBI chr19:55,917,489...55,920,040
Ensembl chr19:55,917,736...55,919,996
JBrowse link
G Rpl17 ribosomal protein L17 increases expression ISO Caffeine results in increased expression of RPL17 protein CTD PMID:31195006 NCBI chr18:70,969,733...70,972,839
Ensembl chr18:70,970,596...70,975,494
JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Rpl27a ribosomal protein L27a increases expression ISO Caffeine results in increased expression of RPL27A protein CTD PMID:31195006 NCBI chr 1:174,132,798...174,135,816
Ensembl chr 1:174,132,798...174,135,816
JBrowse link
G Rpl29 ribosomal protein L29 increases expression ISO Caffeine results in increased expression of RPL29 protein CTD PMID:31195006 NCBI chr 8:115,131,228...115,133,401
Ensembl chr 8:115,131,367...115,133,401
JBrowse link
G Rpl36 ribosomal protein L36 increases expression ISO Caffeine results in increased expression of RPL36 protein CTD PMID:31195006 NCBI chr 9:10,441,228...10,441,981
Ensembl chr 9:10,441,259...10,441,834
JBrowse link
G Rpl36a ribosomal protein L36a decreases expression ISO Caffeine results in decreased expression of RPL36A protein CTD PMID:31195006 NCBI chr  X:105,402,867...105,405,580
Ensembl chr  X:105,402,867...105,405,580
JBrowse link
G Rpl4 ribosomal protein L4 increases expression ISO Caffeine results in increased expression of RPL4 protein CTD PMID:31195006 NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RPL5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link
G Rpl7a ribosomal protein L7a increases expression ISO Caffeine results in increased expression of RPL7A protein CTD PMID:31195006 NCBI chr 3:5,458,985...5,461,627
Ensembl chr 3:5,459,160...5,461,583
Ensembl chr 3:5,459,160...5,461,583
JBrowse link
G Rpn1 ribophorin I increases expression ISO Caffeine results in increased expression of RPN1 protein CTD PMID:31195006 NCBI chr 4:119,997,232...120,018,687
Ensembl chr 4:119,997,268...120,018,679
JBrowse link
G Rpn2 ribophorin II increases expression ISO Caffeine results in increased expression of RPN2 protein CTD PMID:31195006 NCBI chr 3:153,398,373...153,445,633
Ensembl chr 3:153,398,130...153,445,632
JBrowse link
G Rps11 ribosomal protein S11 increases expression ISO Caffeine results in increased expression of RPS11 protein CTD PMID:31195006 NCBI chr 1:101,116,641...101,118,749
Ensembl chr 1:101,116,635...101,118,825
JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Caffeine results in increased expression of RPS14 protein CTD PMID:31195006 NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316
JBrowse link
G Rps18 ribosomal protein S18 increases expression ISO Caffeine results in increased expression of RPS18 protein CTD PMID:31195006 NCBI chr20:5,441,875...5,445,553
Ensembl chr20:5,441,876...5,445,553
JBrowse link
G Rps19 ribosomal protein S19 decreases expression ISO Caffeine results in decreased expression of RPS19 protein CTD PMID:31195006 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
JBrowse link
G Rps20 ribosomal protein S20 decreases expression ISO Caffeine results in decreased expression of RPS20 protein CTD PMID:31195006 NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909
JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO Caffeine results in decreased expression of RPS28 protein CTD PMID:31195006 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440
JBrowse link
G Rps3a ribosomal protein S3a increases expression ISO Caffeine results in increased expression of RPS3A protein CTD PMID:31195006 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO
EXP
Caffeine results in decreased expression of RPS6 protein modified form CTD PMID:21081844 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO Caffeine results in decreased expression of RPS6KA3 mRNA CTD PMID:11793227 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO
EXP
Caffeine results in decreased expression of RPS6KB1 protein modified form CTD PMID:21081844 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO Caffeine results in increased expression of RRS1 mRNA CTD PMID:11793227 NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343
JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,681,648...30,768,038
Ensembl chr 1:30,681,681...30,766,860
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Caffeine results in decreased expression of RUNX2 mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rwdd2b RWD domain containing 2B decreases expression EXP Caffeine results in decreased expression of RWDD2B mRNA CTD PMID:20864626 NCBI chr11:27,085,708...27,094,364
Ensembl chr11:27,085,711...27,094,364
JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases response to substance
multiple interactions
ISO Caffeine results in increased activity of RYR1 protein
RYR1 gene mutant form results in increased susceptibility to Caffeine; RYR1 protein mutant form results in increased susceptibility to Caffeine
[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]
TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]
CTD PMID:14641996, PMID:15210166, PMID:16372898, PMID:16484216, PMID:18719443, PMID:19191329, PMID:21485675 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]; HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Caffeine results in increased expression of S100A10 protein CTD PMID:31195006 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Caffeine results in decreased expression of S100A6 protein CTD PMID:31195006 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sap18 Sin3A associated protein 18 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SAP18 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SAP18 mRNA] CTD PMID:20230807 NCBI chr15:38,069,320...38,073,625
Ensembl chr15:38,069,320...38,073,622
JBrowse link
G Sc5d sterol-C5-desaturase decreases expression EXP Caffeine results in decreased expression of SC5D mRNA CTD PMID:25868845 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
increases methylation
EXP Caffeine results in decreased expression of SCARB1 mRNA; Caffeine results in decreased expression of SCARB1 protein
Caffeine inhibits the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 protein]
Caffeine results in increased methylation of SCARB1 promoter
CTD PMID:25868845, PMID:29800656, PMID:29958987 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of SCD1 mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA
CTD PMID:20864626, PMID:28843594 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scfd1 sec1 family domain containing 1 decreases expression ISO Caffeine results in decreased expression of SCFD1 mRNA CTD PMID:11793227 NCBI chr 6:72,124,408...72,202,703
Ensembl chr 6:72,124,417...72,202,713
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC13 mRNA CTD PMID:11793227 NCBI chr 4:145,686,186...145,699,577
Ensembl chr 4:145,686,193...145,699,577
JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC23A mRNA CTD PMID:11793227 NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SENP6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:87,486,050...87,568,088
Ensembl chr 8:87,486,427...87,563,652
JBrowse link
G Septin7 septin 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:26,412,910...26,476,615
Ensembl chr 8:26,413,233...26,476,611
JBrowse link
G Serbp1 Serpine1 mRNA binding protein 1 decreases expression ISO Caffeine results in decreased expression of SERBP1 protein CTD PMID:31195006 NCBI chr 4:98,027,563...98,044,717
Ensembl chr 4:98,027,554...98,044,566
JBrowse link
G Serpina1 serpin family A member 1 increases expression ISO Caffeine results in increased expression of SERPINA1 mRNA CTD PMID:18444173 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Serpina6 serpin family A member 6 decreases expression ISO Caffeine results in decreased expression of SERPINA6 mRNA CTD PMID:11793227 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Caffeine results in increased expression of SFPQ protein
CTD PMID:20230807, PMID:31195006 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Caffeine inhibits the reaction [Doxorubicin results in increased secretion of SFRP1 protein] CTD PMID:30377735 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sh2b2 SH2B adaptor protein 2 increases expression EXP Caffeine results in increased expression of APS mRNA CTD PMID:20864626 NCBI chr12:23,471,477...23,501,043
Ensembl chr12:23,473,270...23,501,036
JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression EXP Caffeine results in increased expression of SHARPIN mRNA CTD PMID:20864626 NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 decreases expression EXP Caffeine results in decreased expression of SIGMAR1 mRNA CTD PMID:20864626 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of SIRT1 mRNA; Caffeine results in decreased expression of SIRT1 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]
CTD PMID:30776459, PMID:30825513 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein] CTD PMID:30555576 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases expression
ISO Caffeine affects the reaction [SLC16A1 protein results in increased uptake of Butyrates]
Caffeine results in increased expression of SLC16A1 mRNA
CTD PMID:19023563 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Caffeine results in increased expression of SLC17A5 mRNA CTD PMID:20864626 NCBI chr 8:85,891,245...85,926,466
Ensembl chr 8:85,891,257...85,926,450
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Caffeine results in decreased activity of SLC1A1 protein
Caffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]
CTD PMID:23262392 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc25a37 solute carrier family 25 member 37 decreases expression EXP Caffeine results in decreased expression of SLC25A37 mRNA CTD PMID:20864626 NCBI chr15:51,125,764...51,168,384
Ensembl chr15:51,128,268...51,168,384
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Caffeine results in increased expression of SLC2A1 protein CTD PMID:25486098 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a10 solute carrier family 2 member 10 decreases expression ISO Caffeine results in decreased expression of SLC2A10 protein CTD PMID:31195006 NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Caffeine results in increased expression of SLC2A3 protein CTD PMID:25486098 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc30a7 solute carrier family 30 member 7 decreases expression EXP Caffeine results in decreased expression of SLC30A7 mRNA CTD PMID:20864626 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Caffeine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Caffeine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA; [Caffeine co-treated with S 20098] results in decreased expression of SLC6A15 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA; [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA CTD PMID:29107002, PMID:29882086 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases response to substance
affects response to substance
ISO SLC6A3 gene mutant form results in increased susceptibility to Caffeine
SLC6A3 gene polymorphism affects the susceptibility to Caffeine
CTD PMID:11222668, PMID:24403155 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc8b1 solute carrier family 8 member B1 increases expression EXP Caffeine results in increased expression of SLC8B1 mRNA CTD PMID:20864626 NCBI chr12:41,566,980...41,590,294
Ensembl chr12:41,566,981...41,590,244
JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Caffeine results in decreased expression of SMAD2 mRNA; Caffeine results in decreased expression of SMAD2 protein CTD PMID:32663519 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Caffeine results in decreased expression of SMAD3 mRNA
CTD PMID:20230807, PMID:32663519 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smox spermine oxidase increases expression ISO Caffeine results in increased expression of SMOX mRNA CTD PMID:11793227 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMPD3 mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Snx3 sorting nexin 3 increases expression EXP Caffeine results in increased expression of SNX3 mRNA CTD PMID:20864626 NCBI chr20:47,225,382...47,263,390
Ensembl chr20:47,225,619...47,263,390
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of SOD1 mRNA CTD PMID:31756439 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of SOD2 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of SOD2 mRNA
CTD PMID:23099337, PMID:31756439 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Caffeine results in decreased expression of SORL1 mRNA CTD PMID:25868845 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Caffeine results in increased expression of SOWAHA protein CTD PMID:31195006 NCBI chr10:38,836,158...38,838,932
Ensembl chr10:38,836,614...38,838,272
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Caffeine results in decreased expression of SOX9 mRNA; Caffeine results in decreased expression of SOX9 protein CTD PMID:31874197, PMID:32663519 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Caffeine results in decreased expression of SPP1 mRNA CTD PMID:30423288 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqle squalene epoxidase decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of SQLE mRNA
Caffeine results in increased expression of SQLE mRNA
CTD PMID:11793227, PMID:20864626, PMID:25868845 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
decreases expression
EXP
ISO
Caffeine results in increased expression of SQSTM1 mRNA
Caffeine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]
Caffeine results in decreased expression of SQSTM1 protein
CTD PMID:20864626, PMID:21081844, PMID:22927544 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Caffeine results in increased expression of SREBF1 mRNA; Caffeine results in increased expression of SREBF1 protein CTD PMID:30776459 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of SREBF2 mRNA; Caffeine results in increased expression of SREBF2 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]
CTD PMID:30825513 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO Caffeine results in decreased expression of SRSF1 mRNA CTD PMID:11793227 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression ISO Caffeine results in increased expression of SRSF2 protein CTD PMID:31195006 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Ssc4d scavenger receptor cysteine rich family member with 4 domains increases expression ISO Caffeine results in increased expression of SSC4D protein CTD PMID:31195006 NCBI chr12:23,752,823...23,769,466
Ensembl chr12:23,752,844...23,762,877
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO Caffeine results in increased expression of ST13 protein CTD PMID:31195006 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Star steroidogenic acute regulatory protein decreases methylation
increases expression
decreases expression
ISO
EXP
Caffeine results in decreased methylation of STAR promoter
Caffeine results in increased expression of STAR mRNA
Caffeine results in decreased expression of STAR mRNA
Caffeine results in increased expression of STAR mRNA; Caffeine results in increased expression of STAR protein
CTD PMID:22100783, PMID:24717552, PMID:25868845, PMID:30528684 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 decreases expression EXP Caffeine results in decreased expression of STARD4 mRNA CTD PMID:20864626 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
G Stim1 stromal interaction molecule 1 increases expression EXP Caffeine results in increased expression of STIM1 mRNA CTD PMID:20864626 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420
JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA] CTD PMID:20230807 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Caffeine results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Strbp spermatid perinuclear RNA binding protein decreases expression ISO Caffeine results in decreased expression of STRBP mRNA CTD PMID:11793227 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STX4A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:199,287,384...199,295,606
Ensembl chr 1:199,287,710...199,294,979
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Caffeine results in increased expression of SULT1A1 mRNA; Caffeine results in increased expression of SULT1A1 protein CTD PMID:21721019 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP Caffeine results in increased expression of SULT2A1 mRNA; Caffeine results in increased expression of SULT2A1 protein CTD PMID:21721019 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D decreases expression EXP Caffeine results in decreased expression of TAF1D mRNA CTD PMID:20864626 NCBI chr 8:13,861,242...13,871,508
Ensembl chr 8:13,861,459...13,871,354
JBrowse link
G Tbc1d8b TBC1 domain family member 8B increases expression EXP Caffeine results in increased expression of TBC1D8B mRNA CTD PMID:20864626 NCBI chr  X:110,894,831...110,983,269
Ensembl chr  X:110,894,845...110,983,309
JBrowse link
G Tbrg4 transforming growth factor beta regulator 4 decreases expression EXP Caffeine results in decreased expression of TBRG4 mRNA CTD PMID:20864626 NCBI chr14:86,876,800...86,885,603
Ensembl chr14:86,877,627...86,885,584
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Caffeine results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Tcp1 t-complex 1 increases expression ISO Caffeine results in increased expression of TCP1 protein CTD PMID:31195006 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases activity EXP Caffeine results in increased activity of TDO2 protein CTD PMID:8164501 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO Caffeine results in decreased expression of TFDP1 mRNA CTD PMID:11793227 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA] CTD PMID:20230807 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases expression
EXP Caffeine results in increased expression of TGFB1 mRNA
Caffeine results in decreased expression of TGFB1 mRNA; Caffeine results in decreased expression of TGFB1 protein
CTD PMID:29055810, PMID:32663519 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Caffeine results in decreased expression of TGFBR1 mRNA; Caffeine results in decreased expression of TGFBR1 protein CTD PMID:32663519 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; Caffeine promotes the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:7996441, PMID:20230807 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:36,382,029...36,399,625
Ensembl chr 8:36,385,353...36,388,224
JBrowse link
G Tlcd1 TLC domain containing 1 decreases expression EXP Caffeine results in decreased expression of TLCD1 mRNA CTD PMID:20864626 NCBI chr10:65,439,104...65,441,140
Ensembl chr10:65,439,102...65,444,001
JBrowse link
G Tm9sf1 transmembrane 9 superfamily member 1 decreases expression ISO Caffeine results in decreased expression of TM9SF1 mRNA CTD PMID:11793227 NCBI chr15:34,314,645...34,322,172
Ensembl chr15:34,314,656...34,322,115
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 increases expression ISO Caffeine results in increased expression of TMCC2 mRNA CTD PMID:18444173 NCBI chr13:49,132,685...49,169,771
Ensembl chr13:49,132,667...49,169,918
JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression EXP Caffeine results in decreased expression of TMED5 mRNA CTD PMID:20864626 NCBI chr14:2,613,318...2,624,773
Ensembl chr14:2,613,406...2,633,950
JBrowse link
G Tmem69 transmembrane protein 69 decreases expression EXP Caffeine results in decreased expression of TMEM69 mRNA CTD PMID:20864626 NCBI chr 5:135,394,013...135,397,591
Ensembl chr 5:135,394,016...135,397,591
JBrowse link
G Tmem97 transmembrane protein 97 decreases expression ISO Caffeine results in decreased expression of TMEM97 mRNA CTD PMID:11793227 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
ISO
EXP
Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Caffeine results in increased expression of TNF mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Caffeine results in decreased expression of TNF mRNA
CTD PMID:22974838, PMID:23727198, PMID:28089782, PMID:29055810, PMID:30776459 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression ISO Caffeine results in decreased expression of TNFRSF10A protein CTD PMID:31195006 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 increases expression EXP Caffeine results in increased expression of TNFRSF19 mRNA CTD PMID:20864626 NCBI chr15:41,249,820...41,316,203
Ensembl chr15:41,246,308...41,338,284
JBrowse link
G Tnfsf4 TNF superfamily member 4 increases expression ISO Caffeine results in increased expression of TNFSF4 mRNA CTD PMID:18444173 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TNK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:71,348,726...71,388,520
Ensembl chr11:71,348,717...71,387,992
JBrowse link
G Tnks2 tankyrase 2 increases expression EXP Caffeine results in increased expression of TNKS2 mRNA CTD PMID:20864626
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
decreases mutagenesis
ISO
EXP
Caffeine results in increased phosphorylation of TP53 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Bortezomib results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Cytarabine results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of TP53 protein modified form]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [tomentosin results in increased phosphorylation of TP53 protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]; Caffeine results in increased phosphorylation of and results in increased activity of TRP53 protein
Caffeine results in decreased mutagenesis of TRP53 gene
Caffeine inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]
CTD PMID:11751435, PMID:12393500, PMID:12811820, PMID:12907610, PMID:15975959, PMID:16024610, PMID:16777994, PMID:17919456, PMID:17977830, PMID:19028473, PMID:19735649, PMID:22226932, PMID:22927544, PMID:23274516, PMID:23523585, PMID:30555576, PMID:31168028 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449