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Accession:CHEBI:50378 term browser browse the term
Definition:A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
Synonyms:exact_synonym: 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
 related_synonym: 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione;   Formula=C14H10F3NO5;   InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2;   InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N;   Orfadin;   SMILES=[O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F;   nitisinona;   nitisinonum
 xref: CAS:104206-65-7 "ChemIDplus";   DrugBank:DB00348;   Drug_Central:1944 "DrugCentral";   HMDB:HMDB0014492;   KEGG:D05177
 xref_mesh: MESH:C077073
 xref: PMID:14668946 "Europe PMC";   PMID:15297036 "Europe PMC";   PMID:17152330 "Europe PMC";   PMID:17458044 "Europe PMC";   PMID:20883679 "Europe PMC";   PMID:21377430 "Europe PMC";   PMID:21620748 "Europe PMC";   PMID:21752152 "Europe PMC";   PMID:21813063 "Europe PMC";   PMID:21968107 "Europe PMC";   PMID:21968110 "Europe PMC";   PMID:22456946 "Europe PMC";   PMID:22885033 "Europe PMC";   PMID:23146787 "Europe PMC";   PMID:23203167 "Europe PMC";   PMID:23250512 "Europe PMC";   PMID:23311542 "Europe PMC";   PMID:23430914 "Europe PMC";   PMID:23430917 "Europe PMC";   PMID:23486607 "Europe PMC";   PMID:23511227 "Europe PMC";   Patent:EP186118;   Patent:US4774360;   Patent:US5006158;   Patent:US5550165;   Patent:US5668089;   Reaxys:8639943 "Reaxys";   Wikipedia:Nitisinone

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nitisinone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hpd 4-hydroxyphenylpyruvate dioxygenase JBrowse link 12 38,828,606 38,839,956 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        xenobiotic 18322
          mesotrione 5
            nitisinone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      ketone 15918
                                        aromatic ketone 11826
                                          benzophenones 1124
                                            benzophenone 678
                                              mesotrione 5
                                                nitisinone 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.