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ONTOLOGY REPORT - ANNOTATIONS


Term:miglustat
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Accession:CHEBI:50381 term browser browse the term
Definition:A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.
Synonyms:exact_synonym: (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
 related_synonym: BuDNJ;   Butyldeoxynojirimycin;   Formula=C10H21NO4;   InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1;   InChIKey=UQRORFVVSGFNRO-UTINFBMNSA-N;   N-(n-Butyl)deoxynojirimycin;   N-Butylmoranoline;   N-butyl-1-deoxynojirimycin;   NB-DNJ;   SC-48334;   SMILES=CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO;   Zavesca;   miglustatum;   n-Butyl deoxynojirimycin
 xref: Beilstein:5862029 "Beilstein";   CAS:72599-27-0 "ChemIDplus";   DrugBank:DB00419;   Drug_Central:1807 "DrugCentral";   KEGG:D05032
 xref_mesh: MESH:C059896


show annotations for term's descendants       view all columns           Sort by:
 
miglustat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 JBrowse link 4 177,065,266 177,195,942 RGD:6480464
G Ugcg UDP-glucose ceramide glucosyltransferase JBrowse link 5 76,376,722 76,419,564 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          anti-obesity agent 166
            duvoglustat 26
              miglustat 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteromonocyclic compound 16347
                                    piperidines 7422
                                      hydroxypiperidine 413
                                        2-(hydroxymethyl)piperidine-3,4,5-triol 26
                                          duvoglustat 26
                                            miglustat 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.