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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3',4',7-trihydroxyisoflavone
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Accession:CHEBI:50399 term browser browse the term
Definition:A 7-hydroxyisoflavone that is daidzein substituted by a hydroxy group at position 3'.
Synonyms:exact_synonym: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
 related_synonym: 3'-hydroxydaidzein;   3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H;   InChIKey=DDKGKOOLFLYZDL-UHFFFAOYSA-N;   SMILES=Oc1ccc2c(c1)occ(-c1ccc(O)c(O)c1)c2=O
 alt_id: CHEBI:33177;   CHEBI:34315
 xref: Beilstein:251800;   CAS:485-63-2;   HMDB:HMDB0041655;   KEGG:C14313;   KNApSAcK:C00009384;   LIPID_MAPS_instance:LMPK12050055
 xref_mesh: MESH:C061213
 xref: PMID:19577190;   PMID:21378167;   PMID:22497114;   PMID:23265084;   Reaxys:251800


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3',4',7-trihydroxyisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA
3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]
CTD PMID:22914566 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA] CTD PMID:22914566 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA] CTD PMID:22914566 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA
3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]
CTD PMID:22914566 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP3 mRNA] CTD PMID:22914566 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP9 mRNA] CTD PMID:22914566 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA] CTD PMID:22914566 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of TP53 mRNA] CTD PMID:22914566 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            3',4',7-trihydroxyisoflavone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        cyclic ketone 13877
                                          isoflavones 3736
                                            hydroxyisoflavone 3669
                                              7-hydroxyisoflavones 3654
                                                daidzein 243
                                                  3',4',7-trihydroxyisoflavone 8
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