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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:citronellol
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Accession:CHEBI:50462 term browser browse the term
Definition:A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7.
Synonyms:exact_synonym: 3,7-dimethyloct-6-en-1-ol
 related_synonym: 2,3-Dihydrogeraniol;   2,6-Dimethyl-2-octen-8-ol;   3,7-Dimethyl-6-octen-1-ol;   Cephrol;   Elenol;   Formula=C10H20O;   InChI=1S/C10H20O/c1-9(2)5-4-6-10(3)7-8-11/h5,10-11H,4,6-8H2,1-3H3;   InChIKey=QMVPMAAFGQKVCJ-UHFFFAOYSA-N;   SMILES=CC(CCO)CCC=C(C)C;   beta-Citronellol
 xref: Beilstein:1362474;   CAS:106-22-9
 xref_mesh: MESH:C007078
 xref: PMID:20964319;   Reaxys:1362474;   Wikipedia:Citronellol


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citronellol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO citronellol results in decreased activity of ABCB1 protein
[citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
CTD PMID:15890377, PMID:16904803 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CCL3 mRNA] CTD PMID:31926054 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Fbp1 fructose-bisphosphatase 1 multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in increased activity of FBP1 protein] CTD PMID:26944432 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in increased activity of G6PC protein] CTD PMID:26944432 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:26944432 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases activity ISO citronellol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Il10 interleukin 10 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IL10 protein] CTD PMID:31926054 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein] CTD PMID:31926054 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
citronellol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NFKBIA mRNA]
CTD PMID:20506077, PMID:31926054 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
citronellol results in decreased expression of NOS2 protein
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOS2 protein]
CTD PMID:20506077, PMID:31926054 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Olr1513 olfactory receptor 1513 affects binding ISO citronellol binds to OLFR43 protein
citronellol binds to OR1A1 protein
CTD PMID:17601748 NCBI chr10:61,033,113...61,034,051
Ensembl chr10:61,033,113...61,034,051
JBrowse link
G Olr1514 olfactory receptor 1514 affects binding ISO citronellol binds to OR1A2 protein CTD PMID:17601748 NCBI chr10:61,044,411...61,045,355
Ensembl chr10:61,044,411...61,045,355
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO citronellol results in increased activity of PPARA protein CTD PMID:21597168 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO citronellol results in increased activity of PPARG protein
citronellol inhibits the reaction [PPARG protein results in increased expression of PTGS2 mRNA]
CTD PMID:21597168 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 protein]
citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; citronellol inhibits the reaction [PPARG protein results in increased expression of PTGS2 mRNA]
CTD PMID:20506077, PMID:21597168, PMID:31926054 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA protein] CTD PMID:31926054 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein] CTD PMID:31926054 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO citronellol binds to and results in increased activity of TRPV1 protein CTD PMID:20686244 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of citronellol CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
citronellol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 affects activity ISO citronellyl acetate affects the activity of TRPM8 protein CTD PMID:23562495 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects activity ISO citronellyl acetate affects the activity of TRPV1 protein CTD PMID:23562495 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              plant metabolite 17424
                citronellol 20
                  (R)-(+)-citronellol 0
                  (S)-(-)-citronellol 0
                  citronellol acetate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  terpene 9607
                                    monoterpene 1219
                                      monoterpenoid 1188
                                        citronellol 20
                                          (R)-(+)-citronellol 0
                                          (S)-(-)-citronellol 0
                                          citronellol acetate 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.