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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.5.1.15 (dihydropteroate synthase) inhibitor
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Accession:CHEBI:50502 term browser browse the term
Definition:An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
Synonyms:related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   7,8-dihydropteroate synthase inhibitor;   7,8-dihydropteroate synthase inhibitors;   7,8-dihydropteroate synthetase inhibitor;   7,8-dihydropteroate synthetase inhibitors;   7,8-dihydropteroic acid synthetase inhibitor;   7,8-dihydropteroic acid synthetase inhibitors;   DHPS inhibitor;   DHPS inhibitors;   EC 2.5.1.15 (dihydropteroate synthase) inhibitors;   EC 2.5.1.15 inhibitor;   EC 2.5.1.15 inhibitors;   dihydropteroate diphosphorylase inhibitor;   dihydropteroate diphosphorylase inhibitors;   dihydropteroate pyrophosphorylase inhibitor;   dihydropteroate pyrophosphorylase inhibitors;   dihydropteroate synthase inhibitor;   dihydropteroate synthase inhibitors;   dihydropteroate synthetase inhibitor;   dihydropteroate synthetase inhibitors;   dihydropteroic synthetase inhibitor;   dihydropteroic synthetase inhibitors
 xref: Wikipedia:Dihydropteroate_synthase_inhibitor


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co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Hmgb1 high mobility group box 1 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Ifng interferon gamma increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase affects binding
multiple interactions
ISO 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole
CTD PMID:25531135 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
sulfacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfacetamide decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat2 N-acetyltransferase 2 increases acetylation
increases metabolic processing
affects acetylation
ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine
CTD PMID:12222688, PMID:15627487, PMID:15880531, PMID:21317369, PMID:28516247, PMID:30358977 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Acan aggrecan decreases expression EXP Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Alb albumin multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Ifng interferon gamma increases secretion ISO Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il5 interleukin 5 increases secretion ISO Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mir155 microRNA 155 increases expression ISO Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir18a microRNA 18a increases expression ISO Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir21 microRNA 21 increases expression ISO Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Pir pirin increases expression ISO Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:102,724,266...102,755,511
Ensembl chr13:102,724,348...102,756,174
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      biological role 19746
        biochemical role 19251
          enzyme inhibitor 18173
            EC 2.* (transferase) inhibitor 13816
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 1973
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 1973
                  EC 2.5.1.15 (dihydropteroate synthase) inhibitor 35
                    asulam 0
                    asulam-potassium 0
                    asulam-sodium 0
                    sulfacetamide 1
                    sulfacetamide sodium 0
                    sulfacetamide sodium anhydrous + 0
                    sulfachloropyridazine 0
                    sulfadiazine 4
                    sulfamethazine + 2
                    sulfamethizole 0
                    sulfamethoxazole + 32
                    sulfamethoxypyridazine 0
                    sulfathiazole + 0
                    sulfathiourea 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.