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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor
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Accession:CHEBI:50568 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Synonyms:related_synonym: 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitor;   3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitors;   3',5'-cyclic-nucleotide 5'-nucleotidohydrolase inhibitor;   3',5'-cyclonucleotide phosphodiesterase inhibitor;   3',5'-cyclonucleotide phosphodiesterase inhibitors;   3',5'-nucleotide phosphodiesterase inhibitor;   3',5'-nucleotide phosphodiesterase inhibitors;   3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor;   3': 5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors;   3':5'-cyclic nucleotide 5'-nucleotidohydrolase inhibitors;   EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitors;   EC 3.1.4.17 inhibitor;   EC 3.1.4.17 inhibitors;   PDE inhibitor;   PDE inhibitors;   cyclic 3',5'-mononucleotide phosphodiesterase inhibitor;   cyclic 3',5'-mononucleotide phosphodiesterase inhibitors;   cyclic 3',5'-nucleotide phosphodiesterase inhibitor;   cyclic 3',5'-nucleotide phosphodiesterase inhibitors;   cyclic 3',5'-phosphodiesterase inhibitor;   cyclic 3',5'-phosphodiesterase inhibitors;   cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitor;   cyclic 3',5-nucleotide monophosphate phosphodiesterase inhibitors;   cyclic AMP phosphodiesterase inhibitor;   cyclic AMP phosphodiesterase inhibitors;   cyclic nucleotide phosphodiesterase inhibitor;   cyclic nucleotide phosphodiesterase inhibitors;   cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitor;   cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) inhibitors;   nucleoside 3',5'-cyclic phosphate diesterase inhibitor;   nucleoside 3',5'-cyclic phosphate diesterase inhibitors;   nucleoside-3',5-monophosphate phosphodiesterase inhibitor;   nucleoside-3',5-monophosphate phosphodiesterase inhibitors;   phosphodiesterase III inhibitor


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cilostazol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:21408552
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pln phospholamban JBrowse link 20 34,633,157 34,642,904 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc29a1 solute carrier family 29 member 1 JBrowse link 9 17,784,468 17,799,008 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
milrinone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adh1 alcohol dehydrogenase 1 (class I) JBrowse link 2 243,550,655 243,562,243 RGD:6480464
G Akip1 A-kinase interacting protein 1 JBrowse link 1 174,330,628 174,339,494 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Aqp7 aquaporin 7 JBrowse link 5 57,358,297 57,372,332 RGD:6480464
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:6480464
G Aspn asporin JBrowse link 17 14,655,958 14,681,355 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Chtf8 chromosome transmission fidelity factor 8 JBrowse link 19 39,077,580 39,087,880 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 17 57,021,704 57,090,888 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Csrp2 cysteine and glycine-rich protein 2 JBrowse link 7 53,630,675 53,649,309 RGD:6480464
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:6480464
G Dbp D-box binding PAR bZIP transcription factor JBrowse link 1 101,687,896 101,692,845 RGD:6480464
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 JBrowse link 20 31,055,292 31,072,469 RGD:6480464
G Fam171a1 family with sequence similarity 171, member A1 JBrowse link 17 79,030,150 79,149,480 RGD:6480464
G Fhl1 four and a half LIM domains 1 JBrowse link X 159,112,516 159,172,528 RGD:6480464
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6480464
G Gpnmb glycoprotein nmb JBrowse link 4 78,694,447 78,715,685 RGD:6480464
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6480464
G Igkc immunoglobulin kappa constant RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lyz2 lysozyme 2 JBrowse link 7 60,335,968 60,341,264 RGD:6480464
G Msi2 musashi RNA-binding protein 2 JBrowse link 10 75,673,840 76,040,106 RGD:6480464
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:6480464
G Myl1 myosin, light chain 1 JBrowse link 9 73,937,820 73,958,480 RGD:6480464
G Noct nocturnin JBrowse link 2 140,286,661 140,306,869 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:6480464
G Per2 period circadian regulator 2 JBrowse link 9 98,555,154 98,597,362 RGD:6480464
G Postn periostin JBrowse link 2 143,656,820 143,688,087 RGD:6480464
G Reg3b regenerating family member 3 beta JBrowse link 4 109,467,272 109,470,510 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G S100a4 S100 calcium-binding protein A4 JBrowse link 2 189,997,278 189,999,587 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Thbs4 thrombospondin 4 JBrowse link 2 22,343,727 22,385,855 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        biochemical role 19210
          enzyme inhibitor 18097
            EC 3.* (hydrolase) inhibitor 17578
              EC 3.1.* (ester hydrolase) inhibitor 12815
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 1330
                  EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor 78
                    cilostazol 43
                    levosimendan 0
                    milrinone 38
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.