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ONTOLOGY REPORT - ANNOTATIONS


Term:minocycline
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Accession:CHEBI:50694 term browser browse the term
Definition:A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Synonyms:related_synonym: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE;   7-Dimethylamino-6-demethyl-6-deoxytetracycline;   Formula=C23H27N3O7;   InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1;   InChIKey=DYKFCLLONBREIL-KVUCHLLUSA-N;   SMILES=[H][C@@]12Cc3c(ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C;   minociclina;   minociclinum;   minomycin
 alt_id: CHEBI:44053;   CHEBI:6939
 xref: Beilstein:3077644 "Beilstein";   CAS:10118-90-8 "ChemIDplus";   CAS:10118-90-8 "KEGG COMPOUND";   DrugBank:DB01017;   Drug_Central:1813 "DrugCentral";   HMDB:HMDB0015152;   KEGG:C07225;   KEGG:D05045;   KNApSAcK:C00018686;   LIPID_MAPS_instance:LMPK07000002 "LIPID MAPS"
 xref_mesh: MESH:D008911
 xref: PDBeChem:MIY;   PMID:28709717 "Europe PMC";   PMID:31630007 "Europe PMC";   PMID:31719236 "Europe PMC";   PMID:31733348 "Europe PMC";   Patent:US3226436;   Patent:WO2008104734;   Reaxys:3077644 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:71337;   is_tautomer_of CHEBI:77906


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minocycline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIFM1 apoptosis inducing factor mitochondria associated 1 JBrowse link X 130,129,362 130,165,887 RGD:6480464
G APP amyloid beta precursor protein JBrowse link 21 25,880,550 26,171,128 RGD:6480464
G ATF3 activating transcription factor 3 JBrowse link 1 212,565,334 212,620,777 RGD:6480464
G ATF6 activating transcription factor 6 JBrowse link 1 161,766,320 161,964,070 RGD:6480464
G ATP5F1A ATP synthase F1 subunit alpha JBrowse link 18 46,080,248 46,104,233 RGD:6480464
G ATP5PD ATP synthase peripheral stalk subunit d JBrowse link 17 75,038,863 75,046,969 RGD:6480464
G BACE1 beta-secretase 1 JBrowse link 11 117,285,207 117,316,256 RGD:6480464
G BAK1 BCL2 antagonist/killer 1 JBrowse link 6 33,572,552 33,580,296 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G BID BH3 interacting domain death agonist JBrowse link 22 17,734,140 17,774,665 RGD:6480464
G CASP1 caspase 1 JBrowse link 11 105,025,443 105,035,591 RGD:6480464
G CASP12 caspase 12 (gene/pseudogene) JBrowse link 11 104,885,718 104,898,670 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP7 caspase 7 JBrowse link 10 113,679,162 113,730,909 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CCL3 C-C motif chemokine ligand 3 JBrowse link 17 36,088,256 36,090,143 RGD:6480464
G CCL4 C-C motif chemokine ligand 4 JBrowse link 17 36,103,827 36,105,614 RGD:6480464
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 35,871,491 35,880,360 RGD:6480464
G CDKN1B cyclin dependent kinase inhibitor 1B JBrowse link 12 12,717,270 12,722,383 RGD:6480464
G COX5A cytochrome c oxidase subunit 5A JBrowse link 15 74,919,791 74,938,073 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G CYCS cytochrome c, somatic JBrowse link 7 25,118,656 25,125,260 RGD:6480464
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:6480464
G DIABLO diablo IAP-binding mitochondrial protein JBrowse link 12 122,207,662 122,227,456 RGD:6480464
G DLST dihydrolipoamide S-succinyltransferase JBrowse link 14 74,881,913 74,903,743 RGD:6480464
G EGLN1 egl-9 family hypoxia inducible factor 1 JBrowse link 1 231,363,751 231,425,044 RGD:6480464
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 JBrowse link 2 37,099,210 37,157,065 RGD:6480464
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 2 88,556,740 88,627,464 RGD:6480464
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 14 67,360,328 67,386,516 RGD:6480464
G ENO1 enolase 1 JBrowse link 1 8,861,000 8,878,686 RGD:6480464
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 17 64,039,142 64,132,469 RGD:6480464
G FMR1 FMRP translational regulator 1 JBrowse link X 147,911,919 147,951,127 RGD:6480464
G GJC2 gap junction protein gamma 2 JBrowse link 1 228,149,930 228,159,826 RGD:6480464
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 5 153,490,524 153,813,873 RGD:6480464
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 16 9,753,404 10,182,928 RGD:6480464
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C JBrowse link 17 74,842,021 74,860,843 RGD:6480464
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 61,695,513 61,748,259 RGD:6480464
G HLA-A major histocompatibility complex, class I, A JBrowse link 6 29,942,532 29,945,870 RGD:6480464
G HLA-B major histocompatibility complex, class I, B JBrowse link 6 31,353,875 31,357,179 RGD:6480464
G HLA-F major histocompatibility complex, class I, F JBrowse link 6 29,723,340 29,740,355 RGD:6480464
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 125,234,853 125,241,343 RGD:6480464
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2 197,486,584 197,500,274 RGD:6480464
G HTT huntingtin JBrowse link 4 3,074,681 3,243,960 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IFNG interferon gamma JBrowse link 12 68,154,768 68,159,740 RGD:6480464
G IL10 interleukin 10 JBrowse link 1 206,767,602 206,772,494 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G IL6R interleukin 6 receptor JBrowse link 1 154,405,193 154,469,450 RGD:6480464
G INA internexin neuronal intermediate filament protein alpha JBrowse link 10 103,277,138 103,290,346 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 1 58,780,791 58,784,047 RGD:6480464
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 10 48,306,639 48,439,360 RGD:6480464
G MAPKAPK5 MAPK activated protein kinase 5 JBrowse link 12 111,842,228 111,902,222 RGD:6480464
G MMP13 matrix metallopeptidase 13 JBrowse link 11 102,942,995 102,955,732 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MMP3 matrix metallopeptidase 3 JBrowse link 11 102,835,801 102,843,609 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MR1 major histocompatibility complex, class I-related JBrowse link 1 181,033,392 181,061,938 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 JBrowse link 11 117,144,284 117,178,173 RGD:6480464
G PRDX2 peroxiredoxin 2 JBrowse link 19 12,796,823 12,801,800 RGD:6480464
G PRDX3 peroxiredoxin 3 JBrowse link 10 119,167,720 119,178,812 RGD:6480464
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:6480464
G PRTN3 proteinase 3 JBrowse link 19 840,965 848,175 RGD:6480464
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SLC22A6 solute carrier family 22 member 6 JBrowse link 11 62,976,597 62,984,967 RGD:6480464
G SLC22A7 solute carrier family 22 member 7 JBrowse link 6 43,295,710 43,305,538 RGD:6480464
G SLC2A1 solute carrier family 2 member 1 JBrowse link 1 42,925,375 42,958,868 RGD:6480464
G SLC6A3 solute carrier family 6 member 3 JBrowse link 5 1,392,794 1,445,440 RGD:6480464
G SNAP25 synaptosome associated protein 25 JBrowse link 20 10,218,830 10,307,420 RGD:6480464
G SOD2 superoxide dismutase 2 JBrowse link 6 159,669,069 159,762,281 RGD:6480464
G STMN1 stathmin 1 JBrowse link 1 25,884,179 25,906,877 RGD:6480464
G TGFB2 transforming growth factor beta 2 JBrowse link 1 218,345,284 218,444,619 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464
G TPO thyroid peroxidase JBrowse link 2 1,413,288 1,543,673 RGD:6480464
G TUBA1A tubulin alpha 1a JBrowse link 12 49,184,795 49,189,324 RGD:6480464
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:6480464
G VEGFC vascular endothelial growth factor C JBrowse link 4 176,683,538 176,792,922 RGD:6480464
G VEGFD vascular endothelial growth factor D JBrowse link X 15,345,596 15,384,413 RGD:6480464
G VHL von Hippel-Lindau tumor suppressor JBrowse link 3 10,141,778 10,153,667 RGD:6480464
G XBP1 X-box binding protein 1 JBrowse link 22 28,794,560 28,800,572 RGD:6480464
G XIAP X-linked inhibitor of apoptosis JBrowse link X 123,859,812 123,913,979 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23757
    role 23646
      biological role 23609
        antimicrobial agent 20071
          tetracenomycin 88
            minocycline 88
              minocycline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23757
    subatomic particle 23706
      composite particle 23706
        hadron 23706
          baryon 23706
            nucleon 23706
              atomic nucleus 23706
                atom 23706
                  main group element atom 23525
                    p-block element atom 23525
                      carbon group element atom 23236
                        carbon atom 23213
                          organic molecular entity 23213
                            organic group 21896
                              organic divalent group 21868
                                organodiyl group 21868
                                  carbonyl group 21840
                                    carbonyl compound 21840
                                      ketone 18003
                                        oxyketone 9016
                                          alpha-oxyketone 9016
                                            alpha-hydroxy ketone 9016
                                              tertiary alpha-hydroxy ketone 8829
                                                minocycline 88
                                                  minocycline hydrochloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.