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ONTOLOGY REPORT - ANNOTATIONS


Term:minocycline
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Accession:CHEBI:50694 term browser browse the term
Definition:A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Synonyms:related_synonym: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE;   7-Dimethylamino-6-demethyl-6-deoxytetracycline;   Formula=C23H27N3O7;   InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1;   InChIKey=DYKFCLLONBREIL-KVUCHLLUSA-N;   SMILES=[H][C@@]12Cc3c(ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C;   minociclina;   minociclinum;   minomycin
 alt_id: CHEBI:44053;   CHEBI:6939
 xref: Beilstein:3077644 "Beilstein";   CAS:10118-90-8 "ChemIDplus";   CAS:10118-90-8 "KEGG COMPOUND";   DrugBank:DB01017;   Drug_Central:1813 "DrugCentral";   HMDB:HMDB0015152;   KEGG:C07225;   KEGG:D05045;   KNApSAcK:C00018686;   LIPID_MAPS_instance:LMPK07000002 "LIPID MAPS"
 xref_mesh: MESH:D008911
 xref: PDBeChem:MIY;   PMID:28709717 "Europe PMC";   PMID:31630007 "Europe PMC";   PMID:31719236 "Europe PMC";   PMID:31733348 "Europe PMC";   Patent:US3226436;   Patent:WO2008104734;   Reaxys:3077644 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:71337;   is_tautomer_of CHEBI:77906


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minocycline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 JBrowse link X 48,474,944 48,513,563 RGD:6480464
G App amyloid beta (A4) precursor protein JBrowse link 16 84,952,666 85,175,255 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 1 191,170,296 191,183,333 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 1 170,704,457 170,868,585 RGD:6480464
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 JBrowse link 18 77,773,768 77,782,869 RGD:6480464
G Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D JBrowse link 11 115,415,691 115,419,919 RGD:6480464
G Bace1 beta-site APP cleaving enzyme 1 JBrowse link 9 45,838,545 45,862,484 RGD:6480464
G Bak1 BCL2-antagonist/killer 1 JBrowse link 17 27,019,812 27,028,627 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 6 120,893,119 120,917,062 RGD:6480464
G Casp1 caspase 1 JBrowse link 9 5,298,517 5,307,281 RGD:6480464
G Casp12 caspase 12 JBrowse link 9 5,345,442 5,373,034 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp7 caspase 7 JBrowse link 19 56,396,833 56,442,348 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Ccl4 chemokine (C-C motif) ligand 4 JBrowse link 11 83,648,624 83,664,683 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Chil3 chitinase-like 3 JBrowse link 3 106,147,554 106,167,564 RGD:6480464
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 9 57,517,328 57,532,427 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 6 50,562,563 50,566,569 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 5 123,511,330 123,524,164 RGD:6480464
G Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) JBrowse link 12 85,110,822 85,134,091 RGD:6480464
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 8 124,908,587 124,949,254 RGD:6480464
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 17 78,850,504 78,882,572 RGD:6480464
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 6 70,844,484 70,905,241 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha JBrowse link 12 78,862,072 78,887,010 RGD:6480464
G Eno1 enolase 1, alpha non-neuron JBrowse link 4 150,236,692 150,248,873 RGD:6480464
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 JBrowse link 11 106,397,620 106,487,796 RGD:6480464
G Fmr1 FMRP translational regulator 1 JBrowse link X 68,678,536 68,717,963 RGD:6480464
G Gjc2 gap junction protein, gamma 2 JBrowse link 11 59,175,564 59,183,213 RGD:6480464
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) JBrowse link 11 57,011,571 57,330,244 RGD:6480464
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) JBrowse link 16 9,567,901 9,996,083 RGD:6480464
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) JBrowse link 11 115,249,169 115,267,297 RGD:6480464
G H2-M2 histocompatibility 2, M region locus 2 JBrowse link 17 37,480,851 37,483,554 RGD:6480464
G H2-Q1 histocompatibility 2, Q region locus 1 JBrowse link 17 35,320,525 35,328,142 RGD:6480464
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:6480464
G Hspa5 heat shock protein 5 JBrowse link 2 34,772,090 34,776,529 RGD:6480464
G Hspd1 heat shock protein 1 (chaperonin) JBrowse link 1 55,077,833 55,088,243 RGD:6480464
G Htt huntingtin JBrowse link 5 34,761,721 34,912,534 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:6480464
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 19 47,014,681 47,025,327 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6480464
G Mapkapk5 MAP kinase-activated protein kinase 5 JBrowse link 5 121,525,051 121,545,892 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 9 7,272,514 7,283,333 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 9 7,445,822 7,455,975 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mr1 major histocompatibility complex, class I-related JBrowse link 1 155,127,874 155,146,814 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 JBrowse link 9 45,965,311 46,012,690 RGD:6480464
G Prdx2 peroxiredoxin 2 JBrowse link 8 84,969,622 84,974,811 RGD:6480464
G Prdx3 peroxiredoxin 3 JBrowse link 19 60,864,066 60,874,538 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 17 10,840,359 12,063,370 RGD:6480464
G Prtn3 proteinase 3 JBrowse link 10 79,879,667 79,883,174 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 2 36,216,742 36,258,593 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 JBrowse link 19 8,617,996 8,628,299 RGD:6480464
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 JBrowse link 17 46,432,185 46,438,477 RGD:6480464
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 JBrowse link 4 119,108,745 119,137,330 RGD:6480464
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 JBrowse link 13 73,536,128 73,578,672 RGD:6480464
G Snap25 synaptosomal-associated protein 25 JBrowse link 2 136,713,439 136,782,428 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 4 134,468,320 134,473,843 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tpo thyroid peroxidase JBrowse link 12 30,054,659 30,132,984 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 15 98,949,847 98,953,501 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464
G Vegfc vascular endothelial growth factor C JBrowse link 8 54,077,532 54,186,454 RGD:6480464
G Vegfd vascular endothelial growth factor D JBrowse link X 164,373,522 164,402,650 RGD:6480464
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 6 113,623,994 113,631,634 RGD:6480464
G Xbp1 X-box binding protein 1 JBrowse link 11 5,520,641 5,525,993 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 42,059,613 42,109,664 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21038
    role 21018
      biological role 21016
        antimicrobial agent 18094
          tetracenomycin 88
            minocycline 88
              minocycline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21038
    subatomic particle 21032
      composite particle 21032
        hadron 21032
          baryon 21032
            nucleon 21032
              atomic nucleus 21032
                atom 21032
                  main group element atom 20874
                    p-block element atom 20874
                      carbon group element atom 20609
                        carbon atom 20586
                          organic molecular entity 20586
                            organic group 19181
                              organic divalent group 19171
                                organodiyl group 19171
                                  carbonyl group 19143
                                    carbonyl compound 19143
                                      ketone 16249
                                        oxyketone 8609
                                          alpha-oxyketone 8609
                                            alpha-hydroxy ketone 8609
                                              tertiary alpha-hydroxy ketone 8420
                                                minocycline 88
                                                  minocycline hydrochloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.