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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludrocortisone
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Accession:CHEBI:50885 term browser browse the term
Definition:A mineralocorticoid that has formula C21H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
 related_synonym: 9ALPHA-FLUOROCORTISOL;   Formula=C21H29FO5;   InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1;   InChIKey=AAXVEMMRQDVLJB-BULBTXNYSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C;   fludrocortisona;   fludrocortisonum
 alt_id: CHEBI:46556;   CHEBI:5101
 xref: Beilstein:3014278;   CAS:127-31-1;   DrugBank:DB00687;   KEGG:C07004;   KEGG:D07967;   LIPID_MAPS_instance:LMST02030103
 xref_mesh: MESH:D005438
 xref: PDBeChem:ZK5;   Patent:GB792224;   Patent:US2852511;   Wikipedia:Fludrocortisone


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fludrocortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; Fludrocortisone binds to and results in increased activity of AR protein mutant form; Mifepristone inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form] CTD PMID:11956172 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Fludrocortisone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Fludrocortisone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Fludrocortisone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Fludrocortisone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased abundance of Hydrocortisone; [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Fludrocortisone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            fludrocortisone 8
              fludrocortisone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxo steroid 9283
                                          3-oxo steroid 8811
                                            3-oxo-Delta(4) steroid 7939
                                              fludrocortisone 8
                                                fludrocortisone acetate 0
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