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ONTOLOGY REPORT - ANNOTATIONS


Term:genotoxin
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Accession:CHEBI:50902 term browser browse the term
Definition:A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
Synonyms:related_synonym: genotoxic agent;   genotoxic agents;   genotoxins
 xref: Wikipedia:Genotoxicity


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1,4-dithiothreitol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 57,850,870 57,855,607 RGD:6480464
carmustine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MGMT O-6-methylguanine-DNA methyltransferase JBrowse link 28 38,204,611 38,427,482 RGD:6480464
cyclophosphamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CYP2B6 cytochrome P450 2B11 JBrowse link 1 112,817,561 112,833,294 RGD:6480464
eplerenone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AR androgen receptor JBrowse link 24
X
34,713,390
51,969,785
34,731,461
52,167,450
RGD:6480464
glutathione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLDN4 claudin 4 JBrowse link 6 6,492,706 6,506,750 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 26 31,013,607 31,132,998 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 6 18,109,184 18,115,728 RGD:6480464
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 28 323,361 410,367 RGD:6480464
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 11 1,443,528 1,480,501 RGD:6480464
hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLDN4 claudin 4 JBrowse link 6 6,492,706 6,506,750 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 26 31,013,607 31,132,998 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 6 18,109,184 18,115,728 RGD:6480464
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 28 323,361 410,367 RGD:6480464
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 11 1,443,528 1,480,501 RGD:6480464
G SOD2 superoxide dismutase 2 JBrowse link 1 48,943,472 48,955,158 RGD:6480464
L-1,4-dithiothreitol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 57,850,870 57,855,607 RGD:6480464
N-nitrosodimethylamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GJA1 gap junction protein alpha 1 JBrowse link 1 60,941,772 60,944,694 RGD:6480464
propranolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADRB2 adrenoceptor beta 2 JBrowse link 4 60,048,502 60,050,447 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 2 84,406,317 84,408,115 RGD:6480464
G REN renin JBrowse link 38 744,540 766,998 RGD:6480464
G VIP vasoactive intestinal peptide JBrowse link 1 42,941,655 42,950,160 RGD:6480464
quinacrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HEXB hexosaminidase subunit beta JBrowse link 2 57,221,809 57,248,432 RGD:6480464
styrene oxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CYP3A12 cytochrome P-450 3A12 RGD:6480464
G EPHX1 epoxide hydrolase 1 JBrowse link 7 38,964,319 39,004,902 RGD:6480464
succimer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GSR glutathione-disulfide reductase JBrowse link 16 33,633,949 33,680,411 RGD:6480464
troleandomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NR1I2 nuclear receptor subfamily 1 group I member 2 JBrowse link 33 23,444,367 23,456,405 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 223
    role 223
      biological role 223
        aetiopathogenetic role 141
          genotoxin 20
            1,5-dinitronaphthalene 0
            1-naphthol + 4
            2,6-dinitrotoluene 0
            2-naphthol + 0
            4-methoxyestrone + 0
            7-epi-cylindrospermopsin 0
            MeIQx + 0
            N-(2,6-diethylphenyl)-2-chloroacetamide 0
            N-ethyl-N-nitrosourea 0
            N-hydroxy-MeIQx 0
            N-hydroxy-PhIP 0
            acridine + 1
            arsenic trichloride 0
            benzamidoxime 0
            benzo[a]pyrene-7,8-dione 0
            beryllium dichloride 0
            cadmium nitrate + 0
            cadmium nitrate tetrahydrate 0
            camptothecin 0
            catechol + 0
            cisplatin 0
            cobalt(2+) sulfate heptahydrate 0
            cylindrospermopsin 0
            ebselen 0
            ethoxyquin 0
            ethyl methanesulfonate 0
            hydrogen peroxide + 6
            hydrogen sulfide + 7
            hydroxyurea 0
            imidacloprid + 0
            methyl methanesulfonate 0
            mutagen + 7
            o-anisidine 0
            p-anisidine + 0
            parathion-methyl 0
            riddelliine + 0
            riddelliine N-oxide 0
            tolylfluanid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.