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ONTOLOGY REPORT - ANNOTATIONS


Term:teratogenic agent
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Accession:CHEBI:50905 term browser browse the term
Definition:A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
Synonyms:related_synonym: agent teratogene;   teratogen;   teratogeno


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(S)-nicotine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADCYAP1 adenylate cyclase activating polypeptide 1 JBrowse link 6 105,414,628 105,422,294 RGD:6480464
G ADCYAP1R1 ADCYAP receptor type I JBrowse link 18 41,915,180 41,972,327 RGD:6480464
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit JBrowse link 14 11,193,732 11,204,334 RGD:6480464
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 7 47,361,710 47,382,743 RGD:6480464
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 142,803,697 142,937,124 RGD:6480464
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit JBrowse link 8 31,430,933 31,456,385 RGD:6480464
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 4 95,196,992 95,211,084 RGD:6480464
acetylsalicylic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 1 265,930,044 265,934,959 RGD:6480464
G PLA2G1B phospholipase A2 group IB JBrowse link 14 40,314,520 40,322,315 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 9 127,850,164 127,858,866 RGD:6480464
arotinoid acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FABP4 fatty acid binding protein 4, adipocyte JBrowse link 4 55,096,400 55,101,209 RGD:6480464
G GPD1 glycerol-3-phosphate dehydrogenase 1 JBrowse link 5 16,008,179 16,021,676 RGD:6480464
G NR2F1 nuclear receptor subfamily 2 group F member 1 JBrowse link 2 100,447,661 100,457,510 RGD:6480464
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 13 68,301,566 68,433,951 RGD:6480464
G RXRA retinoid X receptor alpha JBrowse link 1 273,698,842 273,797,622 RGD:6480464
G SREBP-1 sterol regulatory element binding protein 1 RGD:6480464
benazepril term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KNG1 kininogen 1 JBrowse link 13 124,521,276 124,557,384 RGD:6480464
clofibrate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACO1 aconitase 1 JBrowse link 10 33,937,833 34,001,895 RGD:6480464
G ACOX1 acyl-CoA oxidase 1 JBrowse link 12 5,450,913 5,479,550 RGD:6480464
G AGT angiotensinogen JBrowse link 14 59,643,030 59,656,835 RGD:6480464
G ALB albumin JBrowse link 8 69,643,427 69,663,152 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 6 54,222,341 54,228,150 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 17 35,366,139 35,415,798 RGD:6480464
G CAT catalase JBrowse link 2 26,493,664 26,533,881 RGD:6480464
G CPT1A carnitine palmitoyltransferase 1A JBrowse link 2 4,250,642 4,293,914 RGD:6480464
G CTSB cathepsin B JBrowse link 14 15,014,139 15,035,081 RGD:6480464
G DIO2 iodothyronine deiodinase 2 JBrowse link 7 103,096,414 103,110,749 RGD:6480464
G EDN1 endothelin 1 JBrowse link 7 8,752,018 8,758,354 RGD:6480464
G FABP1 fatty acid binding protein 1 JBrowse link 3 57,850,511 57,854,966 RGD:6480464
G GPX1 glutathione peroxidase 1 JBrowse link 13 31,916,269 31,917,337 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 153,686,425 153,687,635 RGD:6480464
G KNG1 kininogen 1 JBrowse link 13 124,521,276 124,557,384 RGD:6480464
G LOC110260333 hydroxymethylglutaryl-CoA synthase, mitochondrial-like JBrowse link 4 101,385,486 101,404,273 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 4 12,455,141 12,460,360 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 18 6,209,218 6,228,912 RGD:6480464
G PPARA peroxisome proliferator activated receptor alpha JBrowse link 5 3,302,755 3,321,091 RGD:6480464
G SCD stearoyl-CoA desaturase JBrowse link 14 111,461,560 111,478,033 RGD:6480464
G SLC5A5 solute carrier family 5 member 5 JBrowse link 2 59,869,157 59,885,086 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 13 195,326,573 195,335,273 RGD:6480464
G THRA thyroid hormone receptor alpha JBrowse link 12 22,270,506 22,296,684 RGD:6480464
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:6480464
G TPO thyroid peroxidase JBrowse link 3 132,384,677 132,409,750 RGD:6480464
G TSHR thyroid stimulating hormone receptor JBrowse link 7 103,768,260 103,925,777 RGD:6480464
G TTR transthyretin JBrowse link 6 115,496,338 115,503,974 RGD:6480464
diethyl maleate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PRDX2 peroxiredoxin 2 JBrowse link 2 66,207,829 66,211,474 RGD:6480464
ethanol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACADL acyl-CoA dehydrogenase long chain JBrowse link 15 112,935,631 112,969,381 RGD:6480464
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 JBrowse link 9 57,090,313 57,113,077 RGD:6480464
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 JBrowse link 7 24,205,930 24,208,430 RGD:6480464
G AGPS alkylglycerone phosphate synthase JBrowse link 15 83,146,063 83,285,905 RGD:6480464
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 JBrowse link 4 85,029,914 85,057,650 RGD:6480464
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 14 90,859,209 90,907,084 RGD:6480464
G APP amyloid beta precursor protein JBrowse link 13 189,434,854 189,716,120 RGD:6480464
G ARSK arylsulfatase family member K JBrowse link 2 102,164,089 102,210,293 RGD:6480464
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 JBrowse link 4 50,694,188 50,749,373 RGD:6480464
G C5H12orf57 chromosome 5 C12orf57 homolog JBrowse link 5 63,779,510 63,781,307 RGD:6480464
G CBS cystathionine beta-synthase JBrowse link 13 206,205,942 206,231,363 RGD:6480464
G CCNB1IP1 cyclin B1 interacting protein 1 JBrowse link 7 78,553,680 78,576,057 RGD:6480464
G CD109 CD109 molecule JBrowse link 1 92,081,675 92,241,079 RGD:6480464
G CD47 CD47 molecule JBrowse link 13 151,427,933 151,488,064 RGD:6480464
G CLDN4 claudin 4 JBrowse link 3 11,039,711 11,053,930 RGD:6480464
G CLU clusterin JBrowse link 14 11,336,585 11,352,569 RGD:6480464
G CTH cystathionine gamma-lyase JBrowse link 6 142,454,922 142,486,352 RGD:6480464
G CYP51 cytochrome P450, family 51, subfamily A, polypeptide 1 JBrowse link 9 72,057,506 72,079,587 RGD:6480464
G EEF2 eukaryotic translation elongation factor 2 JBrowse link 2 74,746,541 74,756,687 RGD:6480464
G EIF3L eukaryotic translation initiation factor 3 subunit L JBrowse link 5 9,970,013 9,996,086 RGD:6480464
G FBLN2 fibulin 2 JBrowse link 13 70,757,255 70,830,430 RGD:6480464
G FKBP1A FKBP prolyl isomerase 1A JBrowse link 17 33,910,047 33,935,212 RGD:6480464
G FUCA1 alpha-L-fucosidase 1 JBrowse link 6 81,638,213 81,655,993 RGD:6480464
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 1 140,566,443 140,906,516 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 7 27,209,565 27,253,535 RGD:6480464
G GPX6 glutathione peroxidase 6 JBrowse link 7 22,256,013 22,267,992 RGD:6480464
G GRTP1 growth hormone regulated TBC protein 1 JBrowse link 11 78,618,720 78,637,502 RGD:6480464
G GSR glutathione-disulfide reductase JBrowse link 15 54,382,564 54,433,989 RGD:6480464
G GSS glutathione synthetase JBrowse link 17 38,316,199 38,342,253 RGD:6480464
G GSTA1 glutathione S-transferase alpha 1 JBrowse link 7 46,538,743 46,550,781 RGD:6480464
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 JBrowse link 12 20,269,468 20,271,349 RGD:6480464
G HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 JBrowse link 6 54,125,229 54,144,143 RGD:6480464
G HTRA1 HtrA serine peptidase 1 JBrowse link 14 132,043,044 132,103,590 RGD:6480464
G ITIH5 inter-alpha-trypsin inhibitor heavy chain 5 JBrowse link 10 63,688,416 63,764,566 RGD:6480464
G KIAA1217 KIAA1217 JBrowse link 10 50,706,713 51,032,010 RGD:6480464
G KRT6A keratin 6A JBrowse link 5 17,830,147 17,851,113 RGD:6480464
G LOC100513346 mitochondrial import inner membrane translocase subunit TIM16 JBrowse link 3 37,928,098 38,005,619 RGD:6480464
G MAP1S microtubule associated protein 1S JBrowse link 2 60,003,116 60,043,133 RGD:6480464
G MIOX myo-inositol oxygenase JBrowse link 5 249,312 251,547 RGD:6480464
G MKNK2 MAPK interacting serine/threonine kinase 2 JBrowse link 2 76,510,302 76,522,885 RGD:6480464
G NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 JBrowse link 9 23,106,795 23,161,825 RGD:6480464
G PLEKHO1 pleckstrin homology domain containing O1 JBrowse link 4 98,924,115 98,934,610 RGD:6480464
G PRKD3 protein kinase D3 JBrowse link 3 102,840,666 102,949,128 RGD:6480464
G PRNP prion protein JBrowse link 17 13,694,195 13,705,126 RGD:6480464
G RPL13A ribosomal protein L13a JBrowse link 6 54,551,772 54,568,752 RGD:6480464
G SAFB scaffold attachment factor B JBrowse link 2 73,300,624 73,334,494 RGD:6480464
G SLC7A4 solute carrier family 7 member 4 JBrowse link 14 50,631,693 50,638,381 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 13 195,326,573 195,335,273 RGD:6480464
G SOD2 superoxide dismutase 2 JBrowse link 1 7,679,352 7,689,564 RGD:6480464
G SRGN serglycin JBrowse link 14 72,183,368 72,199,262 RGD:6480464
G STXBP2 syntaxin binding protein 2 JBrowse link 2 71,504,575 71,513,446 RGD:6480464
G TIMP2 TIMP metallopeptidase inhibitor 2 JBrowse link 12 3,254,794 3,300,835 RGD:6480464
G TMEM98 transmembrane protein 98 JBrowse link 12 42,087,691 42,101,152 RGD:6480464
G TNNI3 troponin I3, cardiac type JBrowse link 6 59,366,828 59,377,490 RGD:6480464
G TRAPPC5 trafficking protein particle complex 5 JBrowse link 2 71,470,441 71,472,614 RGD:6480464
G TRPT1 tRNA phosphotransferase 1 JBrowse link 2 7,876,028 7,887,589 RGD:6480464
G WFDC1 WAP four-disulfide core domain 1 JBrowse link 6 4,333,729 4,365,122 RGD:6480464
G WNT5B Wnt family member 5B JBrowse link 5 68,627,158 68,731,938 RGD:6480464
malathion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COX1 cytochrome c oxidase subunit I JBrowse link MT 6,511 8,055 RGD:6480464
G COX3 cytochrome c oxidase subunit III JBrowse link MT 9,800 10,583 RGD:6480464
nicotine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADCYAP1 adenylate cyclase activating polypeptide 1 JBrowse link 6 105,414,628 105,422,294 RGD:6480464
G ADCYAP1R1 ADCYAP receptor type I JBrowse link 18 41,915,180 41,972,327 RGD:6480464
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit JBrowse link 14 11,193,732 11,204,334 RGD:6480464
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 7 47,361,710 47,382,743 RGD:6480464
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 142,803,697 142,937,124 RGD:6480464
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit JBrowse link 8 31,430,933 31,456,385 RGD:6480464
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 4 95,196,992 95,211,084 RGD:6480464
ochratoxin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 RGD:6480464
G ANXA5 annexin A5 JBrowse link 8 102,387,833 102,420,868 RGD:6480464
G ATG5 autophagy related 5 JBrowse link 1 72,343,950 72,520,402 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 1 158,337,403 158,518,214 RGD:6480464
G BECN1 beclin 1 JBrowse link 12 20,041,914 20,054,249 RGD:6480464
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:6480464
G CAT catalase JBrowse link 2 26,493,664 26,533,881 RGD:6480464
G CRYAB crystallin alpha B JBrowse link 9 39,638,505 39,643,530 RGD:6480464
G CYP2A19 cytochrome P450 2A19 JBrowse link 6 49,056,579 49,064,111 RGD:6480464
G DAD1 defender against cell death 1 JBrowse link 7 76,432,040 76,457,403 RGD:6480464
G DNMT1 DNA methyltransferase 1 JBrowse link 2 68,981,564 69,040,364 RGD:6480464
G DNMT3A DNA methyltransferase 3 alpha JBrowse link 3 113,501,972 113,609,148 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 7 27,209,565 27,253,535 RGD:6480464
G GLMN glomulin, FKBP associated protein JBrowse link 4 124,773,957 124,813,336 RGD:6480464
G GSTA1 glutathione S-transferase alpha 1 JBrowse link 7 46,538,743 46,550,781 RGD:6480464
G HDAC1 histone deacetylase 1 JBrowse link 6 88,749,611 88,785,220 RGD:6480464
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 5 80,511,513 80,531,016 RGD:6480464
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 1 265,930,044 265,934,959 RGD:6480464
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 15 101,360,355 101,373,498 RGD:6480464
G ID2 inhibitor of DNA binding 2 JBrowse link 3 127,500,759 127,503,207 RGD:6480464
G IGFBP2 insulin like growth factor binding protein 2 JBrowse link 15 118,822,092 118,850,985 RGD:6480464
G IL1A interleukin 1 alpha JBrowse link 3 43,718,320 43,731,668 RGD:6480464
G IL2 interleukin 2 JBrowse link 8 101,640,938 101,645,683 RGD:6480464
G IL4 interleukin 4 JBrowse link 2 134,986,817 134,994,365 RGD:6480464
G IL6 interleukin 6 JBrowse link 9 91,506,421 91,510,830 RGD:6480464
G JAK2 Janus kinase 2 JBrowse link 1 216,849,744 217,002,310 RGD:6480464
G LOC100522201 histone H2AX JBrowse link 9 46,308,824 46,310,494 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 14 50,083,079 50,165,528 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:6480464
G MTOR mechanistic target of rapamycin kinase JBrowse link 6 71,286,989 71,412,913 RGD:6480464
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 13 22,976,951 22,979,568 RGD:6480464
G NEIL1 nei like DNA glycosylase 1 JBrowse link 7 58,261,761 58,269,001 RGD:6480464
G NEIL3 nei like DNA glycosylase 3 JBrowse link 15 39,416,073 39,632,313 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 15 82,967,485 83,146,185 RGD:6480464
G NPM1 nucleophosmin 1 JBrowse link 16 52,767,263 52,781,862 RGD:6480464
G OGG1 8-oxoguanine DNA glycosylase JBrowse link 13 66,038,669 66,045,478 RGD:6480464
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 10 14,203,157 14,241,164 RGD:6480464
G PCK1 phosphoenolpyruvate carboxykinase 1 JBrowse link 17 57,930,507 57,936,523 RGD:6480464
G PFDN5 prefoldin subunit 5 JBrowse link 5 18,512,637 18,516,928 RGD:6480464
G PPIA peptidylprolyl isomerase A JBrowse link 18 50,563,130 50,566,857 RGD:6480464
G PRDX1 peroxiredoxin 1 JBrowse link 6 165,847,390 165,859,918 RGD:6480464
G PTMA prothymosin alpha JBrowse link 15 132,353,763 132,361,442 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 2 6,594,869 6,602,684 RGD:6480464
G RPS5 ribosomal protein S5 JBrowse link 6 62,967,955 62,974,353 RGD:6480464
G SOCS3 suppressor of cytokine signaling 3 JBrowse link 12 3,643,832 3,647,015 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 13 195,326,573 195,335,273 RGD:6480464
G SQSTM1 sequestosome 1 JBrowse link 2 78,752,768 78,763,998 RGD:6480464
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:6480464
G SUMO1 small ubiquitin like modifier 1 JBrowse link 15 105,820,237 105,850,099 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 6 49,332,169 49,348,642 RGD:6480464
G TIMP2 TIMP metallopeptidase inhibitor 2 JBrowse link 12 3,254,794 3,300,835 RGD:6480464
G TJP1 tight junction protein 1 JBrowse link 1 144,930,387 145,195,857 RGD:6480464
G TLR4 toll like receptor 4 JBrowse link 1 258,044,610 258,054,641 RGD:6480464
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:6480464
G TP53 tumor protein p53 JBrowse link 12 52,939,643 52,953,786 RGD:6480464
G XPA XPA, DNA damage recognition and repair factor JBrowse link 1 239,532,331 239,568,589 RGD:6480464
salubrinal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EIF2A eukaryotic translation initiation factor 2A JBrowse link 13 90,761,453 90,804,274 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 838
    role 815
      biological role 815
        aetiopathogenetic role 421
          teratogenic agent 153
            (S)-nicotine + 7
            (S)-thalidomide + 0
            1,1-dimethylhydrazine 0
            2-(2-methoxyethoxy)ethanol 0
            2-amino-6-hydroxyaminopurine 0
            2-ethoxyethanol + 0
            6-aminonicotinamide 0
            BMS-453 0
            Evans blue 0
            Evans blue free acid 0
            N(6)-hydroxyadenine 0
            N-methyl-N-nitrosourea 0
            acetaldehyde + 1
            acetylsalicylic acid + 3
            ammodendrine 0
            anabasine + 0
            arotinoid acid 6
            azetidine-2-carboxylic acid + 0
            busulfan 0
            dibutyl phthalate 0
            diethyl phthalate 0
            diisobutyl phthalate 0
            dinocap 0
            ethanol + 87
            ethyl methanesulfonate 0
            flubendazole 0
            flumioxazin 0
            flumipropyn 0
            hadacidin 0
            hydroxyurea 0
            isotretinoin 0
            malachite green 0
            mevinolinic acid 0
            nicotine + 7
            ochratoxin A + 55
            phenytoin 0
            solasodine 0
            soraphen A 0
            tazarotene 0
            tazarotenic acid + 0
            thalidomide + 0
            valproic acid + 0
            valpromide 0
            vismodegib 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.