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ONTOLOGY REPORT - ANNOTATIONS


Term:PP121
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Accession:CHEBI:50915 term browser browse the term
Definition:A pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidine which is substituted by a cyclopentyl, 1H-pyrrolo[2,3-b]pyridin-5-yl, and amino groups at positions 1, 3 and 4, respectively. It is a dual inhibitor of tyrosine and phosphoinositide kinases and exhibits anti-cancer properties.
Synonyms:exact_synonym: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
 related_synonym: Formula=C17H17N7;   InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22);   InChIKey=NVRXTLZYXZNATH-UHFFFAOYSA-N;   PP-121;   SMILES=C1(=NC=NC2=C1C(=NN2C3CCCC3)C=4C=NC=5NC=CC5C4)N
 xref: CAS:1092788-83-4;   DrugBank:DB08052;   PDBeChem:KS1;   PMID:18849971;   PMID:23596204;   PMID:24867098;   PMID:26056008;   PMID:26235881;   PMID:26514495;   PMID:27135311;   PMID:27886301;   PMID:31562255


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  CHEBI ontology 19789
    role 19735
      application 19381
        pharmaceutical 19251
          drug 19251
            antineoplastic agent 16918
              PP121 0
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  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19415
                        hydrogen molecular entity 19405
                          hydrides 18376
                            inorganic hydride 17224
                              pnictogen hydride 17187
                                nitrogen hydride 17021
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        aromatic amine 13627
                                          PP121 0
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