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Term:EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
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Accession:CHEBI:50925 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Synonyms:related_synonym: A-kinase inhibitor;   A-kinase inhibitors;   AP50 kinase inhibitor;   AP50 kinase inhibitors;   ATP-protein transphosphorylase inhibitor;   ATP-protein transphosphorylase inhibitors;   ATP:protein phosphotransferase (non-specific) inhibitor;   ATP:protein phosphotransferase (non-specific) inhibitors;   BR serine/threonine-protein kinase 2 inhibitor;   BR serine/threonine-protein kinase 2 inhibitors;   CK-2 inhibitor;   CK-2 inhibitors;   CKI inhibitor;   CKI inhibitors;   CKII inhibitor;   CKII inhibitors;   EC 2.7.11.1 inhibitor;   EC 2.7.11.1 inhibitors;   HIPK2 inhibitor;   HIPK2 inhibitors;   Hpr kinase inhibitor;   Hpr kinase inhibitors;   M phase-specific cdc2 kinase inhibitor;   M phase-specific cdc2 kinase inhibitors;   MKNK2 inhibitor;   MKNK2 inhibitors;   PAK-1 inhibitor;   PAK-1 inhibitors;   PAK1 inhibitor;   PAK1 inhibitors;   PKA inhibitor;   PKA inhibitors;   Prp4 protein kinase inhibitor;   Prp4 protein kinase inhibitors;   Raf kinase inhibitor;   Raf kinase inhibitors;   Raf-1 inhibitor;   Raf-1 inhibitors;   STK32 inhibitor;   STK32 inhibitors;   T-antigen kinase inhibitor;   T-antigen kinase inhibitors;   WEE1Hu inhibitor;   WEE1Hu inhibitors;   Wee 1-like kinase inhibitor;   Wee 1-like kinase inhibitors;   Wee-kinase inhibitor;   Wee-kinase inhibitors;   betaIIPKC inhibitor;   betaIIPKC inhibitors;   cAMP-dependent protein kinase A inhibitor;   cAMP-dependent protein kinase A inhibitors;   cAMP-dependent protein kinase inhibitor;   cAMP-dependent protein kinase inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   calcium-dependent protein kinase C inhibitor;   calcium-dependent protein kinase C inhibitors;   calcium/phospholipid-dependent protein kinase inhibitor;   calcium/phospholipid-dependent protein kinase inhibitors;   casein kinase (phosphorylating) inhibitor;   casein kinase (phosphorylating) inhibitors;   casein kinase 2 inhibitor;   casein kinase 2 inhibitors;   casein kinase I inhibitor;   casein kinase I inhibitors;   casein kinase II inhibitor;   casein kinase II inhibitors;   casein kinase inhibitor;   casein kinase inhibitors;   cyclic AMP-dependent protein kinase A inhibitor;   cyclic AMP-dependent protein kinase A inhibitors;   cyclic AMP-dependent protein kinase inhibitor;   cyclic AMP-dependent protein kinase inhibitors;   cyclic monophosphate-dependent protein kinase inhibitor;   cyclic monophosphate-dependent protein kinase inhibitors;   cyclic nucleotide-dependent protein kinase inhibitor;   cyclic nucleotide-dependent protein kinase inhibitors;   cyclin-dependent kinase inhibitor;   cyclin-dependent kinase inhibitors;   dsk1 inhibitor;   dsk1 inhibitors;   epsilon PKC inhibitor;   epsilon PKC inhibitors;   glycogen synthase a kinase inhibitor;   glycogen synthase a kinase inhibitors;   glycogen synthase kinase inhibitor;   glycogen synthase kinase inhibitors;   hydroxyalkyl-protein kinase inhibitor;   hydroxyalkyl-protein kinase inhibitors;   mitogen-activated S6 kinase inhibitor;   mitogen-activated S6 kinase inhibitors;   non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors;   non-specific serine/threonine protein kinase inhibitor;   non-specific serine/threonine protein kinase inhibitors;   p21 activated kinase-1 inhibitor;   p21 activated kinase-1 inhibitors;   p82 kinase inhibitor;   p82 kinase inhibitors;   phosphorylase b kinase kinase inhibitor;   phosphorylase b kinase kinase inhibitors;   protein glutamyl kinase inhibitor;   protein glutamyl kinase inhibitors;   protein kinase (phosphorylating) inhibitor;   protein kinase (phosphorylating) inhibitors;   protein kinase A inhibitor;   protein kinase A inhibitors;   protein kinase CK2 inhibitor;   protein kinase CK2 inhibitors;   protein kinase p58 inhibitor;   protein kinase p58 inhibitors;   protein phosphokinase inhibitor;   protein phosphokinase inhibitors;   protein serine kinase inhibitor;   protein serine kinase inhibitors;   protein-aspartyl kinase inhibitor;   protein-aspartyl kinase inhibitors;   protein-cysteine kinase inhibitor;   protein-cysteine kinase inhibitors;   ribosomal S6 protein kinase inhibitor;   ribosomal S6 protein kinase inhibitors;   ribosomal protein S6 kinase II inhibitor;   ribosomal protein S6 kinase II inhibitors;   serine kinase inhibitor;   serine kinase inhibitors;   serine-specific protein kinase inhibitor;   serine-specific protein kinase inhibitors;   serine/threonine protein kinase inhibitor;   serine/threonine protein kinase inhibitors;   threonine-specific protein kinase inhibitor;   threonine-specific protein kinase inhibitors;   twitchin kinase inhibitor;   twitchin kinase inhibitors;   type-2 casein kinase inhibitor;   type-2 casein kinase inhibitors
 alt_id: CHEBI:75764


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Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      biological role 227
        inhibitor 113
          enzyme inhibitor 106
            EC 2.* (transferase) inhibitor 24
              EC 2.7.* (P-containing group transferase) inhibitor 20
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10
                  EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor 0
                    (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane 0
                    (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                    (\{6-[4-(methylsulfanyl)phenyl]thieno[3,2-d]pyrimidin-4-yl\}sulfanyl)acetic acid 0
                    2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                    6-bromoindirubin-3'-oxime 0
                    AKT1 kinase inhibitor + 0
                    AT7867 0
                    B-Raf inhibitor + 0
                    CIGB-300 0
                    CZC-25146 0
                    GSK690693 0
                    GW296115X 0
                    HG-10-102-01 0
                    IPA-3 0
                    LRRK2-IN-1 0
                    MLI-2 0
                    N-(2-[(2-aminoethyl)(methyl)amino]-5-\{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino\}phenyl)acetamide 0
                    N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 0
                    N-(2-methoxyethyl)-4-\{[6-(pyridin-4-yl)quinazolin-2-yl]amino\}benzamide 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine 0
                    OSU-03012 0
                    PF-00477736 0
                    PF-4800567 0
                    PF-670462 0
                    PF-670462 free base 0
                    SB 203580 0
                    Y-27632 0
                    alsterpaullone 0
                    caffeine + 0
                    hydrazinocurcumin 0
                    indirubin-3'-monoxime 0
                    quinalizarin 0
                    sorafenib + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      biological role 227
        inhibitor 113
          enzyme inhibitor 106
            EC 2.* (transferase) inhibitor 24
              EC 2.7.* (P-containing group transferase) inhibitor 20
                protein kinase inhibitor 13
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10
                    EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor 0
                      (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane 0
                      (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                      (\{6-[4-(methylsulfanyl)phenyl]thieno[3,2-d]pyrimidin-4-yl\}sulfanyl)acetic acid 0
                      2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                      6-bromoindirubin-3'-oxime 0
                      AKT1 kinase inhibitor + 0
                      AT7867 0
                      B-Raf inhibitor + 0
                      CIGB-300 0
                      CZC-25146 0
                      GSK690693 0
                      GW296115X 0
                      HG-10-102-01 0
                      IPA-3 0
                      LRRK2-IN-1 0
                      MLI-2 0
                      N-(2-[(2-aminoethyl)(methyl)amino]-5-\{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino\}phenyl)acetamide 0
                      N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 0
                      N-(2-methoxyethyl)-4-\{[6-(pyridin-4-yl)quinazolin-2-yl]amino\}benzamide 0
                      N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                      N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine 0
                      OSU-03012 0
                      PF-00477736 0
                      PF-4800567 0
                      PF-670462 0
                      PF-670462 free base 0
                      SB 203580 0
                      Y-27632 0
                      alsterpaullone 0
                      caffeine + 0
                      hydrazinocurcumin 0
                      indirubin-3'-monoxime 0
                      quinalizarin 0
                      sorafenib + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.