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Term:fludrocortisone acetate
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Accession:CHEBI:5102 term browser browse the term
Definition:An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
Synonyms:exact_synonym: 9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
 related_synonym: (11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;   9alpha-fluorohydrocortisone 21-acetate;   9alpha-fluorohydrocortisone acetate;   Alflorone;   Alflorone acetate;   Cortineff;   F-Cortef;   F-Cortef acetate;   Florinef;   Florinef acetate;   Formula=C23H31FO6;   InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1;   InChIKey=SYWHXTATXSMDSB-GSLJADNHSA-N;   SMILES=CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C;   Scherofluron;   U 4845;   fludrocortisone 21-acetate;   fluohydrocortisone acetate;   fluorocortisone acetate
 xref: CAS:514-36-3 "ChemIDplus";   CAS:514-36-3 "KEGG COMPOUND";   Drug_Central:1191 "DrugCentral";   KEGG:C08186;   KEGG:D00986;   PMID:13271122 "Europe PMC";   PMID:13361498 "Europe PMC";   PMID:18193551 "Europe PMC";   PMID:24316163 "Europe PMC";   PMID:3197346 "Europe PMC";   PMID:438959 "Europe PMC";   PMID:8164382 "Europe PMC";   PMID:8248344 "Europe PMC";   Patent:US2957013;   Reaxys:3019450 "Reaxys"

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  CHEBI ontology 19716
    chemical entity 19714
      group 19628
        organic group 18407
          3-oxo-Delta(4)-steroid group 7910
            3-oxo-Delta(4) steroid 7910
              fludrocortisone acetate 0
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  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      ketone 15909
                                        oxyketone 8447
                                          alpha-oxyketone 8447
                                            alpha-hydroxy ketone 8447
                                              tertiary alpha-hydroxy ketone 8262
                                                fludrocortisone acetate 0
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