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ONTOLOGY REPORT - ANNOTATIONS


Term:flurazepam
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Accession:CHEBI:5128 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.
Synonyms:exact_synonym: 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
 related_synonym: Formula=C21H23ClFN3O;   InChI=1S/C21H23ClFN3O/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23/h5-10,13H,3-4,11-12,14H2,1-2H3;   InChIKey=SAADBVWGJQAEFS-UHFFFAOYSA-N;   Insumin;   Ro 5-6901;   SMILES=C(CN(CC)CC)N1C=2C(C(=NCC1=O)C3=CC=CC=C3F)=CC(=CC2)Cl;   flurazepamum
 xref: CAS:17617-23-1 "ChemIDplus";   CAS:17617-23-1 "KEGG COMPOUND";   CAS:17617-23-1 "NIST Chemistry WebBook";   DrugBank:DB00690;   Drug_Central:1218 "DrugCentral";   HMDB:HMDB0014828;   KEGG:D00329
 xref_mesh: MESH:D005479
 xref: PDBeChem:FL7;   PMID:16501350 "Europe PMC";   PMID:20002022 "Europe PMC";   PMID:23035248 "Europe PMC";   PMID:2863335 "Europe PMC";   Wikipedia:Flurazepam


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flurazepam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:6480464
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Trh thyrotropin releasing hormone JBrowse link 4 124,110,716 124,113,242 RGD:6480464
G Trhr thyrotropin releasing hormone receptor JBrowse link 7 83,113,641 83,153,520 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        refrigerant 17091
          ammonia 16690
            organic amino compound 16689
              tertiary amino compound 8527
                flurazepam 5
                  hydroxyethylflurazepam 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  azane 16693
                                    ammonia 16690
                                      organic amino compound 16689
                                        tertiary amino compound 8527
                                          flurazepam 5
                                            hydroxyethylflurazepam 0
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