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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organic univalent group
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Accession:CHEBI:51447 term browser browse the term


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions
EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein CTD PMID:17658243 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Nafenopin CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
9-cis-retinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of 9-cis-retinal CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
all-trans-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Tretinoin results in increased activity of CASP3 protein CTD PMID:16953078 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CLDN1 claudin 1 multiple interactions
increases expression
EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]
Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein
CTD PMID:17035595 NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033
JBrowse link
G CLDN4 claudin 4 increases expression
multiple interactions
EXP Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]
CTD PMID:17035595 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases degradation
multiple interactions
EXP CYP26A1 protein results in increased degradation of Tretinoin
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD PMID:17035595 NCBI chr28:7,423,955...7,432,359
Ensembl chr28:7,428,772...7,432,370
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein CTD PMID:17267746 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G OCLN occludin multiple interactions
increases expression
EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]
Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein
CTD PMID:17035595 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
JBrowse link
G TJP1 tight junction protein 1 increases expression
multiple interactions
EXP Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD PMID:17035595 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574
JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
arachidonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985
JBrowse link
bis(2-ethylhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Diethylhexyl Phthalate results in increased activity of NR1I3 protein CTD PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Sulfobromophthalein results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Sulfobromophthalein CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export EXP ABCC1 protein affects the export of calcein AM CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1B 5-hydroxytryptamine receptor 1B multiple interactions EXP HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] CTD PMID:16880765 NCBI chr12:38,659,088...38,659,546 JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity
EXP JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17392452 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926
JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions
EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]
CTD PMID:14617759, PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Cilostazol results in decreased expression of MYC mRNA CTD PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP Clofibrate results in increased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain increases expression EXP Clofibrate results in increased expression of ACADVL protein CTD PMID:19952500 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990
JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Clofibrate results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767
JBrowse link
G ASL argininosuccinate lyase increases expression EXP Clofibrate results in increased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424
JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Clofibrate results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 increases expression EXP Clofibrate results in increased expression of CPS1 protein CTD PMID:19952500 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697
JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP Clofibrate results in increased expression of CPT2 mRNA CTD PMID:19952500 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Clofibrate results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Clofibrate results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350
JBrowse link
G CYP2B6 cytochrome P450 2B11 decreases expression EXP Clofibrate results in decreased expression of CYP2B6 mRNA CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
G CYP2C18 cytochrome P450 2C21 decreases expression EXP Clofibrate results in decreased expression of CYP2C18 mRNA CTD PMID:19952500 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Clofibrate results in increased expression of CYP2E1 protein CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases expression EXP Clofibrate results in decreased expression of CYP3A12 mRNA CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 decreases expression EXP Clofibrate results in decreased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G CYP4A37 cytochrome P450 4A37 increases expression EXP Clofibrate results in increased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,604,130...13,623,797 JBrowse link
G DLST dihydrolipoamide S-succinyltransferase increases expression EXP Clofibrate results in increased expression of DLST protein CTD PMID:19952500 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 increases expression EXP Clofibrate results in increased expression of ECHS1 protein CTD PMID:19952500 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167
JBrowse link
G GDI1 GDP dissociation inhibitor 1 increases expression EXP Clofibrate results in increased expression of GDI1 protein CTD PMID:19952500 NCBI chr  X:122,141,633...122,146,724
Ensembl chr  X:122,141,566...122,146,824
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Clofibrate results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Clofibrate results in decreased expression of GSTK1 mRNA CTD PMID:19952500 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Clofibrate results in decreased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase increases expression EXP Clofibrate results in increased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clofibrate results in increased expression of HSPD1 protein CTD PMID:19952500 NCBI chr37:7,010,421...7,025,912 JBrowse link
G KRT1 keratin 1 increases expression EXP Clofibrate results in increased expression of KRT1 protein CTD PMID:19952500 NCBI chr27:2,422,150...2,427,160 JBrowse link
G KRT18 keratin 18 decreases expression EXP Clofibrate results in decreased expression of KRT18 protein CTD PMID:19952500 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368
JBrowse link
G LOC100855679 serine--pyruvate aminotransferase, mitochondrial decreases expression EXP Clofibrate results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G LOC474938 glutathione S-transferase A2 decreases expression EXP Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC479911 glutathione S-transferase Mu 3 decreases expression EXP Clofibrate results in decreased expression of GSTM1 mRNA; Clofibrate results in decreased expression of GSTM5 mRNA CTD PMID:19952500 NCBI chr 6:42,187,869...42,191,274 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Clofibrate results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
JBrowse link
G PC pyruvate carboxylase increases expression EXP Clofibrate results in increased expression of PC protein CTD PMID:19952500 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669
JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression EXP Clofibrate results in increased expression of PCK2 protein CTD PMID:19952500 NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865
JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Clofibrate results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Clofibrate results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 decreases expression EXP Clofibrate results in decreased expression of SHMT1 protein CTD PMID:19952500 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Clofibrate results in decreased expression of UGP2 protein CTD PMID:19952500 NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452
JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP Clofibrate results in increased expression of UQCRC1 protein CTD PMID:19952500 NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110
JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Clofibrate results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141
JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases abundance EXP INS protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
desferrioxamine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
emodepside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 protein affects the susceptibility to emodepside CTD PMID:25660379 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Enalapril results in decreased expression of KCND3 mRNA CTD PMID:19732978 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035
JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA] CTD PMID:12019275 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NPPA natriuretic peptide A decreases expression
multiple interactions
EXP Enalapril results in decreased expression of NPPA protein
FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein]
CTD PMID:12019275 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G REN renin increases activity
multiple interactions
EXP Enalapril results in increased activity of REN protein
[Enalapril co-treated with FR 173657] results in increased activity of REN protein
CTD PMID:12019275 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Etodolac results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases activity EXP Fenfluramine results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] CTD PMID:21334356, PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Ibuprofen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ibuprofen results in increased expression of PTGS2 protein CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
leukotriene C4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects transport EXP ABCC1 protein affects the transport of Leukotriene C4 CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Leukotriene C4 CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
lithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Lithocholic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
increases export
EXP ABCB1 protein affects the susceptibility to Loperamide
ABCB1 protein results in increased export of Loperamide
CTD PMID:25660379, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
marbofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA] CTD PMID:31005593 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G FADD Fas associated via death domain increases expression EXP marbofloxacin results in increased expression of FADD mRNA CTD PMID:31005593 NCBI chr18:48,087,447...48,094,497 JBrowse link
G TNF tumor necrosis factor increases expression EXP marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein CTD PMID:31005593 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]
marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:31005593 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] CTD PMID:31005593 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion
EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion
EXP G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] CTD PMID:21334356 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A9 solute carrier family 6 member 9 affects localization
multiple interactions
EXP Monensin affects the localization of SLC6A9 protein
Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]
CTD PMID:19473961 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
nafenopin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Nafenopin CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
nefiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 affects expression
increases expression
EXP nefiracetam affects the expression of PTGS2 mRNA
nefiracetam results in increased expression of PTGS2 protein
CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]
CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
JBrowse link
G RUNX2 RUNX family transcription factor 2 decreases expression
increases acetylation
multiple interactions
EXP Niacinamide results in decreased expression of RUNX2 protein
Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]
CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]
CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Acetaminophen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 increases glucuronidation EXP UGT1A6 protein results in increased glucuronidation of Acetaminophen CTD PMID:11903872 NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941
JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of phenylglyoxylic acid CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G SLC6A9 solute carrier family 6 member 9 multiple interactions
affects localization
EXP Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]
Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein
CTD PMID:19473961 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933
JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458
JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
increases expression
EXP pitavastatin results in increased activity of NOS3 protein
pitavastatin results in increased expression of NOS3 mRNA
CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277
JBrowse link
prochloraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Dinoprostone results in increased expression of REN protein CTD PMID:495730 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression
multiple interactions
EXP Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein
CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G EGR1 early growth response 1 multiple interactions
affects expression
EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein
CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 affects expression
multiple interactions
EXP Ranolazine affects the expression of GATA4 protein
[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein
CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G NAB1 NGFI-A binding protein 1 affects expression
multiple interactions
EXP Ranolazine affects the expression of NAB1 protein
[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein
CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression
multiple interactions
EXP Ranolazine affects the expression of SLC8A1 protein
[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein
CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein CTD PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Rifampin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Ritonavir results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Saquinavir CTD PMID:12702717 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
SDZ PSC 833 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:15492788, PMID:24975508 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
silodosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486
JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases expression
decreases expression
EXP Simvastatin results in increased expression of NOS3 protein
Simvastatin results in decreased expression of NOS3 mRNA
CTD PMID:11087217 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
sincalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Sincalide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
SR 144528 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 multiple interactions EXP SR 144528 binds to and results in decreased activity of CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
succimer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase multiple interactions EXP [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions
EXP BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
CTD PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Sulindac results in decreased expression of PTGS2 protein CTD PMID:12857884 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP Sulindac results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
Temocaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of temocaprilat CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
tetradecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Myristic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Thapsigargin results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP tolfenamic acid results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Troleandomycin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
urea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Urea results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Urea results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
valproic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Valproic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
vasopressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins] CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
multiple interactions
affects response to substance
EXP ABCB1 protein results in increased export of Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]
CTD PMID:24975508, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383
JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476
JBrowse link
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP Win 55212-2 binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    chemical entity 227
      group 220
        organic group 154
          organic univalent group 115
            organoheteryl group + 0
            organyl group + 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    subatomic particle 227
      composite particle 227
        hadron 227
          baryon 227
            nucleon 227
              atomic nucleus 227
                atom 227
                  main group element atom 220
                    p-block element atom 220
                      carbon group element atom 208
                        carbon group molecular entity 208
                          organic molecular entity 207
                            organic group 154
                              organic univalent group 115
                                organoheteryl group + 0
                                organyl group + 115
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.