Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridine orange
go back to main search page
Accession:CHEBI:51739 term browser browse the term
Definition:Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.
Synonyms:exact_synonym: N,N,N',N'-tetramethylacridine-3,6-diamine hydrochloride
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Bis(dimethylamino)acridine hydrochloride;   C.I. 46005;   Formula=C17H19N3.ClH;   Formula=C17H20ClN3;   InChI=1S/C17H19N3.ClH/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;/h5-11H,1-4H3;1H;   InChIKey=VSTHNGLPHBTRMB-UHFFFAOYSA-N;   N3,N3,N6,N6-tetramethyl-3,6-Acridinediamine hydrochloride(1:1);   Rhoduline Orange;   SMILES=[H+].[Cl-].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   basic orange 14
 xref: Beilstein:3575587;   CAS:494-38-2;   CAS:65-61-2;   KEGG:C19315
 xref_mesh: MESH:D000165
 xref: Wikipedia:Acridine_orange


show annotations for term's descendants           Sort by:
 
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        dye 1299
          histological dye 150
            acridine orange 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterotricyclic compound 14586
                                      dibenzopyridine 154
                                        acridines 121
                                          aminoacridines 17
                                            acridine orange cation 3
                                              acridine orange 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.