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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorphenamine
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Accession:CHEBI:52010 term browser browse the term
Definition:A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Synonyms:exact_synonym: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
 related_synonym: 1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine;   1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane;   2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine;   3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine;   Chlorphenamin;   Chlorpheniramine;   Clofeniramina;   Formula=C16H19ClN2;   Haynon;   InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3;   InChIKey=SOYKEARSMXGVTM-UHFFFAOYSA-N;   SMILES=CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1;   chlorophenylpyridamine;   chlorphenaminum;   chlorpheniraminum;   clorfenamina;   clorfeniramina;   gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine;   gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
 alt_id: CHEBI:3644;   CHEBI:52008
 xref: Beilstein:87362;   CAS:132-22-9;   DrugBank:DB01114;   Drug_Central:616;   HMDB:HMDB0001944;   KEGG:C06905;   KEGG:D07398;   LINCS:LSM-1263
 xref_mesh: MESH:D002744
 xref: PMID:10796091;   PMID:11284026;   PMID:16119587;   PMID:16413139;   Patent:US2567245;   Patent:US2676964;   Patent:US2766174;   Reaxys:87362;   Wikipedia:Chlorpheniramine


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chlorphenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Chlorpheniramine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Chlorpheniramine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance ISO CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine CTD PMID:17089107 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity
ISO
EXP
Chlorpheniramine binds to and results in decreased activity of HRH1 protein
Chlorpheniramine results in decreased activity of HRH1 protein
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]
Chlorpheniramine binds to and results in decreased activity of HRH1 protein; Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]
CTD PMID:8111568 PMID:11432448 PMID:12128009 PMID:14569158 PMID:15054595 PMID:16143415 PMID:18360087 PMID:19075512 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine] CTD PMID:14569158 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
affects activity
multiple interactions
ISO Chlorpheniramine results in decreased activity of KCNH2 protein
Chlorpheniramine affects the activity of KCNH2 protein
Chlorpheniramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:16278312 PMID:19885040 PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions
EXP Chlorpheniramine results in decreased activity of MPO protein
Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]
CTD PMID:16437673 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein] CTD PMID:17622767 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP
ISO
Chlorpheniramine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Chlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:12440152 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
dexchlorpheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO dexchlorpheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        pharmacological role 18821
          antagonist 16219
            histamine antagonist 4606
              chlorphenamine 12
                dexchlorpheniramine 1
                levochlorpheniramine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          chlorphenamine 12
                                            dexchlorpheniramine 1
                                            levochlorpheniramine 0
paths to the root