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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
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Accession:CHEBI:52425 term browser browse the term
Definition:An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
Synonyms:related_synonym: EC 3.2.1.18 inhibitor;   EC 3.2.1.18 inhibitors;   N-acylneuraminate glycohydrolase inhibitor;   N-acylneuraminate glycohydrolase inhibitors;   Neuraminidase inhibitors;   acetylneuraminidase inhibitor;   acetylneuraminidase inhibitors;   acetylneuraminyl hydrolase inhibitor;   acetylneuraminyl hydrolase inhibitors;   alpha-neuraminidase inhibitor;   alpha-neuraminidase inhibitors;   exo-alpha-sialidase (EC 3.2.1.18) inhibitors;   exo-alpha-sialidase inhibitor;   exo-alpha-sialidase inhibitors;   neuraminidase inhibitor;   sialidase inhibitor;   sialidase inhibitors


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2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
CMP-N-acetyl-beta-neuraminic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase JBrowse link 4 176,994,129 177,012,445 RGD:6480464
N-acetylneuraminic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase JBrowse link 4 176,994,129 177,012,445 RGD:6480464
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase JBrowse link 5 59,511,738 59,553,421 RGD:6480464
G Nans N-acetylneuraminate synthase JBrowse link 5 62,109,352 62,126,492 RGD:6480464
oseltamivir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        antimicrobial agent 17230
          antimicrobial drug 6135
            antiviral drug 1782
              EC 3.2.1.18 (exo-alpha-sialidase) inhibitor 18
                (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
                (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                5alpha-ergosta-7,22-dien-3beta-ol 0
                7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                7-hydroxy-5-methoxy-6,8-dimethylisoflavone 0
                FR191512 0
                N-acetylneuraminic acid + 3
                apiin + 0
                fattiviracin A1 0
                fluvirucin A1 + 0
                ganoderone C 0
                oseltamivir + 4
                oseltamivir acid 0
                peramivir 0
                peramivir hydrate + 0
                strongylin A 0
                zanamivir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19361
        pharmaceutical 19230
          drug 19230
            antiinfective agent 12984
              antimicrobial drug 6135
                antiviral drug 1782
                  EC 3.2.1.18 (exo-alpha-sialidase) inhibitor 18
                    (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                    (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                    (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                    (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                    (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                    (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
                    (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                    2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                    2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                    5alpha-ergosta-7,22-dien-3beta-ol 0
                    7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                    7-hydroxy-5-methoxy-6,8-dimethylisoflavone 0
                    FR191512 0
                    N-acetylneuraminic acid + 3
                    apiin + 0
                    fattiviracin A1 0
                    fluvirucin A1 + 0
                    ganoderone C 0
                    oseltamivir + 4
                    oseltamivir acid 0
                    peramivir 0
                    peramivir hydrate + 0
                    strongylin A 0
                    zanamivir 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.