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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
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Accession:CHEBI:52425 term browser browse the term
Definition:An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
Synonyms:related_synonym: EC 3.2.1.18 inhibitor;   EC 3.2.1.18 inhibitors;   N-acylneuraminate glycohydrolase inhibitor;   N-acylneuraminate glycohydrolase inhibitors;   Neuraminidase inhibitors;   acetylneuraminidase inhibitor;   acetylneuraminidase inhibitors;   acetylneuraminyl hydrolase inhibitor;   acetylneuraminyl hydrolase inhibitors;   alpha-neuraminidase inhibitor;   alpha-neuraminidase inhibitors;   exo-alpha-sialidase (EC 3.2.1.18) inhibitors;   exo-alpha-sialidase inhibitor;   exo-alpha-sialidase inhibitors;   neuraminidase inhibitor;   sialidase inhibitor;   sialidase inhibitors


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2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
CMP-N-acetyl-beta-neuraminic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cmas cytidine monophospho-N-acetylneuraminic acid synthetase JBrowse link 6 142,756,686 142,775,714 RGD:6480464
N-acetylneuraminic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cmas cytidine monophospho-N-acetylneuraminic acid synthetase JBrowse link 6 142,756,686 142,775,714 RGD:6480464
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase JBrowse link 4 44,034,075 44,084,177 RGD:6480464
G Nans N-acetylneuraminic acid synthase (sialic acid synthase) JBrowse link 4 46,489,329 46,503,438 RGD:6480464
oseltamivir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 98,148,757 98,323,218 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 8 93,166,072 93,197,804 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Pgr progesterone receptor JBrowse link 9 8,898,900 8,968,611 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21269
    role 21253
      biological role 21251
        antimicrobial agent 18131
          antimicrobial drug 6276
            antiviral drug 1799
              EC 3.2.1.18 (exo-alpha-sialidase) inhibitor 18
                (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
                (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                5alpha-ergosta-7,22-dien-3beta-ol 0
                7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                7-hydroxy-5-methoxy-6,8-dimethylisoflavone 0
                FR191512 0
                N-acetylneuraminic acid + 3
                apiin + 0
                fattiviracin A1 0
                fluvirucin A1 + 0
                ganoderone C 0
                oseltamivir + 4
                oseltamivir acid 0
                peramivir 0
                peramivir hydrate + 0
                strongylin A 0
                zanamivir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21269
    role 21253
      application 20687
        pharmaceutical 20070
          drug 20070
            antiinfective agent 13504
              antimicrobial drug 6276
                antiviral drug 1799
                  EC 3.2.1.18 (exo-alpha-sialidase) inhibitor 18
                    (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                    (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                    (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                    (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 0
                    (2S,3S)-3,5,7-trihydroxy-6,8-dimethylflavanone 0
                    (5R)-5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone 0
                    (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                    2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                    2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                    5alpha-ergosta-7,22-dien-3beta-ol 0
                    7-hydroxy-5-methoxy-6,8-dimethylflavone 0
                    7-hydroxy-5-methoxy-6,8-dimethylisoflavone 0
                    FR191512 0
                    N-acetylneuraminic acid + 3
                    apiin + 0
                    fattiviracin A1 0
                    fluvirucin A1 + 0
                    ganoderone C 0
                    oseltamivir + 4
                    oseltamivir acid 0
                    peramivir 0
                    peramivir hydrate + 0
                    strongylin A 0
                    zanamivir 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.