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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:52617 term browser browse the term
Definition:An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.
Synonyms:related_synonym: 2-Amino-7,9-dihydro-1H-Purine-6,8-dione;   8-Hydroxyguanine;   8-oxoguanine;   Formula=C5H5N5O2;   InChI=1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12);   InChIKey=CLGFIVUFZRGQRP-UHFFFAOYSA-N;   SMILES=Nc1nc2[nH]c(=O)[nH]c2c(=O)[nH]1
 xref: CAS:5614-64-2
 xref_mesh: MESH:C024829

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7,8-dihydro-8-oxoguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin multiple interactions ISO [FXN gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased abundance of 8-hydroxyguanine CTD PMID:26954031 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Mt3 metallothionein 3 decreases abundance ISO MT3 protein results in decreased abundance of 8-hydroxyguanine CTD PMID:15190073 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases abundance
multiple interactions
ISO OGG1 protein results in decreased abundance of 7,8-dihydro-8-oxoguanine; OGG1 protein results in decreased abundance of 8-hydroxyguanine
OGG1 protein affects the reaction [Methamphetamine results in increased abundance of 7,8-dihydro-8-oxoguanine]
CTD PMID:18768699, PMID:21873502, PMID:21925250 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Wrn WRN RecQ like helicase decreases response to substance ISO WRN protein results in decreased susceptibility to 8-hydroxyguanine CTD PMID:25730140 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              algal metabolite 13593
                guanine 3972
                  7,8-dihydro-8-oxoguanine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          aminopurine 4398
                                            2-aminopurines 4008
                                              guanine 3972
                                                7,8-dihydro-8-oxoguanine 4
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.