Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:hycanthone
go back to main search page
Accession:CHEBI:52768 term browser browse the term
Definition:A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
Synonyms:related_synonym: 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one;   1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one;   1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one;   Formula=C20H24N2O2S;   Hycanthon;   InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3;   InChIKey=MFZWMTSUNYWVBU-UHFFFAOYSA-N;   Lucanthone metabolite;   SMILES=CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12;   hicantona;   hycanthonum
 xref: Beilstein:1402722 "Beilstein";   CAS:3105-97-3 "ChemIDplus";   CAS:3105-97-3 "KEGG DRUG";   Drug_Central:1383 "DrugCentral";   KEGG:D00541;   LINCS:LSM-5614
 xref_mesh: MESH:D006826
 xref: PMID:1888160 "Europe PMC";   PMID:21935361 "Europe PMC";   PMID:2957147 "Europe PMC";   PMID:5573958 "Europe PMC";   PMID:626982 "Europe PMC";   PMID:7369442 "Europe PMC";   Patent:NL6410359;   Patent:US3294803;   Patent:US3312598;   Reaxys:1402722 "Reaxys";   Wikipedia:Hycanthone
 cyclic_relationship: is_conjugate_base_of CHEBI:67141


show annotations for term's descendants       view all columns           Sort by:
 
hycanthone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        aetiopathogenetic role 18823
          genotoxin 16404
            mutagen 16057
              hycanthone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic molecule 19447
                              organic cyclic compound 19207
                                organic heterocyclic compound 18277
                                  organic heteropolycyclic compound 17583
                                    organic heterotricyclic compound 13736
                                      thioxanthenes 200
                                        lucanthone 193
                                          hycanthone 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.